Greg Oyan @thegoodreturn

@RyanKartje This doesn’t inspire confidence. A lot to work on it seems. Yikes.

@TNDTweets This is stupid. If SJSU were a big game the Coli would be full. When USC plays Oregon, Penn State, etc, the stadium will be full.

@deanwball There’s some prevailing idea that artistic and creative endeavors will keep us all busy and happy. While I wish I had more time for that stuff, work seems to be a fundamental part of human existence. Without it, life would be less meaningful and more boring. IMHO

This is eerily similar to other industries, not just AI. For instance, people are perfectly okay buying clothes, cookware, electronics, etc from China. But, if you want the highest quality product you go to the US or maybe some niche markets in European countries. Not sure if this is good or bad, but it seems like it is following a similar pattern to other industries.

ceteris @ceterispar1bus

a week ago

chinese models topped us models in token usage on openrouter in march and have been up only since. how real are the chinese labs, and what do they mean for the frontier moats? this and more in delphi research's latest report from @accelxr on evaluating the china labs.

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@RyanGreenblatt Impressive work. It's a bit concerning that our ability to understand agents is being outpaced by the progress of sheer capability. No one wants to pump the breaks, so how do we increase our ability to understand?

@JackFarley96 It'd make for a fun sci-fi movie, but that's about it.

As someone who has had melanoma, this is awesome. As someone who has lost family members to other types of cancer, this is doubly awesome. I can’t help but think that AI will yield even more breakthroughs and customer medical solutions will become commonplace. 🙏

Yannick Buccella MD @YannickBuccella

2 weeks ago

A personalized mRNA cancer vaccine passed Phase 3, genuinely great news for melanoma patients! What happens here? They sequence your tumor, find up to 34 mutations unique to it, and build a custom vaccine that trains your immune system to hunt those exact cells. In a phase 2

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@AndrewCurran_ Ridiculous. The last thing these companies need is more government oversight. The government ought to be encouraging these companies to continue innovating at light speed!

@MattWalshBlog While I agree with you that having kids relatively early can be a great choice, people can make their own decisions. This is more of a personal attack than a policy critique. It’s exactly what’s wrong with our politics.

@unusual_whales If true, it's a sign of financial irresponsibility more than anything. I live in one of the most expensive cities in the country and if my household income was $250k I could live pretty comfortably even with a family of 4 or 5....

I think this is a good take. Let individuals take responsibility for their actions. Let people use AI as tools. Perhaps there's a reasonable limit, kind of like how you can't go buy an F-22, but I don't think we're there yet.

John Ennis @johnennis

4 weeks ago

I think I figured out what bothers me so much about Claude My opinion is that it is the human’s job to hold the AI back But Anthropic seems to have that inverted, and they believe it is the AI’s job to hold the human back This tension is why I find Claude so unpleasant to use

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@kimmonismus No, that just isn't true and is too premature to make any sort of ridiculous claim like that. You're currently making assumptions that you can't reasonably prove. Be patient and wait for more releases!

In March 2024, at the age of 35, I was diagnosed with stage IV rectal cancer with a metastasis in my liver. This was a shock: I had no family history, and none of the doctors suspected it. After two years of chemotherapy, radiation, and multiple surgeries, I'm still not cured. Now I'm asking for help to get a personalized cancer vaccine. This is my story so far. Following diagnosis, I was treated with total neoadjuvant therapy at UCLA. I had 6 weeks of radiation and chemotherapy (Xeloda). This was followed by 6 rounds of oxaliplatin infusions and Xeloda. I tolerated this unusually well. During this period, I managed to hike up to over 11,000ft multiple times in the Sierras, and I wrote the main text of a 72 author meta-analysis paper and submitted it to Nature where it is still in review. I showed a good clinical response, and at the end of October I had surgery: I was under for 9 hours, and they cut out a bit of my rectum, 1/3rd of my liver, and gave me a temporary ileostomy. Waking up from this was probably the strangest experience of my life: I felt more machine than man, and I had wild hallucinations form such a large dose of anesthesia. It took a while to feel OK after that surgery. However, I still had the ostomy. I had that reversed at the end of January in another surgery, which took a greater toll on me than I expected. I only just started to feel OK again and I got bad news: I got a positive circulating tumor DNA test (ctDNA), the signatera test from natera. Unfortunately, the ctDNA carried on rising, and in July 2025 a new lesion appeared in a lymph node near my liver (periportal). I was treated with irinotecan and panitumumab infusions, which showed a good response, followed by live MRI guided SBRT radiation treatment to the lesion. However, after finishing this treatment, the ctDNA remained positive and began rising again. I restarted irinotecan and panitumumab infusions, which brought ctDNA back to negative (signatera), although it remained positive on the more sensitive Personalis assay. During this period I had begun to develop stomach pain and digestive symptoms. Then I collapsed vomiting blood while out in Santa Monica and was rushed to the ER. They found out I had a duodenal ulcer that had bled. I had some blood transfused, and I was sent home to complete an intensive course of antibiotics for H. Pylori infection. However, after about a week, I started to get very weak. I collapsed again and went back to the ER in an ambulance. They found my hemoglobin was 5g/dL, a dangerously low level (normal is over 13.5). Multiple blood transfusions didn't bring it up and I collapsed again in the night after passing a large amount of blood. They took me to intensive care and performed an emergency endoscopy where they clipped and sprayed the ulcer. Thankfully this worked and I was discharged after another 3 nights in hospital. Unsurprisingly, nearly bleeding to death wasn't good for me, and my ctDNA began to spike rapidly. I had a PET-CT and it revealed 3 new disease sites in abdominal lymph nodes. I restarted irinotecan and panitumumab infusions after barely recovering from the ulcer incident. This showed an excellent response, with the sites resolving on imaging, although ctDNA remained positive. I've now started bot/bal immunotherapy, a not yet approved immunotherapy treatment that is the first of its kind to show strong results in my kind of cancer, micro-satellite stable colorectal cancer. This was possible thanks to a donation from an anonymous benefactor and supporter of free and open inquiry in science. Hopefully this treatment will be effective, but it is unlikely to be enough on its own to prevent future disease recurrence. I am asking for help to get a personalized neoantigen cancer vaccine, which could substantially increase my chances of surviving this deadly disease that is likely incurable under standard care. While cancer vaccines have shown promising results, they are not yet approved, meaning one has to pay for the design, manufacture, and administration of the vaccine. The total cost of which is $104,133, beyond my means or those of my family. Any help would be greatly appreciated! I've started a GoFundMe here: gofundme.com/f/cancer-vacci…. Please donate and share with anyone who might be interested in helping. I've carried on working throughout this period and I'm still running a research group in statistical genetics at UCLA. I'm hoping to continue making contributions to science for as long as I can, hopefully longer with your help.

@kimmonismus What was your prompt though? Model behavior changes between each model. A prompt that Fable may perform well with may not be interpreted as well by Opus for example.

Here's something I don't fully understand. Right now the models can 'see' patterns better than we can, and can solve problems that humans may have been able to solve on their own with existing data. Is it even possible that models can theorize or develop new theories? I thought not

We've been given a hint of the power of the Astra family of models, which seem to be amazing, and maybe even better than Mythos/Fable. Which leads me to wonder, what the heck is Anthropic going to come out with next? Fable has been the best public model for months. What's next?

I have such a hard time with people hating on the Chosen. It's a fantastic show and has probably done immense cultural good in telling 'generally speaking' the gospel story to many people who may have never heard it. It isn't a replacement or even a supplement to Scripture. It is a TV show that takes creative liberties while also probably being more culturally impactful and evangelistic than almost any Christian media in my lifetime. Christians must understand that people are far far too smart to think that the TV show is somehow authoritative. We all know the show isn't 'truth' but has elements of the gospel story illustrated in a way that brings the story to life in a way that we oftentimes can't imagine.

Nahhhh, I never knew the "cues" to be as obvious as those. Even so, things like playing with hair is way too much of a generality. I can't tell you how many women played with their hair around me who definitely didn't like me. Maybe those are just examples, but it isn't formulaic.

@ryanburge This seems like evidence of incredible marketing and political campaigning to change public opinion. Unfortunately, the reality is that scripture has not changed. This is a problem.

@JunaidAckroyd Anything AI Enablement/Adoption?