Sinha Lab @sinha_lab
Assistant Professor- Division of Critical Care Division of Clinical and Translational Research @WashUAnesthesia #CriticalCare #Biology #Data St Louis, MO Joined June 2016-
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Congrats @kevingbuell & collaborators from around the world for our @JAMA_current paper on individualized treatment effects for oxygen delivery. #ISICEM24 @PCCRG, @em_bioinformant, @DogICUma, @sinha_lab w/@kevingbuell @JonathanCaseyMD @kseitz @EdQian @WesleyHSelf @toddrice_ICU
Congrats @kevingbuell & collaborators from around the world for our @JAMA_current paper on individualized treatment effects for oxygen delivery. #ISICEM24 @PCCRG, @em_bioinformant, @DogICUma, @sinha_lab w/@kevingbuell @JonathanCaseyMD @kseitz @EdQian @WesleyHSelf @toddrice_ICU
Excited to share our just published paper in #journal_CHESTCritCare @journal_CHEST on host-response subphenotypes in #COVID19 chestcc.org/article/S2949-… #OpenAccess #BLUF: Subphenotypes track with severity, predict outcome and are dynamic on follow-up.
Don’t miss the latest research findings on molecular #phenotypes in #sepsis, which could represent a treatable trait in critical illness beyond the patient's syndromic diagnosis From @sinha_lab and colleagues bit.ly/3rg6rFJ
In a study published in @LancetRespirMed, @sinha_lab and colleagues’ research on hypoinflammatory and hyperinflammatory phenotypes across critical illness syndromes paves the way for personalized interventions and improved patient outcomes. anesthesiology.wustl.edu/new-approach-t…
Delighted to announce our new publication from the first meeting of the Delirium Subtyping Initiative in Milan last November! 🧠 doi.org/10.1002/alz.13… @alzassociation @alzdemjournals @WileyGlobal
In collaboration with @DrPhilipVerhoef, @progdoctalk , and @PrenosisInc, we discovered novel COVID-19 subgroups using detailed protein biomarker and EHR data that had differential mortality rates and responses to corticosteroids! Thank you team! journals.lww.com/ccmjournal/Ful…
Really enjoyed @lisa_bastarache talk at #ATS2023!! I’m lucky to have such a talented sister! And thanks to @progdoctalk for a superb session to end the meeting!
Had the exciting opportunity to share some of my work at #ATS2023 today! So many thoughtful questions, so much work to be done. Thanks to my mentors, Twitterless Lorraine @JulesBass6 @CShaver_MD @vekerchberger @progdoctalk for their support. @ATSCritCare @atsearlycareer
Don't sleep on the dead space in ARDS New in @CritCareMed Without volumetric capnography, can still use the ventilatory ratio as shown by @progdoctalk, RR shown in this table
STOP THE SEARCH: I’ve done it- I’ve found the worst #DEI poster of 2023. Now in the lobby of @BarnesJewish. Aside from the DEI stereotype gallery circa 1967- it’s reassuring to know if an Indian Farmer uncleji ever wonders in, we’ve got his back.
@nualameyer expect heterogeneity and test for it. You could get surprising results which may include heterogeneity of treatment effect in certain subclasses #SCCM2023 atsjournals.org/doi/full/10.11… @progdoctalk atsjournals.org/doi/full/10.11… @agordonICU
Plasma metabolic profiling implicates dysregulated #lipid metabolism and glycolytic shift in hyperinflammatory #ARDS (Alipanah-Lechner, @LeligdowiczA, @progdoctalk, @KKangelaris, @AJRogers_ICU et al.) - just accepted in @AJPLung ow.ly/HZQH50Mu5z5 #metabolomics
Charlotte Summers @charlot_summers
17K Followers 6K Following Director of @hlri_Cambridge & Professor of Intensive Care @Cambridge_Uni; Fellow @selwyn1882 Tweets represent only my personal views.Segun Olusanya (He/Hi.. @iceman_ex
19K Followers 3K Following Husband to @monanniecakes| Intensivist @nhsbartshealth| Ultrascoundrel |#FOAMed|@thosewecarry|@ics_updates|@wicsbottomline|@esicm|@tea_empathynhs| 🇳🇬Nida Qadir, MD @NidaQadirMD
11K Followers 1K Following Associate prof & MICU co-director at UCLA. #ARDS 🫁 researcher, #Airway master, #ECMO enthusiast, shoe aficionado, difficult woman. Tweets = my personal views.Michael Harhay @Michael_Harhay
2K Followers 1K Following asst prof @Penn. honorary fellow @MRCCTU. deputy editor @ATSBlueEditor. Views are my own. Here for randomized trial content.Julie Bastarache @JulesBass6
5K Followers 1K Following Physician, scientist, mom. Basic and translational research on acute lung injury, alveolar capillary barrier. #ARDS #sepsis #CellBiology #PulmCCMChris Carroll MD @ChrisCarrollMD
22K Followers 4K Following #PedsICU Critical Care Doc. Deputy Editor @journal_CHEST. Father, educator, #zentensivist, @kate_moorehead’s husband. he/him. 🏳️🌈🏳️⚧️ally. Opinions ownMatt Siuba @msiuba
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13K Followers 2K Following First Generation Physician-Scientist, & many other things. This account is Private - opinions and tweets do not represent any of the organizations I work with.Pat Lyons @_plyons
516 Followers 307 Following Intensivist, healthcare delivery scientist, @NASAWebb stanAshish K. Khanna, MD,.. @KhannaAshishCCM
4K Followers 4K Following Associate professor,VC research @wakeanesthesia CCM anesthesia,autism dad. Chair @SCCM DISCOVERY, Chair @ASA CCM.#bigdata #trials all views are my ownParijat Sen @ParijatSen11
1K Followers 769 Following ILD/Sarcoid/Intensivist/Asst Prof @UK_Healthcare APD @ukypccm Amateur home cook. Music Lover & Cricket enthusiast Tweets reflect personal opinion/biases. 🇮🇳WashU Anesthesiology .. @WUSTL_AnesRsrch
942 Followers 326 Following Research Divisions for @WashUanesthesia. At the forefront of innovative, cutting edge knowledge in both lab-based & clinical research.Giacomo Bellani @GicoBellani
6K Followers 3K Following Professor at @UniTrento and head of Anesthesia and Crit Care at S. Chiara H @ApssTn Trento, Italy. Interest in MV, ARDS, NIV. Father of three. Lazy. Loves AlpsNuala Meyer @nualameyer
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2K Followers 3K Following The NYU Langone Health Division of Pulmonary, Critical Care, and Sleep Medicine Twitter. @nyulangone @NYULangoneBK @NYULangoneLI @bellevuehosp @DeptVetAffairsAlice Gallo, MD @GallodeMoraesMD
9K Followers 2K Following 🇧🇷ian living in Minnesota. PCCM doc & IM APD @mayoclinic. Critical Care has my ❤️ @journal_CHEST SoMe Editor. Proud wife of @jonaspaludo. Opinions are my ownCiara M. Shaver @CShaver_MD
529 Followers 382 Following A basic and translational physician scientist who studies ARDS and lung transplantation. All views stated here are my own.C.V. Cosgriff @cosgriffc
808 Followers 565 Following medical intensivist, physician-scientist @MGHMedicine, @broadinstituteSari Sugarplum @ind_sariiiii
1 Followers 179 Following Spreading smiles and good vibes one tweet at a time. 😊✌️Kevin Seitz @kseitz
296 Followers 693 Following Tweets are my own. RTs and follows are not endorsements.Tythos @Tythos295452
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5 Followers 1K FollowingTA in Pulmonary & Cri.. @TAPulmCritCare
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246 Followers 539 Following Resident in anesthesiology and intensive care - MSc in biostatistics - 🏊🏻♂️🚴🏼♂️🏃🏻♂️ & 👨🏻🍳Kevin Frank @CriticalGestalt
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160 Followers 493 Following Director of Clinical Development @RocheDia by way of @UCSF @SFVAMC @EmoryMSTP. opinions expressed are my own.Inwon Park @emresuscitation
10 Followers 75 Following Emergency Physician / Physician Scientist / Interested in Sepsis, ALI, AKI, Cardiac arrest, Shock, Intravital ImagingJack Cafferkey @Jack_Cafferkey
85 Followers 326 Following junior doctor: anaesthetics, critical care, trials, meta-researchJamie Meegan, Ph.D. @jemeegan
240 Followers 294 Following Microvascular physiologist. Postdoc at VUMC investigating how hemoglobin and oxLDL disrupt endothelium during sepsis.Otavio Ranzani @otavio_ranzani
37K Followers 2K Following Assistant Professor Global Health | Epidemiology | RCTs Critical Care, Infections, Environment, Social #DecolonizeGH, 🇧🇷 @ISGLOBALorg @USPonline. My views.Filippo Sanfilippo @f_g_sanfilippo
466 Followers 531 Following Intensivist & Anesthesiologist. Love research and study. Interested in original questions. Most importantly, a happy father!Prakriti Gupta @gupta_paeds
164 Followers 344 Following Paediatrician, Researcher, Kathak Dancer. MAMC, AIIMS Patna #LINO23 She/her. Views are my own.Brandon Yates, PhD, C.. @DrYatesB
1K Followers 3K Following Scientist | Physical Med & Rehabilitation @Harvardmed @SpauldingRehab| Exercise, Geroscience, Frailty, Gut-muscle-brain axis & ICU Survivorship| #DSPAN | #1914Traumatic Stress Diso.. @SciTech_Trauma
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46 Followers 460 Following ☢️🩺 Fellow @StanfordRadOnc | Radiation Oncologist via @uoftdro @pmcancercentre @sunnybrook | 👩🏾⚕️ via @BrownMedicine @narrativemed | Vainika | Tweets=ownProf Karen English @KEnglishLab
1K Followers 1K Following Scientist, Professor of Immunology, PI @MaynoothUni working on #CellTherapy #MesenchymalStromalCells #Immunomodulation #WomeninSTEM Opinions my ownDr Rebecca Coll @Rebecca_Coll
2K Followers 1K Following Lecturer in Immunobiology at QUB - inflammasome, NLRP3, dose response curve, and bad pun enthusiast. Views expressed are mine alone.Anup @anup_251
235 Followers 1K Following Assistant Professor | Cardiopulmonary Physiotherapist | @PtMchp | @MAHE_Manipal 🇮🇳 | Driving EnthusiastMarc Maybauer @MMaybauer
113 Followers 426 Following Professor and Chief of Critical Care Medicine, Executive Director of Critical Care Organization and Director of Anesthesiology #ECMO #ECLS #ECPR Program @UFKevin Buell @kevingbuell
241 Followers 176 Following PGY-7 Fellow @UChicagoPCCM via @ImperialMed and @VUMCMedicineRes.🇨🇭 ➡️ 🇬🇧 ➡️ 🇺🇸. Interested in research at intersection critical care + ID. Views = minepriti nagari @prit42048
97 Followers 5K FollowingHaopu Yang 杨皓璞 @YangHaopu
75 Followers 290 Following MD/PhD candidate from @Tsinghua_Uni. Currently clinical elective rotation at Mayo Clinic ARZ. Research interest in 🫁#PCCM. 🎾 🏋️& Jazz🎺🎹.Malachi Jessica @Jessica94685818
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1K Followers 2K Following Pulmonary & critical care doctor. Palliative care researcher. Dad. University of Washington @UWPCCM @UWMedicine @HarborviewMC. Views are mine. (he/him)Andrew Barros @AndrewBarros
236 Followers 671 Following Technophile, Father, Academic Intensivist @UVaHealthNews / @UVA_PCCM. iTHRIV Scholar @thriv_i. He/Him/His. Bad takes are clearly mine.Kathryn Hibbert @KHibbert_MD
2K Followers 752 Following Pulm/Crit Care educator, clinician, researcher @HarvardPulm & @MGHMedicine | @WilliamsCollege alum | Travel, Food, Social Justice Enthusiast | Opinions my ownCharlotte Summers @charlot_summers
17K Followers 6K Following Director of @hlri_Cambridge & Professor of Intensive Care @Cambridge_Uni; Fellow @selwyn1882 Tweets represent only my personal views.Segun Olusanya (He/Hi.. @iceman_ex
19K Followers 3K Following Husband to @monanniecakes| Intensivist @nhsbartshealth| Ultrascoundrel |#FOAMed|@thosewecarry|@ics_updates|@wicsbottomline|@esicm|@tea_empathynhs| 🇳🇬Nida Qadir, MD @NidaQadirMD
11K Followers 1K Following Associate prof & MICU co-director at UCLA. #ARDS 🫁 researcher, #Airway master, #ECMO enthusiast, shoe aficionado, difficult woman. Tweets = my personal views.Michael Harhay @Michael_Harhay
2K Followers 1K Following asst prof @Penn. honorary fellow @MRCCTU. deputy editor @ATSBlueEditor. Views are my own. Here for randomized trial content.Julie Bastarache @JulesBass6
5K Followers 1K Following Physician, scientist, mom. Basic and translational research on acute lung injury, alveolar capillary barrier. #ARDS #sepsis #CellBiology #PulmCCMChris Carroll MD @ChrisCarrollMD
22K Followers 4K Following #PedsICU Critical Care Doc. Deputy Editor @journal_CHEST. Father, educator, #zentensivist, @kate_moorehead’s husband. he/him. 🏳️🌈🏳️⚧️ally. Opinions ownMatt Siuba @msiuba
17K Followers 1K Following #Zentensivist & Critical Care APD @CCF_PCCM | #ThePeoplesVentricle🫀Advocate | PH/RV Hemodynamics (especially in ARDS and Liver Disease) | “Shoo-ba”Naftali Kaminski @KaminskiMed
13K Followers 2K Following First Generation Physician-Scientist, & many other things. This account is Private - opinions and tweets do not represent any of the organizations I work with.Pat Lyons @_plyons
516 Followers 307 Following Intensivist, healthcare delivery scientist, @NASAWebb stanAshish K. Khanna, MD,.. @KhannaAshishCCM
4K Followers 4K Following Associate professor,VC research @wakeanesthesia CCM anesthesia,autism dad. Chair @SCCM DISCOVERY, Chair @ASA CCM.#bigdata #trials all views are my ownWashU Anesthesiology .. @WUSTL_AnesRsrch
942 Followers 326 Following Research Divisions for @WashUanesthesia. At the forefront of innovative, cutting edge knowledge in both lab-based & clinical research.Giacomo Bellani @GicoBellani
6K Followers 3K Following Professor at @UniTrento and head of Anesthesia and Crit Care at S. Chiara H @ApssTn Trento, Italy. Interest in MV, ARDS, NIV. Father of three. Lazy. Loves AlpsNuala Meyer @nualameyer
428 Followers 378 Following pulm CCM @Penn. ARDS / sepsis genomics host response. soccer/choir/dance Mom, foodie’s wife. Boola Boola (rhymes w Nuala)Emily Moin @eemoin
14K Followers 2K Following Intensivist, ethicist, epidemiologist, math enthusiast via @UPenn_CCEB @MGHMedicine @PennMEHP @AmherstCollege Es könnte auch anders sein (Tweets my own)NYULangonePCCSM @NYULangonePCCSM
2K Followers 3K Following The NYU Langone Health Division of Pulmonary, Critical Care, and Sleep Medicine Twitter. @nyulangone @NYULangoneBK @NYULangoneLI @bellevuehosp @DeptVetAffairsJack Iwashyna🫁 @iwashyna
13K Followers 3K Following Not paying for Twitter. I work @JohnsHopkins as @JHU_BDPs to help patients + their loved ones heal from critical illnessATS Blue Journal @ATSBlueEditor
19K Followers 329 Following Posting content from the American Journal of Respiratory and Critical Care Medicine; follows do not indicate endorsement. #pulmCC #sleepmed #AJRCCM #RespEd #ATSCCCF @CCCForum
3K Followers 680 Following The Critical Care Canada Forum is a conference focusing on topics relevant to those involved with the care of critically ill patients.The Phlegmfighter @phlegmfighter
7K Followers 3K Following #climate & #nuclearenergy advocate #professor #pulmonary #intensivist #diagnosis #decisionmaking #clinicalreasoning #probability #firstgen superpower=BSdetectorKevin Seitz @kseitz
296 Followers 693 Following Tweets are my own. RTs and follows are not endorsements.Natasha Spottiswoode @NSpottiswoodeMD
489 Followers 189 Following Infectious disease doctor. Scientist. Mountaineer. Advocate. Haver of both adventures and misadventures. Opinions are my own.WashU Anesthesiology @WashUanesthesia
2K Followers 236 Following Official account for Dept. of Anesthesiology @WUSTLmed with a rich history of excellence in the missions of collaborative patient care, education, and research.Dr. Niall Ferguson @nialldferguson
2K Followers 263 Following Professor of Medicine @UofT @uoftmedicine @UHN | Senior Scientist @TGHRI_UHNMihir Atreya @MihirAtreya
363 Followers 279 Following Physician-Scientist, Pediatric Critical Care @CincyChildrens @CincyKidsPCCM #PedsICU. Views are my own.Ali Sanders @dralisanders
2K Followers 150 Following ED Consultant & Clinical Director, Air ambulance doctor, Olympian, Ex Rower, Cyclist, Mum. Opinionated...all opinions my own.Tom Evens @DocTomEvens
3K Followers 1K Following Emergency / HEMS / Ambulance doc and rowing coach. Thinking about performance sport and performance medicineFilippo Sanfilippo @f_g_sanfilippo
466 Followers 531 Following Intensivist & Anesthesiologist. Love research and study. Interested in original questions. Most importantly, a happy father!Prof Karen English @KEnglishLab
1K Followers 1K Following Scientist, Professor of Immunology, PI @MaynoothUni working on #CellTherapy #MesenchymalStromalCells #Immunomodulation #WomeninSTEM Opinions my ownDr Rebecca Coll @Rebecca_Coll
2K Followers 1K Following Lecturer in Immunobiology at QUB - inflammasome, NLRP3, dose response curve, and bad pun enthusiast. Views expressed are mine alone.Kathryn Hibbert @KHibbert_MD
2K Followers 752 Following Pulm/Crit Care educator, clinician, researcher @HarvardPulm & @MGHMedicine | @WilliamsCollege alum | Travel, Food, Social Justice Enthusiast | Opinions my ownEmily Bowman @Emsdoesscience
342 Followers 652 Following Research Fellow @CPH_QUB investigating delirium 🧠 • PhD in cognitive neuroscience and phenotyping • Human Biology BSc • Sometimes a musician • Views my own •Prof. Luigi Vetrugno,.. @LuigiVetrugnoMD
2K Followers 3K Following Associate Professor of Anesthesia and Intensive Care, Pediatrician. Never give up 七転八起 👤 Opinion my own.Alicia N. Rizzo MD Ph.. @AliciaNRizzo
335 Followers 337 Following pulmonary and critical care physician-scientist @MGH_PCCM by way of @DenPulm and @UICmstp, nature enthusiast, and dog momBrian Ashbrock @BAsherEM
62 Followers 220 Following EM and flight physician @CherryStreetEM, now Critical Care Fellow. Golf, video games, and Cincinnati sports.Chandrika Bhat @bhat_chandrika
576 Followers 707 Following Paediatric Rheumatologist, Rainbow Children’s Hospital, Bangalore.Annual Reviews @AnnualReviews
12K Followers 3K Following Nonprofit publisher for the progress of science & the benefit of society. #Mastodon - @[email protected]Esther S. Oh @EstherOh_MDPhD
497 Followers 138 Following President of the American Delirium Society; Associate Professor Johns Hopkins University; geriatrician; clinician scientist, innovator, delirium, Alzheimer’sHeidi Lindroth @minipixie26
1K Followers 1K Following PhD RN Nurse Scientist @Mayo Clinic. Agile Champion, Change Agent. Fascinated by brain. Goal: End Delirium. All tweets are my own.Timothy Girard @timothygirard
2K Followers 582 Following Husband, father, physician, scientist, triathlete, music lover, water skier, tabletop gamer, sojourner. “This skin and bones is a rental.”Gideon Caplan @GideonCaplan
630 Followers 84 FollowingMiles Berger @RealMilesBerger
2K Followers 5K Following Neuroanesthesiologist, periop geriatric cognition/neuro-inflammation & AD researcher, #diversity, Dad, husband, #humor, #MDPhD #double-doc, views are my ownJen Taylor @jentaylorphd
859 Followers 2K Following Neuroscientist 🧠 Yoga 🧘♀️ Meditation 🙏 Anaesthetic Postdoc @sydney_uni Views own (she/her)Colm Cunningham @Cunningham_Colm
2K Followers 914 Following Researches microglia, astrocytes and inflammation in delirium and dementiaRobert D Sanders @ProfRobSanders
314 Followers 261 Following Father, husband and Nuffield Chair of Anaesthetics.Liz Wilcox @1791_mew
919 Followers 746 Following icu doctor, scientist, dog mom 🐕🐩, novice curler 🥌 (she/her/hers)Abhijit Duggal @AbhiDuggalMD
523 Followers 237 Following Vice Chair- Critical Care @CleClinicLungs, Associate Professor @CCLCM #ARDS #ECLS and refractory hypoxemia, #Airway #POCUS #proceduralist. Opinions my ownAleks Leligdowicz @LeligdowiczA
343 Followers 435 Following Critical Care, Human Immunology, Translational Biology, 3 nuggetsBen Yoon @BenYoonMD
250 Followers 172 Following Pediatric critical care physician, clinical researcher. Interested in lungs and ventilators. Here to learn. #PedsICUAvery Bogart @SoonToBeMDPhD
336 Followers 447 Following MD-PhD Candidate @VanderbiltMSTP | Pulm/crit - sepsis - ARDS @LSTCI_Lab | Opinions are my own | She/Her | #DoubleDocs #WomenInMedicine #WomenInSTEMEduardo Mireles-Cabod.. @emireles_c
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438 Followers 454 Following Pulmonary & Critical Care and Biomedical Informatics at VUMC. This is a professional account, not personal (with a few rare exceptions) Tweets are my ownTony Rostron @RostronTony
868 Followers 983 Following Family. Research @uniofnewcastle; anaesthesia and ICM @STSFTrust. @LFC #YNWARobin Kanarek @Rbennk
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94 Followers 45 Following Cardiac Anesthesia and Clinical Informatics @WashUanesthesia // Prev @StanfordMed @ChemSysBio, @MIT Course 7Robert David Stevens,.. @RDStevensMD
412 Followers 59 Following Precision Medicine for Intensive CareCathy Gao-Howard, MD @CatGaoHow
510 Followers 440 Following Pulm Crit at NU via IM at Yale | 🐱 | 😷 | data science and machine learning in the ICU | 🐣👩🍼👨👩👧 | https://t.co/hRDwnPryhK | clover@med-mastodonMelissa McCradden @MMccradden
1K Followers 1K Following Down under in sunny Adelaide doing ethics and machine learning work in healthcare 🏳️🌈 She/her @mdmccradden.bksy.socialKelly Potter, PhD, RN @KP_ICURN
424 Followers 698 Following Nurse scientist & assistant professor @PittCCM | Interests: #delirium heterogeneity, #ICUrehab, ICU recovery, #datascience | 🐶 mom | Views = mine | she/herSam Brusca @Sam_Brusca
663 Followers 526 Following Critical care | Cardiology | Alum @OslerResidency, @NIHCritCare, & @UCSF_CVFellows | Opinions are my ownAngela Jerath MD, MSc @propelresearch
3K Followers 3K Following Cardiac anesthetist+epi at @uoftmedicine | feat. @nytimes @guardian @washingtonpost Assc Prof Founder Propel Research | hobbies: Rethinking status quoJohn Reilly @John_P_Reilly
283 Followers 423 Following Critical Care Doc, Epidemiologist, ARDS & Sepsis Researcher. Living in Philly (Northern Liberties). 🏳️🌈 He/Him/His. Views my own.Patricia Lockwood @TriciaLockwood
108K Followers 1K Following hardcore berenstain bare-it-all | [email protected]Adesuwa "Ade" Akhetua.. @AdeAkhMD
467 Followers 420 Following Emergency doctor, health equity educator & researcher @EmoryEM| @NCSP_UCSF scholar '21-23| @NorthwesternEM c/o 2021| @YaleMed c/o 2017 | Views my own (she/her)Matt Zinter @mattzinter_MD
244 Followers 429 Following Pediatric intensive care physician specializing in critical care for immunocompromised children. Translational researcher in pediatric lung disease.Jason Purnell @jqjp1
3K Followers 1K Following Committed to health equity, educational opportunity, and economic viability for everyone.Congrats @kevingbuell & collaborators from around the world for our @JAMA_current paper on individualized treatment effects for oxygen delivery. #ISICEM24 @PCCRG, @em_bioinformant, @DogICUma, @sinha_lab w/@kevingbuell @JonathanCaseyMD @kseitz @EdQian @WesleyHSelf @toddrice_ICU
Oxygenation targets that are individualized using machine learning analyses of results from randomized trials may reduce mortality for critically ill adults. #ISICEM24 ja.ma/3x1pK8x
We then used published regression models for subphenotyping classifications: pubmed.ncbi.nlm.nih.gov/31948926/ by @sinha_lab pubmed.ncbi.nlm.nih.gov/34476405/ by @CDrohanMD Fair Agreement , Striking Results by both, especially for @sinha_lab model, perhaps due to that IL-6 in the equation...
⬆️ level of support = ⬆️ plasma levels of IL-6, Procalcitonin, and Ang-2. BUT not for sRAGE (epithelial injury?). Inverse pattern. sRAGE peaked early in hospital course, similar to what @danleisman showed in the first wave: atsjournals.org/doi/10.1164/rc…
Excited to share our just published paper in #journal_CHESTCritCare @journal_CHEST on host-response subphenotypes in #COVID19 chestcc.org/article/S2949-… #OpenAccess #BLUF: Subphenotypes track with severity, predict outcome and are dynamic on follow-up.
@sinha_lab Beyond patterns: how to assign biological meaning to ARDS and sepsis phenotypes See the linked Comment from Harm-Jan de Grooth & Olaf Cremer bit.ly/4679aQD
Don’t miss the latest research findings on molecular #phenotypes in #sepsis, which could represent a treatable trait in critical illness beyond the patient's syndromic diagnosis From @sinha_lab and colleagues bit.ly/3rg6rFJ
In a study published in @LancetRespirMed, @sinha_lab and colleagues’ research on hypoinflammatory and hyperinflammatory phenotypes across critical illness syndromes paves the way for personalized interventions and improved patient outcomes. anesthesiology.wustl.edu/new-approach-t…
@sinha_lab Congrats for the work done ! @sinha_lab and colleagues
Reproducibility in science is precious 💎! #sepsis
🧵1/n Delighted to present our paper on molecular phenotypes in sepsis @LancetRespirMed. We observed previously described molecular phenotypes: Hyper/Hypo in 2 sepsis ICU cohorts (even after excluding ARDS pts) and HTE with activated protein C 😱😱😱thelancet.com/journals/lanre…
Congrats @sinha_lab & all teams involved, tremendous work and exciting findings! 🤩👏🙌
🧵1/n Delighted to present our paper on molecular phenotypes in sepsis @LancetRespirMed. We observed previously described molecular phenotypes: Hyper/Hypo in 2 sepsis ICU cohorts (even after excluding ARDS pts) and HTE with activated protein C 😱😱😱thelancet.com/journals/lanre…
@sinha_lab @LancetRespirMed Very nice work. Congrats!
@sinha_lab @LancetRespirMed Important work from @sinha_lab and team! Parsimonious phenotypes observed in sepsis, not just ARDS, and heterogeneity of treatment effect of activated protein C. Congratulations Pratik!
@sinha_lab @LancetRespirMed Fantastic work! Sufficient equipoise for a phenotype enriched adaptive trial of conservative fluid management/statin/rhAPC in adults with sepsis?
@sinha_lab Just truth. The issue will be moving from pragmatic trials (mostly negative) aiming at fast recruitment to trials tailored with precision medicine. A challenge of course but I guess it is the direction to follow.
This study may be a U-turn in the approach to research. Congratulations to the authors!
🧵1/n Delighted to present our paper on molecular phenotypes in sepsis @LancetRespirMed. We observed previously described molecular phenotypes: Hyper/Hypo in 2 sepsis ICU cohorts (even after excluding ARDS pts) and HTE with activated protein C 😱😱😱thelancet.com/journals/lanre…
This kind of work is key to understanding #sepsis and #ARDS to not just create new treatments but to offer the right treatment for the individual patient at the right time in their disease course Incredible work by @sinha_lab
🧵1/n Delighted to present our paper on molecular phenotypes in sepsis @LancetRespirMed. We observed previously described molecular phenotypes: Hyper/Hypo in 2 sepsis ICU cohorts (even after excluding ARDS pts) and HTE with activated protein C 😱😱😱thelancet.com/journals/lanre…
Bravo! #PedsICU
🧵1/n Delighted to present our paper on molecular phenotypes in sepsis @LancetRespirMed. We observed previously described molecular phenotypes: Hyper/Hypo in 2 sepsis ICU cohorts (even after excluding ARDS pts) and HTE with activated protein C 😱😱😱thelancet.com/journals/lanre…
Delighted to announce our new publication from the first meeting of the Delirium Subtyping Initiative in Milan last November! 🧠 doi.org/10.1002/alz.13… @alzassociation @alzdemjournals @WileyGlobal
I could not be more excited that this paper is finally out. It’s the culmination of the question that’s driven my research: what is it about the host response to a given pathogen that leads to such variable outcomes (death vs recovery)? Here's why this project is so cool:
In collaboration with @DrPhilipVerhoef, @progdoctalk , and @PrenosisInc, we discovered novel COVID-19 subgroups using detailed protein biomarker and EHR data that had differential mortality rates and responses to corticosteroids! Thank you team! journals.lww.com/ccmjournal/Ful…
In collaboration with @DrPhilipVerhoef, @progdoctalk , and @PrenosisInc, we discovered novel COVID-19 subgroups using detailed protein biomarker and EHR data that had differential mortality rates and responses to corticosteroids! Thank you team! journals.lww.com/ccmjournal/Ful…