New publication in @NatureAging led by @gesalbla ‼️ Here, we propose and validate a staging system for #Alzheimer's disease based on fluid biomarkers nature.com/articles/s4358… A 🧵 ...
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We used SuStaIn to model the most likely sequence of CSF biomarker abnormalities that occur along the AD continuum. SuStaIn was used because it is a data-driven approach that unravels temporal progression patterns (stages) allowing for multiple different trajectories (subtypes).
@biofinder_study @NatureAging @gesalbla Intriguing 🤔🤔 @morrisjillk @jburns2