Pashtoon Kasi MD, MS @pashtoonkasi
Oncologist | Researcher | ColorectalCancer #CRCSM👨🏼🎓@MayoClinic @PittTweet Alum; 🧬#ctDNA #LiquidBiopsies💡#PrecisionOncology ViewsMy Own. COI @ASCO #ASCO23 coi.asco.org/share/PT3-AL5H… Manhattan, NY Joined May 2012-
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#ctDNA🧬can be broadly divided into tumor-informed🔬🆚tumor-naive🩸 platforms. Different lenses🔎of looking at the cancer through a blood draw. Depending on the clinical question & tumor type, different types available. #ASCODailyNews @ASCO @DrawImpacts dailynews.ascopubs.org/do/ctdna-assay…
Watch Dr. @pashtoonkasi via this @OncLive video discussing the benefits of circulating tumor DNA (ctDNA) in making treatment decisions for #ColorectalCancer patients: bit.ly/4aWRz0d
Couldn’t agree more: Mandard, Dworak, Becker, Rödel,.. an array of ‘historical’ TRG scores. While today we have a heterogenous spectrum of NAT modalities: CT, RCT, IO-CT, IO,.. together with a growing list of next generation molecules. ⏱️ for revision 🧐 + expert consensus🙏
Couldn’t agree more: Mandard, Dworak, Becker, Rödel,.. an array of ‘historical’ TRG scores. While today we have a heterogenous spectrum of NAT modalities: CT, RCT, IO-CT, IO,.. together with a growing list of next generation molecules. ⏱️ for revision 🧐 + expert consensus🙏
Response assessment crudely telling regression%🔢 is missing the bigger picture for patients receiving immunotherapy. 💡Time to revise assessment methods to reflect the pattern👇🏾. Different implications for the same response on chemo☢️🆚 immunotherapy. 📌nature.com/articles/s4138…
@isliquidbiopsy @pashtoonkasi Dr Kasi, Will there be any discussions on Nest1, 🪹 or Nest2 , Bot+Bal? Thank you .
🔎 As the the first study of its kind to use a tumor-informed ctDNA assay in the US, the BESPOKE study utilized ctDNA-based MRD detection to inform adjuvant #chemotherapy in #ColorectalCancer. Learn more from Dr. @pashtoonkasi: buff.ly/4b2KSd7 #ColonCancer
Join @pashtoonkasi at the 20th Anniversary of Circulating Tumor Cells in Granada, Spain from May 24-25, 2024. Dr. Pashtoon Kasi, MD, MS is an oncologist and researcher at Weill Cornell Medicine and NewYork-Presbyterian Hospital. He focuses on treating patients with…
@pashtoonkasi @RareCyte @Forbes Thank you! Do you they will trial for metastatic breast cancer. ER+ HER-?
Hoping for MBC trial
@RagingVentures Once again, another $AGEN related IST (independently sponsored trial) colon cancer trial sees brisk recruitment / doctor referral) It's a good sign when doctors are excited about a phase 1 clinical trial. x.com/pashtoonkasi/s…
@RagingVentures Once again, another $AGEN related IST (independently sponsored trial) colon cancer trial sees brisk recruitment / doctor referral) It's a good sign when doctors are excited about a phase 1 clinical trial. x.com/pashtoonkasi/s…
@Erman_Akkus @ESMO_Open Botensilimab & Balstilimab
@Erman_Akkus @ESMO_Open Botensilimab & Balstilimab
Some very interesting insights here 🧐 1) Technically: glad to see endoscopic biopsies, thus from the surface/luminal side, show clear signals. 👨🏽🔧 2) (very) Early rescoping is informative! 📹 3) Interesting immune cell dynamics early treatment Vs. resection. 🔬 🙌🙌🙌
Some very interesting insights here 🧐 1) Technically: glad to see endoscopic biopsies, thus from the surface/luminal side, show clear signals. 👨🏽🔧 2) (very) Early rescoping is informative! 📹 3) Interesting immune cell dynamics early treatment Vs. resection. 🔬 🙌🙌🙌
@pashtoonkasi @RareCyte You folks are really curing cancer!!! 🌅
@pashtoonkasi @RareCyte pubmed.ncbi.nlm.nih.gov/38263597/ I think there is growing evidence that it is on the order of weeks in at least some patients
More great news!!
@pashtoonkasi @RareCyte Fantastic work, looking forward to other KOLs following NestTrial2.0 and having FDA approval ASAP.
@pashtoonkasi @RareCyte Wow! That is extraordinary to hear - cannot wait to see the full data from this trial.
$AGEN
Vivek Subbiah, MD @VivekSubbiah
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427 Followers 568 Following Always aspiring thoracic surgeon and cancer researcher @MontefioreNYC via @MSK_Thoracic and @WCMSurgeryWatch Dr. @pashtoonkasi via this @OncLive video discussing the benefits of circulating tumor DNA (ctDNA) in making treatment decisions for #ColorectalCancer patients: bit.ly/4aWRz0d
Couldn’t agree more: Mandard, Dworak, Becker, Rödel,.. an array of ‘historical’ TRG scores. While today we have a heterogenous spectrum of NAT modalities: CT, RCT, IO-CT, IO,.. together with a growing list of next generation molecules. ⏱️ for revision 🧐 + expert consensus🙏
Response assessment crudely telling regression%🔢 is missing the bigger picture for patients receiving immunotherapy. 💡Time to revise assessment methods to reflect the pattern👇🏾. Different implications for the same response on chemo☢️🆚 immunotherapy. 📌nature.com/articles/s4138…
@isliquidbiopsy @pashtoonkasi Dr Kasi, Will there be any discussions on Nest1, 🪹 or Nest2 , Bot+Bal? Thank you .
🔎 As the the first study of its kind to use a tumor-informed ctDNA assay in the US, the BESPOKE study utilized ctDNA-based MRD detection to inform adjuvant #chemotherapy in #ColorectalCancer. Learn more from Dr. @pashtoonkasi: buff.ly/4b2KSd7 #ColonCancer
@pashtoonkasi @isliquidbiopsy Fantastic and will you be at ASCO?
Join @pashtoonkasi at the 20th Anniversary of Circulating Tumor Cells in Granada, Spain from May 24-25, 2024. Dr. Pashtoon Kasi, MD, MS is an oncologist and researcher at Weill Cornell Medicine and NewYork-Presbyterian Hospital. He focuses on treating patients with…
Sunday rounds with my coffee. ☕️ @Florez_Lab
@pashtoonkasi @RareCyte @Forbes Thank you! Do you they will trial for metastatic breast cancer. ER+ HER-?
Hoping for MBC trial
💡Timing⏱️of assessing response to #immunotherapy matters. We underestimate how quickly immunotherapy works.👇🏾1️⃣2️⃣days with BOT/BAL #NestTrial🪺all you see are immune cells🟣🟣in the biopsy. At surgery➡️tumor is💯% dead; immune cells have left the party. 📸 @RareCyte #CRCSM
@RagingVentures Once again, another $AGEN related IST (independently sponsored trial) colon cancer trial sees brisk recruitment / doctor referral) It's a good sign when doctors are excited about a phase 1 clinical trial. x.com/pashtoonkasi/s…
We have some incredible news.🗞️ #NEST-2 🪺 BOT/BAL we are at our 12+ patients with MSS #ColorectalCancer within weeks! Further expansion approved🙌🏾. 💡Cohorts: 🟢MSS Colon n=77 🔵➕a 🆕 MSS Rectal cohort n=30 🔴MSI-H n=15 🏃♂️with this story! @OncoAlert nyp.org/advances/artic…
@Erman_Akkus @ESMO_Open Botensilimab & Balstilimab
🆕🗞️Just out 🪺#NEST-1 trial results👇🏾 Are we on the verge of a new drug combo for colon or rectal cancer? Substantial & brisk responses to just☝🏾dose of BOT🟢➕BAL🔹🔹 immunotherapy.🙌🏾 Pattern & kill is unprecedented🌊. @ASCO #GI24 @OncoAlert Abstract 117📍Poster Board H2
Some very interesting insights here 🧐 1) Technically: glad to see endoscopic biopsies, thus from the surface/luminal side, show clear signals. 👨🏽🔧 2) (very) Early rescoping is informative! 📹 3) Interesting immune cell dynamics early treatment Vs. resection. 🔬 🙌🙌🙌
💡Timing⏱️of assessing response to #immunotherapy matters. We underestimate how quickly immunotherapy works.👇🏾1️⃣2️⃣days with BOT/BAL #NestTrial🪺all you see are immune cells🟣🟣in the biopsy. At surgery➡️tumor is💯% dead; immune cells have left the party. 📸 @RareCyte #CRCSM
@pashtoonkasi @RareCyte You folks are really curing cancer!!! 🌅
@pashtoonkasi @RareCyte Fantastic work, looking forward to other KOLs following NestTrial2.0 and having FDA approval ASAP.
@pashtoonkasi @RareCyte pubmed.ncbi.nlm.nih.gov/38263597/ I think there is growing evidence that it is on the order of weeks in at least some patients
More great news!!
💡Timing⏱️of assessing response to #immunotherapy matters. We underestimate how quickly immunotherapy works.👇🏾1️⃣2️⃣days with BOT/BAL #NestTrial🪺all you see are immune cells🟣🟣in the biopsy. At surgery➡️tumor is💯% dead; immune cells have left the party. 📸 @RareCyte #CRCSM
@pashtoonkasi @RareCyte Wow! That is extraordinary to hear - cannot wait to see the full data from this trial.
$AGEN
💡Timing⏱️of assessing response to #immunotherapy matters. We underestimate how quickly immunotherapy works.👇🏾1️⃣2️⃣days with BOT/BAL #NestTrial🪺all you see are immune cells🟣🟣in the biopsy. At surgery➡️tumor is💯% dead; immune cells have left the party. 📸 @RareCyte #CRCSM
@pashtoonkasi @RareCyte Can we have this available globally by Q4 2024? Eagerly waiting.