nic tritsch 🇺🇦 🏳️🌈 #BLM @NicTritsch
Neuroscientist curious to unravel how neurons communicate and how dysfunction leads to Parkinson's disease. Husband and father of 3. 🇫🇷 🇨🇦 tritschlab.org McGill / Hopkins / HMS / NYU Joined April 2013-
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How does the brain select what to consolidate during sleep? New in @ScienceMagazine , our work (science.org/doi/10.1126/sc…) sheds light on the brain's mechanism for selective memory consolidation. 🧵👇1/n
Do you think about dopamine ramps? If so, we hope that this story would be interesting to you and demonstrate that an underappreciated experimental variable has a strong influence on when they appear in a task. Work led by Joey Floeder and helped by @HuijeongJeong @mohebial
Do you think about dopamine ramps? If so, we hope that this story would be interesting to you and demonstrate that an underappreciated experimental variable has a strong influence on when they appear in a task. Work led by Joey Floeder and helped by @HuijeongJeong @mohebial
The Tritsch Lab is looking to hire adventurous postdocs to study (1) how neuromodulators like dopamine and acetylcholine interact to promote learning and action, and (2) how the basal ganglia control the vigor of skilled movements in Parkinson's disease. DM me if interested!
Congrats @ackrok for matching to @nyugrossman’s psychiatry residency program (research track)! Very proud of you!!
Thanks, Dayu! We create a GitHub page for this protocol(github.com/bd125/2024_Mul…). It not only allows recording from multiple brain regions simultaneously but also serves as a cost-effective solution for single-fiber photometry recording. Let us know if you meet any issues.
Thanks, Dayu! We create a GitHub page for this protocol(github.com/bd125/2024_Mul…). It not only allows recording from multiple brain regions simultaneously but also serves as a cost-effective solution for single-fiber photometry recording. Let us know if you meet any issues.
Excited to share new long-brewing work from the lab! Is the world feeling…..at bit too aggressive? Maybe it would be good to just take it down a notch? We have thoughts about this! rdcu.be/dyqAn
Excited about our long-brewing paper exploring dynamics in multi-regional neural circuits in a delayed movement task. Driven by@esthersselva, @yiliu021, and including Jennifer Colonell, Nuo Li and @ShaulDr and others (the MAP collaboration): cell.com/cell/fulltext/… (1/7)
Curious how the brain changes to help one avoid a bully? Happy to share our new work published today in @Nature. Three excellent scientists @TakuyaOsakada, Rongzhen Yan, and @Evan10Jiang jointly pushed the project to its finish line. rdcu.be/dwPrr
New paper alert! Our work on the extra-amygdalar panic circuit has been published @NatureNeuro. Congrats to co-first authors @SJ_J_Kang_24 and Jonghyun Kim along with all co-authors involved. nature.com/articles/s4159… 🧵(1/n)
Is one of your new year's resolution to attend one of the best Neuro Circuits meetings? Then consider registering for @AsconaCircuits this upcoming fall. Deadline is April 30, 2024
Is one of your new year's resolution to attend one of the best Neuro Circuits meetings? Then consider registering for @AsconaCircuits this upcoming fall. Deadline is April 30, 2024
1/3 It's important to note that most mApple-based biosensors exhibit blue light-illuminated photoactivation, and proper controls (e.g. mutant-sensor or biosensor-only controls) should be included in combined use with blue-light optogenetics or dual-color recording.
1/3 It's important to note that most mApple-based biosensors exhibit blue light-illuminated photoactivation, and proper controls (e.g. mutant-sensor or biosensor-only controls) should be included in combined use with blue-light optogenetics or dual-color recording.
@NicTritsch Thank you for bringing the awareness to the community. The photoactivation phenomenon of mApple-based red fluorescent sensors should be handled with caution when using these sensors. We also discussed this issue in our latest paper on GRAB-DA sensors.
Why (and how) we need to professionalize neuroscience By @jvoigts thetransmitter.org/systems-neuros…
Cutting it a bit fine, but it's that time again: The Spike's review of the year in neuroscience 2023: A Review of the Year in Neuroscience link.medium.com/7lJ0d4aTWFb Enjoy! including @jtdudman @Datta_Lab @NicTritsch @jesseGlab @weijima01 and many more
Excited to share this new paper from my group! @jennifer_zachry and @MunirGunesKutlu show that D1 and D2 MSNs in the nucleus accumbens do not have opposing actions and neither population signals reward. Instead, D1 MSNs respond to salient stimuli and D2 MSNs to prediction errors
Excited to share this new paper from my group! @jennifer_zachry and @MunirGunesKutlu show that D1 and D2 MSNs in the nucleus accumbens do not have opposing actions and neither population signals reward. Instead, D1 MSNs respond to salient stimuli and D2 MSNs to prediction errors
When is a dopamine transient not a dopamine transient? When it's a photoconversion artifact from blue-light illumination of an mApple based sensor! Comment on 'Accumbens cholinergic interneurons dynamically promote dopamine release and enable motivation' biorxiv.org/content/10.110…
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8K Followers 1K Following Prof. of Neuroscience @SinaiBrain · Investigating memory stability & flexibility · Advocate for open science · Mom of two littles · Amateur chef · she/herHow does the brain select what to consolidate during sleep? New in @ScienceMagazine , our work (science.org/doi/10.1126/sc…) sheds light on the brain's mechanism for selective memory consolidation. 🧵👇1/n
The best PI you can ask for.
The Tritsch Lab is looking to hire adventurous postdocs to study (1) how neuromodulators like dopamine and acetylcholine interact to promote learning and action, and (2) how the basal ganglia control the vigor of skilled movements in Parkinson's disease. DM me if interested!
Three-photon microscopy for long-term in vivo three-photon imaging of the entire cortical column and subcortical white matter in adult mice reveals region-specific differences in healthy and regenerative #oligodendrocyte formation @EthanHughesLab et al. nature.com/articles/s4159…
Do you think about dopamine ramps? If so, we hope that this story would be interesting to you and demonstrate that an underappreciated experimental variable has a strong influence on when they appear in a task. Work led by Joey Floeder and helped by @HuijeongJeong @mohebial
Mesolimbic dopamine ramps reflect environmental timescales biorxiv.org/cgi/content/sh… #biorxiv_neursci
Congrats to Heechul Jun @jun_heechul, my first and superstar MD-PhD student, for being matched with NYU @nyugrossman @NYULH_Neuro physician-scientist psychiatry residency!
#Match2024 Matched at my top choice - NYU Psychiatry Research Career Accelerated Track! Thanks to my amazing family, colleagues and mentor. So grateful and excited for the new journey and adventures! :)
A few days tardy for #SCN2A Awareness Day, our new paper exploring how SCN2A-related disorders affect cerebellar reflexive learning. This was done with @FamilieSCN2A kiddos and families. Congrats to Chenyu Wang, @guy_bouvier, and team! authors.elsevier.com/a/1ifoD3BtfH99…
Thanks, Dayu! We create a GitHub page for this protocol(github.com/bd125/2024_Mul…). It not only allows recording from multiple brain regions simultaneously but also serves as a cost-effective solution for single-fiber photometry recording. Let us know if you meet any issues.
As promised, here is a detailed step by step protocol to build a low cost multi-fiber recording system and record brainwide activity from your favorite network. All credits go to a fantastic graduate student Bing Dai @Bing19128170. sciencedirect.com/science/articl…
Excited to share new long-brewing work from the lab! Is the world feeling…..at bit too aggressive? Maybe it would be good to just take it down a notch? We have thoughts about this! rdcu.be/dyqAn
Excited about our long-brewing paper exploring dynamics in multi-regional neural circuits in a delayed movement task. Driven by@esthersselva, @yiliu021, and including Jennifer Colonell, Nuo Li and @ShaulDr and others (the MAP collaboration): cell.com/cell/fulltext/… (1/7)
Happy to see our new Review out! Engineering, applications, and future perspectives of GPCR‐based genetically encoded fluorescent indicators for neuromodulators - Rohner - Journal of Neurochemistry - Wiley Online Library onlinelibrary.wiley.com/doi/10.1111/jn…
Glad to see this study finally out in @NatureNeuro Many thanks to all co-authors Feng Chen, @ShaulDr @mlong11215 @NYULH_Neuro @CSHL nature.com/articles/s4159…
Very excited to share the latest chapter in the saga of the singing mice! Using silicon-probe recordings during freely-moving (singing) animals, we describe how motor cortical dynamics enables vocal flexibility. with co-authors Feng Chen, Shaul Druckmann and @mlong11215
Curious how the brain changes to help one avoid a bully? Happy to share our new work published today in @Nature. Three excellent scientists @TakuyaOsakada, Rongzhen Yan, and @Evan10Jiang jointly pushed the project to its finish line. rdcu.be/dwPrr
Interested in probing cell-type and neurotransmitter specific signaling across many locations throughout large, deep brain volumes during behavior? Check out this new paper from our lab led by the intrepid @MaiAnh_T: sciencedirect.com/science/articl…
Someone once told me that every lab is a journey that starts in an empty room(s). Today I got mine. So it begins 🧠🐀
2/3 We conducted a systematic investigation into the photoactivation properties of existing red dopamine sensors and were excited to find that the recently reported rDA2 series is exempt from such phenomena (see also Figure 2g from doi.org/10.1038/s41592…).
3/3 Therefore, the rDA2 suite represents a more ideal choice when combined with blue light, as it requires less effort in adding controls and data interpretation.
1/3 It's important to note that most mApple-based biosensors exhibit blue light-illuminated photoactivation, and proper controls (e.g. mutant-sensor or biosensor-only controls) should be included in combined use with blue-light optogenetics or dual-color recording.
Are you using the red dopamine (DA) sensor RdLight1 in combination with blue light for dual-color optogenetics/photometry? If so, read on... biorxiv.org/content/10.110… 1/n
@NicTritsch Thank you for bringing the awareness to the community. The photoactivation phenomenon of mApple-based red fluorescent sensors should be handled with caution when using these sensors. We also discussed this issue in our latest paper on GRAB-DA sensors.
@NicTritsch Thank you 🙏 for raising awareness of the mApple photoactivation phenomenon as a source of false-positive optogenetic artifacts. For those that are interested, we investigated the underlying mechanism. ncbi.nlm.nih.gov/pmc/articles/P…