Vahidi Lab@UofGuelph 🇨🇦 @VahidiLab
Assistant Professor @uofg | Biochemist | Structural Biologist | Mass spectrometry | NMR spectroscopy vahidilab.ca Guelph, ON, Canada Joined February 2020-
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Vahidi Lab@UofGuelph 🇨🇦 retweeted
CONGRATULATIONS to our Phillips Scholarship Winners, Nicholas Gervais (Shapiro Lab) and Bradley Davis (Vahidi Lab)!!👏👏👏🎉🥳🎈
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Vahidi Lab@UofGuelph 🇨🇦 retweeted
Can enzymes retain catalytic activity in the gas phase? Using tandem MS, molecular dynamics simulations, and enzyme variants courtesy of the @VahidiLab, Kirsty (@kirstynyk) uncovers new insight towards this question. Now published in JACS (@J_A_C_S)! pubs.acs.org/doi/10.1021/ja…
Vahidi Lab@UofGuelph 🇨🇦 retweeted
CIHR funding rate: 13.6%. Early 2000s: 30%+. Canada’s new $1.7B Impact+ program recruits talent — but without increased Tri-Council base funding, we risk further strain on an already stretched system. We’re calling for $1B over 5 years. Support here: tinyurl.com/33c5av46
Vahidi Lab@UofGuelph 🇨🇦 retweeted
Molecular mechanisms of mitochondrial AAA+ proteases - Journal of Biological Chemistry jbc.org/article/S0021-…
Vahidi Lab@UofGuelph 🇨🇦 retweeted
Join 2026 BPS Lecturer Lewis Kay on Tuesday, February 24, 2:00 PM - 3:00 PM at #bps2026 for an informal discussion. Dr. Kay will share insights from his scientific career—from pioneering discoveries to lessons learned along the way—and reflect on how the field continues to evolve
Vahidi Lab@UofGuelph 🇨🇦 retweeted
MCB @ U of Guelph is hiring (again)! 🎉 Tenure-track Assistant Professor in Biochemistry Part of our strategic cluster hire. Apply now 👉 careers.uoguelph.ca/job/Guelph-Ass… #Biochemistry #FacultyJobs #AcademicTwitter #MolBio
Vahidi Lab@UofGuelph 🇨🇦 retweeted
Out in @pnas today Showcasing the power of NMR! NMR and enzyme kinetics show USP7 enzyme transiently sampling a low-populated active state, and its disease-causing variant enhancing these dynamics pnas.org/doi/10.1073/pn… Stellar work by students Gabi Valles and Emilie Korchak
Vahidi Lab@UofGuelph 🇨🇦 retweeted
Congrats to Monica Goncalves and Madison Turner for winning the 2025 Dr. Donald R. Phillips Molecular & Cellular Biology Scholarship! The award recognizes research excellence, academic achievement, and meaningful contributions to MCB. Congrats to their supervisor, @VahidiLab!
Vahidi Lab@UofGuelph 🇨🇦 retweeted
Don’t miss the Ann Oaks Lecture in Biological Sciences, with Dr. Lewis Kay, professor of molecular genetics, biochemistry & chemistry @UofT 🗓️May 28 at 2 p.m. 📍ALEX 100 More info: uoguelph.ca/cbs/events/202…
Vahidi Lab@UofGuelph 🇨🇦 retweeted
Vahidi Lab@UofGuelph 🇨🇦 retweeted
Excited to share our new publication with @VahidiLab! We reveal how human mitochondrial ClpP is allosterically activated—even by inhibitors—unlocking new strategies to target ClpP in AML. pnas.org/doi/10.1073/pn…
Vahidi Lab@UofGuelph 🇨🇦 retweeted
New findings from #UofG researchers could help unlock better treatments for leukaemia and tuberculosis. The studies focus on specialized enzymes that destroy damaged proteins and reveal how these enzymes can be switched on or off. Learn more: uoguel.ph/fxwpf
Vahidi Lab@UofGuelph 🇨🇦 retweeted
A fantastic lab and an excellent PI!
Credit to outstanding trainees and collaborators, including @NatalieZeytuni and @UdayAdwaith
New #UofG research may unlock better treatments for leukemia and tuberculosis, which affect millions worldwide. “If we can trap these enzymes, there is a chance we can make some very potent therapeutics," says Dr. Siavash Vahidi. @UofGCBS Read more: news.uoguelph.ca/2025/04/protei…
Vahidi Lab@UofGuelph 🇨🇦 retweeted
New #UofG research may unlock better treatments for leukemia and tuberculosis, which affect millions worldwide. “If we can trap these enzymes, there is a chance we can make some very potent therapeutics," says Dr. Siavash Vahidi. @UofGCBS Read more: news.uoguelph.ca/2025/04/protei…
Now published at: doi.org/10.1073/pnas.2…
1/🧵Human ClpP protease is targeted in cancer therapy with the activator ONC201 @chimerix Yet all structures of ClpP have captured it in its inactive state, even when bound to activators! ClpP is paradoxically activated by inhibitors at low concentrations before inhibition starts
Vahidi Lab@UofGuelph 🇨🇦 retweeted
Thrilled to share our new paper revealing an auto-inhibited state of the M. tuberculosis 20S proteasome—highlighting allosteric sites with therapeutic potential. A fantastic collaboration with the @VahidiLab! 🔗 nature.com/articles/s4146… #cryoEM #TBresearch #StructuralBiology
Vahidi Lab@UofGuelph 🇨🇦 retweeted
Mechanism of allosteric activation in human mitochondrial ClpP protease | PNAS pnas.org/doi/10.1073/pn…
Vahidi Lab@UofGuelph 🇨🇦 retweeted
Bit of a late post, but I had the incredible opportunity to attend and present my work at the Biophysical Society Annual Meeting this year! It was my first #BPS and also my first conference outside Canada. I got to learn from so many inspiring biophysicists doing amazing science!
Vahidi Lab@UofGuelph 🇨🇦 retweeted
Professor Lewis Kay @LEK_Lab @UofT is honoured with the 2025 Alexander Hollaender Award in Biophysics awarded by the U.S. National Academy of Sciences @theNASciences for outstanding contributions to the field of biophysics utoronto.ca/celebrates/lew… #NMRnews #NMRchat #NMR 🧲
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