Bryan Haffer @Bryan_Haffer

We are incredibly proud to share that the FDA has approved Signatera™ CDx as a companion diagnostic for use with adjuvant atezolizumab (Tecentriq®) in muscle-invasive bladder cancer. This is the first FDA-approved molecular residual disease (MRD) companion diagnostic in history – a milestone to celebrate on many levels! Today’s news speaks volumes to the transformation well underway in MRD-guided cancer care. Signatera has become a cornerstone of precision oncology, with extensive support from more than 185 peer-reviewed publications. By detecting microscopic amounts of tumor DNA in the blood, Signatera can identify MRD earlier than standard tools, allowing physicians to intervene sooner and improve outcomes for patients. Just as importantly, Signatera can help identify patients who are MRD-negative and may be able to avoid unnecessary therapy and its associated toxicity. Altogether, this has a tremendous impact on the lives of patients and their loved ones. This approval was supported by the landmark Phase III IMvigor011 study, published in The New England Journal of Medicine, which demonstrated the power of MRD-guided treatment decisions in bladder cancer. We’d like to thank our esteemed collaborators at @Genentech and @Roche, the principal investigators of IMvigor011, and our clinical trial participants for their contributions to this major milestone in cancer care. Read the full press release here: ow.ly/M0GZ50Z0isa #PrecisionMedicine #Oncology #Natera

@ClankoMedia It’s a business. Money talks.

MN HP 17s Top Scorers from the Spring Festival this weekend!

My Jeep is still at Apple Jeep and the Mopar warranty was approved after providing my last 3 recent oil change records. I only service my Jeep at Jeep dealerships. I keep every one of my service receipts. Jeep should have a system that centralizes all Jeep service records that can be seen regardless of the dealership.

@Jeep @OfficialMOPAR took my 2020 Jeep Sahara Altitude into Apple Chrysler Dodge Jeep in Shakopee, MN on March 24th due to an engine warning light. Apple service tech couldn’t find an issue but, recommended $3100 in maintenance (engine and transmission) based on mileage (98k). Picked up on March 30th and immediately notified Apple about ticking when accelerating. Dropped off again on April 2nd. Discovered metal fragments in oil and recommending long block replacement on April 6. Apple submitted Mopar Warranty claim to Jeep and no decision since then. Apple has no loaner vehicles. Been without a vehicle since March 24th. What is going on?

@GovTimWalz How about lowering State Income Taxes? Regulating Insurance Company Premium Increases? Real Estate Taxes? Vehicle Registration Fees? Fixing Fraud? The leadership of this state is disgraceful! You’re the sole reason people are leaving the state.

@Kathryn24622592 @KurtSupeCPA Interesting idea. Also protects the investment because the home is not marital property. The investment would remain with their child if the couple didn’t work out.

@ClankoMedia After 14U, every age group is diluted

@spittinchiclets @BizNasty2point0 The politics. It’s everywhere.

If the highways here in MN, especially in the city, were updated to 2026, there would be no need for public transportation! Take I35 to I94 into Minneapolis and tell me one lane is enough to go to U of M! Who designed the cloverleafs to enter and exit highways? Super short! Passing lanes disappear? Focus on safer roadways that do not slow down traffic! Fix that problem!

@NHLFoley How many minutes per game did each of the players average? Did they play power play? What were the average points per game for the other players on their lines?

Holy cow - it's finally beginning. The house of cards is collapsing! Here's Minnesota DHS whistleblower Faye Bernstein going public, breaking down the retaliation she faced. She was quite literally barred from DHS and investigated over accusations of racism - and it all started after she tried to address fraud seven years ago. Tim Walz’s administration tried to cover it up. REPOST this everywhere! #thinblueline #Lawenforcement

Whoever is leading these new policy decisions needs to be fired. Your company exists to serve customers. Have any of these updated policies done anything to better serve your customers? If the policy decisions do not start with this important question first, they should not be implemented.

@carkerpox Leadership thinking they know what their customers need and want more than their customers. Abandoning the identity of the business to try and reinvent or compete with others who already own that identity is a risky proposition.

@FluentInFinance Without any idea of where, what, and how the government utilizes those tax dollars! Probably don’t want to know!

Which assay correlates with the patient’s clinical features and outcome? What each assay is measuring is different. The tumor informed assay is measuring molecular residual disease, a fingerprint of the patient’s tumor. The tumor-naive assay may be looking at methylation signatures &/or specific driver mutations targeted within the panel. These assays are not the same but, the hope is that the results would correlate, especially at LoDs above 100PPM and matching the patient’s clinical features.

Imposing term limits on members of the U.S. Congress requires amending the Constitution, as confirmed by the Supreme Court’s 1995 ruling in U.S. Term Limits v. Thornton, which struck down state-level attempts to add qualifications for federal office beyond those in the Constitution. There are two primary paths under Article V to achieve this, but neither is simple or guaranteed due to political resistance. The first method involves Congress itself proposing the amendment: It needs a two-thirds supermajority vote in both the House and Senate, followed by ratification by three-fourths (38) of the state legislatures or conventions. In theory, this could happen quickly—potentially within weeks if there were broad support—but in practice, it’s unlikely because incumbents benefit from the status quo and have repeatedly blocked such proposals, including recent ones like Rep. Ralph Norman’s 2023 resolution, which failed in committee. The second, and arguably easiest and fastest realistic path, is through an Article V convention called by the states to bypass Congress entirely. This requires two-thirds (34) of state legislatures to pass resolutions calling for a convention specifically on term limits; the convention would then propose the amendment, which still needs ratification by 38 states. As of early 2025, at least 10 states (including Florida, Alabama, Missouri, and others) have already passed such resolutions, with momentum from groups like U.S. Term Limits pushing for more. This approach avoids D.C. gridlock and could move faster if public pressure builds through voter initiatives or state-level campaigns, though it carries risks like a runaway convention debating unrelated issues. Other ideas, like state-imposed limits via referendums, have been invalidated by the courts, and simply voting out incumbents doesn’t create enforceable term limits. Overall, the state convention route is the most viable shortcut given congressional opposition, but success depends on coordinated grassroots efforts and could still take years

@Milajoy @SchepisPeterJ @ grok what was the signal chat?

@dish_answers Followed

@megynkelly @realDonaldTrump No thank you, Megyn. There’s a large majority of Americans living in MN that do not agree with the fraud, systemic high taxation, and criminal leadership