Lin @Bioinfo_Lin
PhD candidate in computational biology, SJTU. Interested in single-cell and spatial omics. Shanghai, China Joined September 2022-
Tweets14
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Following617
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Mark
@Cancer_Cell review out—led by @liuyunho @Yibo_Dai #SpatialOmics advances (tech, analytics, applications). Single cells → niches/communities → tumor ecosystems + a roadmap to translation. Grateful to editors, reviewers, support from @MDAndersonnews @break_cancer @NIH @theNCI
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Lin retweeted
How does tumour heterogeneity arise? How can we predict cancer cell plasticity? In 2 studies, we trace #glioblastoma heterogeneity to a spatial cancer cell trajectory w. atlassing bit.ly/4mkrWgs & predict plasticity w. snRNA/ATAC+deep learning bit.ly/3FbI6Ic 🧵
Lin retweeted
Want to hear about the latest updates/new techniques in single cell and spatial genomics? Check out the full agenda for our Single Cell Genomics Day on Friday, 3/29. All talks will be live-streamed (no registration required) at satijalab.org/scgd
Lin retweeted
"scPerturb: harmonized single-cell perturbation data" is out now in Nature Methods!
Lin retweeted
Immensely proud to share our four papers on #SingleCell dissection of #Alzheimers Disease coming out in @CellCellPress today, reporting 2.3M #scRNA profiles and 850k #scATAC profiles across 427 post-mortem human brain samples from AD and non-AD donors in a wonderful #interdisciplinary collaboration with @DrLiHueiTsai between @MIT @MIT_Picower @MIT_CSAIL @BroadInstitute @RushUniversity Paper 1: scRNA + vulnerability + resilience cell.com/cell/fulltext/… Paper 2: scATAC + GWAS + Epigenome Erosion cell.com/cell/fulltext/… Paper 3: Microglia States + reprogramming cell.com/cell/fulltext/… Paper 4: DNA damage + gene fusions cell.com/cell/fulltext/… MIT News: news.mit.edu/2023/decoding-… Issue: cell.com/cell/current News & Views: cell.com/cell/fulltext/…
Lin retweeted
Our review+perspective paper on "Current and future directions in network biology" is online (arxiv.org/abs/2309.08478). This has been a Herculean effort by many co-authors, thank you all! Special thanks to @marinkazitnik, @_michellemli, @aydin_wells, and all section coordinators.
Lin retweeted
Rules for becoming a better bioinformatician in 2023 frankligy.medium.com/rules-for-beco…
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Lin retweeted
Top challenges in scDNA-seq data analysis: 1. determining the correct clustering resolution for subclone detection 2. estimating accurate DNA ploidy info of single cells from read depth 3. reconstructing phylogenetic lineages that utilizes both DNA mutations and CNA events
Lin retweeted
Important questions in single cell RNA analysis: 1. how accurate are cell type frequencies in scRNA-seq or snRNA-seq data? 2. how to remove doublets, can conflicting lineage markers be used? 3. how to not over-integrate data which could also reduce true biological signal
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