JCO Precision Oncology @JCOPO_ASCO
Original research, reports, opinions, and reviews advancing the science and practice of #precisiononcology. Part of @JCO_ASCO family of journals. ascopubs.org/journal/po Joined July 2016-
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#JCOPO report showing #RET fusions may be a negative prognostic factor in patients w/ solid tumors w/ further emphasis for broader genomic testing since RET-specific TKIs for these tumors may improve outcomes beyond current standard of care options. ➡️ brnw.ch/21wJeRF
Data from @AACR GENIE Biopharma Collaborative cohort show timing of NGS after diagnosis varied significantly by clinical characteristics suggesting applied researchers should examine the sensitivity of their findings to the timing of genomic sequencing. ➡️ brnw.ch/21wJdft
Across >2,500 pts w/ #mNSCLC, timely CGP before 1L initiation w/ increased targeted therapy use decreased expenditure on ICPIs among ALK/EGFR/RET/ROS1 driver-positive pts supporting importance of timely CGP to inform optimal 1L therapy selection. ➡️ brnw.ch/21wJawy #NSCLC
Read about TARGET, a randomized non-inferiority trial to compare pretest genetic education via a webtool for noninferiority to traditional genetic counseling (GC) in patients with #ProstateCancer (PCA). ➡️ brnw.ch/21wJ86I @LoebStacy @vedangiri #pcsm
#JCOPO article highlighting that the B-cell signature significantly shapes the overall tumor gene expression profile and influences patient prognosis in ER-positive #breastcancer. ➡️ brnw.ch/21wJ5o8 #bcsm
#ctDNA analysis of palbociclib-treated patients with metastatic #BreastCancer in the TREnd trial revealed an independent prognostic role of ESR1 mutations. ➡️ brnw.ch/21wJ3bB #mBC
1/2 Dual publication @JCOPO_ASCO @theNCI @eaonc NCI-MATCH Subprotocol K2 positive PhII trial ➡️ activity of #Erdafitinib in treatment-refractory tumors w/#FGFR1-3 mutations or fusions, adding to evid for potential tumor agnostic indication? ascopubs.org/doi/10.1200/PO… @OncoAlert
Phase II Study of Erdafitinib in Patients With Tumors With Fibroblast Growth Factor Receptor Mutations or Fusions: Results From the NCI-MATCH ECOG-ACRIN Trial (EAY131) Subprotocol K2 | JCO Precision Oncology @jgong15 ascopubs.org/doi/10.1200/PO…
Wow! A lot of BRAF inhibitors in pre-clinical development @AACR #aacr24 👉Targeting All BRAF Alterations: The (Re)-Search Continues | JCO Precision Oncology @OncoAlert @JCOPO_ASCO @JCO_ASCO ascopubs.org/doi/10.1200/PO…
🎧 In this JCO Precision Oncology Conversations podcast ep, @thenasheffect speaks with Lauren C. Leiman & Dr. Emma Alme about their #JCOPO publication, “Recommendations for the Equitable and Widespread Implementation of #LiquidBiopsy for #CancerCare.” ➡️ brnw.ch/21wIwaa
Some activity noted in tumors with class II and III BRAF mutations. More research necessary!
🧬Peritoneal Tumor DNA-liquid biopsy (ptDNA) in gastric cancer @JCOPO_ASCO ✅Sensitivity 85.2% (66.5 to 100.0) specifity 91.5% (86.5 to 96.6), reference test: cytology 🚨8.5% of cytology-negative patients had positive ptDNA 🚨ptDNA positivity: -Risk of peritoneal-specific…
How can you critically evaluate clinical prostate cancer genomic test reports, and learn to spot red flags? Check out this piece by @G_Vandekerkhove, @vedangiri, and colleagues in @JCOPO_ASCO ascopubs.org/doi/10.1200/PO…. Thanks to @PCF_Science for support!
Report in #JCOPO from the @ASCO #TAPUR study demonstrating that regorafenib did not demonstrate antitumor activity in heavily pretreated patients w/ BRAF-mutated solid tumors: brnw.ch/21wIjfQ
#JCOPO study evaluating 99mTc-MDP bone scan index (automated bone scan index [aBSI]) and circulating tumor cell (CTC) analyses as potential biomarkers of prognosis and activity in patients with #mCRPC receiving radium-223. ➡️ brnw.ch/21wIhYs #pcsm
.@ChristianRolfo et al. demonstrate that early liquid biopsy in aNSCLC in parallel with path dx is associated with shorter time to treatment: brnw.ch/21wIgRk #LCSM
Phase 2 trial validates that trametinib plus low-dose dabrafenib is active and tolerated in adv. BRAFV600/NRASQ61 wild-type #melanoma w the highest antitumor activity observed in melanoma harboring alternative activating MAPK pathway alterations: brnw.ch/21wIfna #melsm
This #JCOPO study demonstrated that ctDNA dynamics may have limited ability to monitor therapeutic efficacy in patients with heavily pre-treated metastatic malignancies on #PARP or #VEGF inhibitors. ➡️ brnw.ch/21wIesl
NCI-MATCH Subprotocol E Phase II trial of osimertinib in non-lung pts: 15% ORR, PR in neuroendocrine and epithelial carcinoma: brnw.ch/21wIdeW @MonicaChenMD @HelenaYu923 @LeciaSequist @christine_lovly @EdithMitchellMD @CarlosArteagaMD
.@ASCO #TAPUR confirms and extends olaparib antitumor activity in pretreated patients w/ BRCA1/2 mutated #pancreaticcancer: brnw.ch/21wIcRd #pancsm
Vivek Subbiah, MD @VivekSubbiah
34K Followers 2K Following Chief, Early-Phase Drug Development|@SarahCannonDocs #Oncologist, #Phase1trials, #PrecisionMedicine. Tweets=My own.ASCO @ASCO
147K Followers 2K Following Account of the American Society of Clinical Oncology & its affiliate the Association for Clinical Oncology. Assoc tweets labeled #ASCOAdvocacy. RTs ≠ endorse.Pashtoon Kasi MD, MS @pashtoonkasi
18K Followers 11K Following Oncologist | Researcher | ColorectalCancer #CRCSM👨🏼🎓@MayoClinic @PittTweet Alum; 🧬#ctDNA #LiquidBiopsies💡#PrecisionOncology ViewsMy Own. COI @ASCO #ASCO23Jarushka Naidoo @DrJNaidoo
9K Followers 929 Following Professor of Medical Oncology @CancerCentreIre | Thoracic Oncologist | Immunotherapy & Immune toxicity | Adjunct faculty Johns Hopkins UniversityOncLive.com @OncLive
44K Followers 2K Following Healthcare publisher of oncology focused articles, videos, panel discussions, and much more that run the gamut of oncology care and management.Ben Westphalen @BenWestphalen
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40 Followers 132 Following Hematologist Oncologist at Mayo Clinic . Tweets/Opinions are my own and not the views of my employer. Retweets are not endorsements .Santiago Guerrero @sxguerrero
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147K Followers 2K Following Account of the American Society of Clinical Oncology & its affiliate the Association for Clinical Oncology. Assoc tweets labeled #ASCOAdvocacy. RTs ≠ endorse.Pashtoon Kasi MD, MS @pashtoonkasi
18K Followers 11K Following Oncologist | Researcher | ColorectalCancer #CRCSM👨🏼🎓@MayoClinic @PittTweet Alum; 🧬#ctDNA #LiquidBiopsies💡#PrecisionOncology ViewsMy Own. COI @ASCO #ASCO23OncLive.com @OncLive
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46K Followers 521 Following Medical oncology journal with a specific interest on targeted agents, immune therapies, personalised medicine, molecular pathology, bioinformatics, and more.Journal of Clinical O.. @JCO_ASCO
50K Followers 1K Following @ASCO's credible, authoritative resource for disseminating clinical oncology research. Home of @JCOOP_ASCO, @JCOGO_ASCO, @JCOCCI_ASCO, & @JCOPO_ASCO.chadi nabhan MD, MBA,.. @chadinabhan
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10K Followers 620 Following Chief, Division of Breast Oncology @DanaFarber Tennis fan Mother of two teenage girlsPhilippe Aftimos, MD .. @aftimosp
6K Followers 4K Following Med Onc, Clinical Trials Development Leader @JulesBordet #BreastCancer #PrecisionMedicine. Citizen of wokistan. Ecolo and vegan💚🌱Oud 🎼 💛💙⚽️Views are mine.Mike Thompson, MD, Ph.. @mtmdphd
23K Followers 4K Following Views my own. VP Clinical Partnerships @TempusLabs #PrecisionMedicine #mmsm #lymsm #CCC19 @COVID19nCCC @ASCO COI: https://t.co/A6GQmWYvauTargeted Oncology @TargetedOnc
20K Followers 4K Following Oncology news and insights from leading researchers and cancer centers.Nicole Kuderer, MD, M.. @NicoleKuderer
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1K Followers 537 Following Medical oncologist and researcher in gastrointestinal and genitourinary cancers @CedarsSinai. Hematology/Oncology fellowship @cityofhopeEd Esplin, MD, PhD @EdEsplin
1K Followers 1K Following Clinical Geneticist, MD, PhD, FACMG, CGAF, FACP @ Invitae posts my ownJCO Global Oncology @JCOGO_ASCO
12K Followers 284 Following Cancer care, research and care delivery issues unique to countries and settings with limited healthcare resources. Part of @JCO_ASCO family of journals.JCO Clinical Cancer I.. @JCOCCI_ASCO
5K Followers 200 Following Clinical research based on biomedical informatics methods applied to cancer-related data, information, and images. Part of @JCO_ASCO family of journals.Miami Cancer Institut.. @MiamiCancerInst
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5K Followers 6K Following Co-founder @MassiveBio | Director of Oncology Research @capitalhealthnj | Using #tech #AI & #genomics to fight cancer at global scale 🌎 🚀 🧬 🖥️ - My OpinionXiuning Le MD PhD @LeXiuning
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868 Followers 496 Following I am a physician and scientist working to develop new medications for gastrointestinal malignancies -- particularly pancreatic cancer and neuroendocrine tumors.Mike Pishvaian @MPishvaian
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815 Followers 164 Following West Baltimore Native, Urologic Oncologist and Director of Minority Men’s Health @caseurology “If there is no struggle there is no progress” Fredrick DouglassChris Barbieri @Chris_Barbieri1
2K Followers 927 Following Urologic Oncologist, #prostatecancer translational researcher, husband, father, Eagles fan. Views my own. RT≠EDaniel E Spratt @DrSpratticus
10K Followers 519 Following Vincent Smith Professor and Chair of Radiation Oncology University Hospitals Seidman Cancer Center Case Western Reserve University SOM. *TWEETS are my own*Spyros Basourakos @SBasourakos
415 Followers 695 Following @UroOnc Fellow at @MayoUrology | Residency at @WCMUrology | Former researcher at @MDAndersonNews | Views my own | 🇬🇷Daniel Stover, MD, FA.. @StoverLab
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228 Followers 500 Following GU medical oncologist and physician-scientist focused on #bladdercancer | Assistant Professor @OSUCCC_James @OhioState | Views my ownWilmot Cancer Institu.. @WilmotCancer
3K Followers 912 Following The Wilmot Cancer Institute is the leader in cancer care and research in the greater Rochester and Finger Lakes Region.JCO Oncology Practice @JCOOP_ASCO
14K Followers 332 Following Impactful information & insights to changes & challenges inherent in delivering equitable, high-quality oncology care. Part of @JCO_ASCO family of journals.Foregut Team NIH @NCICCR_Foregut
737 Followers 693 Following Official Twitter account of the NIH Foregut Team. (Esophageal, stomach, pancreas & hepatobiliary tumors.) [email protected] Privacy: https://t.co/47s9FxzVVeSarah Silvergleid @silver_gleid
73 Followers 807 FollowingLucia Pia Ciccone, MD @LpCiccone
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580 Followers 3K Following Heme/Onc | @Buckeyes | @Dallascowboys | @OhioState PharmD | #WVU PGY-1 | Prior Malignant Hematology & PGY2 @Moffittnews & Heme/Onc @ Baycare & TGH. Tweets = OwnJohnathan Ebben MD, P.. @JohnEbbenMDPhD
1K Followers 2K Following Oncology Fellow. Scientist. Entrepreneur. Turning basic science into medicine. Crowdsourcing precision oncology wisdom with @TumorBoardTuesEli Van Allen @VanAllenLab
9K Followers 2K Following Clinical Computational Oncology @DanaFarber @harvardmed @broadinstitute | Chief - Population Sciences | Prev.: @Stanford @UCLA @UCSF | Discl.: https://t.co/EmrHxvg76NChildren's National H.. @ChildrensNatl
38K Followers 4K Following We don’t want kids to just grow up, we want them to #GROWUPSTRONGER. Official feed for Children's National Hospital.Oncology Nursing News @OncNursingNews
10K Followers 711 Following Capturing the voice of nursing professionals in the oncology news landscape.NCI Media Relations @NCIMedia
41K Followers 465 Following Official Twitter account of the NCI Media Relations Branch, which supports journalists & writers reporting on cancer research (privacy: https://t.co/47s9FxzVVe )Moffitt Cancer Center @MoffittNews
50K Followers 4K Following Moffitt Cancer Center is a global leader in patient care, research and education with a mission to contribute to the prevention and cure of cancer.The Cancer Letter @TheCancerLetter
26K Followers 2K Following The leading independent source for information on the issues that shape #oncology since 1973. Editor: @PaulBGoldberg | Historical initiative: @cancerhistprojOncology Nursing Soci.. @oncologynursing
25K Followers 126 Following Professional association of more than 35,000 members committed to promoting excellence in oncology nursing and the transformation of cancer care.@priyanka_kanth @ClinicalLung @priyanka_kanth Great question. In our @JCOPO_ASCO study (ascopubs.org/doi/10.1200/PO…) 87 #lungcancer #patients had PGVs in #Lynchsyndrome genes. We're working on #somatictesting of tumors from #lungcancer #patients to assess which might be #Lynchsyndrome driven. Stay tuned...
Rare Pediatric Invasive Gliofibroma Has BRAFV600E Mutation and Transiently Responds to Targeted Therapy Before Progressive Clonal Evolution [Mar 27, 2019] @KanevaMD et al. @JCOPO_ASCO ow.ly/isF750I3NcZ #PrecisionMedicine #btsm
Clinical, Genomic, and Transcriptomic Data Profiling of Biliary Tract Cancer Reveals Subtype-Specific Immune Signatures [Jun 8, 2022] @kabir_mody et al. @MarkYarchoan @JCOPO_ASCO ascopubs.org/doi/full/10.12… #hpbcsm #PrecisionMedicine
Rare Pediatric Invasive Gliofibroma Has BRAFV600E Mutation and Transiently Responds to Targeted Therapy Before Progressive Clonal Evolution [Mar 27, 2019] @KanevaMD et al. @JCOPO_ASCO ow.ly/isF750I3NcZ #PrecisionMedicine #btsm
'...we are likely underestimating the prevalence of the inherited risk for #lungcancer. Utilization of #universal #germlinetesting can increase the detection of clinically actionable #germline variants over the guideline-based approach.' @ClinicalLung clinical-lung-cancer.com/article/S1525-… c/w…
.@jgong15 @CSCancerCenter publishing amazing research in @JCOPO_ASCO!
1/2 Dual publication @JCOPO_ASCO @theNCI @eaonc NCI-MATCH Subprotocol K2 positive PhII trial ➡️ activity of #Erdafitinib in treatment-refractory tumors w/#FGFR1-3 mutations or fusions, adding to evid for potential tumor agnostic indication? ascopubs.org/doi/10.1200/PO… @OncoAlert
🚨Thanks Dr Rafeq Naqash @thenasheffect for the kind invitation to @JCOPO_ASCO conversations podcast 🎤on our paper📝“Liquid Biopsy of Lung Cancer Before Path Diagnosis” @Al3ssandroRusso @lpasquina @ASCO sites.libsyn.com/427415/liquid-…
@isliquidbiopsy @TischCancer @ASCO @JCOPO_ASCO
🚨Thanks Dr Rafeq Naqash @thenasheffect for the kind invitation to @JCOPO_ASCO conversations podcast 🎤on our paper📝“Liquid Biopsy of Lung Cancer Before Path Diagnosis” @Al3ssandroRusso @lpasquina @ASCO sites.libsyn.com/427415/liquid-…
Quantifying the Value of Molecular Tumor Board: Discordance Rec Rate & Drug Cost Avoidance [Oct 20, 2022] @mkwalters305 et al. @JCOPO_ASCO ascopubs.org/doi/abs/10.120… #PrecisionMedicine #hpeonc Table 2
Implementation & Utility of an Integrated Academic-Community #PrecisionMedicine MTB [Jul 5, 2017] @meburkard et al. @JCOPO_ASCO ow.ly/7Gln30dvnrx
@VivekSubbiah @jgong15 @JCOPO_ASCO #ASCO24 entrance @VivekSubbiah 😎
1/2 Dual publication @JCOPO_ASCO @theNCI @eaonc NCI-MATCH Subprotocol K2 positive PhII trial ➡️ activity of #Erdafitinib in treatment-refractory tumors w/#FGFR1-3 mutations or fusions, adding to evid for potential tumor agnostic indication? ascopubs.org/doi/10.1200/PO… @OncoAlert
2/2 Dual publication @JCOPO_ASCO @theNCI @eaonc NCI-MATCH Subprotocol K1 PhII trial ➡️ no activity (0% ORR) of #Erdafitinib in tumors w/#FGFR1-4 amplifications, informative that not all #FGFR alterations may be targetable ascopubs.org/doi/10.1200/PO… @OncoAlert @JCO_ASCO @ASCOPost
@jgong15 Nice work. Congrats on the back to back publications @JCOPO_ASCO 👏🏼
Quantifying the Value of Molecular Tumor Board: Discordance Recommendation Rate & Drug Cost Avoidance [10/20/22] @mkwalters305 @JimW9200 @antonyruggeri @mullane_michael Hunt, Wilson, Ramczyk, @mtmdphd @JCOPO_ASCO ascopubs.org/doi/abs/10.120… #PrecisionMedicine #hpeonc @Aurora_Cancer
Quantifying the Value of Molecular Tumor Board: Discordance Rec Rate & Drug Cost Avoidance [Oct 20, 2022] @mkwalters305 et al. @JCOPO_ASCO ascopubs.org/doi/abs/10.120… #PrecisionMedicine #hpeonc Table 1. Recommendation Discordance Definition
Quantifying the Value of Molecular Tumor Board: Discordance Rec Rate & Drug Cost Avoidance [Oct 20, 2022] @mkwalters305 et al. @JCOPO_ASCO ascopubs.org/doi/abs/10.120… #PrecisionMedicine #hpeonc Table 2
Our recent publication clinically validating PROphet® #NSCLC is now the top feature in @JCOPO_ASCO! If you haven't read it yet, now's the time: ascopubs.org/doi/10.1200/PO… #liquidbiopsy #proteomics #biomarker #precisiononcology @drgandara @APDicker @ChrisDingmanCCO @oferorama
Happy to share our work in @JCOPO_ASCO on real-world OS & Tx patterns by PTEN status in met #CSPC using @flatironhealth PTEN LOF ass w/ significantly ⬇️OS vs intact PTEN regardless of 1L Tx @RyonGraf @CleClinicMD @neerajaiims @montypal @PCF_Science pubmed.ncbi.nlm.nih.gov/38547419/
Excited to share our work on “Identification of Pancreatic Cancer Germline Risk Variants With Effects That Are Modified by Smoking”, published today in JCO Precision Oncology @JCOPO_ASCO ascopubs.org/doi/10.1200/PO…