Mini-Review: "Frameworks of Health Outcomes for Performance Specifications in Laboratory Medicine"
by Patrick M Bossuyt & others
#LabMedX#MedX#PathX
👇 buff.ly/KycFHsH
#bcsm The ⬆️ trend in stage IV breast cancer diagnoses should concern all of us.
De novo stage IV disease can no longer be dismissed as “rare,” & metastatic recurrence still remains poorly tracked in the U.S.
From 2010-2021, incidence ⬆️ overall, across ages, & across multiple subtypes. We desperately need better understanding of WHY this is happening, along with better metastatic disease tracking, stronger data collection, & more research/funding. 📈➡️📉
“In this cohort study of individuals with stage IV breast cancer, incidence increased significantly overall, across ages, & for both sexes from 2010 through 2021. The percentage of individuals with stage IV vs stages I to III diagnoses also increased.”
#metastaticbreastcancerjamanetwork.com/journals/jaman…
Facing limited staff & rising demand, Stanford Cancer Center South Bay used #CLSI AUTO15 to streamline chemistry autoverification, cutting turnaround times, freeing staff for complex cases, & delivering faster, reliable results for better patient care. buff.ly/beTxU9Q
Channing J. Der, PhD, and Jen Jen Yeh, MD, describe the scientific foundations of a phase 1–2 study of daraxonrasib to treat metastatic pancreatic ductal adenocarcinomas.
Learn about the science behind the study in the editorial “Advances in RAS Therapeutics for Pancreatic Cancer,” from the University of North Carolina at Chapel Hill (@unc): nej.md/4neOTCE
The past decade has witnessed phenomenal progress in the therapeutic options available for persons with hemophilia A and B, conditions characterized by deficiencies in coagulation factor VIII and factor IX, respectively.
Science behind the Study: nej.md/3Y6RTWY
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The past decade has witnessed phenomenal progress in the therapeutic options available for persons with hemophilia A and B, conditions characterized by deficiencies in coagulation factor VIII and factor IX, respectively.
Science behind the Study: nej.md/3Y6RTWY
🧵 1/12
Highlights from Disease Outbreak News on #Ebola disease caused by Bundibugyo Virus Disease, Democratic Republic of the Congo & Uganda - 16 May 2026:
🔴 As of 15 May, a total of 246 suspected cases and 80 deaths (4 deaths among confirmed cases) have been reported. 65 contacts have been listed, with 15 identified as high-risk.
🔴 Most of the suspected cases are between 20 and 39 years old, with females accounting for over 60%, suggesting significant risks associated with household and caregiver transmission.
🔴 Insecurity in the affected areas and movement restrictions are hampering the surveillance and follow up efforts. Several listed contacts became symptomatic and died before they could be isolated.
🔴 Ituri province’s role in #DRC as a commercial and migratory hub and proximity to #Uganda and South Sudan increases the risk of regional exportation and cross-border transmission.
Read the full Disease Outbreak News here: bit.ly/43cOnM2
Among adults with multiorgan metastatic #ColorectalCancer, adding local debulking to chemotherapy did not improve survival and increased serious adverse events.
ja.ma/3QjR3EI
The oncogenic KRAS mutation has been the subject of intense investigation. In The Lancet, a new phase 3 trial reports on adagrasib versus docetaxel in KRASG12C-mutated non-small-cell lung cancer.
This and more in our latest issue 👉 hubs.li/Q03BTV6C0
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That "immortal time" is so frequent in survival analyses for #causalinference is fascinating.
Because "immortal time" doesn't exist in the data, *we* create it when misanalyzing data.
Our paper pubmed.ncbi.nlm.nih.gov/39494894/ summarizes why immortal time arises & how to prevent it.
🔥 🔥 "Establishing Reference Values in Healthy Participants for the Cardiac #Troponin T High-Sensitivity Gen 6 Assay: REF-TSIX Global Reference Study"
by Lori B Daniels & others
#LabMedX#PathX#MedX
👇 buff.ly/QT3WFMA
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