EPFL Blue Brain Project @BlueBrainPjt
The aim of the EPFL Blue Brain Project is to build biologically detailed digital reconstructions and simulations of the mouse brain. epfl.ch/research/domai… Joined September 2012-
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📌13 May 📍Lausanne, Cylure 🔎Cristina Colangelo @EPFL_en speaks about the Blue Brain Project🔎Gilles Allai @CHUVLausanne about therapeutical revolution in #Alzheimer 🔎Kevin Richetin @krichetin about #Dementia
Thrilled to be participating in this year's edition of @pintofscienceCH ! Grab a drink and come and say hi 👋 13th May 🐟Cylure Binchroom 🍺, Lausanne 7pm
Thrilled to be participating in this year's edition of @pintofscienceCH ! Grab a drink and come and say hi 👋 13th May 🐟Cylure Binchroom 🍺, Lausanne 7pm
This Saturday, Blue Brain scientist @LidaKanari is presenting a talk at @appliedmldays - A topological understanding of the brain: from single cells to neuronal networks - Don't miss it! Info 👉 2024.appliedmldays.org #amldepfl2024
The 1st in a series of papers by the BBP Connectomics team exploring the functional role of such higher-order brain structure, we introduce new tools to measure it structurally & in the context of neuronal activity.
We discovered that the structure of internal connectivity significantly influences cell assembly formation. Our study suggests the brain optimizes computational efficiency by favoring specific motifs over random synapse distribution.
In our in silico model of rat somatosensory regions, we mimic brain activity to uncover the dynamics of cell assembly formation. From external stimuli to internal calculations, we trace the journey of neuronal activation.
Ever wondered how neurons wire together to coordinate their activity? Our research investigates the balance between external inputs and internal wiring in shaping cortical cell assemblies. Using in silico models, we reveal fresh insights into brain function.
This Friday, Blue Brain scientist Michael Reimann is presenting their poster at #COSYNE2024 - Connectivity of an electron-microscopic reconstruction reveals specific inhibitory competition between large motifs of neurons - Join the conversation! Info 👉 cosyne.org
We were delighted to welcome a distinguished Spanish delegation from the Ministry of Science, Innovation, and Universities for a productive visit to the Blue Brain Project. Great discussions on current and future collaborations! @EvaOrtegaPaino #neuroscience #Geneva
This Thursday, Blue Brain Scientist Polina Litvak is presenting their poster at Thalamocortical Interactions GRC - Exploring the impact of corticothalamic feedback & simulated behavioral state on sensory adaptation in a thalamoreticular circuit model 👉 grc.org/thalamocortica…
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536K Followers 1K Following Welcome to the new way to cloud. Questions? ➡️ https://t.co/BFKBu3t6xk For do-ers & makers ➡️ @GoogleCloudTech Watch #GoogleCloudNext now on demand ⬇️I'm glad to be presenting my work at AMLD @EPFL this Saturday and I'm looking forward to the interesting discussions! Thanks a lot @srikipedia for the invitation.
This Saturday, Blue Brain scientist @LidaKanari is presenting a talk at @appliedmldays - A topological understanding of the brain: from single cells to neuronal networks - Don't miss it! Info 👉 2024.appliedmldays.org #amldepfl2024
Please make some noise to the cool high-order structure - function work of my (mostly) twitterles colleagues. I think it's super relevant to modelers using simplified (even distance dependent) connectomes as it shows what one looses with such an approach.
📢Preprint alert! Our latest manuscript, "Efficiency and reliability in biological neural network architectures" was just shared on BiorXiv, go check it out! doi.org/10.1101/2024.0…
Happy to see this out! Shout-out to reviewers, you've actually made this paper better! Three more publications are coming using similar methods delving into the link between high-order cortical structure and function.
📢New Publication Alert! Our paper "Cortical cell assemblies and their underlying connectivity: An in silico study" is out in @PLOSCompBiol. We plunge into the world of cortical connectivity to understand the formation of functional cell assemblies. 👉doi.org/10.1371/journa…
El primer día pude visitar, junto con la @EmbEspSuiza, la @MisionGinebra y @aso_acech el @BlueBrainPjt. Se trata de un proyecto que, continuando con el legado de Ramón y Cajal, estudia el cerebro aunando 3 ideas: 1. Tecnología 🤖 2. Salud 👨⚕️ 3. Neurociencia 🧠
I'm a Dr. now! Alongside the rules governing plastic changes I also learned how to fail and start over again and again... Will never forget that!
Congratulations to Blue Brain's Dr. @andris_ecker! András successfully defended his thesis Principles of Network Plasticity in Neocortical Microcircuits 🍾 Amazing job! #Neuroscience #SimulationNeuroscience
Today BOARD XX16, 1-5 PM at @SfNtweets, come see our poster on simulating #neuropixels recordings with unprecedented detail; a key step to probing the #darkmatter problem in #neuroscience. Thx to @SteinmetzNeuro and Jennifer Colonell for the insightful chats at their poster!
Here's a pic of our #SfN23 virtual poster. We 1) used a comprehensive biophysically detailed cortical circuit model of the rat somatosensory cortex S1, 2) showed that it replicates in vivo data 3) mapped spike sorting biases in simulated large-scale dense #ephys, e.g #neuropixels
Hi #SfN2023 #SfN23🧠 Check out how atomic units of information are encoded in the cortex by time-warped spike time patterns (in vivo), and how we calibrated the new @BlueBrainPjt 4.2 million detailed neuron model of the primary somatosensory cortex ➡️ Poster XX20, Wednesday PM!
Our November issue is now live! On the cover this month, authors from the @BlueBrainPjt describe a universal workflow for building detailed neuronal models. Full issue: cell.com/patterns/issue… Cover paper: cell.com/patterns/fullt…
Bottom-up modeling offers the allure of assembling well-constructed components, yielding remarkable outcomes sans extensive parameter tweaking. Our recent cortical plasticity preprint showcases this, revealing sparse changes in an in vivo-like state: biorxiv.org/content/10.110…
Breakdown and rejuvenation of aging brain energy metabolism biorxiv.org/content/10.110… The main part of almost 6 years of my PhD project. From the despair to miracles. #brainmetabolism #brainaging #agingmetabolism #computationalmodeling #neuroscience @BlueBrainPjt
@CNSorg: Come see our detailed ground truth model of #neuropixels #ephys recordings with #kilosort 3 spike sorting. We build on the work from @marius10p, @SteinmetzNeuro, @computingnature et al. Our model captures lots of biological variability in the cortex. Feedbacks welcome !
Tuesday, Blue Brain Scientist Steeve Laquitaine is presenting his poster at the #Computational #Neuroscience Meeting - Using the Neocortical Microcircuit as a Realistic Ground Truth To Map Spike Sorting Biases - Find out more – cns2023.sched.com/event/1O6tf/p2… #CNS2023 @sl_neuro
Why do some people think faster than others? Don't miss this @BlueBrainPjt Virtual talk - June 26th Prof. Huib Mansvelder - Cortical Neuronal Diversity Supporting Human Cognition Find out more and join via – buff.ly/43Tew1o #neuroscience
This was a terrific project to work on with @cyrille_favreau and Sarah.
Happy to share the beautiful collab with the lab for Experimental Museology, celebrating science and research @EPFL_en. The original dome is rendered as a 180deg navigable half-sphere. Enjoy your journey! youtu.be/flMC2YOUe-o #artscience #neuroscience #simulationneuroscience
Happy to have contributed to this with Sarah Kenderdine and @peter_morse 😀
Happy to share the beautiful collab with the lab for Experimental Museology, celebrating science and research @EPFL_en. The original dome is rendered as a 180deg navigable half-sphere. Enjoy your journey! youtu.be/flMC2YOUe-o #artscience #neuroscience #simulationneuroscience
Shoutout to @dav1dcg and @BlueBrainPjt (and my lab mates) for saving me SO many hours of my life automating electrophysiology data analysis. Highly recommend using eFEL in Python for ephys data analysis (and the tutorial from @dav1dcg ) efel.readthedocs.io/en/latest/inde…
New preprint on leveraging MCMC method to build and generalise detailed electrical models of cortical neurons: biorxiv.org/cgi/content/sh… with @maria__reva at @BlueBrainPjt
Les scientifiques du @BlueBrainPjt ont mis au point un modèle informatique révolutionnaire du microcircuit thalamique dans le cerveau de la souris, qui apporte de nouvelles informations sur le rôle de cette aire cérébrale dans le fonctionnement du cerveau. actu.epfl.ch/news/un-nouvea…
Scientists at the @BlueBrainPjt have developed a groundbreaking computational model of the thalamic microcircuit in the mouse brain, offering new insights into the role this region plays in brain function and dysfunction. actu.epfl.ch/news/new-circu…
Work by colleagues at the #BlueBrainProject at @EPFL_en and @unil indicates that targeting Astrocytes May Slow #Alzheimer's Disease
New study suggests targeting astrocytes may prevent neuron decline in #Alzheimer's. Researchers found overexpressing a protein in astrocytes preserved short term memory in mice. #neuroscience #aging Discover more - actu.epfl.ch/news/targeting… Read in GLIA - doi.org/10.1002/glia.2…
@wake_sleep @BlueBrainPjt @CAMH_KCNI Congrats Sean and team!