Matthew Ho @MatthewHoMD

@pennmedicine Heme/Onc Fellow via @UCDmedicine; @thebianchilab; @mayoMN_imres Philadelphia, PA Joined July 2020

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Rahul Banerjee, MD, FACP @RahulBanerjeeMD

4 months ago

We talk about bsAb revolution coming across the field of oncology - now more of it in classical hematology as well! Letter in big @TheLancet: Time-limited teclistamab in dara-refractory ITP with basically instant platelet normalization 👏 #MMsb bsAbs to the rescue!

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Matthew Ho @MatthewHoMD

4 months ago

@Abeykyahaiyaar @TrackYourHeart It is. Look at the green box for the goal time - < 90 min if transported to PCI-capable facility - < 120 min if transported to non-PCI-capable facility before transfer to PCI-capable one > 120: fibrinolysis + transfer to PCI-capability.

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Matthew Ho @MatthewHoMD

5 months ago

@TheBianchiLab Thank you so much Giada! I got my start in MM research because of you and will always be grateful for the time and effort you spent mentoring me, and for all the help and guidance you continue to provide.

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Matthew Ho @MatthewHoMD

5 months ago

@RahulBanerjeeMD @NatureMedicine Thanks for sharing Dr Banerjee! Re point 2: we did not necessarily observe CD4-specific activity in maraviroc. Maraviroc inhibited BCMA-CART proliferation in vitro (both CD4 and CD8 subsets) without affecting cytotoxicity. @paruzzol is working on validating this in vivo!

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Saarang Deshpande, MD @SR_DeshpandeMD

a year ago

🧵A brief thread on #CardiovascularSurgery and #PCI approaches for patients with heparin-induced thrombocytopenia (HIT) 🩸 Happy to share our review on this topic was recently published: mp.pl/paim/issue/art… #hemetwitter #hemesky #classicalhematology *not covering aHIT 1/8

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WolverHeme @WolverHeme

a year ago

Check out our latest episode "The Aquila Study: Blowing Hot Air or a Soaring Success for Smoldering Multiple Myeloma" with @ManniMD1 @ajperissinotti and @Berninini 🦅💨 #myeloma #badblood creators.spotify.com/pod/show/wolve…

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Sanjeev Sethi @SethiRenalPath

a year ago

Simple concept of GN. It’s all about location! 1. Subendothelial deposits/injury by Ig, immune-complexes, complement, other mechanism leads to influx of leukocytes= inflammation=GN 2. Subepithelial deposits/injury= protected by GBM & endothelial cells=no inflammation=No GN. 1/3

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Matthew Ho @MatthewHoMD

2 years ago

@WilliamAird4 A I think. Normal bilirubin, elevated urobilinogen. Bilirubin broken down in colon to urobilinogen, reabsorbed and filtered by kidneys. Hemolysis results in elevated bilirubin and therefore elevated urobilinogen.

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William Aird @WilliamAird4

2 years ago

1/6 TPE-FREE MANAGEMENT OF IMMUNE TTP (iTTP) Retrospective study from Austria and Germany ADAMTS13 activity at baseline <10% in all patients Treatment group (TPE-free): 42 acute iTTP episodes in 41 patients received TPE-free management with caplacizumab + steroids +/- Ritux

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Matthew Ho @MatthewHoMD

2 years ago

@the_nEuRiUM @JasmineNephro It has not. Good catch! I got confused with my Roman numerals!

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Matthew Ho @MatthewHoMD

2 years ago

@NicoGagelmann Interested in learning what this is!!

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Anand Patel @Anand_88_Patel

2 years ago

A comprehensive review in @BloodJournal on risk stratification/scoring in MPNs ashpublications.org/blood/article/…

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The Phlegmfighter @phlegmfighter

2 years ago

Here is our article that defines and disambiguates both #ockhamsrazor and #hickamsdictum for #differentialdiagnosis link.springer.com/article/10.100… And a blog post with additional information: medicalevidenceblog.com/2024/10/hickam… And tweetorial as promised

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Adam Rodman @AdamRodmanMD

2 years ago

Our first RCT on using an LLM on diagnostic reasoning is out! And the results are 🔥🌶️... adding ChatGPT did NOT improve diagnostic accuracy or reasoning, and the AI alone outperformed ALL the humans. What does this mean? A 🧵⬇️ x.com/EricTopol/stat…

Eric Topol @EricTopol

2 years ago

A small randomized trial of generative #AI for diagnosis again (as seen in a few previous studies) shows higher performance for #AI than physicians + AI. May indicate that physicians need to be trained on how to incorporate AI. jamanetwork.com/journals/jaman…

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Laura Heacock, MD @heacockmd

2 years ago

1/ Challenge accepted. I have run a series of breast mammograms (x-rays), ultrasounds and MRIs through versions of GPT4 and posted the results here previously. Even though it's data contamination to repost images I already used on X, it's an easy bench mark. So how did Grok do on breast radiology? A little better than GPT4v, but not a single diagnosis correct. 👇

Elon Musk @elonmusk

2 years ago

Try submitting x-ray, PET, MRI or other medical images to Grok for analysis. This is still early stage, but it is already quite accurate and will become extremely good. Let us know where Grok gets it right or needs work.

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Mithu Maheswaranathan, MD @MithuRheum

2 years ago

🆕 Infographic on Systemic Lupus Erythematosus! • Recognize signs/symptoms of #lupus and when SLE should be on your DDx • Learn what labs to send if you suspect SLE: And don’t forget to ☑️ UA/UPC ratio! 🫘 #RheumTwitter #MedX #MedTwitter #NephTwitter #Rheumatology

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Matthew Ho @MatthewHoMD

2 years ago

Great reminder that Na delivery to distal tubules and aldosterone needed for kaliuresis. - diuretics (including caffeine) increase Na delivery to distal tubules —> k loss - hypovolemia decreases Na delivery to distal tubules —> reduction in K excretion

Trisha Laxamana MD ❄️🗽🇵🇭 @NephroloTrish

2 years ago

Hypokalemia #Nephpearls and the most interesting case I have ever heard of — Rhabdomyolysis from Caffeine (Coffee/Cola)-Induced Hypokalemia‼️ by @VelezNephHepato @OchsnerNephro @ASNKidney #KidneyWk ☕️ @NYUnephro fellows discussing how much caffeine we’ve taken for exams! LOL!

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Tiffany Caza @Tiff_Caza

2 years ago

Pseudo-AKI - some drugs cause an increase in creatinine due to decreased creatinine secretion. Cystatin C will be normal. #KidneyWk

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Matthew Ho @MatthewHoMD

2 years ago

@Syed2192 If perfusing (warm, good UOP, no AMS), would trial rate control, which may improve BP. If underlying rEF, wouldn’t use NDHP CCB. Consider adding dig for inotropy.