Liang-Bo Wang @lbwang2
Scientist, Oncology Bioinformatics at @moderna_tx. PhD in Computational and Systems Biology from @WUSTLdbbs. Genomics 🤘. blog.liang2.tw Taipei Joined September 2012-
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Today Cell, Cancer Cell and Cell Reports Medicine are pleased to publish the 1st wave of Pan-#Cancer multiomics papers looking at over 1000 patients across 10 #tumor types from @theNCI Clinical Proteomic Tumor Analysis Consortium #CPTAC (1/n) @Cancer_Cell @CellRepMed #openaccess
We are excited to announce a collection of new human reference genome sequences that reflect much more global diversity! nature.com/articles/s4158…
webR v0.1.0 has just been released! I'm super excited to see what people create by using webR in their own projects 😃. The docs are at docs.r-wasm.org and I've written an introductory blog post talking more about the kind of things webR can do at tidyverse.org/blog/2023/03/w….
english.cw.com.tw/article/articl… Thanks to Commonwealth Magazine @CWM_en for publishing a summary version of my article detailing my experience of becoming a Taiwanese citizen as a Taiwan Gold Card holder. Please share it forward to those who may benefit from it. Thank you
Our single-cell MPRA paper is finally out! Super excited about the potential of this technology to study cell-type specific gene regulation 🥰
Out today in @NatureGenet, our group’s single-cell MPRA technology for testing activities of gene regulatory elements in whole tissues. Congrats to Siqi Zhao and the rest of the crew for their great work! nature.com/articles/s4158…
We are delighted to share our work, now available in @Nature: nature.com/articles/s4158… Our scoring system can be accessed here: kinase-library.phosphosite.org Coming soon --> the tyrosine kinome and an improved system with many new functionalities & features! #TheKinaseLibrary #KL
Our paper on insulators is out on Biorxiv! We tested the activity of insulators across thousands of genomic locations to figure out where insulators function. Oh, and I successfully defended today :) biorxiv.org/content/10.110…
Thanks to DuckDB's R client implementing DBI and ensembldb taking a standard DBI connection to create an EnsDB instance, it's straightforward to replace SQLite with DuckDB. I had fun using DuckDB :) More details about this exercise at blog.liang2.tw/posts/2022/10/…
Gene-specific lookup using DuckDB is indeed slower than SQLite. This is expected because SQLite w. index is designed to retrieve specific rows fast. But since the query takes < 100ms to run, performance hit shouldn't be too bad unless we run this kind of queries in a loop.
I converted a ensembldb EnsDb SQLite db to DuckDB and saw a nice speedup (4-6x) in genome-wide queries! DuckDB's filesize is smaller too (index not needed), and it can be even smaller by offloading tables to external compressed parquet files (still 3x speedup).
Overall, my presentation summed up my experience using Snakemake during my PhD. It's been one of my best investment in bioinformatics tools that greatly boosted my productivity 😎 If this has piqued your interest, check out the official resources at snakemake.github.io
Besides data processing pipeline, I also enjoyed managing my personal research projects using Snakemake (eg, data freeze, analyses, and figures). I will recommend making the scripts reproducible first before assembling everything in a pipeline.
I made a presentation at my local #bioinfo meetup about #snakemake and how to best utilize this #workflow management tool as a researcher. The slides are available at blog.liang2.tw/2022Talk-snake… details👇🏼
Finally sharing this collaborative work with my amazing labmates Avi and Siqi! We asked how chromosome position and cellular environments impact gene expression noise by developing a new single-cell method (with a genomicsy name just because) 😉 biorxiv.org/content/10.110…
I designed this cover for my PhD thesis using #DALL-E and #StableDiffusion, I'm quite happy with the result! Took a few steps to combine the strengths of both engines, I found SD: beautiful images, DALLE: gets the story right; look at the steps below: (1/5+2)
After more than two years of working on this project, we are delighted to share our effort in harmonizing the tumor microenvironment (TME) of glioblastoma (GB) at single-cell resolution and providing insights into the tumor architecture (biorxiv.org/cgi/content/sh…). Details 🧵👇🏼 1/N
‼️ ONLINE NOW @NatureGenet 📰 Spatially restricted drivers and transitional cell populations cooperate with the microenvironment in untreated and chemo-resistant pancreatic cancer 🧑🏾🤝🧑🏻 Li Ding @reykajayasinghe @DeNardoLabWUSM and colleagues ⬇️ go.nature.com/3AEvt3n
There are different versions of the human genome annotation but which do you use? The Matched Annotation from @NCBI and EMBL-EBI (MANE) collaboration is the answer and brings new meaning to the phrase: two heads are better than one. ebi.ac.uk/about/news/res…
Jim Huang @jserv
12K Followers 8K Following "A hacker, a lecturer, a father" // Adjunct faculty at @NCKU_official
PeterWolf (彼得臥�... @PeterWolfTW
575 Followers 284 Following 卓騰語言科技執行長工 (GM of Droidtown Linguistic Tech.) 歡迎贊助 ArticutAPI_Taigi (基於 Articut 的台語 NLP 系統的 API) 開發計劃。(Side-project Donation: https://t.co/m2oO37U7CO)
Stephen Oh @mpndoc
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WashU Medicine Geneti... @WashUGenetics
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catcatcatcat @4catcatcat
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Jas @jas9
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Konstantinos Kyriakid... @kokyriakidis
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just-js @justjs14
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BeGenomics @BeGenomics
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Kuan-Hao Chao @KuanHaoChao
382 Followers 278 Following Senior Deep Learning Scientist @Illumina | CS Ph.D. @JohnsHopkins @JHUCompSci | Teaching machines to learn biology 🧬💻
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other shore flower @JUJUBADad1
92 Followers 2K Following The road to success is always bumpy. If you want to live a good life, persistence is the hope of victory!
Rock WU @Rock_wu
257 Followers 2K Following 生物医药领域6年研发经历和12年猎头经验,希望为生物医药行业做点贡献, 电话/微信:13564288425,欢迎关注我的领英:https://t.co/uPmU6oNMn6
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Wei Ruxuan @Kumi_s6688
77 Followers 1K Following I'm Carmen and I usually go golfing or diving with friends on weekends
Zong Yan Liu @6zongyan
4 Followers 49 Following Ph.D. student @Cornell with @EdBuckler | You can never cross the ocean until you have the courage to lose sight of the shore.
Wikkyyyyyyy @WikkyChen
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Won Kyun Koh @Wonky07
145 Followers 344 Following 🎗🇰🇷 PhD Candidate of @challenlab @WUSTLdbbs @WUSTLmed | Aplastic anemia survivor ➡️ please support @aamdsif | he/him
Larry Spears @LarryDSpearsJr
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Juo-Chin Robin Yao, P... @jcrobinyao
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MindWalk Corp. (forme... @BioStrandBV
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McDonnell Internation... @McDonnellAcad
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Jim Huang @jserv
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山寨一身 @c9s
10K Followers 2K Following Founder of @bbgotrading @phpbrew / A self-taught engineer|trader|pianist 藍勾只是好玩沒在做流量 / 不定期刪文 🇹🇼🐶🛹🎹
PeterWolf (彼得臥�... @PeterWolfTW
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Sheng Chih Jin @PETERJIN999
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Ming "Tommy" Tang @tangming2005
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47K Followers 2K Following Deputy Director General of EMBL, Director of EMBL-EBI. I have an insatiable love of biology. @[email protected]. I also work with ONT, Dovetail + GeL.
WashU Medicine Geneti... @WashUGenetics
2K Followers 1K Following Department of Genetics at Washington University School of Medicine Hiring faculty&postdocs: https://t.co/HqjVvmLNn3
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alex rubinsteyn @iskander
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Professor Georgina Lo... @ProfGLongMIA
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Professor Richard Sco... @ProfRAScolyer
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134K Followers 2K Following They call me Johnny off the spot Blonde Clay Figurine, Girl with Oversized Jacket | Blender Artist. Handcrafted | Perfect Gift for Fans. Home Decor (1-count)
MBTA @MBTA
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382 Followers 278 Following Senior Deep Learning Scientist @Illumina | CS Ph.D. @JohnsHopkins @JHUCompSci | Teaching machines to learn biology 🧬💻
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73 Followers 73 Following PhD student Tsai Lab @tonytsai00 LSK Lab @SolnicaKrezelL WashU DBBS/DRSCB @WashUDevBio
Shao-Yu Jheng @JhengShao
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George Stagg @gwstagg
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573 Followers 670 Following Genomics x Software | @exaibio | @JHUCompSci and NTU (Taiwan) alum | Sports fan
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252 Followers 2K Following Software engineer | Translating Python doc (zh_TW) | 🐱 Cat slave
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204 Followers 47 Following Quantitative Systems and Synthetic Biology & Cybergenetics @Inria and @InstitutPasteur
The HPy Project @HPyProject
252 Followers 22 Following A new C API: enabling Python's evolution; binary compatible across many versions of CPython, PyPy & GraalVM; easy to debug; as fast or faster than the old API
15 @ artistalley.org ... @fifteenai
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26K Followers 4K Following Writer & author of MADE IN TAIWAN 🧋 Please email, no DMs. 📧 clarissapwei at gmail
Foreigners in Taiwan ... @foreignersinTW
31K Followers 2K Following We blog to help convince foreigners to come to Taiwan and teach them how to survive here. Run by US expats. 我們是台灣的外國人!我們透過部落格幫助外國人了解怎麽在台灣生存及旅遊!(美國人管理)RIP Ken
Simz @SimzArts
370K Followers 349 Following Illustrations / Character Designs / Comic Books / Partnered Twitch Streamer
Internal Tech Emails @TechEmails
595K Followers 890 Following Internal tech industry emails that surface in public records. 🔍

























