DAShED @dashedstudy
Diagnosis of Acute Aortic Syndrome in the ED: An observational cohort study of people attending the ED with symptoms consistent of Acute Aortic syndrome (AAS) emergeresearch.org/trial/dashed/ Joined July 2022-
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High-sensitivity troponin has transformed MI detection, but front-door loading and unselective testing risk overdiagnosis & missed pathology. Our @EJ_EmergencyMed viewpoint article out today argues for reclaiming clinical reasoning in ED chest pain care journals.lww.com/euro-emergency…
🚨 Emergency Medicine Journal Club Acute Aortic Syndrome: Can decision rules help diagnosis? Join us for a discussion of the DAShED study, chaired by Prof. Gordon Fuller 🧠 🗓️ 30th Sept | 🕑 2–3pm 🔗 Register: us06web.zoom.us/webinar/regist…
Delighted our ASES study summary ‘Diagnostic strategies for suspected acute aortic syndrome; systematic review, meta-analysis, decision-analytic modelling & value of information analysis’ has been published in the @NIHRresearch HTA journal; download here: journalslibrary.nihr.ac.uk/hta/GGOP6363
Great to see @dashedstudy is the paper of choice for the next meeting of the new UK emergency medicine journal club on the 30th September at 2pm on Zoom, focussing around diagnostic approaches to acute aortic syndromes presenting to ED. Register here us06web.zoom.us/webinar/regist…
Case-control designs show high bias resulting in inaccurate estimates and lack of representativeness of test accuracy when applied in a clinical setting
Our ASES study also shows that diagnostic biomarkers for AAS, other than D-dimer, are not ready for routine clinical use. Large cohort studies are required to evaluate multiple biomarkers in an appropriate population with suspected AAS; emj.bmj.com/content/41/11/…
Primary research is required to evaluate this strategy in practice and determine how suspicion of AAS is identified
Our ASES decision analytical modelling of strategies for investigating suspected AAS shows that a strategy based on the Canadian clinical practice guideline using ADD-RS>1 or ADD-RS=1 with raised D-dimer to select patients for CTA appears cost-effective emj.bmj.com/content/early/…
I suggested a strategy based on D-Dimer & ADD-RS/Canadian will probably reduce the number of CTAs, be cost-effective & not lead to increased missed AAS but that a properly designed & funded implementation study is now required to provide clinicians with a safe effective strategy
What is the evidence around diagnosing Acute Aortic Dissection in the ED? At @EuropSocEM #eusem2024 I summarised the results of DAShED, ASES & PROFUNDUS. Here is a copy of my presentation; bit.ly/4f6Rr0l
Summary on aortic disection diagnostic by @HannahSchaubro1 #ESCGuidelines @escardio #ESCCongress 2024 #cvAcute
Catch up on the review of the @dashedstudy and get a sneak peek into DAShED2. Learn how this phase addresses what to do once #aorticdissection is considered but a CT scan isn't absolutely necessary. The recording is now available. #AortaEd aorticdissectioncharitabletrust.org/inside-look-at…
A great summary of the NIHR funded ASES study from Professor Steve Goodacre with insight from Valerie Lechene, an aortic dissection survivor who participated in the research
If you missed our live session, the replay of the ASES research webinar is now available. Delve into the latest on aortic dissection diagnosis with insights from experts and survivors. Don't miss out on this crucial #AortaEd aorticdissectioncharitabletrust.org/insights-from-…
Professor Matt Reed talks through the DASHED 2 trial
#ResearchLetter #March2024 Survey of current policy regarding the recognition and management of acute aortic syndrome in Great Britain emj.bmj.com/content/41/3/1… @AorticDissectCT @mattreed73 @RCollEM @emerge_research
#OriginalResearch #March2024 Diagnosis of Acute Aortic Syndrome in the Emergency Department (DAShED) study: an observational cohort study of people attending the ED with symptoms consistent with acute aortic syndrome emj.bmj.com/content/41/3/1… @mattreed73 @emerge_research
@EMManchester @RCEMLearning @KirstyChallen @robertohle Link to the publication pubmed.ncbi.nlm.nih.gov/37945311/
Thank you @TheSGEM for choosing to cover @dashedstudy and for a very thorough and fair review
Diagnosing acute aortic syndrome in the emergency department. thesgem.com/2024/02/sgem43… #EBM #FOAMed
We definitely need to sort out the question of what you do once you ‘think aorta’ when the patient doesn’t absolutely need a scan (2.5% in DAShED) because we cannot CTA everyone - DAShED2 is in preparation and will attempt to answer this key clinical question
@davehartin It’s worse than that @davehartin the @dashedstudy showed us that there are no ‘good’ screening tests, including gestalt to spot the diagnosis Simply thinking aorta won’t work More here at @stemlyns stemlynsblog.org/the-dashed-stu…
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