Faisal S.S. @ImmunityForever

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"These are the very early days ... but the AI buzzsaw is real," 🪚@AndrewYang says.

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I’ve had a number of conversations with folks inside and outside government about the current situation with Anthropic, and here is what I believe to be true: — As we know, Anthropic publicly released its Mythos class models earlier this week under the commercial name Fable. — Fable is Mythos with guardrails. But if those guardrails fail, then you’ve exposed Mythos and its advanced cyber capabilities to people who shouldn’t have them. (Keep in mind that Anthropic itself widely promoted the idea that Mythos was a cyberweapon and needed to be regulated as such. They asked for government regulation of Mythos and championed the guardrails on Fable. If there is a vulnerability — big or small — it is Anthropic’s responsibility to patch.) — A highly credible trusted partner of both Anthropic and the USG who was testing Fable came forward with a jailbreak of those guardrails. The Admin asked Dario to fix the jailbreak or de-deploy the model. Dario refused. — In their blog post, Anthropic defended its decision by saying the jailbreak isn’t serious. That is not what the trusted partner and the USG believe; nor is that kind of minimizing language consistent with Anthropic’s brand as the AI safety company. It’s difficult to fathom how they could claim a jailbreak allowing operability of a cyber weapon could be defined as not “serious.” — In the past, Anthropic has always said that safety must be top priority and taken super seriously. In this case, Anthropic prioritized the continued offering of the consumer model over safety. — In reaction, the Admin issued the export control. The Admin did this reluctantly. It’s been very surprised that Anthropic hasn’t wanted to cooperate with a reasonable safety request (ie fixing the jailbreak issue). Anthropic’s reaction is very much at odds with their branding and ethos as a safe AI research community. — The Admin’s hope now is that Anthropic remediates the safety issue, the export control is lifted, and Fable goes back into general release. The Admin wants all of this to happen as soon as possible. It is frankly bewildered that Anthropic hasn’t wanted to comply with safety requests that it previously said were its highest priority. — Those trying to misdirect and tie this action to the prior DoW/Anthropic issues are wrong. The Admin values Anthropic’s technical capabilities and feels that this issue, while serious, should be easily resolved. The ball is in Anthropic’s court.

Two icons. One trophy. 🏆 Pete Sampras and Andre Agassi met in the 1999 ATP Finals championship match.

Alan Turing's items, including his OBE and scientific papers, were stolen in 1984 from Sherborne School, which he attended as a student. The items were later recovered after being found in a filing cabinet purchased at an auction by a solicitor who recognized the significance of the documents and objects.

Anthropic Co-Founder and President Daniela Amodei sits down with The Circuit to discuss the intense weight the AI boom has placed on the shoulders of its leaders. Amodei tells Emily Chang the AI industry is trying to learn from the mistakes of social media giants to self-regulate early bloom.bg/4xpBEDW

Introducing Claude Fable 5: a Mythos-class model that we’ve made safe for general use. Its capabilities exceed those of any model we’ve ever made generally available.

The first participant to receive partial cellular reprogramming for eye disease (advanced glaucoma) in a pilot study of 12 patients was treated. Using 3 of the 4 Yamanaka stem cell factors to potentially achieve cellular rejuvenation @Nature nature.com/articles/d4158…

Interviewer: “Are you glad that Novak Djokovic exists?” Nadal: “No. I like challenges but I am not stupid.” 😂

I got to spend all day today with Jensen in Taiwan: talking with thousands of engineers and eating street food at a night market. Jensen is received as a rockstar in Taiwan, like it's Beatles in the 60's. It's mind-blowing and fun to watch. But most importantly, through all the interactions and all my conversations with him, he remained the same humble, kind, thoughtful, funny guy he always was, even as a kid who went to these same night markets many years ago. Btw, we tried a crazy amount of different street food. It's legit some of the most delicious food I've ever had. I can't wait to share video of it, including a ton of our conversations and hangout. When I can pause for a moment from all the travel to edit the video, I'll post it. Can't wait to continue talking to Jensen and engineers at Computex this week, and exploring more of Taiwan, and of course roaming the night markets for some more delicious street food. Days like these, even more than usual, I feel like the luckiest kid in the world. Love you all! ❤️

In her first wide-ranging interview since leaving OpenAI, @miramurati shared more than ever before about what she’s building at her AGI startup, @thinkymachines lab. The former OpenAI CTO laid out her vision for a future where humans and AI work together more closely -- “like a tandem bike” -- and where people aren’t pushed out of the loop as machines become more capable. via @BloombergLive

Humanity is disappearing 😔 wsj.com/health/wellnes…

Our internal data shows Claude is accelerating AI development—a possible path to recursive self-improvement, or AI autonomously building a more capable successor. It’s happening faster than we thought, and the implications deserve greater attention. anthropic.com/institute/recu…

🚨Claude Code just gave me a complete research paper with a single prompt. The paper has a strong argument and even beats AI-detection app, Pangram. With a little editing, it can pass for 100% human, and can be easily submitted for peer review. Here's the workflow I used:

A vaccine that could provide protection against multiple pathogens would be invaluable, particularly during pandemics in which knowledge of the causative pathogen is limited. In a new Science study, researchers found that a nasal vaccine designed to stimulate innate immune cells and T cells provided protection against both viral and bacterial lung infections in mice. scim.ag/4vyBMzh

Introducing Claude Opus 4.8: it builds on Opus 4.7 with sharper judgment, more honesty about its own progress, and the ability to work independently for longer than its predecessors. Available today at the same price.

Historic foreign selling of Korean (memory) and Taiwanese (TSMC) stocks (chart Goldman)

Just published @NEJM Marked and durable reduction of LDL cholesterol with one shot PCSK9 gene base editing @skathire nejm.org/doi/full/10.10…

Nearly 20 years ago, researchers discovered something fascinating: some people are naturally protected from heart attacks because one of their PCSK9 genes is turned off, leading to low cholesterol from birth. That observation sparked a simple but ambitious question: can we give that same protection to others? Results from the Heart-2 Phase 1 trial released today show early clinical evidence that could open the door to new possibilities. These are results in 35 people and we have a lot left to learn. But, the results could potentially mean an entirely different way of treating high cholesterol — one infusion, lifelong cholesterol lowering. See the thinking behind this approach: lilly.com/news/stories/t…