Celeste Karch @karchlab
Professor. Washington University School of Medicine. Genomics, stem cell models, molecular mechanisms of AD and other tauopathies. She/her. sites.wustl.edu/karchlab St Louis, MO Joined March 2017-
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V337M and R406W are the first known mutations in the microtubule-associated protein tau gene that give rise to filaments with the Alzheimer tau fold. biorxiv.org/content/10.110…
Our latest paper is in press today @PLOSBiology led by @eteleeb & @omharari on brain high-throughput multi-#omics & molecular heterogeneity in #Alzheimers. We found a multimodal profile with⬆️Braak tau, #synaptic, #endocytosis, #phagosome, & #mTOR pathways dx.plos.org/10.1371/journa…
This was quite fun to co-write! New review on retrotransposons and endogenous retroviruses in neurodegenerative disorders from @joshdubnau and yours truly: go.shr.lc/3wcE0Ls
Hi everyone! We are looking for a postdoctoral fellow with expertise in RNA biology and/or molecular virology. Please circulate: wustl.wd1.myworkdayjobs.com/en-us/external…
Multiple microglia talks next week at the Engineering iPSC symposium @jacksonlab @ChanZuckerberg. You can register to attend online until May 3 😁
Multiple microglia talks next week at the Engineering iPSC symposium @jacksonlab @ChanZuckerberg. You can register to attend online until May 3 😁
The people who we mentor are not us and their goals are not usually our goals. So, instead of focusing on what we would do, we can help them focus on what they should do in light of: -their priorities -their choices -their strengths -their path
Join @MEDA_WashU leaders Drs. @JessSFisher @FeliciaGomez02 @Agriffithebiol1 for a Power #Mentorship workshop "Creating a mentoring team" tomorrow 4/25 @WUSTLABBGS Inspire conference 10:15am! @IDEASDOM_WUSM ⏬
Join @MEDA_WashU leaders Drs. @JessSFisher @FeliciaGomez02 @Agriffithebiol1 for a Power #Mentorship workshop "Creating a mentoring team" tomorrow 4/25 @WUSTLABBGS Inspire conference 10:15am! @IDEASDOM_WUSM ⏬
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A huge congratulations to Dr. Gan for receiving the 2024 Jessica M. and Natan Bibliowicz Award for Excellence in Mentoring Women Faculty! It is a pleasure to receive your guidance daily in our lab. @WeillCornell #WCMDiversityWeek diversity.weill.cornell.edu/about-us/diver…
ATTN: JOB POSTING! #ADNI Engagement Core Health Disparities Scientist position @ @UWMadison w/ #DrOziomaOkonkwo!⭐️ Apply by 4/26/24 @ 11:55pm CT: jobs.wisc.edu/jobs/health-di… Pls #RT🙏🏽 @beyoung40 @MoraPinzonMD @ytquiroz @annyreyesNeuro @marquine_maria @BlackInNeuro @BlackInGeron
Check out our latest @biorxivpreprint Collaborative work with the @GeschwindLab to explore shared and distinct molecular signatures in cortical #organoids from 70 hiPS cell lines representing 8 different neurodevelopmental disorders, idiopathic autism spectrum disorder patients…
WiSTEM would like to invite you to a free screening of Picture A Scientist, on 5/2, 5:30pm at Moore Auditorium. Picture a Scientist is an award-winning, 2020 documentary on the stories of Nancy Hopkin , Raychelle Burks , geoscientist Jane Willenbring , and others. RSVP!
Out now in @TheLancetNeuro A comparison of tau PET pathology in Down Syndrome (DS) and Autosomal Dominant Alzheimer Disease (ADAD). thelancet.com/journals/laneu…
I am thrilled to share our lab's latest work documenting sex-differences (SD) in P2RY12's regulation of microglial morphology, synapse density and locomotory behavior. This work is our lab's first dive (of hopefully many)into microglial SD led by @OJ_uweru jneuroinflammation.biomedcentral.com/articles/10.11…
Happy WashU Psychiatry Research Day to those who celebrate! I’m lucky to be part of a lab who makes incredible discoveries and shows up to support one another 🫶🧬🔬🧪 @washupsychres @WashUONR @wustlcrm @WUADRC
Happy to share this review article on microglial phagocytosis mechanisms in development informing disease. Great collaborative effort between @becca_beiter and @patwsheehan in the lab. sciencedirect.com/science/articl…
***Hot off the @JAMANeuro e-press*** While seeking to investigate clinicopathologic heterogeneity and glial activation patterns of #Alzheimers...we created a corticolimbic index (CLix) to better capture the individuality of tangle distribution. jamanetwork.com/journals/jaman…
Microglia pack a toolbox for life 🧰🛠️ @TrendsImmuno @kzengeler sciencedirect.com/science/articl…
In the latest issue! Single-cell dissection of the human motor and prefrontal cortices in ALS and FTLD dlvr.it/T5RGJd
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123 Followers 162 Following FTD Center Without Walls (CWOW) team from UCSF and WashU, working to understand tau metabolism. Funded by the NIH.V337M and R406W are the first known mutations in the microtubule-associated protein tau gene that give rise to filaments with the Alzheimer tau fold. biorxiv.org/content/10.110…
Our latest paper is in press today @PLOSBiology led by @eteleeb & @omharari on brain high-throughput multi-#omics & molecular heterogeneity in #Alzheimers. We found a multimodal profile with⬆️Braak tau, #synaptic, #endocytosis, #phagosome, & #mTOR pathways dx.plos.org/10.1371/journa…
Congratulations to Abhinav Diwan, MD, on his appointment as the inaugural Charlie W. Shaeffer, MD, Professor of Cardiology at WashU Medicine! Learn more: medicine.wustl.edu/news/diwan-nam…
This was quite fun to co-write! New review on retrotransposons and endogenous retroviruses in neurodegenerative disorders from @joshdubnau and yours truly: go.shr.lc/3wcE0Ls
Hi everyone! We are looking for a postdoctoral fellow with expertise in RNA biology and/or molecular virology. Please circulate: wustl.wd1.myworkdayjobs.com/en-us/external…
Multiple microglia talks next week at the Engineering iPSC symposium @jacksonlab @ChanZuckerberg. You can register to attend online until May 3 😁
Looking forward to speak at @jacksonlab and @ChanZuckerberg’s Engineering iPSC symposium, highlighting genome editing in #iPSC to study Alzheimer’s disease development Join me May 6th: jax.org/iPSC2024
Tough times for me personally at the moment…not above a bit of ‘shop therapy’ in the form of new 🪴, a lovely/unique vase & a message that truly resonates 🙂
I have no wish to leave this valley of tears today, but if that happens, let it be known that I was a honest scientist. In >40 years of science, I have been wrong, sloppy, lazy, insufficiently vigilant/competent, and much more - but I was never dishonest.
My vitals have crashed septically today, so I was rushed to the Zurich ICU by helicopter. I am stable now. If things go sideways, I hope the university won't shut my lab. Nobody else does prions in Switzerland.
The people who we mentor are not us and their goals are not usually our goals. So, instead of focusing on what we would do, we can help them focus on what they should do in light of: -their priorities -their choices -their strengths -their path
Favourite birthday card & image showing why it is 100% accurate 🤣
Lovely dinner with the lab family! Fantastic group of people 😍Welcoming new members to the lab, celebrating important achievements, and toasting to the success of the ones moving on to new adventures 😃
Join @MEDA_WashU leaders Drs. @JessSFisher @FeliciaGomez02 @Agriffithebiol1 for a Power #Mentorship workshop "Creating a mentoring team" tomorrow 4/25 @WUSTLABBGS Inspire conference 10:15am! @IDEASDOM_WUSM ⏬
The Association of Black Biomedical Graduate Students (ABBGS) at Washington University in St. Louis is excited to invite you to the 2nd INSPIRE (Interdisciplinary Conference for Networking, Please register here: shorturl.at/hkzFZ.
@MEDA_WashU @FeliciaGomez02 @Agriffithebiol1 @WUSTLABBGS @IDEASDOM_WUSM #Mentorship is vital to your success. The more the better. How many mentors do you have and how do you find them? Join us to learn more!
I am incredibly honored and grateful to be elected to the @americanacad. This could not have happened without the amazing creativity and hard work of past and present lab members and the support and mentorship of many colleagues within and outside @DukeU medschool.duke.edu/news/eroglu-el…
This morning I had an accident resulting in a large soft-tissue hemorrhage. In the ER, I went suddenly into hypovolemic shock. The ER team reacted immediately by squeezing 500ml Ringer/ephedrine and saved my life. I am now in the ICU, heavily cabled but stable.
Thanks to @washupsychres for a fantastic visit! I had so much fun chatting with @karchlab and everyone else!
We are delighted to announce Professors Camillo Padoa-Schioppa @CamilloPadoaSch and Andreas Burkhalter are among the AAAS Fellows! Congratulations for this well-deserved honor.
Congratulations to the nine WashU faculty members who were selected as @aaas fellows, marking a momentous milestone as the AAAS Fellows program celebrates its 150th year. bit.ly/49J1RjF
Applications for a Postdoc position with us @UKDRI @EdinUniNeuro are still open for 2 more weeks! 🥼🔬🧠 Check us out, get in touch and apply below! 👇 bowleslab.co.uk elxw.fa.em3.oraclecloud.com/hcmUI/Candidat…
A huge congratulations to Dr. Gan for receiving the 2024 Jessica M. and Natan Bibliowicz Award for Excellence in Mentoring Women Faculty! It is a pleasure to receive your guidance daily in our lab. @WeillCornell #WCMDiversityWeek diversity.weill.cornell.edu/about-us/diver…