Tanja Dudenbostel, MD, FASH, FAHA @DrDudenbostel
Physician-Scientist, Director of Hypertension, Associate Professor, CV Health and CVD Prevention. Editor. Opinions are my own. Huntsville, AL, United States Joined September 2017-
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These new data on cardiac outcomes from SSaSS add important new insight into the case for switching from regular salt to potassium-enriched salt in China and around the world@MaoyiT @lijing_l @BruceNeal1 ahajournals.org/doi/10.1161/HY…
CENTENNIAL REVIEW: Mineralocorticoid Receptors in Vascular Smooth Muscle: Blood Pressure and Beyond ahajournals.org/doi/10.1161/HY…
Editorial: Cardiovascular Benefits of Potassium-Enriched Salt Substitution: Promises and Challenges of Secondary Analyses ahajournals.org/doi/10.1161/HY…
K+-deficient diets, typical of ultra-processed foods, increase blood pressure. Study unveils a mechanism: a new signaling pathway, the K+ switch, and its powerful influence on renal salt rete... @PAWellingMD @dhekidney @RickGrimmPhD @rofe6065 @LamaQusairi ahajournals.org/doi/10.1161/HY…
Answer to @DrDudenbostel #HYPHIP
Wow how time flies by when you are doing something interesting and fun! The end of our chat has arrived, sadly, because I was learning a lot and really enjoying talking to @ashleylpitzer @annetkiraboc1 @LErtuglu Thank you so much to you all for being here with us today! #HYPHIP
@annetkiraboc1 @guto_montezano @ashleylpitzer @HyperAHA In our previous study using CITE-sequence analysis, we found no significant change in the expression of any RAAS-related gene in APCs after salt loading and depletion. @HyperAHA #HYPHIP @guto_montezano frontiersin.org/journals/physi…
@LErtuglu @ashleylpitzer @annetkiraboc1 @HyperAHA @CVimmunology @endocelldoc It would be interesting to know beyond vascular dysfunction, maybe looking at non-invasive measurements in the subjects going on the salt-sensitivity protocol. Not sure if all makes sense though. #HYPHIP @ashleylpitzer @annetkiraboc1 @LErtuglu @HyperAHA
@guto_montezano @ashleylpitzer @LErtuglu @HyperAHA A14 salt-sensitive people have super sensitive and high expression of SGK1. Our data indicates not through the MR. It’s the GR. Aldo does not correlate with salt-sensitive hypertension #HYPHIP @HyperAHA
Q14 @ashleylpitzer @annetkiraboc1 @LErtuglu In your data, you didn't see a role for aldosterone. Do you know if in isolevuglandin-activated APCs, MR activation is increased? And What about cortisol? #HYPHIP @HyperAHA
@DrDudenbostel @guto_montezano @HyperAHA @ashleylpitzer More in women even in pre-menopause but amplified by menopause
@DrDudenbostel @guto_montezano @HyperAHA @ashleylpitzer We are not yet powered to answer this for immune mechanisms - it is ongoing but all large clinical trials that have rigorously phenotyped salt-sensitivity find it mainly in women
@DrDudenbostel @guto_montezano @HyperAHA @annetkiraboc1 @ashleylpitzer A11 Thank you for this important Q, @DrDudenbostel! Previous studies showed that women are affected by SS more. We are studying possible sex differences in immune-cell salt sensitivity in ongoing studies! @HyperAHA #HYPHIP pubmed.ncbi.nlm.nih.gov/34569287/
Q 11 Are there any gender differences in salt-sensitivity? Differences in response to salt loading? #HYPHIP @guto_montezano @HyperAHA @annetkiraboc1 @ashleylpitzer
~~In OnE HoUr~~ Join @guto_montezano for a #HypHIP Live Chat with @anetkiraboc1, @LErtuglu, @ashleylpitzer Monday April 22, 16:00-17:00 UTC Salt Series: Eicosanoid-regulated Myeloid ENaC and Isolevuglandin formation in Human Salt-sensitive Hypertension ahajournals.org/doi/10.1161/HY…
~~ToDaY~Mon April 22 11 AM CST ~ Join @guto_montezano for a #HypHIP Live Author Chat with @anetkiraboc1 @LErtuglu @ashleylpitzer @HyperAHA #salt 🧂 Series: 🤓Learn more about Eicosanoid-regulated Myeloid ENaC and Isolevuglandin formation in #APCs in Human 🧂 Salt-sensitive…
~~ToDaY~Mon April 22 11 AM CST ~ Join @guto_montezano for a #HypHIP Live Author Chat with @anetkiraboc1 @LErtuglu @ashleylpitzer @HyperAHA #salt 🧂 Series: 🤓Learn more about Eicosanoid-regulated Myeloid ENaC and Isolevuglandin formation in #APCs in Human 🧂 Salt-sensitive…
~~ToDaY~~ Join @guto_montezano for a #HypHIP Live Author Chat with @anetkiraboc1, @LErtuglu, @ashleylpitzer Mon April 22, 16:00-17:00 UTC Salt Series: Eicosanoid-regulated Myeloid ENaC and Isolevuglandin formation in Human Salt-sensitive Hypertension ahajournals.org/doi/10.1161/HY…
It is today in a few hours that we will chat with @ashleylpitzer @annetkiraboc1 @LErtuglu about their work on #hypertension #Immunology #salt Join us and let's learn more on this important topic! #HYPHIP @HyperAHA @AnastasiaSMihai @Carmendemigue12 @DrDudenbostel @fjorios
It is today in a few hours that we will chat with @ashleylpitzer @annetkiraboc1 @LErtuglu about their work on #hypertension #Immunology #salt Join us and let's learn more on this important topic! #HYPHIP @HyperAHA @AnastasiaSMihai @Carmendemigue12 @DrDudenbostel @fjorios
The May issue has been released! Make sure you check it out today! ahajournals.org/toc/hyp/81/5
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zahifayad @zahifayad
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Taben M. Hale, PhD @TMHalePhD
2K Followers 2K Following #Cardiovascular #pharmacologist #physiologist researching #fibrosis #hypertension #DOHAD #autonomic regulation 🇨🇦
Adil Rasheed @adil__rasheed
2K Followers 2K Following Assistant Professor @ImmunologyAU #onacholesteroll @atvbahajournals Editorial Board & Diversity Council Member
Steve Jones @StevenPJones
914 Followers 510 Following Cardiovascular scientist. Just personal opinions; no official positions/endorsements.
Jose L. Lopez, MD @jllbmd
572 Followers 666 Following 🫀Cardiology #FIT @UMJFKcards | Ambassador @TEHTP_INC | @HMSPostgradCE FCR Graduate | @UNPHURD MD | 🇩🇴 Dominican | Opinions = own
Francesca Giampieri @FrancescaGiamp5
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Cajetan von Koenig @C_von_Koenig
103 Followers 313 Following CardioVascular Medical Devices Consulting CV MedTech
GerdLi™ @gerdliinc
2K Followers 3K Following World’s 1st premium natural antacid Physician engineered Gluten free | Vegan | Non-GMO
Lina Ayasrah @Lina_Ayasrah
923 Followers 3K Following MS5 @UJ_MED '25 | Interested in IM &🫀🩺 | @ACCintouch Med Student Leadership | opinions my own.
James Olzmann @OlzmannLab
10K Followers 7K Following Associate Professor @UCBerkeley & Investigator @czbiohub. Lipid droplets, ferroptosis, ubiquitin, chembio, molecular therapeutics. Diversity, equity, inclusion.
Andrea Guala @andreaguala6
436 Followers 870 Following Senior, tenure-track researcher and La Caixa Junior Leader. Vall d’Hebron Institute of Research and Hospital. Leading training activities @VascAgeNet
Anna Foged Thomsen @anna_foged
368 Followers 479 Following MD, PhD, Cardiologist fellow | Special interest in EP Imaging and VT | 100% runner | Co-founder of @RigsHeart🫀
Samira Soltani @SamiraSoltaniMD
371 Followers 239 Following Cardiology resident | Hanover Medical School | Interventional Cardiology and Imaging | Heart Failure
Amin Yehya, MD, MS, F.. @AminYehyaMD
2K Followers 714 Following Advanced Heart Failure and Transplant Cardiologist, Sentara Heart Hospital. Associate Professor of Medicine, Eastern Virginia Medical School. ❤️🩹 🔁 💝
Sanjog Kalra @SanjogKalra
4K Followers 1K Following Interventional Cardiologist Specializing in Complex, High Risk Coronary Revascularization, Chronic Total Occlusions and Mechanical Circulatory Support
Amr S. Gamal, MBBCh, .. @AmrGama00480068
793 Followers 863 Following Dad, husband, Consultant Interventional Cardiologist, Lancashire Cardiac Centre, 🇬🇧, Honorary Clinical Lecturer, University of Liverpool | Views are my own |These new data on cardiac outcomes from SSaSS add important new insight into the case for switching from regular salt to potassium-enriched salt in China and around the world@MaoyiT @lijing_l @BruceNeal1 ahajournals.org/doi/10.1161/HY…
CENTENNIAL REVIEW: Mineralocorticoid Receptors in Vascular Smooth Muscle: Blood Pressure and Beyond ahajournals.org/doi/10.1161/HY…
Editorial: Cardiovascular Benefits of Potassium-Enriched Salt Substitution: Promises and Challenges of Secondary Analyses ahajournals.org/doi/10.1161/HY…
🤩 My PhD student @LilyRen62385572 first first-authored paper has been accepted for publication in BMC Nursing! This marks a significant milestone in their academic journey. Congratulations on your hard work. @UBCNursing @UBCOSOT #AcademicMilestone
K+-deficient diets, typical of ultra-processed foods, increase blood pressure. Study unveils a mechanism: a new signaling pathway, the K+ switch, and its powerful influence on renal salt rete... @PAWellingMD @dhekidney @RickGrimmPhD @rofe6065 @LamaQusairi ahajournals.org/doi/10.1161/HY…
We are looking forward to seeing you tomorrow at ESC Preventive Cardiology 2024: this is a very special edition of the congress, celebrating 20 years since the EAPC was created! esc365.escardio.org/preventive-car… #ESCPrev2024 @SilCastelletti @PeroneFrancesco @gbiondizoccai @s_gati…
Absolutely delighted to welcome Dr. @DanielJDrucker @SinaiHealth @UofT @UofTmedicine to give @StanfordDeptMed Medicine Grand Rounds this Wednesday. Looking forward to the compelling story of the development of GLP-1 agonists!
@guto_montezano @annetkiraboc1 @LErtuglu @HyperAHA Thanks for having us! We're excited to talk about the paper! #HYPHIP @HyperAHA
@guto_montezano @annetkiraboc1 @fjorios @LErtuglu @HyperAHA Endothelial cells can produce IsoLGs and present them as antigens to CD8+ T cells in response to hypertensive stimulus, Angiotensin-II. @DavidPatrickLab biorxiv.org/content/10.110…
@DrDudenbostel @guto_montezano @ashleylpitzer @annetkiraboc1 @HyperAHA @CVimmunology @endocelldoc We did not see a difference in baseline pulse pressure between salt-sensitivity tertiles, but pulse pressure significantly decreased from salt-loading to depletion in salt-sensitive people compared to salt-resistant @HyperAHA #HYPHIP
@guto_montezano @fjorios @ashleylpitzer @LErtuglu Q12 - in our initial paper published in @jci we performed a comprehensive analysis and found IsoLgs as extremely potent compared to other lipid mediators #HYPHIP @HyperAHA
Answer to @DrDudenbostel #HYPHIP
@DrDudenbostel @guto_montezano @ashleylpitzer @annetkiraboc1 @HyperAHA @CVimmunology @endocelldoc We did not see a difference in baseline pulse pressure between salt-sensitivity tertiles, but pulse pressure significantly decreased from salt-loading to depletion in salt-sensitive people compared to salt-resistant @HyperAHA #HYPHIP
@guto_montezano @ashleylpitzer @annetkiraboc1 Thank you so much for hosting this wonderful session @guto_montezano and thanks to everyone for all the great questions! @HyperAHA #HYPHIP
@ashleylpitzer @annetkiraboc1 @LErtuglu another Q from @DrDudenbostel we missed #HYPHIP
@LErtuglu @guto_montezano @ashleylpitzer @annetkiraboc1 @HyperAHA @CVimmunology @endocelldoc Did see differences in pulse pressure as a crude estimate of arterial stiffness? #hyphip @guto_montezano @HyperAHA @LErtuglu @annetkiraboc1
@ashleylpitzer @annetkiraboc1 @LErtuglu it was amazing having you here with us today and congrats on your paper. I am looking forward to more from you all and get to see all your salt studies and other ones as well! A heartfelt thank you and I hope you enjoyed the chat! #HYPHIP
@guto_montezano @ashleylpitzer @LErtuglu @HyperAHA A15 We have not tested K. Hypothesis it would be protective but we need to study this #HYPHIP @HyperAHA
Wow how time flies by when you are doing something interesting and fun! The end of our chat has arrived, sadly, because I was learning a lot and really enjoying talking to @ashleylpitzer @annetkiraboc1 @LErtuglu Thank you so much to you all for being here with us today! #HYPHIP
@fjorios @annetkiraboc1 @ashleylpitzer @HyperAHA @guto_montezano A12 Yes both innate and adaptive immunity appear to play key roles! This is a very interesting point to look into in future studies! @fjorios @HyperAHA #HYPHIP
@annetkiraboc1 @guto_montezano @ashleylpitzer @HyperAHA In our previous study using CITE-sequence analysis, we found no significant change in the expression of any RAAS-related gene in APCs after salt loading and depletion. @HyperAHA #HYPHIP @guto_montezano frontiersin.org/journals/physi…
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