Natalie Vokes @NIVokes
Asst professor @MDAndersonNews. Lung cancer and clinical computational oncology. Tweets are my own. Houston, TX Joined March 2013-
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🫁 Never-smoker NSCLC is not one immunotherapy story, it is a biomarker story. In a large retrospective analysis, Gariazzo, Elkrief, Concannon et al. evaluated 741 patients with metastatic NSCLC without actionable genomic alterations who had never used tobacco and received ICI-based regimens. Overall outcomes were modest: 📌 ORR: 23.2% 📌 Median PFS: 4.5 months 📌 Median OS: 16.8 months But the study identified important predictors of benefit: 🧬 PD-L1 ≥90% 🧬 TMB ≥90th percentile 🧫 High TIL density 🔥 Immune-enriched transcriptomic profiles 🛡️ Increased MHC class I/II antigen presentation and T-cell activity Another key signal: PD-(L)1 + CTLA-4 combinations outperformed chemo-immunotherapy and PD-(L)1 monotherapy in median PFS and OS. The takeaway is clear: Never-smoker, AGA-negative NSCLC should not be viewed as uniformly resistant to immunotherapy. A selected subgroup with very high PD-L1, high TMB, and immune-rich tumors may derive meaningful benefit. For clinical decision-making, this study supports moving beyond smoking history alone and toward deeper immune and molecular profiling. oncodaily.com/oncolibrary/lu… @alessandra_dodi @DiFedericoMD @doctordegio @pecci_federica1 @mihaela_aldea @NarjustFlorezMD @JuliaRotow @XinAnnWang @ACortelliniMD @FedericoCappuz1 @DrMarkAwad @stescalera @giulio_metro @NIVokes @AdamJSchoenfeld @BRicciutiMD
Dr. Natalie Vokes shared the latest insights on novel frontline combinations with checkpoint inhibitors for metastatic non-small cell lung cancer at #ASCO26. The session explored emerging strategies aimed at improving outcomes and expanding treatment options for patients with advanced lung cancer. @NIVokes #EndCancer
🫁 What’s next for 1L #NSCLC #without actionable genomic alterations? Excellent, well-balanced discussion by Dr. @NIVokes , highlighting key advances and putting new data into clear clinical context. A complex and rapidly evolving treatment landscape. #NSCLC #LungCancer #ASCO26 #ThoracicOncology @UTMDAnderson @ASCO
@drgandara Important to understand though if driven by MTAP or CDKN2A or other genes in the locus
🌟Three of the 15 inaugural @AACR Trailblazer Award recipients are previous Mark Foundation early-career grantees. It’s a privilege to watch @efapostolou29, @TuomasTammela, and @NIVokes continue to grow their careers and tackle cancer’s most difficult questions.
🟢 𝗔𝗔𝗖𝗥 𝗔𝗻𝗻𝗼𝘂𝗻𝗰𝗲𝘀 𝗥𝗲𝗰𝗶𝗽𝗶𝗲𝗻𝘁𝘀 𝗼𝗳 𝗔𝗔𝗖𝗥 𝗧𝗿𝗮𝗶𝗹𝗯𝗹𝗮𝘇𝗲𝗿 𝗖𝗮𝗻𝗰𝗲𝗿 𝗥𝗲𝘀𝗲𝗮𝗿𝗰𝗵 𝗚𝗿𝗮𝗻𝘁𝘀 𝟮𝟬𝟮𝟲 The latest initiative from American Association for Cancer Research highlights where the future of oncology is being built. oncodaily.com/career/aacr-tr… @AACR @KarenODixon @JJMilnerLab @jontsai @NIVokes @YMerbl @TuomasTammela #AACR #oncology #OncoDaily #cancer #grant
Congratulations to our Dr. Natalie Vokes on receiving an @AACR Trailblazer Cancer Research Grant, announced at this morning's #AACR26 opening ceremony. This grant will support her research into CDKN2A/MTAP-deleted non-small cell lung cancer. #EndCancer
@IDEOlogyHealth All of these time points would be valid times to check as we incorporate new biomarkers into practice
@IDEOlogyHealth Good data from the cocoon trial supporting prophylaxis!
@IDEOlogyHealth OS data supports combination, but have to consider patient-specific factors and goals
Biomarker complexity is rapidly increasing, yet the cost and accessibility of the technologies needed to implement them are not always keeping pace In @JTOonline, our comprehensive study of the routinely-assessed TTF-1 expression in lung adenocarcinoma jto.org/article/S1556-… 1/7
Special mention to @LeiDeng3 and Bolun Liu for their analysis of NCDB dataset, and the teams of @BRicciutiMD, @DiFedericoMD, @alissajcooper and @AdamJSchoenfeld for their collaboration. Hope that such studies can pave the way for better treatment options in these rare tumors!
Delighted to share this multi-institutional collaboration dissecting outcomes in sarcomatoid lung cancer, a rare and hard to treat subtype. While chemotherapy may have limited efficacy, we found that many of these tumors are PDL1 high and responsive to immunotherapy.
Outcomes to ICIs and genomic features in PSC remain underexplored compared with other NSCLC subtypes. Hong et al. present the findings from their multicenter retrospective study on clinicogenomic features and #immunotherapy associations in PSC. bit.ly/3MDgrTX @NIvokes
Outcomes to ICIs and genomic features in PSC remain underexplored compared with other NSCLC subtypes. Hong et al. present the findings from their multicenter retrospective study on clinicogenomic features and #immunotherapy associations in PSC. bit.ly/3MDgrTX @NIvokes
New #JITC article: Causal AI-based clinical and radiomic analysis for optimizing patient selection in combined immunotherapy and SABR in early-stage NSCLC: a secondary analysis of the phase II I-SABR trial bit.ly/47kd782 @StevenLin_MDPhD @liao_zhongxing @dave_qian @ca_chung @NIVokes @JiaWu_PhD @JoeChangMD @MDAndersonNews
🚨 Excited to share our 2 new studies published today in @TheLancetOncol — one offering deeper insight into refining #ICI for PD-L1–negative & 🧬#STK11-mutant #NSCLC, and the other exploring #ICI vs 💊#BRAF/MEKi in #BRAF V600E #NSCLC. @OncoAlert @IASLC #LCSM. /W✨@DiFedericoMD✨ These studies aren’t full answers — but we hope they help sharpen strategies and spark further progress in tailoring immunotherapy for NSCLCs historically seen as resistant. Heartfelt thanks to the co-authors, patients, collaborators & reviewers who made this possible. @marinagarassino @MarceloCorassa @peters_solange @pecci_federica1 @ACortelliniMD @dplanchard @RobertoFerrara_ @CoreyLangerMD @FawziAbuRous @mihaela_aldea @XinAnnWang @DanaFarber @DanaFarberNews @DrMarkAwad @NIVokes @StephenVLiu @NarjustFlorezMD @alessi_joao @DrJNaidoo @Alfdoc2
NSCLC MTAP-del BMS-986504 (MTA-coop PRMT5i) in pretreated pts: ORR 29% · DOR 10.5m · DCR 80% Active in EGFR/ALK/KRAS subgroups. Well tolerated, low heme tox. ➡️ Next step: MountainTAP-9 & 29 #LungCancer #Oncology #TargetedTherapy #wclc25 @IASLC @OncoAlert
Loving the poster vibes at #WCLC2025! 😎 Connecting with mentors & friends = best part. Always learning! 📚💡@drgandara @ChristineBestv1 @NIVokes
Great to see so much data coming out in this space, with many clinical trials now available or coming for patients with MTAP deletions including at @MDAndersonNews and other centers
Be ready to screen MTAP loss in all pts with advanced NSCLC, regardless of driver. @mihaela_aldea shows incidence, highest in ALK/RET/EGFR/ROS1. AMG193 paved the way at #ESMO24. BMS-986504 confirms druggability: 29% ORR + many durable SD (slide @CharuAggarwalMD). #WCLC25
Important paper put out by stellar MDA colleagues! Congrats to all co- authors. @LaurenByersMD @NIVokes John Heymach @MDAndersonNews
KEAP1 and STK11/LKB1 alterations enhance vulnerability to ATR inhibition in KRAS mutant non-small cell lung cancer dlvr.it/TMVKGH
Stephen V Liu, MD @StephenVLiu
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Eli Van Allen @VanAllenLab
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Jarushka Naidoo @DrJNaidoo
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Mark Lewis, MD, FASCO @marklewismd
96K Followers 35K Following Director, GI Oncology, @Intermountain. Interests: neuroendocrine tumors, cancer syndromes, empathy (even had a Whipple myself). Tweets my own.
Eric K. Singhi, MD @lungoncdoc
7K Followers 1K Following Thoracic Medical Oncologist, Assistant Professor @MDAndersonNews | Patient education & young-onset lung cancer | 🫁#cancer #lcsm @LungCancerRx | Views my own
Elizabeth McKenna @ElizSMcKenna
19K Followers 5K Following Executive Editor of Cancer Discovery @CD_AACR, published by @AACR. @BBS_Harvard/@DanaFarber alum. Native New Yorker. Views/likes/RTs are my own. She/her
Xiuning Le MD PhD @LeXiuning
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Aakash Desai, MD, MPH... @ADesaiMD
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Christine Lovly, MD, ... @christine_lovly
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ASCO @ASCO
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Dr. Estela Rodriguez @Latinamd
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Gonzalo Recondo @GRecondoMD
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H. Jack West, MD, FAS... @JackWestMD
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Sarah Abou Alaiwi @sarahaboualaiwi
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MedPage Today @medpagetoday
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Tejas Patil @TejasPatilMD
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Alliance for Clinical... @ALLIANCE_org
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Brain Tumor Network @BTNcares
942 Followers 694 Following Providing personalized navigation to patients and caregivers in the US at every stage of the primary brain tumor experience at zero cost.
Daniel Rosas 🩸🦀 @DocOncMD
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Mohamed Osman @MHosmanMD
442 Followers 595 Following MD | Postdoctoral Fellow @WeillCornell | Studying Cancer Evolution @FaltasLab
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89 Followers 467 Following Translational lung cancer scientist at Cancer Research Center of Lyon / Centre Leon Berard. Lead, BOLERO Consortium on #BRAF-mutant NSCLC: https://t.co/Iyxs0Q
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Greg Hendon @GregHendon
4 Followers 244 Following “Let us be eager to leave what is familiar for what is true.” - Francis Chan
rabmanduky @rabmanduky
466 Followers 2K Following biotech,love special event situations.econ major,special event situations are my specialty.frauds sux
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645 Followers 223 Following 🔬 Science serves people, not the other way around. Biotech Executive | 🇺🇸 Patriot | 💕 Ethic | 💡 Turning discoveries into impact #WomenInSTEM #Proudmum
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138 Followers 243 Following Heme-Onc Fellow @PennMedicine II Alum of @DukeU, @UTSouthwestern, and @PennIMResidents
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Young Lung Cancer Ini... @YoungLungCancer
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stefania rocco @stefaniarocco4
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764 Followers 1K Following General Thoracic Surgeon, Former PostDoc Fellow at Massachusetts General Hospital, Harvard Medical School
IDEOlogy Health @IDEOlogyHealth
790 Followers 1K Following Creating Aha! Moments In Healthcare® https://t.co/Jbw6GvFtph CME Conferences: @GUconference @TLCconference @NashvilleHeme @TXGIconference
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850 Followers 3K Following Pediatric Hematologist and Oncologist ! Max Cancer Care ! MAMC I UCMS ISir Ganga Ram Hospital l Hodophile | Love exploring | Dreamer | Believer
Stephen V Liu, MD @StephenVLiu
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Toni Choueiri, MD @DrChoueiri
45K Followers 349 Following Chief GU Cancers @DanaFarber II Prof Medicine @HarvardMed II ⚽ lover II @PanMass 🚲rider.
Eli Van Allen @VanAllenLab
9K Followers 2K Following Clinical Computational Oncology @DanaFarber @harvardmed @broadinstitute | Chief - Population Sciences | Prev.: @Stanford @UCLA @UCSF | Discl.: https://t.co/EmrHxvg76N
Ziad Bakouny, MD, MSc @ZiadBakouny
4K Followers 2K Following PGY-5 Heme/Onc @MSK_DeptOfMed | via @USJLiban @DanaFarber @BrighamMedRes | @ASCO #IMG CoP & #JCOCCI Assoc Editor | Opinions my own | FCOI: https://t.co/dYsEwGGqP1
Jarushka Naidoo @DrJNaidoo
12K Followers 1K Following Professor of Medical Oncology @CancerCentreIre | Thoracic Oncologist | Immunotherapy & Immune toxicity | Adjunct faculty Johns Hopkins University
Mark Lewis, MD, FASCO @marklewismd
96K Followers 35K Following Director, GI Oncology, @Intermountain. Interests: neuroendocrine tumors, cancer syndromes, empathy (even had a Whipple myself). Tweets my own.
Eric K. Singhi, MD @lungoncdoc
7K Followers 1K Following Thoracic Medical Oncologist, Assistant Professor @MDAndersonNews | Patient education & young-onset lung cancer | 🫁#cancer #lcsm @LungCancerRx | Views my own
Elizabeth McKenna @ElizSMcKenna
19K Followers 5K Following Executive Editor of Cancer Discovery @CD_AACR, published by @AACR. @BBS_Harvard/@DanaFarber alum. Native New Yorker. Views/likes/RTs are my own. She/her
Xiuning Le MD PhD @LeXiuning
2K Followers 378 Following Associate Professor Thoracic Head and Neck Medical Oncology MD Anderson Cancer Center
Tatiana Prowell, MD @tmprowell
60K Followers 9K Following Oncologist serving people w/ #cancer in #MedEd #SciComm & #bcsm. Past ASCO Ed Chair. Cofounder @HCWvsHunger. #LongCovid. Team hope/good trouble/go high. No FCOI
FabriceAndre @FAndreMD
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Christine Lovly, MD, ... @christine_lovly
8K Followers 879 Following Thoracic Medical Oncologist. Physician Scientist. Division Chief @CityofHope. Dog lover. Believer that kindness counts. Views = my own. @Oncoalert
Lecia Sequist, MD, MP... @LeciaSequist
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ASCO @ASCO
151K Followers 2K Following Account of the American Society of Clinical Oncology & its affiliate the Association for Clinical Oncology. Assoc tweets labeled #ASCOAdvocacy. RTs ≠ endorse.
Dr. Estela Rodriguez @Latinamd
8K Followers 3K Following Associate Director Community Outreach- 🫁Thoracic Oncology, University of Miami @SylvesterCancer , 🇵🇷Boricua, Co-founder @KidsHelpingKidsSucceed
Gonzalo Recondo @GRecondoMD
2K Followers 975 Following MD PhD | Medical Oncologist | Executive Director - Global Development Lead @Amgen | Views expressed are my own
Christian Rolfo @ChristianRolfo
7K Followers 2K Following Director Division of Medical Oncology. Assoc Director Early Phase Clinical Trials The James Comprehensive Cancer Center. Prof. The OSU.Liquid Biopsy T/RT my own
Jill Feldman @jillfeldman4
9K Followers 4K Following Lung Cancer Patient and Advocate, Co-Founder @EGFRResisters, wife, mom of 4, #LCSM #LungCancer #EndStigma #StandUpToJewishHate #RockChalk
H. Jack West, MD, FAS... @JackWestMD
22K Followers 3K Following VP of Global Medical Affairs @SMMT_Tx; Founder,@CancerGRACE; fmr author/ed @UptoDate. Tech-friendly for an old guy. Likes/RTs ≠ endorsement
Geoff Oxnard MD @geoff_oxnard
4K Followers 146 Following Drug & diagnostic developer | Thoracic oncology, Boston Medical Center | Husband, father of 4, splitter of wood | Opinions my own
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880 Followers 527 Following Thoracic medical oncologist at MSK. Lung cancer, immunotherapy, cell therapy & early drug development. Occasional dad jokes. Sad Mets fan. Views my own
IDEOlogy Health @IDEOlogyHealth
790 Followers 1K Following Creating Aha! Moments In Healthcare® https://t.co/Jbw6GvFtph CME Conferences: @GUconference @TLCconference @NashvilleHeme @TXGIconference
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1K Followers 427 Following Chief Sci Off & Med Dir Memorial Can Inst/Memorial Health Syst Past Pres. FLASCO, old account @luiseraez1 was dc, personal site
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Ticiana Batista (Leal... @LealTiciana
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Alessio Cortellini @ACortelliniMD
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Keyan Salari @KeyanSalari
417 Followers 271 Following Urologic oncologist and surgeon-scientist @MGHUrology @MGHCancerCenter. Views are my own.
Sarah Waliany, MD, MS @SWaliany
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Rajat Thawani @rajatthawani
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434 Followers 266 Following Associate Professor of Epidemiology & Biostatistics, School of Public Health @uofmemphis
Chul Kim @chulkimMD
4K Followers 892 Following Director of Thoracic Oncology at Georgetown University @Lombardicancer / Lung Cancer, Thymic Tumors, Phase I / #SoMeEditor @ClinicalLung / Secretary of ITMIG
Triparna Sen (Sen-Lab... @triparnasen
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TLC Conference @TLCconference
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Ana I. Velázquez Ma�... @AnaVManana
7K Followers 5K Following Medical oncologist & researcher focused on #LungCancer 🫁 @UCSFCancer @ZSFGCare | Assistant Prof. @UCSF | Views are my own. Boricua 🇵🇷 aunque naciera en la 🌙
Adrian Sacher, M.D. @DocSacher
1K Followers 1K Following Lung oncologist, tumor immunology & KRAS researcher, advocate for lung cancer patients and learners @pmcancercentre, @uoftmedicine, @UofT. He/Him/Il. 🏳️🌈
Shankar Siva @_ShankarSiva
9K Followers 862 Following Radiation Oncologist at the Peter MacCallum Cancer Centre @petermaccc, Professor of Medicine, University of Melbourne, Australia 🇦🇺. Views are my own. #radonc
Srinivas Viswanathan @srviswanathan
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Chris Labaki @Chrislabaki1
1K Followers 946 Following PGY-2 @BIDMC_IM | Research Associate @DanaFarber | via @DanaFarber @USJLiban
. @TheBiotechBear
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KRAS Kickers @KRASKickers
4K Followers 5K Following #KRAS 🎯cancer patient group for reliable Knowledge Research Advocacy & Survivorship. Survival of the strategic. #KickCancersKRAS - 🚫 #KRASholes
Jonathan Eisen @phylogenomics
62K Followers 8K Following Prof. @UCDavis studying #phylogenomics & #microbiomes. Other: #BirdPhotography, #RedSox, #Type1, Conservation, MarineBio. Past: @harvard @stanford @JohnsHopkins
Jason Westin, MD FACP... @Lymphoma_Doc
8K Followers 3K Following Professor @MDAndersonNews, Lead of Lymphoma/Myeloma Service Line, Director of Clinical Research, Section Chief of Aggressive/Indolent Lymphomas, Opinions mine
Aadel Chaudhuri, MD P... @aadel_chaudhuri
3K Followers 834 Following Professor & Vice Chair for Translational Research @MayoRadOnc | Co-Director of Cancer Precision Medicine @MayoClinic | Co-Founder @liquidcelldx & @DropletBiosci
Elisa Aquilanti MD @ElisaAquilanti
40 Followers 135 Following Neuro-oncologist and physician scientist @DanaFarber
Benjamin Besse @BenjaminBesseMD
8K Followers 90 Following Medical Oncologist- Lung cancer, thymic & NUT carcinomas. Head of Clinical Research @GustaveRoussy, Head of Scientific Chairs Council @EORTC. Tweets are my own.
Yuri Kim @yurikim_mdphd
417 Followers 212 Following Advanced HF/Transplant & CV Genetics @BrighamWomens @harvardmed | Alum @Lab_Olson @StanfordMed @BrighamMedRes @MGHCVFellows | Tweets my own & not medical advice
Allison Chang @aebchang
896 Followers 371 Following Neuroscientist ➡️ Thoracic Medical Oncologist specializing in #earlydetection #AI #ML @mghcancercenter @harvard Cat mom. Human mom. Wife. Opinions mine.
Zahraa Rahal @ZahraaRahal
1K Followers 2K Following PGY-1 Internal Medicine Resident @BrighamMedRes | Research Fellow’25 @MDAndersonNews @humam_kadara’s lab | MD’21 @AUBMC_official |
D. Ross Camidge @DRCamidge
986 Followers 183 Following Oncologist, podcaster, writer - fan of truth, creativity and humor - @drcamidge.bsky too and more
Misty Dawn Shields @drshieldsmd
2K Followers 2K Following Translational Thoracic Oncologist #MDPhD, #SCLC, @TheShieldsLab, Indiana University, HHMI Med Into Grad Scholar/IASLC ILCF/ASCO CDA, founder @SCLCSMASHERS 🫁🤍
Kathryn Gallaway, MD @KE_Gallaway
371 Followers 871 Following 34 y/o G2P2 presents w/ insatiable thirst for knowledge of unknown etiology | Philosophy @RiceUniversity | MD @UTSWNews | Associate Medical Director @DAVAOnc
DAVA Oncology @DAVAOnc
2K Followers 2K Following DAVA Oncology is a strategic consulting company committed to delivering high quality oncology education and expanding access novel cancer therapies.
Clarissa Mathias @clarissamathias
794 Followers 378 Following
Cissa Mathias @cissamathias
687 Followers 640 Following Maria Cecília Mathias - Medical Oncologist and GI Fellow @grupoOncoclínicas 🦀 Former Oncology Fellow @ ICESP | 🤓 Baiana ❤️💙🤍and proud of it! 🇧🇷
David Braun @BraunMDPhD
4K Followers 1K Following Oncologist, physician-scientist @YaleCancer @YaleMed | cancer immunotherapy, genomics, kidney cancer | tweets ≠ medical advice. ASCO FCOI:https://t.co/IsIqZTpy9c
Christina Marie @Christi18524418
194 Followers 2K Following
Fred R. Hirsch @fred_hirsch
5K Followers 59 Following I am Executive Director at the Center for Thoracic Oncology at Mount Sinai Hospital , NYC and Professor of Medicine at Icahn Medical School at Mount Sinai, NY
Melissa L. Johnson @MLJohnsonMD2
3K Followers 636 Following Medical oncologist whose focus is drug development for lung cancer patients being treated in the community.
Simona Cristea @simocristea
9K Followers 451 Following director of applied AI @TempusAI; prev: faculty @DanaFarber, group leader @Harvard & phd @eth
Marty Taylor, MD PhD @DrMartyTaylor
416 Followers 129 Following @BrownMedicine GI pathologist, cancer & transposon biologist, dad, climber, woodworker, photographer, track&field @Princeton ‘05 & @HopkinsMedicine ‘15
Alexandre Reuben, Ph.... @AReubenPhD
366 Followers 326 Following Assistant Professor / Immunologist @MDAndersonNews @GSBSImmunology Department of Thoracic / Head & Neck Medical Oncology https://t.co/ZdQWBFernd
Jeevan Puthiamadathil @jeevanpmd
79 Followers 143 Following Thoracic Oncologist, Division of Oncology 2, @FDAOncology; opinions are my own | @theNCI, @gtown_medres @GUMedicine
Alissa Cooper, MD @alissajcooper
697 Followers 440 Following Thoracic oncologist @danafarber | Formerly at @MSKCancerCenter | Former fellow @MGHCancerCenter @danafarber | Views my own
Samantha Hoffman, PhD @SamHoffmanMed
860 Followers 1K Following MD student @harvardmed. PhD @VanAllenLab @BBS_Harvard. @Stanford alumna.You might like
