Gaslight 👻 @RetailGaslight

I like health and fitness I like bioenergetics I like making money in liquid markets Follow me for the worst controlled N=1 experiments you've ever seen Joined February 2025

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Gaslight 👻 @RetailGaslight

5 hours ago

@_9th_Life_ Pinealon and epitalon were game changers for me, I have a vial of DSIP I haven’t tried yet. Honestly the highest ROI thing I’ve done for my sleep is those nasal breathing strips

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Gaslight 👻 @RetailGaslight

6 hours ago

@sonofearle Thank you

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MOTS-c, the whole picture. 🧵 We can start with what you all already see posted on here. MOTS-c is a mitochondrial-derived peptide composed of 16 amino acids and is encoded directly into mtDNA (specifically the 12S rRNA region). It acts as a “mitokine” and signals to the nucleus (and the rest of the body, more on this later) how the mitochondria are doing. MOTS-c is created in the mitochondria and translocated to the nucleus in response to stress or exertion. Exercise, for example, stimulates endogenous MOTS-c production.

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Gaslight 👻 @RetailGaslight

6 hours ago

@QuesoVaries Done

Gaslight 👻 @RetailGaslight

7 hours ago

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Gaslight 👻 @RetailGaslight

a day ago

There isn’t a single MOTS-c post on here that appropriately explains the molecule, its effects, and the implications. (Hint: the term “exercise mimetic” doesn’t begin to cover it) Should I do it?

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Gaslight 👻 @RetailGaslight

6 hours ago

@crypto_incense Done

Gaslight 👻 @RetailGaslight

7 hours ago

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Gaslight 👻 @RetailGaslight

7 hours ago

@PeptidePartners Bang

Gaslight 👻 @RetailGaslight

7 hours ago

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Gaslight 👻 @RetailGaslight

7 hours ago

@youngwoofy Here you go

Gaslight 👻 @RetailGaslight

7 hours ago

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Gaslight 👻 @RetailGaslight

7 hours ago

Citations -Lee C, et al. (2015). The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance. Cell Metabolism, 21(3), 443–454. -Reynolds JC, et al. (2021). MOTS-c is an exercise-induced mitochondrial-encoded regulator of age-dependent physical decline and muscle homeostasis. Nature Communications, 12, 470. -Wang M, et al. (2023). MOTS-c repairs myocardial damage by inhibiting the CCN1/ERK1/2/EGR1 pathway in diabetic rats. Frontiers in Nutrition, 10, 1060684. -Domin R, et al. (2023). MOTS-c serum concentration positively correlates with lower-body muscle strength and is not related to maximal oxygen uptake — a preliminary study. International Journal of Molecular Sciences, 24(19), 14951. -Lu H, et al. (2024). The mitochondrial genome-encoded peptide MOTS-c alleviates nonalcoholic steatohepatitis by inhibiting inflammation and apoptosis. Cell Reports (related NASH studies). -Zheng Y, et al. (2023). MOTS-c: A promising mitochondrial-derived peptide for metabolic disorders and aging. Frontiers in Endocrinology (mechanistic review). -Wan W, et al. (2023). MOTS-c: Effects and mechanisms related to stress, metabolism and aging. Journal of Translational Medicine, 21, 885.

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Gaslight 👻 @RetailGaslight

7 hours ago

Cancer Mitochondrial health and metabolic flexibility influence cancer risk and progression in complex ways. AMPK activation can suppress certain pro-tumor metabolic pathways, and reduced chronic inflammation/insulin resistance are generally protective. However, the relationship between MOTS-c and cancer is not well established yet, some mitochondrial peptides show promise in early research, but this remains highly speculative and should not be viewed as a treatment replacement. If you or someone you know is battling cancer, consult the primary care physician before exploring MOTS-c as an adjunctive treatment.