Aurelie Cobat @AurelieCobat

6/ They also further confirm that the absence of replication of our initial findings by other groups may be explained by the age distribution of their case cohorts, which mostly included patients over the age of 60 years (jci.org/articles/view/…)

1 4 14 2K 1

Casanova Lab @casanova_lab

a year ago

5/ These findings replicate and extend our previous observation published in @ScienceMagazine (science.org/doi/10.1126/sc…)

1 4 13 2K 0

Casanova Lab @casanova_lab

a year ago

4/ Our results demonstrate that the search for rare variants conferring a strong predisposition to life-threatening COVID-19 benefits from focusing on younger patients

1 4 9 864 0

Casanova Lab @casanova_lab

a year ago

3/ We showed that patients w/ predicted LOF variants were significantly younger than the other patients (43.3 vs. 56.0 years)

1 4 10 1K 0

Casanova Lab @casanova_lab

a year ago

2/ We performed a genome-wide rare variant burden association screen in 3269 patients w/ life-threatening COVID-19 and 1,373 SARS-CoV-2-infected controls. We found a strong enrichment in rare predicted LOF variants @ 15 loci involved in TLR3- & TLR7-dependent type I IFN immunity

1 5 13 2K 0

Download Image

Casanova Lab @casanova_lab

a year ago

1/ We are thrilled to share our latest paper published in @GenomeMedicine 🧬entitled “Rare predicted loss-of-function variants of type I IFN immunity genes are associated with life-threatening #COVID19”! Check it out at genomemedicine.biomedcentral.com/articles/

4 37 87 11K 8

Aurelie Cobat @AurelieCobat

3 years ago

2) Autoantibodies neutralizing type I IFNs are present in ~4% of uninfected individuals over 70 years old and account for ~20% of COVID-19 deaths immunology.sciencemag.org/content/6/62/e…

0 0 1 0 0

Aurelie Cobat @AurelieCobat

3 years ago

Proud to share amazing new results! 1) X-linked recessive TLR7 deficiency in ~1% of men under 60 years old with life-threatening COVID-19 immunology.sciencemag.org/content/6/62/e…

0 0 3 0 0

Casanova Lab @casanova_lab

4 years ago

Here is the other paper, which shows that neutralizing auto-Abs to type I IFNs account for at least 10% of critical cases of #COVID19, even in a greater proportion in men: an auto-immune phenocopy of the corresponding inborn errors science.sciencemag.org/content/early/… @ScienceMagazine

11 110 248 0 5

Download Image

Casanova Lab @casanova_lab

4 years ago

Here is the first paper, which shows that variants in only 13 influenza susceptibility candidate genes that govern TLR3- and IRF7-dependent production of type I IFNs account for at least 3.5% of critical cases of #COVID19 science.sciencemag.org/content/early/… @ScienceMagazine

5 91 188 0 2

Download Image

Aurelie Cobat @AurelieCobat

4 years ago

Happy to share our new article published @PLOSPathogens: journals.plos.org/plospathogens/… #plospathogensauthor

0 0 4 0 0

Casanova Lab @casanova_lab

4 years ago

Pleased to share the logo and website (covidhge.com) of our #COVIDHumanGeneticEffort to discover monogenic inborn errors of immunity to SARS-CoV2 in previously healthy patients < 50 years admitted to an ICU. Please RT.

11 297 323 0 13

Download Image

Aurelie Cobat @AurelieCobat

4 years ago

Read my latest review on "Human genetics of HCV infection phenotypes in the era of direct-acting antivirals" published with @SpringerNature in Human Genetics. Link: rdcu.be/b2bZm