Tao @TaoChelab
Washington University in St. Louis; Structure and function of GPCRs St Louis, MO Joined November 2017-
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Congrats to @KYoojoong @rgumpper @RothLabUNC Bitter taste receptor activation by cholesterol and an intracellular tastant nature.com/articles/s4158…
My honor to receive this award. Thank you @ASPET, and thanks to the nominators and committees. @WUSTL_AnesRsrch @ClinicPharmSTL
My honor to receive this award. Thank you @ASPET, and thanks to the nominators and committees. @WUSTL_AnesRsrch @ClinicPharmSTL
Asenapine as a potent TAAR1 agonist nature.com/articles/s4146… Congrats @NeuroStructure
Wow!! congrats @arshukla and gang! science.org/doi/10.1126/sc…
Thanks Christian. Thanks for managing the giant paper. Great teamwork
Thanks Christian. Thanks for managing the giant paper. Great teamwork
Thanks for visiting WashU, Ruth. Great meetings and talk.
Congratulations @TaoChelab @sushmajumdarlab @LameesHegazy and all authors. Great piece of work.
I'm excited to see the final project from my PhD @peptide_drugs published today in @NatureComms. Great collaboration with @UWproteindesign @TaoChelab @sushmajumdarlab @TheCraikGroup @ParisaH_Lab Spetea and Muttenthaler Lab #GPCRs #opioidreceptor #peptides nature.com/articles/s4146…
Very happy to see this published: computer-assisted design of #cyclic #peptide-conjugates for the #kappa #opioid receptor! #GPCR #Rosetta #pain nature.com/articles/s4146… @EdinMuratspahic @UWproteindesign @TaoChelab @MedUni_Wien
Glad to share our review on opioid receptors. This is something we think worthwhile to try in the future, hope they are useful. @zenbrainest Molecular basis of opioid receptor signaling sciencedirect.com/science/articl…
Best wishes to @RothLabUNC alum @hustzsc who is starting his lab at Peking University!!
We have contacted @jacksonlab and will deposit our mice from this paper as soon as possible so they will be available to anyone who wishes to use them. Please RT biorxiv.org/content/10.110…
We are thrilled to share our latest structures of doublet microtubule from sea urchin sperm and bovine sperm. This is a wonderful collaboration with Tzviya Zeev-Ben-Mordehai @TzviyaZBM , Alan Brown @alanbrownhms, and Susan Dutcher @DutcherLab.
Incoming graduate student desk, @Fisk1866 student Vida Storm Robertson highlights @Nature paper from Tao Che's lab @WUSTL Using cryo-EM, authors studied κ-opioid receptorto ligands & selectivity of 4 types of Gi/o-family proteins to KOR/ligand complexes. buff.ly/3MUhyem
This was so much fun! Thanks for coming out @ClinicPharmSTL and friends @Jutkiewicz_Lab @DrSusieLIngram1 @MPuthenveedu @jordacular @sushmajumdarlab @TaoChelab @ElgendyBE @reamalhasani @JohnStreicher1 and more! @WUSTL_AnesRsrch @UHSPedu #ASPET2023
St. Louis scientists are making significant strides in finding safer alternatives to treat pain w/o the risk of addiction. This research by @TaoChelab at @ClinicPharmSTL brings hope for a brighter, opioid-free future. @WashUanesthesia @UHSPedu kmov.com/2023/05/12/st-…
Congratulations @TaoChelab! Such a proud and exciting time for the @ClinicPharmSTL! @WUSTL_AnesRsrch @UHSPedu
Very glad to share our recent work on kappa opioid receptor. Congratulations to everyone involved in this work! Great teamwork! Ligand and G-protein selectivity in the κ-opioid receptor disq.us/t/4g4kkwl
Get your INRC workshop proposals in today!! @INRCmeeting
GPCR usually have varying degrees of ligand-independent constitutive activity. Our recent study dig out why some receptor exhibit the high levels of constitutive activity. pnas.org/doi/10.1073/pn…
BryanRoth @zenbrainest
16K Followers 518 Following James Black: 'the prismatic qualities of the assay distort our view in obscure ways and degrees'Susruta Majumdar @sushmajumdarlab
333 Followers 94 FollowingJohn Janetzko @jjanetzko
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628 Followers 90 FollowingRob Gereau @robgereau
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1K Followers 914 Following neuroscientist interested in opioids and migraineDrGPCR @DrGPCR
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105 Followers 327 Following PhD student in Bo Li lab @CSHL/@SBUNeurobiology, systems neuroscience, addictionKouki Kawakami @kk_kawakami
444 Followers 402 Following HEKato Lab (JSPS-PD, UTokyo) ← A Inoue Lab (Tohoku Univ.) / GPCRSUNIL KUMAR @Kr_Sunil_92
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80 Followers 2K Following former philosophy grad student, current research assistant, soon to be med student (he/him)Emily @teng88002
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0 Followers 62 FollowingWillow Coyote-Maestas @willowcoyote
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397 Followers 879 Following Neuro Ph.D Candidate @umpharmacology | opioids, pain, behavior | first-gen 🇬🇾🇮🇳 | @NYUniversity ‘16 | Formerly @SinaiBrain | she/her/hersWashU Office of Neuro.. @WashUONR
1K Followers 871 Following Driving opportunities for the #WashUNeuroCommunity to connect. @WUSTLmed @WUSTLArtSci @WashUengineers @BrownSchoolMatt Prekupec @MattPrekupec
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113 Followers 487 Following MD/PhD student at the Medical College of Wisconsin. GPCRs and Protein dynamics! TTRPG, Astrophotography, and Heavy Metal enthusiastHarryJQ @JianHua01594303
2 Followers 26 FollowingBryanRoth @zenbrainest
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333 Followers 94 FollowingJohn Janetzko @jjanetzko
2K Followers 3K Following Incoming Asst. prof. Univ of Colorado @CU_BMG. Chemist, sometimes structural biologist, bike racer 🚴🏼♂️, 👦 & 🐶 dad, 🇨🇦. Prev. Stanford/Harvard/UToronto.Seva Katritch @sevakat1
628 Followers 90 FollowingRob Gereau @robgereau
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426 Followers 581 Following GPCRs, Psychedelics, and Pharmacology. BFA+BA WUSTL ‘16. PhD UNC '24. MD UNC ‘26ish he/him/they/them.Zoe McElligott (since.. @nanopharmNC
14K Followers 7K Following Neurosci w/ tiny farm. AWARD WINNING PEARS! #FriendsWithLyricalGenius #TheEldestMillennial She/Her, views expressed here are not as a representative of UNC-CH.WashU Anesthesiology .. @WUSTL_AnesRsrch
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10K Followers 131 Following Professor and Sonu Agrawal Memorial Chair, IIT KanpurReid Olsen @GpcReid
766 Followers 680 Following Director of Cellular Pharmacology & head of GPCR Pharmacology @ExscientiaAI. Aspiring drug hunter, ooccasional sleeper, dog person. Opinions and views my own.zara weinberg 🧪�.. @weinberz
8K Followers 5K Following cell signaling, synbio, publication anarchist, mentoring, teaching, curiosity, caring. #NIHMOSAIC Scholar w/ @HanaScientist 🧙🏻♀️👩🏻🔬🏳️🌈⚧ she/hermbruchas @mbruchas
3K Followers 1K Following Neuroscientist, GPCRs, Food, Music, Wine, Beer, Travel, Books, Outdoors, BBQ, Video/Board Games, Hockey, Cosmology. (views mine / not my lab’s or University’s)Wayland Cheng Lab @WChengLab
648 Followers 492 Following Biophysical and structural studies of ligand-gated ion channels. Lipid modulation. @WUSTL_AnesRsrch Washington University Department of AnesthesiologyReceptor Biology Lab @StuartMaudsley
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552 Followers 391 Following pain researcher, clinical pharmacist, @WUSTLmed @WashUanesthesia, @NeuPSIG Chair, tennis enthusiast (VamosRafa)Can Cao @CanCao_Natural
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149K Followers 49K Following Science integrity consultant, PhD. #ImageForensics Previously @ Stanford and (gasp!) uBiome. She/her. elisabethbik.bsky https://t.co/V4MR7WVHiT 🇳🇱🇺🇸Michel Bouvier @Michel_Bouvier
1K Followers 153 Following Molecular pharmacologist, Professor of Biochemistry & Molecular Médecine @uMontreal, General Director @IRIC_umontreal . Avid readernature @Nature
2.6M Followers 4K Following Research, News, and Commentary from Nature, the international journal of science. For daily science news, get Nature Briefing: https://t.co/wGmQlQ8a4DKeri Martinowich @martinowk
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228 Followers 322 Following Assistant Professor @WashUanesthesia, @WUSTLmed. Into ion channels, cell signaling, neuroscience, physiology, inflammation. Mentorship and Learning.ASPET @ASPET
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149 Followers 52 Following Assistant Professor Medical College of Wisconsin Department of Cell Biology, Neurobiology, and AnatomyBen Garcia @GarciaLabMS
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757 Followers 420 Following The Schulte lab investigates activation mechanisms of Class F GPCRs with the aim to target these receptors therapeutically.Haoqing Wang @haoqing_wang
109 Followers 234 FollowingWillow Coyote-Maestas @willowcoyote
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2K Followers 320 Following @Harvard based software consortium CryoEM Crystallography NMR https://t.co/mcs7ceU3m8 https://t.co/Ovx8eptlKG https://t.co/5DppKzu5BF @[email protected] @sbgrid.bsky.socialJohn Streicher @JohnStreicher1
2K Followers 1K Following I'm a biomedical scientist at the University of Arizona. I study opioid receptor signal transduction, with the goal of developing non-addictive pain drugsKarl Deisseroth @KarlDeisseroth
26K Followers 265 Following https://t.co/NCSpb81NTR https://t.co/vxqoQhBORdJuliet Mwirigi @JulietMwirigi
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113 Followers 487 Following MD/PhD student at the Medical College of Wisconsin. GPCRs and Protein dynamics! TTRPG, Astrophotography, and Heavy Metal enthusiastwang'tian @wangtian1996
4 Followers 92 FollowingWilliam McCallum @willieneuro
346 Followers 941 Following Emory Neuroscience PhD student . . . 🧠🧐. . . . coadvised @emoryalvarezlab 🐭 & Sam Sober 🐔 he/himNathan Winters @_NathanWinters_
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139 Followers 559 Following Biophysicist, Microscopy, Biosensor, Optogenetics, Single molecule, Deep learning, ...Catherine Cahill @PainlabQ
850 Followers 409 Following I'm an opioid neuropharmacologist studying the intersection between pain and addiction.kj @delmukappaoid
224 Followers 306 Following anthropologist, biochemist, drug enthusiast, musician, omphaloskeptic, neuropharmacologist in training,paul lodder @paul__lodder
49 Followers 236 Following building https://t.co/krPmvCrTLc built: https://t.co/Uop2gy7Vds https://t.co/QUtXWti5cdGriffett Lab @ Auburn @GriffettLab
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150 Followers 291 Following Scientist at Bristol Myers Squibb | Drug Product Development | Photography EnthusiastUri Manor 💔 @manorlaboratory
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565 Followers 502 Following peptidomics and drug discovery💊 inspired by nature🌱🐜…#Peptides #MolPharm #MedChemjianming @DrJianming_Han
27 Followers 164 FollowingYoojoong Kim @KYoojoong
100 Followers 220 Following Postdoc in Roth lab at UNC Chapel Hill, Structural biologist interested in GPCRs and cryoEM | PhD @POSTECH2020Jiafei Mao @Jiafei_Mao
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132 Followers 244 Following Postdoctoral Researcher at the Florey Institute in the Drug Discovery Innovation Lab.Julie Finkel @Julie_Finkel
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52 Followers 144 Following fascinated with adorable GPCRs and their charming molecular mechanism. PhDone!Twitter gets me involved in progress of scienceMicroscopy & Spectros.. @thermosciEMSpec
6K Followers 1K Following Thermo Fisher’s go-to source for microscopy news and updatesKappa antagonist for depression: "adjunctive treatment with aticaprant significantly reduced depressive symptoms versus placebo, without resulting in significant safety signals," nature.com/articles/s4138…
Important insights into #serotonin by @WackerLab "Structural insights into the unexpected agonism of tetracyclic antidepressants at serotonin receptors 5-HT1eR and 5-HT1FR" Stay tuned for more on these intriguing 5-HT receptors! DOI: 10.1126/sciadv.adk4855
Structural insights into the unexpected agonism of tetracyclic antidepressants at serotonin receptors 5-HT1eR and 5-HT1FR | Science Advances science.org/doi/10.1126/sc…
Tetracyclic Antidepressants Activate Understudied Serotonin Receptors: science.org/doi/10.1126/sc… Congrats to @NeuroStruct, @allyparp, and Audrey Warren for their study in @ScienceAdvances with help from @martafilizola, @NCCATinfo, and @GradSchoolSinai!
Happy to see this out in @NeuroCellPress. Huikun Wang, a staff scientist in our lab, demonstrates that ventromedial prefrontal cortical dynorphin signaling constrains threat-driven passive defensive behavior and switches in network states. Thread below. cell.com/neuron/abstrac…
If you know anyone that would be interested in working on human brain transcriptomics - we have one more research associate position that we are trying to fill to join these projects 🧠🔬!
We have several open research assistant/associate positions on our extended team (me, @kr_maynard, @CerceoPage). Projects are generating transcriptome-scale maps in various human 🧠 regions to understand spatial gene expression in neuropsychiatric & neurodevelopmental disorders
Working with @DrGPCR @NicoleAPerry1 and @StuartMaudsley on this article collection has been a great experience. A big thank you to Yamina for the invitation to be a part of this effort and to all the authors whose exciting science made this issue such a success!
It’s finally out! A real team effort. @LaurenSlosky @StuartMaudsley Thank you @yaminaberchichefoe your leadership. Editorial: GPCRs: signal transduction frontiersin.org/articles/10.33…
The new structures elucidates why bile acids are perceived as bitter-tasting compounds.😜
Nature research paper: Bitter taste receptor activation by cholesterol and an intracellular tastant go.nature.com/3U7ZW3v
Congrats to @KYoojoong @rgumpper @RothLabUNC Bitter taste receptor activation by cholesterol and an intracellular tastant nature.com/articles/s4158…
My first paper from the Roth lab is finally out! Huge thanks to everyone involved, especially Bryan @zenbrainest . This wouldn't have been possible without Bryan's support and the incredible team @RothLabUNC nature.com/articles/s4158…
Congrats to @KYoojoong @rgumpper @RothLabUNC Bitter taste receptor activation by cholesterol and an intracellular tastant nature.com/articles/s4158…
Congrats to @rgumpper who just accepted a tenure-track position in Chemical Biology @UNC !! @RothLabUNC
10/10/2012. I was up early! Holding my son in one hand, I checked the @NobelPrize website on my iPhone4🤭! And, there it was 👇 - what a magical moment! After initial celebrations, I rushed to update my faculty applications – all three of my referees were Nobel laureates now! 3/n
Let me rewind a bit. I always wanted to return home after my PhD & post-doctoral work. Our son was born in Sep. 2012 @DukeHospital and we knew that the moment has arrived! I started preparing my applications for a faculty position in India - a dream that I had all along! 2/n
Drawing inspiration from Zhuangzi's "Free and Easy Wandering," where he vividly portrays the transformation of a fish Kun into a bird Peng, our proposed FSCA method, @CellCellPress, presents a groundbreaking concept in polypharmacological drug design. authors.elsevier.com/a/1iqgh_278y%7…
Really enjoyed our conversation @yaminaberchiche 🙏 for the opportunity and hope others will enjoy listening 🎧
Ep.145 of the Dr.GPCR Podcast is out! 🎧 Listen to Dr. John Janetzko as he talks about what sparked a challenging passion for studying and understanding the molecular basis of G protein-coupled receptor desensitization and trafficking. ▶️bit.ly/3x9fgE5 #gpcr #drgpcr
Congratulations to our newly minted PhD 🎉🍾 Dr Zoé Valbret, we are very proud of you!! @ZoeValbret @UNIGEnews
I’ll be back next week for #FluorescenceFriday - but, does anyone know, what this is? Looks super interesting, attached really tightly to the shell.
Thrilled to announce that our collaborative work with @DR_WANG_SIBCB and Prof. Eric Xu at SIMM has just been published in @CellCellPress. Hope this work can provide a different angle for understanding and designing polypharmacology. cell.com/cell/fulltext/…
@zenbrainest @DR_WANG_SIBCB Congratulations on the great work @DR_WANG_SIBCB @chengjj_iHuman, and Eric Xu
Amazing paper from @DR_WANG_SIBCB and others! Flexible scaffold-based cheminformatics approach for polypharmacological drug design! cell.com/cell/fulltext/…