André Jefremow @anjefus
Erlangen, Deutschland Joined April 2010-
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André Jefremow retweeted
I’ve just updated the last 2 years of this IBD trial timeline I think it may be useful to gain perspective: decades of trial names together reminds us how much the field has evolved and how fast it is still moving Now including >250 trials🤩 Full quality ibd-eii.com/cheat-sheet/
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André Jefremow retweeted
MUST READ📖 Joint @RomeFoundation & @IOIBD1 RAND/UCLA Recommendations for #Evaluation & #Managmt of #IBD with #IBS-like Symptoms @AGA_Gastro pubmed.ncbi.nlm.nih.gov/42066865/ 📝Nomenclature: IBD with IBS-like symptoms Evaluation🩺 🧫 Therapies 🥗Diet 💊Drugs💉 🧠Brain gut behavioral tx
@ibdtweets That does not explain why the dosages of Risa (UC>CD) and Miri (CD>UC) differ regarding which disease needs a higher dosage.
@ibd_india I have talked with the company about this issue. They told me that upadacitinib is resorbed within two hours After taking the pill so it should be fine in most cases.
André Jefremow retweeted
One-off application of CAR T-cell therapy leads to long term remission for a range of autoimmune diseases including SLE and more recently, IBD. Is this game changing therapy in the making? #UEGWeek
André Jefremow retweeted
CAR T-cell therapy was effective for a patient with multi-drug refractory ulcerative colitis. nejm.org/doi/full/10.10…
André Jefremow retweeted
CD19 CAR T-Cell Therapy in Multidrug-Resistant Ulcerative Colitis | New England Journal of Medicine nejm.org/doi/full/10.10…
André Jefremow retweeted
The gastroenterology and immunology communities are buzzing after a landmark NEJM publication (Sept 25, 2025) reported the first successful use of autologous CD19 CAR T-cell therapy in ulcerative colitis (UC). The patient, who had exhausted biologics and immunosuppressants, achieved sustained remission with mucosal healing—off all medications—for more than eight months. So, what exactly is CAR-T, and why is this so exciting for IBD? 👇
André Jefremow retweeted
Therapeutic B-cell targeting: the next big thing in #IBD treatment for selected pts? @RajaAtreya #MarkusNeurath 🌍✨ #Crohns #Colitis #MedTwitter @IBD_FloMD @fgomollon @Y_ECCO_IBD @ibddoctor @IBDMD @DignassAxel @RestelliniS nejm.org/doi/full/10.10…
André Jefremow retweeted
Cellular therapy is making big moves in so many spaces!! 🔥 🎯 In a patient with treatment-resistant ulcerative colitis, CD19 CAR T-cell therapy led to drug-free remission and mucosal healing, suggesting that B-cell targeting may offer a novel therapeutic pathway. @NEJM nejm.org/doi/full/10.10…
André Jefremow retweeted
Exciting times ahead 🥹
WOW @NEJM CD19 CAR-T led to complete remission (clinical, biochemical, mucosal) in MDR UC Patient failed on steroids, cyclosporine, 5-ASA, anti-TNF, JAKi, S1Ps, vedo, p19 By day 50 activity index 7↘️0 maintained 14 wks of FU ⬆️7kg Mild adverse efect resolved spontaneously link👇
@GI_Pearls „One can argue that science, art, and ethics constitute the ultimate trifecta of medical practice“ Sapira‘s Art & Science of Bedside Diagnosis
@GI_Pearls Life‘s not always black and white and neither is the answer to the question. If there is nothing scientific then why ask this question at all? If we see science as a principle of investigation, medicine indeed is science.
@OxytocinTussi @doc_khan454 @drkeithsiau Why at evening?
@drkeithsiau I read it, too. That was new for me, never heard it before. @EvidenceOpen gives a NNT of 50. I would have guessed a thousand or something.
@drkeithsiau Despite of the individuality of treatment response (e. g. previous treatment failures) I honestly doubt some of the numbers. For example, when you compare the weeks between IFX, 5-ASA und Aza, it seems far from real life experience. How did they come up with These numbers?
@ShomronH @Bealoquebea @AmJGastro @DiegoCasas8 @MLongMD @JasmohanBajaj Ostomy, missing segments etc. But most of all I dislike those ridiculous long wash-out periods, like 12 weeks for ustekinumab. What‘s the point in treatment failure?
@WilliamAird4 Finally something useful. 😀😀
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