Philip Haycock 🎗 @Prime2

Does the (live) shingles vaccine protect against dementia? We provide important evidence in a new preprint using hospital data from the whole of England in a regression discontinuity design where we *don't* show strong evidence of a causal effect +

A long thread on a quasi experimental study modelled on the @Nature paper using Welsh data and suggesting live shingles vaccine protects against dementia. Sadly in 20 times the sample size using precisely the same quasi experimental design we showed no such apparent protection

Gus Hamilton @gushamilton

6 days ago

Does the (live) shingles vaccine protect against dementia? We provide important evidence in a new preprint using hospital data from the whole of England in a regression discontinuity design where we *don't* show strong evidence of a causal effect +

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New study from us looking at how germline cancer risk (estimated through polygenic scores) correlates with survival for patients who develop cancer. Led by postdoc Danielle Kurant + collaboration with 23andme. 🧵:

Thank you to everyone who has been motivating me to continue my mission to help & fight for our #ChildhoodCancer Warriors. I could not do this without you. 💛

Many new Followers & wanted to introduce myself. I founded a national #ChildhoodCancer Charity after my precious 13 year old Daughter died from #BrainCancer & honored to have helped hundreds of Children w/ cancer since. Thank you for your Follow & support. 🙏🏻

Charlotte’s Brain Tumour Journey 10 years ago today 30.9.2025 18.2.1997 – 24.2.2016 Diagnosis to death: 951 days This morning Charlotte reached breaking point & wrote to the team herself about her brain stem biopsy: “I can’t wait another week for this biopsy, it just isn’t fair. I’ve been awake most of the night with a splitting headache. By next week it will be 10 weeks since the 3 mm anomaly was spotted. In 6 weeks it grew to 3 cm; by now I assume 5 cm? I’m having odd symptoms pain in my left ear lobe, numbness on the left side of my mouth and lips. I woke up again at 4 am with a painful headache and I’m scared. Apart from anything else I’m in pain and thinking the longer we wait, the worse it will get. I’ve cancelled everything. Can somebody else do this biopsy? I’d planned it so I could work on my YouTube channel on Monday and Tuesday, knowing the operation was behind me. Please can you fit me in before the weekend? I can’t go on like this any longer.” There was a quick response: they would arrange a platelet transfusion on Friday 2 October to check her count and see if another was needed. Charlotte would be admitted on Wednesday 7 October and the biopsy carried out on Thursday. (Biopsy was bought forward to 4th October 2015) If you can support a self funding charity where 100% of your donation goes to Charlotte's Lab, KCH, London we would be so grateful. Please RT with thanks charlottesbag.com

💔 #ChildhoodCancer 💔

During Gold September's Childhood Cancer Awareness Month please be aware of the "Golden Glow." The Glow can indicate more than 20 different eye diseases and conditions, including cancer. Many are highly treatable when caught early. Learn more at KnowTheGlow.org #WeAreYoungSIOP #GoldSeptember2025 #InspiredToAct #ChildhoodCancerAwareness @knowtheglow

Please remember all the #ChildhoodCancer Warriors who died & never forget them. We must fight, share their stories & continue to advocate for them. This is my precious Ashley who died from #BrainCancer at only 13. We’d be so grateful for a follow to give our Children a voice. 🙏🏻

During this #GoldSeptember2025 we are going to share some of the activities that have been planned for this month, with the aim of joining forces to raise awareness of childhood cancer. If you know of any other projects you would like to share, please let us know! #WeAreYoungSIOP #GoldSeptember2025 #InspiredToAct #ChildhoodCancerAwareness

10 Years ago today 14.9.2015 Charlotte's brain tumour journey raising awareness 18.2.97 - 24.2.2016 Age 19 years 5 days Diagnosis to death 951 days Today was the first real sign that things were starting to go wrong.  At 8.00 am this morning, Charlotte noticed and showed me that her eye flickered and got stuck for a second or two before returning to normal. charlottesbag.com

Charlotte’s Brain Tumour Journey 10 years ago today 11.9.2015 18.2.1997 – 24.2.2015 From diagnosis to death: 951 days Yet another phone call we were dreading. It came at 1pm. I knew it would be the consultant, as the MDT usually finishes around 12.30. He told us the words no parent wants to hear: unequivocal disease progression. A biopsy was deemed too risky, so instead they would explore the adult drug development portfolio and see if Charlotte’s archival tissue could be used for targeted therapy. If those cells from two years ago were too old, then a biopsy might still have to be done. His last words to us were: “We keep fighting.” I cannot even begin to describe the emotions. Now all our hope rests on a clinical trial. charlottesbag.com

Already seeing companies skipping over #ChildhoodCancer Awareness Month (September) & choosing to go straight to "going Pink!” As always, Children who are already deemed not profitable are also consistently being ignored by big brands. When will the lives of Children come first?

One in five Children diagnosed w/ cancer in the U.S. will not survive. For the ones who do, the battle is never over… Your support will give our #ChildhoodCancer Warriors a mighty voice. 🎗️

Unfortunately the survival rates for brain cancer essentially have not improved in 20 years. For the brain cancer subtype I have, glioblastoma IDH wild type, 50% survival rate is still about six months and it is essentially incurable. Over the past 15 years there have been vast improvements in the treatment and outcomes of patients with many other types of cancer. These are wonderful improvements! Unfortunately brain cancer has essentially had no improvement in survival during this time and remains extremely low. For example, 15 years ago, in patients with advanced (metastatic) melanoma, survival rates in melanoma and brain cancer were similar (less than 5% at five years). Now because of incredible advances in melanoma diagnosis, staging and treatment, patients five year survival rate for AJCC stage IV melanoma is greater than 50%. In contrast, for patients with aggressive brain cancer, 3 year survival outcomes haven’t changed and remain less than 5%. Currently in Australia, more patients die each year from brain cancer than any other cancers in Australians under 40 years old. We need to push the field forward in a coordinated and well funded scheme. One of the excellent teams in brain cancer research is the Bill Walsh Brain Group in the Kolling Institute at Royal North Shore Hospital. The collaboration between the research laboratory and the clinical care provided by neuro-oncology clinicians at the hospital provides opportunities to do translational clinical and pre-clinical research. The research team, including Dr Alex Yuile, neuro-oncology medical oncologist, and Dr Amanda Hudson, among other talented, dedicated and experienced researchers, is doing some excellent work. Some of the work they do is funded and supported by The Brain Cancer Group. We have to support coordinated research teams in their efforts to understand the disease, including through scientific research, to achieve better outcomes for people with brain cancer and the community! #glioblastoma #braincancer #Brainstorm @thebraincancergroup @KollingINST @NthSydHealth @COBLH @SydneyLHD @Sydney_Uni

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My mum was recently among the many women who annually are diagnosed with breast cancer. I’m running a half marathon soon, hoping to raise funds for @BreastCancerNow supporting vital research improving outcomes for women like her. Thank you for any support! givestar.io/gs/gainsboroug…

This is my Ashley who was battling #BrainCancer & her loving aunt Natalie who was fighting #BreastCancer at the same time. They both were fighters & thankful they both had each other during this difficult time to talk about their battles. When our Ashley died at 13, her aunt was devastated & left Earth shortly afterwards. I HATE cancer!! Cherish every moment with you loved ones because you never know... ❤️ Ashley ❤️ #Forever13 ❤️ Natalie ❤️ #Forever34

More Children die from cancer than any other disease, more than all other childhood illnesses combined. Yet, #ChildhoodCancer research is severely underfunded. We must advocate for our Children, or nothing will change.

September is Childhood Cancer Awareness Month, Golden September! As part of the campaign, every year Childhood Cancer International (CCI) and SIOP want to paint social media gold with this frame, which, despite being a very simple gesture, has a huge impact on raising awareness. Don't wait any longer, make your commemorative frame and share it on your social media. It's very easy! Follow the instructions: STEP 1: On any web browser, go to twibbonize.com/goldseptember2…. STEP 2: Upload a photo from your phone or computer. STEP 3: Download the photo with the frame. STEP 4: Share the photo on any social media using the hashtag #GoldSeptember2025 so we can see them. You can also use the hashtags: #GoldSeptember2025 #InspiredToAct #ChildhoodCancerAwareness And of course, tag us at The Young SIOP Network @youngSIOP #WeAreYoungSIOP

Brain cancer Charlotte 18.2.1997 – 24.2.2015 Diagnosis to death: 951 days charlottesbag.com

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