We recently have had a very late admission from the National Institutes of Health that Sars Cov 2 is chronic I've been spending 4 years advocating for infection prevention of SARS Cov 2 and saying it is likely persistent and chronic This is why I looked upon calls for relying on the spread of infection as maintenance of 'immunity" with horror. In 2021 Marc Veldhoen published a commentary in Nature Immunology arguing that SARS Cov 2 vaccinations would not be necessary soon because the infection itself would maintain immunity. The commentary also makes claims that this would drive down organ seeding of sars cov 2 and also protect the vulnerable. If anything, it is only that sars cov 2 has become even more capable of replicating in organs like our intestines, and this is reflected in wastewater data, so the opposite has occurred. Also, due to synchrony and evolution, situations where endemic infection is encouraged do the opposite of protect the vulnerable, they make their infection more likely. For this reason, apologism for pro-infection policy and the pseudoscientific rationales as provided by Marc Veldhoen in "Endemic SARS-CoV-2 will maintain post-pandemic immunity" deserve harsh criticism and reprimand. nature.com/articles/s4157… Effectively, we have ensured many are infected with a chronic virus that causes impairment AND we have enabled the evolution of that virus to infect the gut in a more prolific manner. Immunologists like Marc Veldhoen and Paul Bleicher have claimed the T cell evasion of the virus is not an issue for most people, and neither is the immune dysregulation. Both of these features of SARS Cov 2 are important for establishing chronic infection and harming CD8 immunity by overstimulation in an uncoordinated fashion. Marc Veldhoen and Zeynep Tufekci have spent years telling people that individuals with Long Covid are part of a vulnerable subset, when it turns out at least a fifth or a quarter of individuals have proof of chronic infection When I use highly technical language like downregulation of MHC 1 by SARS Cov 2 I am accused of technobabble. When I use straight speak like saying the virus evades T cells, I am called an alarmist and was pointed to "fundamental immunology." The T cell dysregulation is absolutely an issue, as is the immune ageing. Everyone makes mistakes, but to dismiss them in an arrogant fashion and try to bury the past means these individuals have certainly not learned from them, nor admitted fault.
We recently have had a very late admission from the National Institutes of Health that Sars Cov 2 is chronic I've been spending 4 years advocating for infection prevention of SARS Cov 2 and saying it is likely persistent and chronic This is why I looked upon calls for relying on the spread of infection as maintenance of 'immunity" with horror. In 2021 Marc Veldhoen published a commentary in Nature Immunology arguing that SARS Cov 2 vaccinations would not be necessary soon because the infection itself would maintain immunity. The commentary also makes claims that this would drive down organ seeding of sars cov 2 and also protect the vulnerable. If anything, it is only that sars cov 2 has become even more capable of replicating in organs like our intestines, and this is reflected in wastewater data, so the opposite has occurred. Also, due to synchrony and evolution, situations where endemic infection is encouraged do the opposite of protect the vulnerable, they make their infection more likely. For this reason, apologism for pro-infection policy and the pseudoscientific rationales as provided by Marc Veldhoen in "Endemic SARS-CoV-2 will maintain post-pandemic immunity" deserve harsh criticism and reprimand. nature.com/articles/s4157… Effectively, we have ensured many are infected with a chronic virus that causes impairment AND we have enabled the evolution of that virus to infect the gut in a more prolific manner. Immunologists like Marc Veldhoen and Paul Bleicher have claimed the T cell evasion of the virus is not an issue for most people, and neither is the immune dysregulation. Both of these features of SARS Cov 2 are important for establishing chronic infection and harming CD8 immunity by overstimulation in an uncoordinated fashion. Marc Veldhoen and Zeynep Tufekci have spent years telling people that individuals with Long Covid are part of a vulnerable subset, when it turns out at least a fifth or a quarter of individuals have proof of chronic infection When I use highly technical language like downregulation of MHC 1 by SARS Cov 2 I am accused of technobabble. When I use straight speak like saying the virus evades T cells, I am called an alarmist and was pointed to "fundamental immunology." The T cell dysregulation is absolutely an issue, as is the immune ageing. Everyone makes mistakes, but to dismiss them in an arrogant fashion and try to bury the past means these individuals have certainly not learned from them, nor admitted fault.
@fitterhappierAJ You have to worry about someone claiming (as a support for their argument) that their evidence is bog standard immunology from 45 years ago. It kind of suggests that, around that time, they stopped reading the literature.
I have, like many of those I follow or those that follow me, followed you since the very beginning. Astonishing, yet expected as genuine intellectual queries with honesty can go a long way, how he has consistently been right yet despised by some outside their field (of expertise if any). Psychosocially, this is typical of regressed organizations (e.g., CDC, some UN) or societies. Narcissistic wishes to exploit situations for one’s own grandiosity that are on the increase when a society regresses are almost always accompanied by mediocrity as seen amongst those that pushed wrong theories at a huge cost to society.
@fitterhappierAJ Why do people listen to Zeynep? She has no -- ZERO -- qualifications that give her standing to discuss things as if she's an MD, immunologist, epidemiologist of (a few weeks ago) seismologist. She is a sociologist.
@fitterhappierAJ @threadreaderapp please unroll
@fitterhappierAJ If an attempted intervention against a disease causes immune system dysfunction, allowing an infection to persist but only in those who have taken the intervention, is the disease really chronic? nature.com/articles/s4146…
"Recently a very late admission from NIH #COVID_19 Sars Cov 2 is chronic I've been spending 4 years advocating for infection prevention of SARS Cov 2 and saying it is likely persistent and chronic I looked at relying on the spread of infection as maintenance of 'immunity" with horror. Everyone makes mistakes, but to dismiss them in an arrogant fashion and try to bury the past means these individuals have not learned, nor admitted fault."
@fitterhappierAJ I have been listening to you from the beginning! Thank you for your insights and hard work
@fitterhappierAJ @DrEricDing It makes me sad to see Gavin Yamey’s response to Veldhoen… he was my professor in grad school and I had a ton of respect for him.