Xiuning Le MD PhD @LeXiuning
Associate Professor Thoracic Head and Neck Medical Oncology MD Anderson Cancer Center faculty.mdanderson.org/profiles/xiuni… Houston, TX Joined March 2020-
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🎀 💗Strong team work! BH-30643 represents a next-generation #EGFR #TKI that is potentially 10x more potent than osimertinib, strong CNS penetrance, and able to overcome on-target EGFR resistance! @Exon20Group @EGFRResisters @UTMDAnderson @mollylisc @geoff_oxnard @jjeancui
🆙 #ASCO26 #LCSM Rapid Oral 🔥SOLARA: BH-30643 (Macrocyclic OMNI-EGFR TKI) in EGFRm ✅C797S+ ORR 59% ✅C797S VAF >99%📉in 7/9 ctDNA+ pts ✅G3 AEs 18% (mainly T-bil) 🎙️ @LeXiuning @HHorinouchi 🔢3014 ☑️NCT06706076 🔗 asco.org/abstracts-pres… @OncoAlert @Larvol @ASCO @IASLC
Kicking off #ASCO26 by celebrating the Giants of Cancer Care induction ceremony! 🎀Congratulations to Dr. Wakelee @HwakeleeMD for Thoracic Malignancy 🎀Congratulations to Dr. Kopetz @skopetz for GI Maligancy @UTMDAnderson 🎀Congratulations to Dr. William Wierda for Leukemia 💐💐💐With friends @drgandara @JoelNealMD @riess_md
At #ASCO26, the @UTMDAnderson Thoracic Medical Oncology Department will deliver an incredible 9 oral presentations💐💐💐 highlighting advances across ##EGFR, #HER2, #KRAS, #KEAP1/STK11, #SCLC, IO, #peri-operative, all lung cancer subgroups. For perspective, thoracic medical oncologists from China have 16 oral presentations. 👩⚕️🧑⚕️ 👩🔬🧑🔬Our entire MDA Thoracic team @FSkoulidis @NIVokes @LaurenByersMD @lungoncdoc Drs. Heymach, Cascone, Zhang, @mvnegrao @YYElamin @AnneTsao2 are deeply proud and excited 😀to help shape the future of lung cancer research and patient care alongside outstanding collaborators and industry partners.
Dr. Stephen Liu @StephenVLiu gave the insightful vision on how #AI will impact our clinic, including patient care, physician wellness, clinical research and drug development. @StephenVLiu at #RomeLung26 Thank you @FedericoCappuz1 @BRicciutiMD for organizing this fantastic #lung #summit
Exciting program with impressive global faculty at #RomeLung26 with chairs @FedericoCappuz1 and @BRicciutiMD starting the meeting!
Strongly support my @UTMDAnderson colleague Dr. Hussein Tawbi @HTawbi_MD for #SITC Director election ❤️💐 👉Hussein is an internally renowned #physicianscientist immune-oncology leader who has helped redefine what immunotherapy can achieve in some of the most challenging clinical settings. 👉His leadership of the CheckMate 204 study established the role of nivolumab + ipilimumab in melanoma brain metastases, a historically underserved population, 👉He led RELATIVITY-047 which enabled the approval of nivolumab + relatlimab, introducing LAG-3 as a new checkpoint target. His voice and compassion, grounded in patient care and scientific rigor, would be an outstanding addition to the #SITC Board as we navigate the next era of immunotherapy innovation. 🚀
The #SITC election starts on Friday! The three At-Large Directors who receive the plurality of votes will begin three-year terms in 2027. Read the biographies and platform statements of this year’s candidates at sitcancer.org/get-involved/2…
Strongly support Dr. Zhen Su @MyOncology , my friend, colleague, and mentor for SITC Director election. 💪❤️ 👉When he served as the global oncology leader at #MerckKGaA/#EMDSerono, he translated complex immune biology to approvals, then becaome impactful therapies for patients. He has multiple global approvals across agents such as #avelumab, #tepotinib, #erbitux and others. 👉Now as the CEO of #Marengo, he is a true architect with vision, taking first-in-class T-cell agonist programs from platform stage into human studies and secured strong partnerships. 👉Zhen has been a long-standing contributor to the #immuno-oncology community, including leadership roles within #SITC. His vision of bringing early discovery to global commercialization will continue shaping the development of next generation immunotherapies. 🚀
The #SITC election starts on Friday! The three At-Large Directors who receive the plurality of votes will begin three-year terms in 2027. Read the biographies and platform statements of this year’s candidates at sitcancer.org/get-involved/2…
Appreciate @StephenVLiu and @CharuAggarwalMD organizing a fantastic US Focus Meeting Lung Cancer. I discussed 1L EGFR-mut NSCLC landscape evolution with friends and colleagues @riess_md @JuliaRotow @JustinGainor @ShirishGadgeel @BalazsHalmosMD. Nashville is a charming city with such fun characters.
Inaugural US Focus Meeting on Lung Cancer from @_MDEducation starts in Nashville with EGFR session. Great overviews by Drs. @LeXiuning Liza Villaruz @ZPiotrowskaMDand panel chaired by @CharuAggarwalMD. Great areas for discussion including LCT, bispecifics, and ADCs.
@StephenVLiu But super productive?!
😊 🩷 Nice to see friends and colleagues in the #lungcancer community from different continents at #ELCC26. @caliraf @Alfdoc2 @HHorinouchi @MartinReck2 @Tony_Calles @DoctorJSpicer @fred_hirsch @bensolomon1 @NReguart @BalazsHalmosMD @BrendonStilesMD @mollylisc @karenkellymd @ThomasW35874311 @NadalErnest @DrSanjayPopat 😊 🩷 Safe travels ✈️ 💐💐💐Grateful for the wonderful organization between @IASLC and @esmo for an impactful and fun #ELCC26.
We discussed innovations in ADCs to overcome topo-payload ADC resistance. 🔥Novel payloads include dual-cytotoxic, radioligands, immune stimulators or engagers, oligonucleotides (siRNA), degraders, and small molecule inhibitors. 🤣 Yes, "Any-Drug-Conjugates (ADC)" ❤️💡
💥 Beyond traditional ADCs at #ELCC26! @LeXiuning ▪️Masked ADCs → tumor-activated targeting ▪️Nanobodies & peptides: better penetration, new epitopes ▪️Bicycle toxin conjugates: ultra-small, fast delivery 🎯 Innovation across 3 axes: target, linker, payload From ADCs to
Honored to be delivering two educational lectures at 🔜 #ELCC26 @myESMO🇩🇰 in Copenhagen. 📍 March 26. 👉Beyond traditional ADCs: Advances in targeting, conjugation, payload design, and emerging modalities 📍 March 28 👉Mechanisms of resistance: Lessons from EGFR-mutant and ALK-rearranged NSCLC 💐Grateful to the conference chairs @DrSanjayPopat @APassaroMD for your excellent work on organizing #ELCC26. 💗Looking forward to great discussions and connecting with global colleagues @HHorinouchi @ThomasW35874311 @Alfdoc2 @caliraf @tnewsomdavis @YYElamin @lungoncdoc
Please (re)watch the powerful Special Speech delivered by Dr. Ross Camidge @DRCamidge at #TTLC26 @IASLC An internationally renowned thoracic oncologist, Dr. Camidge shared something profoundly personal: his own diagnosis and treatment journey with stage IV #EGFR-mutant #NSCLC. His reflections were thoughtful and deeply human. It is a reminder that before we are physicians or patients, we are human beings: vulnerable yet resilient. Please: ❤️ Act with urgency. ❤️ Treat with respect and gentleness. ❤️ Move forward with courage and hope. @ShirishGadgeel @lungoncdoc @KarenReckampMD @TejasPatilMD
At #TTLC26, @DRCamidge shared powerful insights shaped by both clinical expertise and personal experience living with #lungcancer. His presentation reminds us why continued innovation in #lungcancer research is essential to improving patient outcomes every day.
❤️ ❤️ So happy and proud to wrap up a successful #TTLC26 @IASLC 💐🎊 👉 This year, we set new records: 🥇 🔥 the highest attendance, 🥇 🔥 the greatest number of submitted abstracts, and 🥇 🔥 unprecedented sponsorship support. 👉 This year, we hosted two extraordinary keynote speakers: my mentor Dr. John Heymach @MDAndersonNews and his mentor Dr. Bruce E. Johnson. Seeing multiple generations of thoracic oncology leadership on one stage was a powerful reminder that progress in our field is built on mentorship, collaboration, and legacy. Let it continue. ❤️ ❤️ Special appreciation to my dear co-chairs @ShirishGadgeel @KarenReckampMD and Dr. Paul Bunn, and outstanding @IASLC staff, especially Kelly Heemsbergen, for being consistently knowledgeable, responsive, and supportive behind the scenes. 👉 See you all again at hashtag #TTLC27
#TTLC26 @IASLC @YYElamin @MDAndersonnews Dr. Yasir Elamin discussed the landscape for 1L #EGFR mutant #lungcancer until now, and offered insights to the near future. 👉Intensification works for PFS and OS 👉More intensification strategies are coming.
#TTLC26 @IASLC Day 1. Opening Keynote by Dr. John Heymach, focusing on "heterogeneity" in Thoracic Oncology @lungoncdoc @ReckampK @ShirishGadgeel @MDAndersonNews 👉 EGFR classical vs. PACC vs. Ex20ins 👉 EGFR Ex20ins - near vs. far loop 👉 KRAS - co-mut STK11 KEAP1 vs. TP53 👉 SCLC - transcriptional profiling
Vivek Subbiah, MD @VivekSubbiah
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Stephen V Liu, MD @StephenVLiu
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Lecia Sequist, MD, MP... @LeciaSequist
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H. Jack West, MD, FAS... @JackWestMD
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IASLC @IASLC
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Aakash Desai, MD, MPH... @ADesaiMD
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Naoki Furuya, MD, PhD @NaokiFuruyaMD
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呼吸の案内人 @LungLaughMD
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Andrea @dealcs
103 Followers 349 Following Masters in Genetics and Molecular Biology. Now searching for some epigenetics biomarkers in cervical cancer during my PhD thesis. #DNAmethylation
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MY @Yudiman
213 Followers 5K Following Grateful for the sacrifice my parents made leaving 🇷🇺 as they couldn’t get ahead being ✡️ there. Grateful for my family, 🇺🇸, and those that defend her.
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Dr. Hemalatha Ramacha... @hemrams
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Hyein Jeon, MD @HyeinJeon_MD
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Teja Voruganti @TejaVorugantiMD
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Alliance for Clinical... @ALLIANCE_org
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Zamzam @z_alhashami
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Chloe Givens Woods, P... @drchloewoods
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biotech wave bar @RichardWil54406
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Jarushka Naidoo @DrJNaidoo
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Lecia Sequist, MD, MP... @LeciaSequist
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Jill Feldman @jillfeldman4
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IASLC @IASLC
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Aakash Desai, MD, MPH... @ADesaiMD
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Tom Powles @tompowles1
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Tony Zhuang @tonygazibo
397 Followers 496 Following Heme/Onc Fellow @MDAndersonNews via @EmoryMedicine, @UTHSCMedicine & @RiceUniversity. Nature enthusiast & lifelong learner
Paul Stockhammer @StockhammerPaul
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Annals of Oncology @Annals_Oncology
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670 Followers 447 Following Professor of Radiology at MD Anderson Cancer Center. Thoracic radiologist. Tweets are my own.
Nirmal Raut @oncologician
7K Followers 6K Following Masters of molecular oncology (CNIO ) Medical Oncologist by profession (Lung is close to my heart), researcher by passion, precision oncology,liquid biopsy.
Byoung Chul Cho, M.D.... @cbcbc1971
95 Followers 3 Following Professor, Division of Medical Oncology, Yonsei Cancer Center, Yonsei University College of Medicine
Giuseppe Banna @gbanna74
2K Followers 1K Following Consultant Medical Oncologist for Lung and Urology Cancer aiming to Clinician Scientist #lungcancer #urologycancer. I love my work but my family is my life
CA: A Cancer Journal ... @CACancerJournal
11K Followers 2K Following As the flagship journal of the American Cancer Society, CA publishes the latest cancer statistics, ACS guidelines, and reviews on the current state of cancer.
Raffaele Califano @caliraf
1K Followers 488 Following Thoracic Oncologist @TheChristieNHS, Honorary Professor @UoM_DCS . Member @myesmo Educational Publication WG. Views are my own No DMs or medical advice given.
TerriConneran @TerriConneran
1K Followers 883 Following T like Trouble @KRASKickers Too spunky for #LungCancer Kicking cancer’s #KRAS #research #advocate #survivor #hope ❤️🤣🙏#biomarker NO #KRASholes
Vinay Jain @vinaykjain17
153 Followers 273 Following
DAVA Oncology @DAVAOnc
2K Followers 2K Following DAVA Oncology is a strategic consulting company committed to delivering high quality oncology education and expanding access novel cancer therapies.
ONCO BRUNO @brunolarvol
7K Followers 7K Following @LARVOL | 100 experts building onco super intelligence | 200,000 KM curves digitized | free for non-commercial use | ex-IBM
Federica Pecci @pecci_federica1
468 Followers 539 Following Research Fellow at @DanaFarber Thoracic Oncology
jamei_zhang @jaemi_zhang
2K Followers 329 Following Chinese entrepreneur living in the US. I run my own business and enjoy traveling and fishing. Let’s connect and share good vibes together.
Misty Dawn Shields @drshieldsmd
2K Followers 2K Following Translational Thoracic Oncologist #MDPhD, #SCLC, @TheShieldsLab, Indiana University, HHMI Med Into Grad Scholar/IASLC ILCF/ASCO CDA, founder @SCLCSMASHERS 🫁🤍
OncoAlert @OncoAlert
42K Followers 147 Following 🌐 Worldwide Network of Oncology Professionals & Patient Advocates with the common goal of ending cancer, we are Oncology360 degrees 🌎 We are #OncoAlert 🚨
Susan Combs Scott, MD @SusanScottMD
965 Followers 492 Following Thoracic Medical Oncologist at Johns Hopkins at Sibley @hopkinskimmel @sibleyonline
Biagio Ricciuti, MD, ... @BRicciutiMD
618 Followers 35 Following Thoracic Medical Oncologist at @DanaFarber | @harvardmed #Immunotherapy #KRAS #BRAF #MET #LungCancer
Raffaele Colombo @raffcolo
3K Followers 907 Following ADCs, targeted therapies, chemistry, biotech, pharma. Director @ Zymeworks
Ana I. Velázquez Ma�... @AnaVManana
7K Followers 5K Following Medical oncologist & researcher focused on #LungCancer 🫁 @UCSFCancer @ZSFGCare | Assistant Prof. @UCSF | Views are my own. Boricua 🇵🇷 aunque naciera en la 🌙
Dr. Antonio Calles �... @Tony_Calles
12K Followers 4K Following Medical Oncology 🏥 Hospital General Universitario Gregorio Marañón ⎪@myESMO Faculty 🫁 ⎪#endlungcancer #lcsm
Alissa Cooper, MD @alissajcooper
697 Followers 440 Following Thoracic oncologist @danafarber | Formerly at @MSKCancerCenter | Former fellow @MGHCancerCenter @danafarber | Views my own
Mark Wildgust (he/him... @MAWildgust
1K Followers 821 Following VP of Oncology Global Medical Affairs at Johnson & Johnson, focused on bringing new treatment options for pts with cancer. Tweets/views shared are my own
Dhru Deb, PhD @CancerSciArtist
224 Followers 289 Following Cancer researcher by day, visual artist by night & New Yorker at heartYou might like
