Onlypathology @onlypathology

A 25-year-old man presented with personality changes, abnormal movements, jaundice and pruritus. MRI showing gaint panda sign. Diagnosis? A. Wilson's disease B. Huntington's disease C. Hemochromatosis D. Sarcoidosis

WHO changed glioma classification forever • Molecular first, not histology • IDH defines biology • Grade ≠ disease • Grade 1 = only circumscribed Simple way to remember 👇 #MVOnco #Glioma #NeuroOncology #MedEd #Oncology

AML with recurrent mutations. Nice visual abstract. Taken from the last issue of Cytopathology. #pathologymcq #hematology #inisshematopathology #hematologymcq #molecular #molecularhaematology #medschool #medicine #pathologyresidents #pathologists #pathboards #PathTwitter

👇🔥#OriginalResearch #OpenAccess🔓 "Novel histological repertoire of crypt-associated anomalies in inflamed colon mucosa" by Rubio et al. jcp.bmj.com/content/early/… #GIpath

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Join the virtual 3rd ISGyP Annual Meeting "Making diagnoses in gynaecological pathology 2023 FIGO staging of endometrial carcinomas", Oct 21, for free! Expert lectures in #gynpath Open to all pathologists & trainees. Register free at us02web.zoom.us/webinar/regist…

Thank you all, as always, for your comments and interactions. What a lonely place Twitter/X would have been if we were to share cases and get crickets. This biopsy came to me with a preliminary diagnosis of nodular fasciitis, and I wasn't opposed to that interpretation, but something didn't feel quite right. The cells were not the "tissue culture" myofibroblasts of nodular fasciitis, and SMA was negative. I ran a number of stains on top of the ones received, and I added a histiocytic marker (CD163) based on the cells' somewhat fluffy cytoplasm, associated inflammatory cells, and rare classic foamy histiocytes. Lo and behold, the only positive stain was CD163. I called the pathologist and asked about a history of trauma or infection, and sure enough, he dug up a recent history of redness and pain at the same site. These resolved but a mass showed up instead. So, I think the diagnosis is an exuberant fibrohistiocytic reaction at the site of a prior inflammatory process, likely a ruptured cyst. Not a very exciting diagnosis, but a diagnosis nonetheless. Here are a few learning points: 1. Reactive histiocytic proliferations can be quite exuberant, spindled, and mitotically active, and may lead to an overdiagnosis of neoplasia. Also, be aware of so-called postoperative/reactive spindle cell nodules which are myofibroblastic in nature and can show a moderate degree of cytologic atypia pubmed.ncbi.nlm.nih.gov/10664632/ 2. Remember that calling something benign spindle cell proliferation without a definite diagnosis may well lead to an unnecessary excision. 3. Have a low threshold for contacting clinicians/EMR in search of additional clinical information. Morphology is key, but history will often save the day. - IHC: SMA (negative) and CD163 (positive) @wusm_pathology @washupathedu #breastpath #PathTwitter #PathX #pathology

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Traditional serrated adenoma (TSA) and tubular adenoma (TA) in the same biopsy cup. The nuclei in the TSA are much smaller and paler than those in the TA, even in the proliferation zones (the ectopic crypt formations).

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I’m excited to share that the IHC update for #dermpath & #bstpath I wrote with @JMGardnerMD for @ArchivesPath is now available! 😁 You can read the full article here: meridian.allenpress.com/aplm/article/d… Have a great holiday weekend #pathtwitter / #pathX! 🔬🦠🧬

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A beautiful example of Whipple disease from the catch. A former colleague, Dr Christina Arnold, wrote a lovely summary of this lesion some time ago. #UMiamiPath Am J Surg Pathol. 2012 Jul;36(7):1066-73. PMID: 22743287.

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Epithelial displacement at the site of a previous biopsy. Common: Papillary lesions and DCIS. 🎯The displaced cell blocks may not have myoepithelial cells. Only make the diagnosis of invasion outside this biopsy site or if you see features of a recognized type of invasive Ca.

Details, details, details … 🔬 👇These subtleties in “clearing” of cytoplasm can be helpful especially in biopsies for #renal masses. #GUPath

I’ve been preparing a teaching session on granulocytes- one of my favourite topics! Here's a thread on some key points and new developments #blooducation

Join me for an interactive teaching session on Salivary gland pathology and cytology 👇🏽👇🏽#PathTwitter You can preview cases here: [pathpresenter.net/public/display…) July 21st, at 7:15 am Central US time, 7:15 pm Phnom Penh or HCMC time Register here: zoom.us/meeting/regist…

Photogenic Friday. Fibroadenoma with periductal adenosis and myoepithelial hyperplasia. Behold the fibroadenomyoepithelioma! 🙂 @wusm_pathology @washupathedu #breastpath #PathTwitter #pathology

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🔥A TIP for diagnosing MALT Lymphoma starts with low magnification. 🎯I search for the muscularis mucosa and see it at the highest magnification. 👉Physiologic lymphoid collection typically does not infiltrate the muscularis mucosa. Here is a gastric MALT Lymphoma. #gipath

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Histology flash card Renal angiomyolipoma (AML) Most common benign renal tumour Oft incidental find ⬆️♀ 80% sporadic 20% assoc TSC / LAM TSC (tuberosclerosis complex)➡️75% pts renal AML Histology Triphasic (variable proportions) -Smooth muscle -Blood vessels -Adipose tissue

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Thrilled to share our comprehensive guide on using #flowcytometry in the Dx of chronic myeloid neoplasms & post-AML clonal hematopoiesis. Co-authored w/the fabulous ⁦@SibaElHussein⁩ full text and schematics👇🏻#hemepath #mdssm ⁦@ElsevierNews⁩ sciencedirect.com/science/articl…

Prostate biopsy shared by Dr. Samson Fine @rovingatuscap What is this finding? What is it pathognomonic for? Answers & more pics: kikoxp.com/posts/19841 More posts from Dr. Fine on his Kiko profile: kikoxp.com/samson_fine1 #pathologists #pathology #pathTwitter #GUpath #urology

Small bowel, Adult #GIpath #BSTpath #Pathresidents #PathTwitter

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Is your life a 'storm' right now? It's not an accident. God has a plan.