Bio Advances @BioAdvances

Discussing advances in cancer, immunotherapy, and biotechnology. This is a dedicated science channel. My personal, more eclectic, profile: @NickYoder86 Joined March 2025

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Grok @grok

a year ago

@VikingHippo69 @acnewsitics The sentiment "The GOP lied to us" likely stems from recent GOP tax and budget bills passed in May 2025. These extend 2017 tax cuts, favoring high earners (e.g., $70,000 for top 1%), while cutting Medicaid and SNAP, impacting lower-income groups and immigrants. Public frustration, like boos at Rep. Hinson's town hall, reflects feelings of betrayal. However, the GOP defends these as fulfilling Trump's economic growth agenda. The debate centers on balancing tax relief with social program cuts, causing division among supporters.

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Patrick Collison @patrickc

a year ago

Something I've been thinking about: gene editing drugs (like Casgevy, Luxturna, Zolgensma) are a new paradigm in therapeutics, where it may be possible to cure many diseases with single administrations rather than managing them continuously via drugs that require ongoing use. Despite that promise, though, the CRISPR-focused biotech firms (CRSP, NTLA, EDIT, BEAM) have not been doing well. There are a lot of problems with imperfect financial incentives in healthcare. Is this an important new one? In particular: why would insurance companies pay enough for the benefits here? An average enrollee lasts only a few years in the US, so any given insurance company internalizes only a small portion of the benefit from a permanent cure. But if insurance companies (rationally) underfund, pharma companies will then (rationally) underinvest. In theory, single-payer systems should pay more because of better incentive alignment, but in practice they don't have a tradition of paying enough for pharma innovation. (For the most part, they tend to ride on US coattails.) So what do we do?

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David Sinclair @davidasinclair

a year ago

My partner Serena’s mom is dying from ALS. The NIH grant supporting the scientists in my lab working hard on a cure was just terminated. No words

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Bio Advances @BioAdvances

a year ago

Vaccines are the greatest advance in sanitation since fire.

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Nicholas Fabiano, MD @NTFabiano

a year ago

Severe exercise reversibly reduces brain myelin content. Myelin lipids may act as glial energy reserves in extreme metabolic conditions. 🧵1/12

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Research Bites @Research_Bites

a year ago

🧠💉 Exciting research suggests that getting the herpes zoster vaccine may lower the risk of dementia! A study showed that those vaccinated had a 20% reduced chance of a new dementia diagnosis. #Health #DementiaResearch - Read more: doi.org/10.1038/s41586…

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Samuel Hume @DrSamuelBHume

a year ago

I wrote this for the Guardian - check it out!

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Uri Alon @UriAlonWeizmann

a year ago

Excited to share our new study revealing the intricate dynamics of pregnancy & postpartum physiology! We analyzed 40M lab tests from 300K pregnancies and 160K women (cross-sectional), we mapped week-by-week changes starting from preconception to months-long postpartum recovery.

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Bio Advances @BioAdvances

a year ago

Leading cause of death by age.

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Eric Topol @EricTopol

a year ago

Of >105,000 participants with 30-year follow-up, only 9.3% achieved healthy aging (age 70, w/o any chronic diseases). Their diet was significantly associated with this outcome🧵 @NatureMedicine

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Uri Alon @UriAlonWeizmann

a year ago

Theory predicted two kinds of fibrosis, hot and cold. We show in vivo that hot and cold fibrosis describe heart failure, and heart attack, respectively, showing that they are very different disease states. @MiyaraShoval @MiriAdler @Tzahore

Shoval Miyara @MiyaraShoval

a year ago

Our work made it to the cover of @CellSystemsCP! 🥳 Cold and hot fibrosis define clinically distinct cardiac pathologies Check out our paper here: cell.com/cell-systems/f… @UriAlonWeizmann @Tzahore @MiriAdler @WeizmannScience @HebrewU

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Shoval Miyara @MiyaraShoval

a year ago

It’s finally here! My PhD work, five years in the making, is now published in @CellSystems🚨 Cold and hot fibrosis define clinically distinct cardiac pathologies. 🧵 cell.com/cell-systems/f…

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Isomorphic Labs @IsomorphicLabs

2 years ago

We're excited to announce #AlphaFold 3 with @GoogleDeepMind in @Nature: our new AI model for predicting biomolecule structures with unprecedented breadth and accuracy. Expanding beyond proteins to tackle DNA, RNA, small molecules to fuel advances in biology & drug design 🧵

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Nicholas Fabiano, MD @NTFabiano

a year ago

95% of the body's serotonin is produced in the gut. You are what you eat.

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a year ago

Another huge AI breakthrough in drug delivery: Delete (Deep Lead Optimization Enveloped in Protein Pocket) tackles lead optimization by refining drug candidates directly within their 3D protein pockets. 👇

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Nicholas Fabiano, MD @NTFabiano

a year ago

Reducing sugar intake in the first 1000 days of life is associated with a reduced risk of chronic diseases in adulthood. 🧵1/8

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Bio Advances @BioAdvances

a year ago

Positive effects of Creatine on cognitive function and depression

Nicholas Fabiano, MD @NTFabiano

a year ago

Our paper was just published in European Neuropsychopharmacology. 🧵1/10

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Ming "Tommy" Tang @tangming2005

a year ago

1/ 🧵 No, you do not always Need Single-Cell RNA-seq Single-cell RNA-seq is popular and powerful, but it's not always the best choice. Here's why you should think carefully before diving in.

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Bio Advances @BioAdvances

a year ago

An excellent discussion about “Day Science” and “Night Science”, the cyclic application of rigorous tools and philosophical wondering.

Itai Yanai @ItaiYanai

a year ago

I want to tell you a story about computers, creativity and awe! (1/N)🧵 Sydney Brenner once said in 2012 that “nobody has actually read the human genome. I mean, computers have processed the human genome, but we all know computers are stupid.” (This is a talk I gave last week..)

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Itai Yanai @ItaiYanai

a year ago

The actual scientific process then has periods of day science & night science. Periods where we are testing, with our robust experiments, controls & power analyses. And periods when we reflect on what it means and seek new ideas for the next round of day science.