Mordes Lab @MordesLab
Integrating neuropathology, stem cells, and multi-omics to study neurodegeneration #ALS #dementia @UCSFPath @INDUCSF 🧠🔬🌻 mordeslab.ucsf.edu San Francisco, CA Joined February 2022-
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Huge congrats to @JulieSmeyers for being awarded a Springboard Fellowship from Target ALS! targetals.org/2025/12/08/spr…
Excited to share our @CellReports article! We investigated how the loss of TBK1 function contributes to ALS and dementia using human stem cell-derived neurons and advanced proteomics. Many thanks to all co-authors for their great work and collaboration! sciencedirect.com/science/articl…
Regulation of translation elongation and integrated stress response in heat-shocked neurons: Cell Reports cell.com/cell-reports/f…
Deciphering distinct genetic risk factors for FTLD-TDP pathological subtypes via whole-genome sequencing: nature.com/articles/s4146…
In this study, we observed that a C9ORF72-ALS/FTD dipeptide repeat protein perturbs the phosphorylation of RNA binding proteins and STMN2 expression, and found that SRSF7 sustains STMN2 levels in induced neurons. Congrats to @JulieSmeyers and Karen! #ALS actaneurocomms.biomedcentral.com/articles/10.11…
Excited to share new study from the lab, work led by @JohnPAndrews_MD and grateful for all the collaborators who made this possible including @ChangLabUcsf @ucscgenomics
Today in @NatureNeuro, researchers led by @LabNowakowski, @ChangLabUcsf & Mircea Teodorescu (@ucscgenomics) demonstrate the first use of optogenetics to modulate seizure activity at the network level in human brain tissue: nature.com/articles/s4159… @JohnPAndrews_MD @UCSFstemcell
Inhibition of RNA splicing triggers CHMP7 nuclear entry, impacting TDP-43 function and leading to the onset of ALS cellular phenotypes cell.com/neuron/fulltex…
Had a great time at the Oktoberfest IND collaboration hour! Thanks to everyone who stopped by.
Out @ScienceMagazine! New tech to activate ALS gene therapies only in the right cells at the right time - Increased safety to have more options for ALS. We do it by taking advantage of cryptic splicing. science.org/doi/10.1126/sc… @UCLIoN @TheCrick @OscarWilkins16 @MaxZYJChien
Had a lot of fun at lab lunch! Welcome to the lab, Nicole and Lisa!
Deciphering Distinct Genetic Risk Factors for FTLD-TDP Pathological Subtypes via Whole-Genome Sequencing medrxiv.org/content/10.110…
The Target ALS #DataEngine just got bigger! We’ve expanded datasets across all core collections, added a user manual, and released new demo videos. Now it’s easier than ever to explore and utilize rich data for #ALSResearch. Explore the updates: bit.ly/3yVk2GF
Rapid iPSC inclusionopathy models shed light on formation, consequence, and molecular subtype of α-synuclein inclusions: Neuron cell.com/neuron/fulltex…
Excited to finally share work from a past life! In this small study we dissect neuronal vulnerability, myelin dysfunction and microglia activation in #ALS read our full work on @NatureAging nature.com/articles/s4358…
Check out the data that goes along with our new manuscript & conduct an exciting secondary analysis of your own! @RCFNeuro @alzdemjournals
New data from the @YokoyamaLabUCSF and @UCSFmac is now available on AD Workbench. Researchers can use this dataset to identify novel disease associations, cell-specific impacts, and therapeutic targets for Alzheimer’s. Access data via AD Workbench: bit.ly/45C3zmA
Excited to share this review on one of my favorite biological problems: Selective vulnerability in neurodegenerative disease, and how recent technologies are yielding new insights into the underlying mechanisms. Out in @NatRevNeurosci today! nature.com/articles/s4158…
Exciting study from the Gitler Lab: TDP-43 nuclear loss in FTD/ALS causes widespread alternative polyadenylation changes biorxiv.org/content/10.110…
Really excited about our latest preprint, where we uncovered a neuroprotective role for neuronal polyunsaturated fatty acids in FTD and ALS. Led by @AshlingGiblin and @AlexCammack biorxiv.org/cgi/content/sh… 1/9
Are you an incoming UCSF grad student interested in doing research in neurodegeneration? If you are, join us at the IND OPEN HOUSE @ Helen Diller on 11/15 to meet our current trainees and faculty and to discuss their research! Register here: forms.gle/sqTX5GLNoHiGym…
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