Alex McClelland @alexjmcclelland
PhD student working on proteases @TheSainsburyLab Norwich, England Joined January 2011-
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Really enjoyed writing this commentary with @wenboEffector. We highlight exciting work by Xiao et al (2024) and discuss the future of structure-guided engineering in disease management in agriculture. Check it out! @TheSainsburyLab @aBIOTECH5 link.springer.com/article/10.100…
0/ Very happy to announce my last PhD paper is finally out, years after my PhD completion. I had been very busy with my postdoc research, but made it back to this work! A journey into #Bioengineering secreted proteases for #PlantImmunity. 🌱🔬 biorxiv.org/content/10.110…
Bioengineering secreted proteases converts divergent Rcr3 orthologs and paralogs into extracellular immune co-receptors biorxiv.org/content/10.110…
A really lovely seminar today by student-invited speaker @gun_doe ! Thank you for visiting @TheSainsburyLab
WE HAD THE GREATEST RAIL AND TRANSIT SYSTEM IN THE WORLD AND WE RIPPED IT ALL OUT FOR CARS AND SPRAWL
Ufff… Sevilla half marathon done. Great weather and atmosphere. This was a collaboration between @unisevilla and @TheSainsburyLab 😁 #MedioSevilla24 #SevillaHoy @franfuerom @DraegerMarkus @pabdelcer @alexjmcclelland @daniel_luedke
Was fitting that I wore my @UCRiverside hoodie today, where @Hui84282116 joined us in the @wenboEffector lab over 4 years ago! We will miss you, Hui, at @TheSainsburyLab. Best of luck on your new adventures as a group leader! See you in Beijing 😉
The UK government changed the minimum income threshold to sponsor a partner visa from £18,600 to £38,700 overnight. Many families, including my own, may be forced either to live separately or to leave Britain to be together. Please sign this petition petition.parliament.uk/petitions/6526…
The UK government changed the minimum income threshold to sponsor a partner visa from £18,600 to £38,700 overnight. Many families, including my own, may be forced either to live separately or to leave Britain to be together. Please sign this petition petition.parliament.uk/petitions/6526…
I am thrilled to report a cool method for transgene-free plant genome editing in the T0 generation led by Drs. Xiaoen Huang and Hongge Jia. It is particularly useful for transgene-free genome editing of vegetatively propagated and perennial plant species. nature.com/articles/s4147….
Do you wanna hear about targeted gene knock-ins and purple potatoes? Then come along to poster P-255! #ISMPMI
If you’re at #2023ISMPMI, come and have a look at my poster at P-093! I am introducing my PhD project with @wenboEffector at @TheSainsburyLab focusing on bacterial effectors that hydrolyze NAD+ in the host plant cell! (Tomorrow 12:30-1:30pm)
Come visit my poster P081 on HLB disease at today from 12:30-1:15 pm. Would love to chat about transcriptional regulation of this obligate pathogen 🍊🧫#2023ISMPMI
Had a great time presenting at this year’s student ASM!
Had a great time presenting at this year’s student ASM!
Resurrected protease!! Our good ol' PIP1 is saved from the nasty potato blight pathogen... @Paradise_Mtian >> Enhanced late blight resistance by engineering an EpiC2B-insensitive immune protease. @MariSchuster et al. biorxiv.org/content/10.110…
Extremely excited to preprint this fascinating story. Spearheaded by super-talented postdoc Hui Li @Hui84282116 we found how virulence function diversity may be achieved in an effector repertoire! @TheSainsburyLab #mpmi #effectorsrock x.com/biorxiv_plants…
Extremely excited to preprint this fascinating story. Spearheaded by super-talented postdoc Hui Li @Hui84282116 we found how virulence function diversity may be achieved in an effector repertoire! @TheSainsburyLab #mpmi #effectorsrock x.com/biorxiv_plants…
Was my great pleasure to organize #TSLAM2023 with such a talented, enthusiastic group of scientists. A massive thanks to the student committee, our keynote @xanderjones82, and @brockingtonian for the botanic garden tour!
Was my great pleasure to organize #TSLAM2023 with such a talented, enthusiastic group of scientists. A massive thanks to the student committee, our keynote @xanderjones82, and @brockingtonian for the botanic garden tour! https://t.co/rjKKMxhQCg
Excited to share our new preprint on single cell transcriptome analysis of Arabidopsis-fungal interactions where we found cell type-specific expression of NLRs and infection-site-specific responses! Kudos to @BozengTang @LiFeng0630 and @sardineboy_DING doi.org/10.1101/2023.0…
Sophien Kamoun @KamounLab
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154 Followers 170 Following PhD student, John Innes Centre & Kew 🌿 working on diterpene biosynthesis with flasks and a computer ⚗️🖥️Maria Sindalovskaya @MSindalovskaya
344 Followers 868 Following Rotation PhD student at @JohnInnesCentreGetGenome @GetGenome
2K Followers 1K Following We empower scientists throughout the world by providing equitable access to genomics technology and genomics-related training and education.Postdoctoral Researcher (Hogenhout Group) - John Innes Centre - Applications are invited for a Postdoctoral researcher to join the group of Prof Saskia Hogenhout (twitter: @SaskiaHogenhout) at the John Innes ... - ift.tt/7bPIfpu
The Fellowship of the TSLytherins undertook an adventurous 5 km (turned 17 km) hike in the Peak District to wrap up #TSLAM2024 @TheSainsburyLab
Never forget that Dodger Stadium had to clear 1800 Mexican American families and three neighborhoods for a massive parking lot and stadium.
Scoring from first on a single? All in a day's work for Masyn Winn. 🔥
The Pmk1-regulated Vts1 is no match for the dedicated @pbamoah001 #TSLAM2024 whose characterization efforts have started to reveal a novel role in mediating appressorium development in the blast fungus
Had a great time presenting my work at #TSLAM2024. Big thanks to our keynote speaker, Dr Leo James from @MRC_LMB, and @mattrwengler for organising!
Great talk by @adnroide at #TSLAM2024 guiding us through the use of AF2 to identify novel effector targets
📄 New Publication: Zig, Zag, and ’Zyme: leveraging structural biology to engineer disease resistance @alexjmcclelland @wenboEffector @aBIOTECH5 Full text ➡️ link.springer.com/article/10.100… tsl.ac.uk/publications/1…
Set in a small town in Maine during the 1950s, an eight-year-old boy befriends a gentle alien robot at the same time a U.S. government agent arrives in the town to destroy it. Catch Brad Bird's THE IRON GIANT in 35mm on Sunday 26th May! 🎟 👉 bit.ly/2rMTsZA
@alexjmcclelland @wenboEffector @TheSainsburyLab Thank you, Alex! Appreciate very much!👍👍👍
Job alert‼️We are searching for a #postdoc to study the "Manipulation of protein translation by bacteria". If you're interested in #proteostasis, processing bodies, TOR, condensates & pathogens etc. apply ♻️ 🔬🦠 Please share 📢 More info here and below theustunlab.com/positions/
Arabidopsis WALL-ASSOCIATED KINASES are not required for oligogalacturonide-induced signaling and immunity biorxiv.org/content/10.110…
Miracle cure or wishful thinking? Proposed treatment for citrus greening gets mixed reviews from growers wuft.org/agriculture/20…
Landmark: a fungal effector with polygalacturonase (PG) activity produces immune-suppressive oligogalacturonides (OGs) as a virulence mechanism; however, when in a complex with PGIPs, PGs produce OG polymers with longer chains that can trigger immunity. science.org/doi/10.1126/sc…
A very good reading link.springer.com/article/10.100…
@BBCSport bruv any cricketer'd be jumping out of his trainers for a snag like that innit. you lot just running your gabber when that ball was absolutely twatted. proper catch that by mullins mate. class.
Feeling pretty good right now, just got back from court and the jury found me so not guilty that the judge gave me credit against a future crime of my choice. My lawyer told me "that almost never happens"