John Lam @jlam

NEW: Major posts are vacant. Waves of scientists are gone. Ebola looms. How RFK Jr. manages HHS: “If the C.E.O. lacked deep expertise in the company’s business and the leaders of its most important divisions were missing, investors would revolt." nytimes.com/2026/06/07/us/…

Heart disease kills more people than every cancer combined. Lilly just published Phase 1b data in the NEJM on a single injection that could prevent most of it. Permanently. The science starts with a genetic accident. A small percentage of people are born with a broken PCSK9 gene. Their livers clear LDL cholesterol so efficiently that researchers tracking them over 15 years found up to 88% fewer coronary events. The effect was so large it looked like a data error. The reason is timing. Statins lower your cholesterol at age 45. A broken PCSK9 gene lowers it from birth. Decades of low LDL compound into plaque that never forms in the first place. You can't reverse 40 years of arterial damage with a pill. You can prevent it entirely with a gene. VERVE-102 is a base editor. Single IV infusion. One letter changed in your liver cells' DNA. The PCSK9 gene turns off permanently. Phase 1b results across 35 patients: 88% reduction in PCSK9 protein, 62% drop in LDL cholesterol at the highest dose. Durable at 18 months. The effect didn't fade. Lilly paid $1.3 billion to acquire Verve Therapeutics for this program. The global statin market does roughly $16 billion a year selling daily pills that patients take for life. If a single infusion replaces 30 years of daily medication, Lilly didn't buy a drug. They bought the retirement plan for an entire drug class. One shot to join the genetic lottery that most of the population lost.

Crémieux @cremieuxrecueil

2 weeks ago

Eli Lilly has done it. They've gone and made what seems to be a powerful, permanent gene therapy for LDL cholesterol. That means they'll be able to effectively prevent most heart disease with a single infusion!

558 2K 15K 5.8M 7K

While Trump has railed against drugs coming into the U.S., his DOJ has declined to prosecute nearly 5,000 federal drug cases, including trafficking and money laundering — 45% higher than the average of the prior three new administrations. propublica.org/article/trump-…

@aplinkkeliai @RepMikeLevin That’s not what @RepMikeLevin wrote. Reread it. He didn’t write, six people could read the doc. He wrote, six people had clearance to read it.

@JamesCh89793620 @aftab_usa @guyatthediner You mean, delete the cars, not just petro burners, but all the tire-particulate sloughing ones too.

Thomas Massie is sounding the alarm. Congress is about to pass a liability shield for Bayer — a foreign corporation — that would strip Americans of the right to sue when glyphosate gives them cancer. Massie: “This is not to grant farmers immunity. This is to grant corporations immunity. If you contract non-Hodgkin’s lymphoma from this chemical — you won’t be able to sue.” Bayer has already paid billions settling cancer lawsuits. This bill ends future lawsuits permanently. RFK Jr. built his brand on MAHA. Trump is urging Republicans to pass it anyway.

JULIAN ASSANGE FILES CRIMINAL COMPLAINT AGAINST NOBEL FOUNDATION OVER “INSTRUMENT OF WAR” PEACE PRIZE WikiLeaks Founder Alleges 2025 Award to María Corina Machado Constitutes Misappropriation, Facilitation of War Crimes Under Swedish Law, Seeks Freeze of 11 million SEK ($1.18 million USD) of Pending Transfers to Machado STOCKHOLM — 11:00am CET December 17, 2025 Julian Assange today filed a criminal complaint in Sweden accusing 30 individuals associated with the Nobel Foundation, including its leadership, of committing serious suspected crimes, including the crime of gross misappropriation of funds, facilitation of war crimes and crimes against humanity, and the financing of the crime of aggression. The complaint shows that Alfred Nobel's 1895 will explicitly mandates that the peace prize go to the individual who during the proceeding year “conferred the greatest benefit to humankind” by doing “the most or the best work for fraternity between nations, for the abolition or reduction of standing armies and for the holding and promotion of peace congresses.” Assange argues that “The political decision of the Norwegian selection committee does not suspend the fiduciary duty of Swedish funds administrators”. “Any disbursement contradicting this mandate constitutes misappropriation from the endowment”. The complaint, submitted simultaneously to the Swedish Economic Crime Authority (Ekobrottsmyndigheten) and the Swedish War Crimes Unit (Krigsbrottsenheten), states that the suspects, including Nobel Foundation Chair Astrid Söderbergh Widding and Executive Director Hanna Stjärne, converted “an instrument of peace into an instrument of war,” through suspected “serious criminality” including: 1) Breach of trust, gross misappropriation and conspiracy in relation to the pending 11 million SEK ($1.18 million) disbursement of the Peace prize monies to Maria Corina Machado, whose prior and ongoing actions categorically exclude her from the criteria set out in Alfred Nobel's will; 2) Facilitation of war crimes, including the crime of aggression and crimes against humanity, breaching Sweden's obligations under Article 25(3)(c) of the Rome Statute, because the accused are aware of Machado's incitement and endorsement of the U.S. commission of international crimes, and knew or ought to have known that the disbursement of Nobel monies would contribute to extrajudicial killings of civilians and shipwrecked survivors at sea and are in breach of their obligation to cease disbursements. Assange notes that the members of the Nobel Foundation have previously exercised their supervisory authority over the prizes and their disbursements by withholding Literature Prize disbursements in 2018. “Failure to intervene here, despite U.S. war crimes off the Venezuelan coast and Machado’s key role in furthering aggression” incurs criminal liability. “Alfred Nobel's endowment for peace cannot be spent on the promotion of war,” Assange states. The accused have concrete legal obligations because they are tasked with “ensuring the fulfillment of the intended purpose of Alfred Nobel’s will, that is, to end wars and war crimes, and not to enable them.” MACHADO'S INCITEMENT OF THE LARGEST U.S. MILITARY BUILDUP SINCE THE IRAQ WAR MAKE HER CATEGORICALLY INELIGIBLE The complaint notes how the Nobel announcement and ceremony have occurred in what military analysts describe as “the largest U.S. military deployment in the Caribbean since the Cuban Missile Crisis”—now exceeding 15,000 personnel, including the aircraft carrier USS Gerald R. Ford. The escalation continues as President Trump announced on December 10, two days after the Nobel ceremony, that U.S. strikes would be “starting by land.” The Venezuela strategy is part of what Trump’s Secretary for War, Peter Hegseth, calls a shift toward “maximum lethality, not tepid legality” and “going on the offence”. Against this backdrop, Assange states that “Machado has continued to incite the Trump Administration to pursue its escalatory path”, including by entering into a conspiracy to give the U.S. administration access to $1.7 trillion in oil reserves and other natural resources through privatization once Maduro is ousted. “Using her elevated position as the recipient of the Nobel Peace Prize, Machado may well have tipped the balance in favour of war, facilitated by the named suspects.” Assange states in the criminal complaint. The complaint lists evidence of this incitement of U.S. military intervention, as well as praising Israeli Prime Minister Benjamin Netanyahu's conduct in Gaza. Her statements include: - “Military escalation may be the only way... the United States may need to intervene directly” (30 October 2025) - Machado called U.S. military strikes on civilian vessels, which have killed at least 95 people to date, “justified” and “visionary”. - Machado dedicated the prize to U.S. President Trump, because he “finally has put Venezuela... in terms of a priority for the United States national security” - Historical statements including 2014 testimony before U.S. Congress where she said: “The only path left is the use of force” The filing cites extensive third-party expert and institutional opposition to Machado receiving the award: - 21 Norwegian peace organizations declared: “Machado is the opposite of a peace laureate.” - Nobel Peace Prize laureate Adolfo Pérez Esquivel stated: “Giving the prize to someone who calls for foreign invasion is a mockery of Alfred Nobel's will.” - The Peace Research Institute Oslo (PRIO) confirmed Machado “has called for military intervention in Venezuela.” REQUESTED ACTION The complaint notes that “There is a real risk that the funds derived from Nobel’s endowment have been or will be intentionally or negligently diverted from their charitable purpose to facilitate aggression, crimes against humanity, and war crimes.” Assange requests that Swedish authorities: 1. Immediately freeze of the pending SEK 11,000,000 monetary prize transfer and any remaining related budget and secure return of the medal. 2. Investigate the named persons and Foundation officers and associated entities for breach of trust, facilitation of war crimes and crimes against humanity, and conspiracy. 3. Seize of board minutes, emails, group chats, financial records. 4. Interrogate Widding, Stjärne and other suspects. 5. Fully investigate domestically or refer the matter to the ICC (Rome Statute Art. 25(3)(c)). “This complaint seeks the immediate freezing of all remaining funds and a full criminal investigation lest the Nobel Peace Prize be permanently converted from an instrument of peace into an instrument of war,” Assange concludes.

Trump’s second-term pardons are historic in their enormity—billions in fines erased, allies protected, donors rewarded, DOJ undermined, and election norms threatened. Corruption looks less like an exception and more like the rule, says Cato’s Dan Greenberg. ow.ly/PiYw50YqcO0

🚨 Rep. Neguse just exposed a $143 million no-bid contract live on camera: The company has no headquarters. No website. No prior federal contracts. It was incorporated 8 days before receiving the contract. Its registered address belongs to a political operative. One of its subcontractors is a political firm tied directly to Kristi Noem from her time as South Dakota governor. Neguse asked Noem where the company is headquartered. “I don’t know.” $143 million of taxpayer money. Vanished into a ghost company. Connected to the Secretary of Homeland Security herself. This is the agency running DOGE. Cutting waste. Eliminating fraud.

@raiderboi925 @rohindhar Methinks Costco lacks suitable items in the smaller quantities selected by SF Chronicle for comparison. And how should they apportion the membership fee?

🚨BREAKING: The Trump administration is rounding up PREGNANT CHILDREN in ICE custody and moving them to Texas… According to reporting from The Texas Newsroom and The California Newsroom, the administration has ordered that all pregnant unaccompanied minors be concentrated into one facility in San Benito, Texas. Some of these girls are as young as 13 years old. The Office of Refugee Resettlement, the agency responsible for unaccompanied minors, previously placed pregnant teens in shelters or foster homes equipped for high-risk pregnancies. That was the longstanding policy, and that changed when Trump returned to office. Now, they are being transferred… sometimes across state lines… into a state where abortion access is outlawed. This is not accidental. Internal emails show ORR leadership directing staff to place “any pregnant children” into this Texas program moving forward. While, at the same time, the administration revoked Biden-era guidance that allowed minors to be moved to states where abortion was still legal. ICE’s own internal policy says pregnant, postpartum, and nursing women should not be detained except in exceptional circumstances. Yet, pregnant women are being shackled, denied prenatal care, separated from their families, and transported out of state. A federal judge in Minnesota already rebuked the administration for illegally detaining a refugee mother who was still breastfeeding her five-month-old baby. And while all this is happening, more than 400 children have been moved into ORR shelters since Trump returned to the White House. Advocates are warning this mirrors family separation tactics… parents arrested, children “referred” to ORR, and then shuffled through a system that has already been exposed for losing track of migrant kids in the past. Which seems to be the goal as the Trump administration rolls back family reunification parole. Now, pregnant children are being transferred into a state where abortion is banned, after being taken into federal custody and moved across state lines. That single policy choice concentrates vulnerable children in one place, strips them of medical autonomy, and puts the government in total control of their bodies. And all of that is happening as they are separated from family support… That is how trafficking systems operate. That is the creation of a trafficking pipeline. And it is happening under federal authority.

This is a spectacularly important study. Published in Nature, it provides solid evidence that this platform pushes those on the right further to the right, more pro-Trump, more pro-Russia,… And that these effects are programmed into the platform nature.com/articles/s4158…

🚨 BREAKING: CBS News uncovers a bombshell 69-page DEA memo hidden in the Epstein files. detailing a 5-year federal probe into Jeffrey Epstein for wire transfers linked to "illicit drug and/or prostitution activities" in the US Virgin Islands and New York. Launched in 2010 and still ongoing in 2015, it tracked ~$50M in shady transfers to accounts in Switzerland, France, Cayman Islands, and NY. Memo names 14 other redacted targets (shocker!). It exposes new Epstein-linked probes: ICE investigations in West Palm Beach, Las Vegas, and Paris, plus an FBI case from 2006 active through 2015. Insane twist: SDNY prosecutors who nabbed Epstein in 2019 claim they NEVER knew about this DEA investigation. The web just got deeper.

DOJ removed, withheld Epstein files related to accusations about Trump npr.org/2026/02/24/nx-…

The FBI interviewed one of Jeffrey Epstein’s victims four times over her allegation that Donald Trump assaulted her when she was underage—but most accusations against the president appear to have been removed from the government’s documents. trib.al/hydqL6o

🚨 Pam Bondi is a foreign agent. Not was. IS. Once you register under FARA, that history doesn't disappear. It's federal record. She registered with the Department of Justice through Ballard Partners to lobby Congress on behalf of FOUR foreign governments: 🇶🇦 Qatar 🇩🇴 Dominican Republic 🇿🇼 Zimbabwe 🇽🇰 Kosovo The Qatar deal? $115,000 PER MONTH. She was listed as "Key Personnel." Personally and substantially involved in influencing American policy for a foreign nation. Then she becomes Attorney General. And on DAY ONE she: Guts FARA criminal enforcement Disbands the Foreign Influence Task Force Reduces the entire law to "civil guidance" She didn't reform anything. She killed the system that governs people like HER. So ask yourself: Who is she protecting? 👀 How many unregistered foreign agents are operating freely right now because the enforcer just burned the rulebook? Why did she list ZERO lobbying clients as conflicts of interest on her Senate questionnaire? Why is a registered foreign agent running the agency that polices foreign agents? The receipt is in comments and attached 👇 No conspiracy theory needed. Her own paperwork tells the whole story 🔥

@PalmerLuckey Cute window latch, but i’d have swapped the cam and the keeper, to keep hands on the cam handle further from delicate parts.

x.com/i/article/2004…

BREAKING: Music legend Bruce Springsteen just released this incredible song that will be sure to piss Trump off beyond belief. “Streets of Minneapolis”. He wrote this song about Alex Pretti and Renée Good Saturday and recorded it yesterday. Share it far and wide and play it as loud as you can

WOW! An ICE agent in Minneapolis tells an American citizen "If you raise your voice, I will erase your voice." Stop telling me that the Trump administration isn't Fascist. They are threatening people for "raising their voice," and how exactly will ICE "erase our voice?" Kill us?