Zu-Hang Sheng @zuhangsheng
A neuroscientist at NINDS/NIH studying neuronal mitochondria/lysosomes and energy metabolism. Opinions are my own. https://t.co/4myWbN5PZg Joined July 2019-
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thrilled to share our latest review discussing presynaptic perspectives of neurodevelopmental disorders by focusing on impaired axonal transport and disturbed assembly and maintenance of presynapses. hubs.la/Q02rGTT70
thrilled to share our latest review discussing presynaptic perspectives of neurodevelopmental disorders by focusing on impaired axonal transport and disturbed assembly and maintenance of presynapses. hubs.la/Q02rGTT70
Delighted to share our review. Congrats to Gui-Jing Xiong! Thank JCB editor @andrea_marat for handling this review so well, and the reviewers who provided constructive comments. Very happy to publish with @JCellBiol.
Delighted to share our review. Congrats to Gui-Jing Xiong! Thank JCB editor @andrea_marat for handling this review so well, and the reviewers who provided constructive comments. Very happy to publish with @JCellBiol.
Really Fun visiting UNC Chapel Hill and meeting faculty and graduate students in Department of Pharmacology. Many thanks to Juan Song @Songlaboratory for hosting. It was great hearing about all of exciting research form the Song Lab and others!
Really Fun visiting UNC Chapel Hill and meeting faculty and graduate students in Department of Pharmacology. Many thanks to Juan Song @Songlaboratory for hosting. It was great hearing about all of exciting research form the Song Lab and others!
I am shocked and saddened to learn of the passing of Bill Catterall, my postdoc mentor and a pioneer and giant in ion channel research. It is a great loss for science.
Thrilled to share that #NIHOxCam scholar @aditi_k37 recently passed her First Year Report!! Aditi is co-mentored by @zuhangsheng in the NINDS and @LakatosLab at @Cambridge_Uni. Way to go Aditi 🎉
Delighted to share our review led by @sunan_li and invited by co-editors @inna_slutsky and RH Swerdlow. We overview recent advances in how oligodendrocytes support axonal energy metabolism in health and neurological disorders. authors.elsevier.com/a/1gsm73Q9h2Ee…
TRAK adaptors regulate the recruitment and activation of dynein and kinesin in mitochondrial transport nature.com/articles/s4146…
.@zuhangsheng et al review how axonal endolysosomal trafficking, distribution, and lysosomal functionality support neuronal health & become disrupted in several neurodegenerative diseases bit.ly/3Lnqo2O From our Cellular Neurobiology 2022: bit.ly/3NQFD5Y #SfN22
...including an intriguing role for Syntaphilin in reducing Split-Miro-dependent fly hyperactivity @zuhangsheng. The use of the LOV2/Zdk1 module was inspired by the beautiful work of @JeffreyHaren @WittmannTorsten and colleagues on EB1. 9/10
We have liftoff! Great overviews of the official launch of the iPSC Neurodegenerative Disease Initiative (iNDI). Large-scale, NIH-funded resource of genetically-engineered isogenic iPSC lines harboring neurodegeneration-related mutations. nia.nih.gov/news/new-web-p…
Thanks to a great collaborative effort with Neuron editors @NeuroCellPress, and @XiutangC, @nigg_huang. The maintenance of axonal mitochondria & energy metabolism is one of the most interesting topics to power neuronal survival, function, & regeneration.
Thanks to a great collaborative effort with Neuron editors @NeuroCellPress, and @XiutangC, @nigg_huang. The maintenance of axonal mitochondria & energy metabolism is one of the most interesting topics to power neuronal survival, function, & regeneration.
Happy to share a featured review out in the new issue @NeuroCellPress on Programming axonal mitochondrial maintenance and bioenergetics in neurodegeneration and regeneration. Congrats to @XiutangC, @nigg_huan, and the Sheng Lab: research.ninds.nih.gov/sheng-lab. cell.com/neuron/fulltex…
I am grateful to be one of the highlights in the NINDS Director’s post on the celebration of Asian American, Native Hawaiian, and Pacific Islander Heritage Month 2022.
I am grateful to be one of the highlights in the NINDS Director’s post on the celebration of Asian American, Native Hawaiian, and Pacific Islander Heritage Month 2022.
VERY intriguing findings from @jltwiss1 and colleagues - "...axonal translation of the RNA binding protein Khsrp mRNA following nerve injury serves to promote decay of other axonal mRNAs and slow axon regeneration." academic.oup.com/nar/advance-ar…
Join us this week for two great #nCyto talks by Sandhya Koushika and Zu-Hang Sheng! Thursday, May 5. Register at bit.ly/35ZV1Ly
Check out our review in @NeuroCellPress, contributed by @XiutangC and @nigg_huang. We overview recent advances in how neurons maintain a healthy pool of axonal mitochondria and potential strategies that target bioenergetic restoration within axons. authors.elsevier.com/a/1ewBi3BtfH1X…
Schematic diagram showing motor–adaptor complexes mediating kinesin and dynein motor recruitment to LE/LY membranes for MT-based transport along axons. From a review by Roney, Cheng, and @zuhangsheng @NINDSnews. bit.ly/3Lnqo2O #Neuroscience #Trafficking
Very excited we have a new preprint out! This was a joint effort between @koslovergroup @SaurabhMogre @ErikaHolzbaur and I to computationally model autophagosomal maturation in axons biorxiv.org/content/10.110…
Neuronal #endolysosomal transport & #lysosomal functionality in maintaining axonostasis by Roney J, X Cheng @zuhangsheng @NINDSnews @NIH @IRPatNIH via @JCellBiol @RockUPress #openaccess rupress.org/jcb/article/22…
Christophe Leterrier @christlet
22K Followers 3K Following NeuroCyto lab PI 🤹🏻 @INP_Marseille @CNRS @univAMU 🧠 Neuronal cell biology 🦠 Super-resolution microscopy 🔬 ➡︎ @[email protected] / http://christlet.bsky.sociJuan S. Bonifacino @BonifacinoJuan
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4K Followers 351 Following Bioreactor-grown mitochondrial transplant therapy for chronic disease and aging.See you at @IJMonod on May 31st! ijm.fr/ijm-seminars-c…
Thank you @JHUArtsSciences Deans Office for the wonderful celebration with cake and champagne and flowers. I am fortunate to be part of a collaborative and supportive team!
Image shows neurodevelopmental disorder (NDD)-linked mutations in motors and adaptors. Xiong and @zuhangsheng @NIH_NINDS review recent advances in presynaptic mechanisms of NDDs by focusing on impaired axonal transport of presynaptic cargos. hubs.la/Q02rGRLx0 #Neuroscience
1/ A new paper from PhD student Marius Hedtfeld tests in vitro phase separation assays as predictors of localisation in cell compartments. authors.elsevier.com/sd/article/S10… We explain why homotypic or simple heterotypic LLPS assay are unlikely to predict macromolecular localization...
Excited to share our paper by @DePaceRaffa @SaikatSls et al. showing that BORC-dependent transport of lysosomal vesicles into the axon is crucial for the axonal movement of a large cohort of mRNAs, mainly those encoding ribosomal and mitochondrial proteins nature.com/articles/s4159…
I had a blast at the 2nd Sino-France Joint Meeting on Bioimaging in Beijing organized by @PKU1898 and @Fr_BioImaging - great time meeting the vibrant Chinese microscopy community and hearing about awesome science. Thank you @Orangeroad2017 for the invitation!
Presynaptic perspective: Axonal transport defects in neurodevelopmental disorders. New review from Gui-Jing Xiong and Zu-Hang Sheng (@zuhangsheng) @NIH_NINDS: hubs.la/Q02rGQwY0 #Trafficking #Neuroscience
Very interesting: Myelinating oligodendrocytes do not produce nor metabolize lactate? onlinelibrary.wiley.com/doi/10.1002/gl…
Glycolytic oligodendrocytes likely to release pyruvate to axons, while also funneling lactate of astroglial origin. Unexpected expression pattern of LDH in mature white matter tracts. Great study by Erik Spaete, Sandra Goebbels et al. onlinelibrary.wiley.com/doi/10.1002/gl…
My family is taking part in the 2024 A Walk in the Park for Fight Parkinson's on Sunday April 21st. If you have the means, we would love your support. Your donation will help all those living with Parkinson's get the valuable support they need. awalkinthepark.org.au/s/2854/3737/t
I am excited this is now published with @eLife. LRRK2/actin cytoskeleton/synapses is a favorite recurring theme of mine 😊. A fun collaboration with @ElisaGreggio_ "LRRK2 regulates synaptic function through BDNF signaling and actin cytoskeleton" doi.org/10.7554/eLife.…
New review in @JCellBiol: Xiong and Sheng @zuhangsheng @NIH_NINDS summarize recent advances in presynaptic mechanisms of neurodevelopmental disorders by focusing on impaired axonal transport of presynaptic cargos. hubs.la/Q02rGR-B0 #Trafficking #Neuroscience
New review: Xiong and Sheng @zuhangsheng @NIH_NINDS summarize recent advances in presynaptic mechanisms of neurodevelopmental disorders by focusing on impaired axonal transport of presynaptic cargos. hubs.la/Q02rGTT70 #Trafficking #Neuroscience
Free webinar from Dr. Yulong Li: Spying on Neuromodulation with Novel Genetically Encoded Fluorescent Sensors. Feel free to attend and communicate with us. CET 2:00 PM, March 28th (Thursday) bityl.co/Oz7l
Please join #NINDS for Clinical #Neuroscience Grand Rounds on 9/19 at 8:30 am EST featuring Drs. Zu-Hang Sheng and John Lynch from @NINDSnews. Watch here: nih.zoomgov.com/j/1606474344?p…
Happy to share our study now online @NatureComms Lots of data demonstrating a metabolic function for the #AMPK related kinase #NUAK1 in cortical neurons This work was supported by @FRM_officiel @Telethon_France and @ERC_Research nature.com/articles/s4146…
So proud of this beautiful new work from Dan Dou, and so grateful to Virginia Lee for inspiring this study!
Dou, Aiken & @ErikaHolzbaur @PennMedicine show that #Parkinsons disease-associated hyperactive LRRK2 decreases the trafficking of synaptic vesicle proteins within neurons by disrupting the regulation of the synaptic vesicle precursor protein RAB3A. hubs.la/Q02qgtts0
🧠 Join us for a riveting seminar with Dr. Zu-Hang Sheng @zuhangsheng from the @NIH_NINDS, hosted by Dr. Juan Song @Songlaboratory! Dr. Sheng explores the intricate mechanisms of organelle transport and their impact on synaptic function and energy balance! Don't miss out! 🌟
It was fun to share our our work with a very engaged audience. Was really nice to get lots of thoughtful questions, especially from students.
Seminar on #snaptic #vesicles tranport by @WormlockHolmes in #iiserpune #biology
My great pleasure to host Dr. Zuhang Sheng @zuhangsheng from NIH for an inspiring seminar on mitochondrial reprogramming and energy metabolism for neuroregeneration @UNC_PHCO.