LJ Mitchell @eviljinious

@UnitedCanucks26 Hahahaha. Clueless

In 2025, we published a bold proposal to use fusion reactors for gold production. And now we’ve done it: Mercury transmuted into stable gold, using fusion neutrons, at 10x the record set by CERN in 2025. We’ve reduced alchemy to a series of difficult but tractable engineering problems.

Let me explain why is @VardaSpace is such an important company A patient who has cancer has cells that have proteins that are activated leading to growth, replication and then damage. Targeted drugs work on these cells in 2 ways: 1. Inhibit the receptor (the protein), essentially jamming its function until the drug wears off. An example is Tamoxifen, used in breast cancer to block oestrogen receptor binding. 2. Degrading the receptor altogether so signalling doesn't work and the cell needs to spend time recreating the receptor before it can work again, an example being Fulvestrant which degrades the receptor itself. The second option here is important to understand because the effect of it significantly out lasts how long the drug lasts in your system. One type of these drugs is called PROTACs - it's a newer type of cancer drug that destroys these proteins (proteolysis) removing functions often related to cancer signalling. Now these drugs are complex, 15+ chemical steps and can be upto 4x more heavy than normal drugs. With each molecule taking many shapes, when packed together, they often don't form a uniform lattice shape. On Earth, gravity leads to convection currents that feeds these molecules unevenly into the forming crystal, too fast resulting in non-uniform crystal formation. These drugs: - Dissolve poorly when ingested - Have difficulties crossing cell membranes - Lead to unpredictable bioavailability - Require high doses in order to get enough drug in the system Varda here by @WillBruey and @zebulgar aims to solves this with undisturbed crystal formation growth in microgravity. With a new purer drug you get: - Predictable bioavailability - A more stable drug - A better outcome for patients This is Varda

Varda Space Industries @VardaSpace

2 days ago

We’re 3 for 3 in orbit this October. This time, it’s space drugs. W-7 carries pharmaceutical hardware and a promising new type of cancer medicine known as a protein degrader. Microgravity will help overcome one of its biggest limitations: poor solubility.

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Karen Gillan, who is a Highlander, says Henry Cavill's Scottish accent in the Highlander reboot is absolutely "bang on" She also says he was so dedicated to authenticity, he was even correcting people who were mispronouncing Gaelic words (via @Collider)

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@BradRTorgersen Never gets old

Some stats on #php2shell. In the 10 hours before it was publicly announced, across the @Cloudflare network we saw thousands of attempts to exploit it. That jumped to tens of thousands in the 45 minutes post announcement, hundreds of thousands within 2 hours, and millions now.

holy fucking shit. openai just had thousands of ai agents go through roughly 40,000 scientific papers in 32 minutes to identify promising new directions for neurodegenerative disease research. i swear the most exciting ai developments lately aren’t even the model releases. it’s watching these systems begin to tackle actual scientific problems. this is insane.

OpenAI @OpenAI

15 hours ago

GPT-Rosalind surfaced a new lead for drug discovery: could restoring cholesterol transport protect neurons from degeneration? DCTN1 is a gene linked to Perry syndrome, a rare neurodegenerative disorder. In mouse-brain data, disrupting it increased expression of genes involved in

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AHORA! Pandillas huyen de la persecución militar en Haití

@CTVNews Women don’t exist for @ctvnewa

@Mark_Wilson_ The current Canadian military is 80-% pure garbage and that percentage gets higher each year

A lot of Canadians actually believe this nonsense

Rebel News @RebelNewsOnline

8 hours ago

Prime Minister Mark Carney commits $2.5 billion so Ontarians can "build the connected and electric vehicles of the future," calling it the next step in Canada's plan to lead global EV production.

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@8teAPi @aaronburnett those dirty casuals at work :)

TLDR: ChatGPT discovers way of potentially preventing Alzheimer’s after 32 minutes of literature search. We will only know for sure in 2036. Check back then!

OpenAI @OpenAI

15 hours ago

GPT-Rosalind surfaced a new lead for drug discovery: could restoring cholesterol transport protect neurons from degeneration? DCTN1 is a gene linked to Perry syndrome, a rare neurodegenerative disorder. In mouse-brain data, disrupting it increased expression of genes involved in

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"A surprising number of political leaders express sympathy for Canada as a victim of President #Trump’s bullying, but behind closed doors grumble about the naivety of @CanadianPM Carney’s advice that middle powers just need to be braver."🤔

The Economist @TheEconomist

5 days ago

Canada’s prime minister believes that middling powers must act together against large aggressors, or they’ll “be on the menu”. Register for free to discover why coalitions of the willing have their limits, however economist.com/international/…

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@aaronburnett

@aaronburnett I read that and thought of our conversation :)

🚨 EXCLUSIVE: Glasgow's Kelvingrove Museum has removed Egyptian mummies from display because there was no 'informed consent from the deceased individual'👇 mol.im/a/16227743 #Exclusive #Scotland #Glasgow #Museums #EgyptianMummies #Woke @MailOnlineScot

What a night at THE TERMINAL LIST Season 2 premiere in NYC. So cool to see it on the big screen at the same time it was playing in over 70 theaters across the country.  All episodes are now streaming on Prime Video. Have you watched it yet?

Pou chèf gang yo ak manm gang yo k ap kenbe kat konpatriyòt nou yo an otaj ann Ayiti: Mesye nou kidnape yo pa konbatan. Yo se teknisyen nan domèn avyasyon ki fè pati misyon nou ann Ayiti, nan kad yon misyon entènasyonal. Misyon nou an gen sèlman pilòt ak pèsonèl teknik, ki gen kòm travay prensipal fè evakyasyon medikal epi sove lavi moun, pa fè lagè. Men, nou te kidnape yo yon fason lach pandan yo t ap retounen apre yo te fin achte manje nan yon makèt nan zòn nan. Se poutèt sa, jodi a nou te lanse yon operasyon militè pou pote yo sekou. Nou gen yon sèl objektif: fè kat konpatriyòt nou yo retounen lakay yo vivan, san okenn mal. Men, mwen vle pou nou menm, chèf gang yo, konprann yon bagay byen klè: atak jodi a pa anyen devan sa k ap vini si nou pa remèt toule kat otaj yo vivan. Epi pa pran pawòl nou yo pou menas san fondman. Nou deja fini ak gang yo nan El Salvador, e nou kapab fini ak nou tou. Nou toujou gen tan pou evite sa. Remèt nou kat konpatriyòt nou yo vivan, san okenn mal, epi tout bagay ap retounen jan sa te ye anvan kidnaping lan. Desizyon an nan men nou.

@nayibbukele Bravo