@ZKForTre Was more interested in if a fasting c peptide would be the “better” one to get if insulin is noisy. Mainly asking for myself. Thanks for your content - I find value in it.
Hantavirus is incredibly deadly.
One of the only reasons that we don't have an issue with it, is we've never seen any outbreaks manage to evolve human-to-human transmission before.
It's always been rodent-to-human contact.
If we have H2H in Hantavirus that ship needs to be stranded at sea until every, single, person is cleared.
Because that would make the previous pandemic look like childs play.
A Mayo Clinic-developed artificial intelligence (AI) model can help specialists detect pancreatic cancer on routine abdominal CT scans up to three years before clinical diagnosis. It identifies subtle signs of disease before tumors are visible, when curative treatment may still be possible. The findings, published in Gut, mark a milestone in Mayo Clinic's multiyear research effort to enable earlier detection of one of the deadliest cancers.
Learn more: mayocl.in/4eippBP
The @IMFNews published "Tokenized Finance" yesterday. The abstract describes the features that make tokenization work inside the regulated financial system: atomic settlement, embedded compliance, continuous liquidity management.
That's not a wish list. It's a checklist. And it's worth going through it.
MILESTONE: 40,000 signatures collected! 🗳️
• Over 15K signed in the past 3 days
• Record inflow of 6,200 in a single day
• Current signatures: 44.015
The paper gain tax petition is now eligible to be placed on the agenda of the House of Representatives.
This obliges the House to formally consider and debate the issue.
But don’t stop here. More signatures mean more weight. Every vote counts. Link in comments if you haven't signed it yet.
#StopBox3
The Dutch government is destroying long term compounding by introducing a 36% tax on unrealized gains.
As a Dutch citizen and long term investor, I’m at a loss for words about the lack of vision behind this new tax. I normally don’t post anything politically related, but what
As a Dutch citizen, still sign the petition
Explosion in signatures as we got more attention globally on Twitter
We got 4k signatures today alone!
Now we got 35k signatures total
We need 40k signatures
Sign if you stil didn't:
petities.nl/petitions/stop…
Christine Lagarde, president of the ECB:
“Creating incentives for investments in Europe is a better approach to prevent capital outflows to other regions than imposing taxes.”
Yesterday, I sent an open letter to all 75 Dutch senators about the proposed 36% tax on unrealized gains.
• They vote in mid March
• As it stands, 43 are in favor and 32 are against
• If it passes, the tax takes effect in 2028
I’ll keep doing what I can to shift the balance, but we need people behind this.
So if you’re Dutch, please share this with friends and family, send it to news outlets, contact our politicians, and help raise awareness.
Tomorrow I’ll go back to my regular content, with occasional updates on this tax.
The Dutch government is destroying long term compounding by introducing a 36% tax on unrealized gains.
As a Dutch citizen and long term investor, I’m at a loss for words about the lack of vision behind this new tax. I normally don’t post anything politically related, but what our government is planning to do is disastrous for long term investors.
This is the sad truth.
Most people here start investing to protect themselves against inflation and ever rising pension ages. They’re trying to put hard earned money to work, hoping they can retire before the age of 71. And they had a real shot at that before this bill.
If you started at 25 with €10,000 and contributed €1,000 every month, you could compound to €3,320,000 over 40 years. If you lived prudently, you could retire early and live off it for the rest of your life.
With the new capital tax? After 40 years of compounding, you’d end up at €1,885,000. That’s a €1,435,000 difference.
This tax denies generations the chance of early retirement, punishes those who take risks, and introduces severe liquidity issues for people who have been compounding successfully for years. And to what end? To fill a €2.4 billion tax hole.
I’m beyond words.
If you’re Dutch like me, please share this visual with fellow investors to increase awareness.
Hopefully we can make our politicians understand the severity of this tax, and the breadth and depth of its destructive implications.
~ Jan
NETHERLANDS HOUSE PASSES 36% TAX ON UNREALIZED GAINS
As expected, the Dutch House of Representatives has approved a 36% tax on unrealized capital gains, with only forward loss offsets permitted.
The proposal now moves to the Senate, where parties that supported the bill also
If someone argues that retail traders can be successful but they have to "keep grinding" or "persevere" and that person
- Runs a funded trader business
- Sells subscriptions to retail traders
- Sells paid access to a chat
- Produces 'trader education' content that they sell ads against
- Participates in affiliate programs (e.g. Kalshi)
then you should discount everything they say. Their continued future profits depend on a steady stream of punters willing to "keep grinding" despite the losses.
Last quarter I rolled out Microsoft Copilot to 4,000 employees.
$30 per seat per month.
$1.4 million annually.
I called it "digital transformation."
The board loved that phrase.
They approved it in eleven minutes.
No one asked what it would actually do.
Including me.
I told everyone it would "10x productivity."
That's not a real number.
But it sounds like one.
HR asked how we'd measure the 10x.
I said we'd "leverage analytics dashboards."
They stopped asking.
Three months later I checked the usage reports.
47 people had opened it.
12 had used it more than once.
One of them was me.
I used it to summarize an email I could have read in 30 seconds.
It took 45 seconds.
Plus the time it took to fix the hallucinations.
But I called it a "pilot success."
Success means the pilot didn't visibly fail.
The CFO asked about ROI.
I showed him a graph.
The graph went up and to the right.
It measured "AI enablement."
I made that metric up.
He nodded approvingly.
We're "AI-enabled" now.
I don't know what that means.
But it's in our investor deck.
A senior developer asked why we didn't use Claude or ChatGPT.
I said we needed "enterprise-grade security."
He asked what that meant.
I said "compliance."
He asked which compliance.
I said "all of them."
He looked skeptical.
I scheduled him for a "career development conversation."
He stopped asking questions.
Microsoft sent a case study team.
They wanted to feature us as a success story.
I told them we "saved 40,000 hours."
I calculated that number by multiplying employees by a number I made up.
They didn't verify it.
They never do.
Now we're on Microsoft's website.
"Global enterprise achieves 40,000 hours of productivity gains with Copilot."
The CEO shared it on LinkedIn.
He got 3,000 likes.
He's never used Copilot.
None of the executives have.
We have an exemption.
"Strategic focus requires minimal digital distraction."
I wrote that policy.
The licenses renew next month.
I'm requesting an expansion.
5,000 more seats.
We haven't used the first 4,000.
But this time we'll "drive adoption."
Adoption means mandatory training.
Training means a 45-minute webinar no one watches.
But completion will be tracked.
Completion is a metric.
Metrics go in dashboards.
Dashboards go in board presentations.
Board presentations get me promoted.
I'll be SVP by Q3.
I still don't know what Copilot does.
But I know what it's for.
It's for showing we're "investing in AI."
Investment means spending.
Spending means commitment.
Commitment means we're serious about the future.
The future is whatever I say it is.
As long as the graph goes up and to the right.
Hopefully this was useful to some of your.
The point here isn’t that swmid is bad. It’s fine, it’s a useful fair, but it’s not magic, it’s not novel, and it’s NOT ALPHA!
/END 🧵
According to @macrocephalopod, if I don’t get people to retweet to follow me I am going to get cooked on my bet that I will get to 30K followers by year end.
I made this bet ~3 weeks ago and my plan was to post frequently for 2 weeks and then beg for my highbie followers to lend a brother a hand to teach my counterparty not to make bets where reflexivity is involved and I have a chance to shape the outcome.
2K Followers 7K FollowingOn the front lines of security as a GSOC Manager. Harvard & CompTIA CySA+ certified. Threat-focused and passionate about locking down corporate spaces
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168 Followers 3K FollowingHe/Haw/Xi Reichsbank President 1980-1923 Uncategorizable. Tweets are Solely for my own amusement. My Way of joking is to tell the truth. - G.B. Shaw
11K Followers 7K Following31 years old. Everyone deserves healthcare, food, shelter, education, and a living wage. Free the oppressed, abolish ICE, defund the police.
3K Followers 3K FollowingGot 2 x MSc in diabetes.
Then (irony maxing) diabetes got me.
Reversed it with laughably normal food.
No fads, loin cloths, or guru energy - just what works ⬇️
20K Followers 337 FollowingSurgeon & Medical Expert | Science Over Hype | Evidence-Based Health & Nutrition | My substack for more in depth discussion https://t.co/HDz2E3Grdt
226K Followers 1K FollowingFind my specials on Netflix and Prime Video or come see me on The Big Dumb Eyes tour. #TheBreadwinnerMovie is now out in theatres nationwide!
1K Followers 71 FollowingFounder and CTO: @ComputeDesk. Exited Pace Revenue to FLYR. Formerly VP of Research at Winton, particle physics researcher at Harvard and CERN
133K Followers 997 FollowingGP https://t.co/cvXKvUFfbd. Founder of @carryhq_ (sold to @AngelList). Founded @teachable (sold to @hotmart). Not financial advice, views are personal.
6K Followers 1 FollowingUSVC is how you invest in venture capital. Start with as little as $500 for broad exposure to private tech companies. Built by @AngelList
4.7M Followers 458 FollowingCutting-edge research, news, commentary, and visuals from the Science family of journals. Follow @NewsfromScience for stories from our News team.
4K Followers 752 FollowingHealthspan is the first online medical clinic dedicated to fighting age-related diseases and increasing human performance by fighting cellular senescence.
13K Followers 2K FollowingPast President Argentine Lipid Society. Internal Medicine Doctor. School of Medicine Professor. Lipidologist. Atherosclerosis. CV Prevention.
17K Followers 2 FollowingAI has killed software and tech stocks. Valuations are at multi-decade lows. Stock prices are in the trash. This is a once in a lifetime opportunity to buy fear
20K Followers 453 FollowingTrading executive: 20y+ @kochincglobal. Now at @nyuniversity, @OxfordEnergy. Author of "Virtual Barrels". Opinion only, no advice.