Impaired cognition after COVID Editorial in @NEJM by Cliff Rosen and myself nejm.org/doi/full/10.10… With an illustration of mechanisms of cognitive dysfunction in #LongCovid 👇
Thank you for putting viral persistence and cognitive impairment "front and center"! And, thank you for not using that horrible (to patients) acronym: PASC. The mechanisms look correct to me, although you could have mentioned he ability of SARS-CoV-2 to move directly between neurons.
What is Brainfog? Cognitive fatigue after a period of concentration or social interaction Difficulty Concentrating Sensitivity to Bright Light Sensitivity to Noises Headpressure Often accompanied by headache and increased neck and throat (cranial nerve? ) soreness. It often worsens when other Long Covid symptoms flare-up, suggesting that it is inflammation related. It is likely a manifestation of Microglial activation in the brain due to SARS-CoV-2 viral persistence.