Hi, @M_Saad_Yousuf on the UTD CAPS account tweeting about my new paper (loom.ly/kXfcSH4) out in PNAS. Neuropathic pain affects 10% of the population. Here we establish TMEM97/Sigma2 receptor as a bona fide pain target using a highly specific TMEM97 modulator FEM-1689. 🧵
3
2
14
2K
1
@M_Saad_Yousuf We wanted to understand how targeting TMEM97 can reduce pain by addressing two important questions: do these sigma2R/TMEM97 compounds act selectively via the receptor, and what is their downstream mechanism on nociceptive neurons?
@UTDPainCenter @M_Saad_Yousuf Congrats @M_Saad_Yousuf @UTDPainLab and team 🎉 - look forward to reading this one.
@UTDPainCenter @M_Saad_Yousuf Congrats!!!!