Andres M Bran @drecmb
CTO b12 Labs | YC S25 | https://t.co/u3rprn2qhQ Prev PhD @EPFL | @mpiMathSci. Building Crows for Chemists, Automating Synthesis 🐦⬛🚀 b12-labs.com San Francisco, CA Joined April 2016-
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Protein folding had its AlphaFold moment, where at a certain point everything could suddenly be solved. Computer aided synthesis planning hasn’t gotten there yet. We are launching Selenium, and the results we have seen have impressed us and many people. If you don't want to read the whole thread you can test the tool at app.b12-labs.com 👇🧵
AI can design more molecules than we can make. Today, we’re launching Selenium to change that! 🧪 Selenium is @b12Labs' agentic retrosynthesis system. Give it a target molecule, and it develops practical synthesis routes from purchasable starting materials. Read more:
@KadriJibraan @arubikscube Try it to see if true ;)
@Biggiethelad1 RXN falls under the 'traditional tools' category! single step model + search algo = not great strategies :)
Protein structure had its AlphaFold moment. Chemical synthesis is next! Today, we’re launching Selenium: our agentic synthesis system. Give it a molecule. It thinks like a chemist and develops practical routes to make it. Bring us your hardest target. 🧪
AI can design more molecules than we can make. Today, we’re launching Selenium to change that! 🧪 Selenium is @b12Labs' agentic retrosynthesis system. Give it a target molecule, and it develops practical synthesis routes from purchasable starting materials. Read more:
Very excited about this launch - we have been getting great feedback from experienced retrosynthesis domain experts dealing with very different chemistry types. Would love you to try and test it!
AI can design more molecules than we can make. Today, we’re launching Selenium to change that! 🧪 Selenium is @b12Labs' agentic retrosynthesis system. Give it a target molecule, and it develops practical synthesis routes from purchasable starting materials. Read more:
Selenium is open for folks in academia and non-profits! Sign up at app.b12-labs.com and read more b12-labs.com/blog/selenium-… Try your hardest target 🔥🔥
We’re also opening free access to academic and nonprofit researchers. We want these capabilities in the hands of people who will push them furthest. Bring Selenium your hardest target: the ambitious molecule, or the AI-designed structure that looks too complex to make. We’d
We’re also opening free access to academic and nonprofit researchers. We want these capabilities in the hands of people who will push them furthest. Bring Selenium your hardest target: the ambitious molecule, or the AI-designed structure that looks too complex to make. We’d love to see what Selenium finds! 🔥 #AgenticSynthesis #Retrosynthesis #DrugDiscovery #AI4Chemistry
AI can design more molecules than we can make. Today, we’re launching Selenium to change that! 🧪 Selenium is @b12Labs' agentic retrosynthesis system. Give it a target molecule, and it develops practical synthesis routes from purchasable starting materials. Read more: b12-labs.com/blog/selenium-… Try Selenium: app.b12-labs.com What molecule have your current synthesis tools given up on? #AgenticSynthesis #Retrosynthesis #DrugDiscovery #AI4Chemistry
@Satpathology Probs of success depends heavily on the asset itself - screening the same boring molecules over and over won't get us far here. Very bullish on design models (Iso, Boltz, etc), but making those molecules will quickly become the bottleneck
@curiouswavefn Math is also kinda made up, and as long as the rules are respected the math can be correct. You can even come up with rules of your own! With chem and bio there's hardly any such rules and only appealing guesses or good heuristics - so yeah lab is king
@michellearning It's not the main bottleneck - just as coding was never really the bottleneck. Yet coding agents are quite useful and enable to build many more things on the same components. Do agree there's much more to it than NL, but it does enable part of your last point
@Dorialexander Fair enough - maybe less about the data than abt the physical deployment of intelligence and the loops created out of that
@m_goes_distance Automated synthesis of complex molecules - synthesizing what the desgin models want b12-labs.com @b12Labs
If you want to get much much better performance in retrosynthsis and reaction optimization then just using LLMs, and actual execution of experiments talk to us we have been building and evaluating agents in this exact space for years. @b12Labs
New Anthropic Science Blog: Making Claude a chemist. To manipulate a molecule, chemists first need to understand its structure. Their main tool is NMR spectroscopy. We found Opus 4.7 matches—and on some tasks beats—dedicated NMR software. Read more: anthropic.com/research/makin…
@AnthropicAI Such an exciting direction! Esp what's next: synth planning and mechnisms. We did just that recently cell.com/matter/fulltex… and claude (Sonnet 3.7) was the first model ever achieve good scores at these tasks! We're continuing to build evals just for this at @b12Labs 🔥
Andrew White 🐦�... @andrewwhite01
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