Another study explores SARS-CoV-2 impact on the cognition. We still don’t know whether cognitive decline emerges with the onset of COVID-19 and whether it is more pronounced in patients with #LingCovid or severe COVID-19. 1/
A longitudinal cohort study compared the cognitive performance of 276 patients with COVID-19 to that of 217 controls across 4 neuroinflammation or vascular disease-sensitive domains of cognition using data collected both before and after the pandemic starting in 2015. 2/
Longitudinal models indicated a significant decline in cognitive throughput following COVID-19, after adjustment for pre-COVID-19 functioning, demographics, and medical factors 3/
The effect sizes were large; the observed changes in throughput were equivalent to 10.6 years of normal aging & a 59.8% increase in the burden of mild cognitive impairment ➡️ Cognitive decline worsened w/ Covid severity & concentrated in participants reporting #LongCovid 4/
Conclusions: 1-Infection with SARS-CoV-2 is associated with cognitive impairment equivalent to 10.6 years of normal aging and a 59.8% increase in mild cognitive impairment 5/
2-LongCovid & severe disease appeared to accelerate the cognitive deterioration, especially in executive function. Cognitive impairment affects daily, occupational, & social functioning. 6/6 medrxiv.org/content/10.110…
@vipintukur How did the do this study with non Covid patients and Covid-19 patients if they weren’t aware of Covid in 2015?
@vipintukur I am 81, a retired family doc, and have had COVID 3 times in spite of the strictest practical efforts. After last bout (3/23) I have experienced a rather much more subtle, but significant cognitive decline along these same parameters. Ugh!