BalintKintsesLab @KintsesLab
Enthusiastic team of genome engineering and phage therapy aficionados sysbiol.brc.hu/kintses-balint… Szeged, Hungary Joined December 2022-
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New preprint: We mapped global receptor-binding protein compatibility across 1,270 Klebsiella and Acinetobacter phages — identifying conserved adapter domains that define host-range modules for programmable phage engineering doi.org/10.64898/2026.… #phage #AMR #syntheticbiology
Turns out phages go beyond binding to mucus. Many latch onto epithelial cells, get internalized, and traffic to the ER using Ig-like adhesins encoded by some of the most abundant gut phages. Our new preprint is out: doi.org/10.64898/2026.… #phages #preprint #microbiome
Köszönjük a megtisztelő elismerést, és a rengeteg támogatást! #Straub-plakett #HUNREN #SZBK
#KintsesBálint kapta a #Straub-plakettet, a #HUNREN Szegedi Biológiai Kutatóközpont elismerését. Gratulálunk 👏 hun-ren.hu/tudomanyos_kis… #SZBK @BiologicalRese1 @KintsesLab
Excited for #ESCMIDGlobal kicking off this week—hope to see you in Vienna! 🇦🇹 Our lab is presenting two posters: Sunday: P2395 | Session 05a Monday: P1835 | Session 03g Come say hi and chat phages & resistance!
Excited to share a new collaboration with the @Csaba_Pal_Lab, out now in @NatureMicrobiol! The study highlights how ESKAPE pathogens adapt to emerging antibiotics:
🚨 Excited to share that our new study, “ESKAPE pathogens rapidly develop resistance against antibiotics in development in vitro” is just published in @NatureMicrobiol. For details, see the 🧵below and read the paper here: nature.com/articles/s4156…
After a year of hard work and breakthrough success, we came together for a festive Christmas party. 🧑🔬🍕@ApjokGabor even brewed our own beer—fittingly named Scientists' Bloody Sweat! 🍻 Cheers to innovation and teamwork!Happy holidays from all of us at the Kintses Lab! 🎅#LabLife
Thank you @phagedirectory and @JessicaSacher for this, excited to see our work being shared! Check out the full story in this week's Capsid & Tail! #AMR #PhageTherapy #Acinetobacterbaumanii
A team of Hungarian scientists (@KintsesLab & @balazs_papp_lab) created a global ‘superbug map’ for A. baumannii strains, paving the way for scalable phage therapy to combat AMR infections. Check out the feature blog post in this week's Capsid & Tail to learn more!
Fantastic news! Congratulations @AzeredoLab
📢 Historic day for Portugal and phage therapy! 🇵🇹 A framework was approved, allowing magistral preparation of personalized phage products. 🙌 Grateful to Jean-Paul Pirnay, my group @AzeredoLab Portuguese patients, and doctors who signed a petition inspired by the Belgium model.
The guest speaker of today's Institute of Genetics seminar was Bálint Kintses, head of the Laboratory of Translational Microbiology at the BRC Institute of Biochemistry. His work on bacteriophage cocktail therapy was published in Cell.
Thrilled to be featured on @NakedScientists, discussing our work recently published in @CellCellPress on guiding phage therapy with genomic surveillance! #AntibioticResistance #PhageTherapy #GenomicSurveillance
News pod: @dr_michaelmarks from @LSHTM on mpox; Steve Baker from @Cambridge_Uni on antibodies for AMR; @balint_kintses from @BiologicalRese1 on a superbug map; Elizabeth Graham @ucl on Mayans; Michael Ishida on robot fish; and @EdiaCharlotte on dinosaurs. thenakedscientists.com/podcasts/naked…
Excited to see our work on guiding phage therapy with genomic surveillance featured in @NatureMicrobiol News & Views! Thanks to @PhageForward and Lorenz Leitner for highlighting our research! #PhageTherapy #GenomicSurveillance #AntibioticResistance @CellCellPress
News & Views: @PhageForward and Lorenz Leitner discuss the recent @CellCellPress paper from @KintsesLab @balint_kintses Guiding phage therapy with genomic surveillance nature.com/articles/s4156…
Did you know that today, October 22nd, is World Phage Day? This day also marks the beginning of World Phage Week (October 22nd-28th), dedicated to raising awareness about the life-saving potential of #bacteriophages. #WorldPhageDay #WorldPhageWeek #PhageTherapy
Excited to share that our new paper in @CellCellPress, in collaboration with the @balazs_papp_lab, has been featured in GEN!
First "Superbug Map" May Advance Phage Therapy for Acinetobacter baumannii Scientists have created a global "superbug map," paving the way for scalable #phagetherapy to combat antibiotic-resistant infections in hospitals. hubs.li/Q02TPBcN0
Magistral phage preparation according to the Belgium model of phage therapy is being discussed by the Portuguese government. @azeredo_joana and @DPP_Pires were at the parliament to present the concept as a result of a petition initiated by two patients who received phage therapy.
Now online! Genomic surveillance as a scalable framework for precision phage therapy against antibiotic-resistant pathogens dlvr.it/TDpzHm
🤝 Shoutout to @chngin_the_wrld! We hope our work advances the wider application of Acinetobacter phage therapy pioneered by the Patterson case. 🙌11/11
🙏 Gratitude: This journey has been incredible. The work was a collaboration between @KintsesLab, @balazs_papp_lab, @Csaba_Pal_Lab from @BiochemBrc, @BiologicalRese1, the National Public Health Centre (Hungary). Huge thanks to our incredible team and international partners! 10/11
🌐 Bridging fields: #Pathogengenomicsurveillance has revolutionized epidemiology and vaccine development, but its potential in phage therapy remains untapped. Our study highlights the need to bring these fields together. 9/10
🏥 Clinical impact: By enabling hospitals to prepare in advance, we can save lives, reduce the spread of superbugs, and make phage therapy a routine part of healthcare. 8/10
🔄 From personalized to scalable: Traditionally, phage therapy is personalized and time-consuming. Our map identifies locations where patients need the same phages, scaling up phage therapy and allowing clinical trials. 7/10
⏳ Timing is everything: Superbug variants spread slowly, remaining prevalent for about 6 years in a region, allowing us to prepare region-specific phage treatments in advance. 6/10
💡 Key discovery: Despite hundreds of bacterial variants, only a few strains dominate in each region. This means we can prepare region-specific phage treatments that could tackle up to 80% of local infections. 5/10
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