Craig E Brown @CraigEdBrown
Professor at UVic. interested in neuroscience, micro-circulation, hockey. Lab website: https://t.co/mYMRXqmTMS uvic.ca/medsci/people/… Victoria, British Columbia Joined January 2018-
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New finding from the lab. This surprised us since it went against the common assumption that increasing peri-infarct blood flow is best for stroke recovery. Congrats to Kamal and the team! biorxiv.org/content/10.110…
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peterattiamd.com/link Nice write up on our paper by @PeterAttiaMD
Was a pleasure to contribute a little to this new work from Tuan Trang and Yuta Kohro molecularbrain.biomedcentral.com/articles/10.11…
Main findings: 1) dendritic spines in peri-infarct and ipsi motor cortex most disrupted by stroke but generally recover by 6 wks, 2) ipsi S2 and contra-lateral S1 show minimal changes despite extensive connections, 3) neurons innervating stroke site survive just fine (supp fig).
Happy to share new paper from MSc grads Myrthe and Jenna. We asked the question, when part of the brain dies during stroke, what happens to local and distant cortical neurons that innervate the stroke site (in S1 cortex) or those that receive outputs? journals.sagepub.com/doi/10.1177/02…
The pathobiology of neurovascular aging: Neuron cell.com/neuron/abstrac…
Craig E Brown retweeted
Endothelial Response to Blood-Brain Barrier Disruption in the Human Brain | JCI Insight insight.jci.org/articles/view/…
Craig E Brown retweeted
Happy to share our study on the beneficial role of the innate immune system on vascular remodeling in retinal disease and potential negative impact of steroids. @MasayukiHata7 @UMontreal @ARVOinfo @CIHR_IRSC @_BrightFocus @AmDiabetesAssn @iserworld pnas.org/doi/10.1073/pn…
@psapieha @MasayukiHata7 @UMontreal @ARVOinfo @CIHR_IRSC @_BrightFocus @AmDiabetesAssn @iserworld Congrats! Looks interesting, will have a read.
Craig E Brown retweeted
That Trudeau would expect @cafreeland to deliver the FES after telling her ON FRIDAY he was firing her is peak chauvinistic arrogance. Wtf did he think she was going to do? LOL Then he sat around all weekend and released a vid of him baking buns. IDIOT
Craig E Brown retweeted
iFlpMosaics are now published @naturemethods. A compendium of novel genetic tools and related methods for inducing and analysing genetic mosaics in a high-throughput manner. nature.com/articles/s4159… Tweetorial 👇
Craig E Brown retweeted
Excited to share our work, new in @ScienceMagazine: science.org/doi/10.1126/sc…. We explored how sex chromosomes, gonadal hormones, and their interaction shape cellular responses in aging and #Alzheimers mouse models. This led to key insights on Tlr7 and neurodegeneration 🧵(1/5)
@TheTravelAssist @westjet The always being late thing prevents people from making connections. We missed our connection and there were was no plan B. We were on hold for 2.5 hours with @westjet customer service. Same crap happened when we went to Mexico in January. Being awful is Westjet’s new norm
@westjet screwed us on our Europe trip. Of course no one is surprised by this. Canadians have few travel options and are forced to put up with this crap. Its especially bad for small city travellers that always have to make a connection vancouver.citynews.ca/2023/07/25/air…
Happy update. In response to losing a day of holiday and 1 night hotel in Paris, @WestJet offered us a $15 food voucher. They really do care!!
@jonjazzpics Thanks! We speculate in the discussion but don’t know. However since inhibiting notch can promote angiogenesis in mature brain, Perhaps could be useful in disease conditions where inducing angiogenesis could be beneficial. Stroke, dementia perhaps? More work to be done.
Congrats to the team! Here we directly image and quantify cerebral #angiogenesis and pruning in vivo. Found interesting regional differences and dependence on #notch signalling. Where you look does matter! cell.com/cell-reports/f…
Craig E Brown retweeted
The epidemiology of type 1 diabetes mellitus in older adults go.nature.com/4hR0q8e #diabetes #T1DM #T1D
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