Alejandra Tomás @TomasLab_ICL
Senior Lecturer in Cell Biology @imperialcollege. Interested in lipid and spatiotemporal regulation of signaling of metabolically relevant receptors. imperial.ac.uk/people/a.tomas… London, UK Joined June 2009-
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ER interactions enabling GLP-1RA-induced mitochondrial remodelling and optimal β-cell function #islets biorxiv.org/content/10.110…. @tomaslab_ikl @imperialcollege
Our data does indeed indicate that ER - mitochondria contact sites are very important for GLP-1R responses, hence we very much predict a role for these sites in type 2 diabetes and obesity
Our data does indeed indicate that ER - mitochondria contact sites are very important for GLP-1R responses, hence we very much predict a role for these sites in type 2 diabetes and obesity
A quick reminder about Denise Wootten's talk tomorrow at 11 am at the Hammersmith Campus, with free lunch afterwards and the opportunity to discuss with her. Hope to see lots of you there!
Thanks for joining us at #EMGPCRs2024! Over 2 days, we've seen invaluable insights and meaningful discussions exploring recent advances for new discoveries and therapeutic solutions. What were your key takeaways? 👇
Well done to Greg for a great presentation of our work on GLP-1R and GCGR signalling at membrane contact sites at the #EMGPCRs2024 meeting today in Birmingham
Our latest review on the regulation of the glucagon receptor family by lipids is now out: pubmed.ncbi.nlm.nih.gov/38614123/
Looking forward to Denise's visit and seminar. Hope to see loads of Network Members there to hear about her research and for a chance to meet her over (free!!) lunch afterwards.
Looking forward to Denise's visit and seminar. Hope to see loads of Network Members there to hear about her research and for a chance to meet her over (free!!) lunch afterwards.
Great job @YusmanManchanda presenting her data on GIPR variants @ EISG 24. Well done!
cell.com/cell-reports/f… Excited for my first first-author paper! I'd like to thank all the co-authors @msolimena @miRNA375 @Andi_Microscopy @TomasLab_ICL for their contribution, especially Dr. KiaWee Tan and my supervisor @Oidevall for their guidance during this crazy journey!
#Epigenetic studies reveal differential DNA methylation at Nnat represents a novel means through which beta cell heterogeneity is established during development #islets #diabetes @DiabetologiaJnl link.springer.com/article/10.100… #insulin
Very proud to be leading this exceptional team and project which aims to change the landscape on metabolic GPCR targeting 👇
Very proud to be leading this exceptional team and project which aims to change the landscape on metabolic GPCR targeting 👇
It is not everyday that one gets to celebrate getting a Wellcome Trust Discovery Award funded. Congratulations also to my co-applicants: @Emma_R_McGlone @TateScience @Bernardino_Lab Christian Siebold, Ben Jones, Sarah Rouse
This event will include presentations from MDR's @gfrost59, @TomasLab_ICL and Prof Tricia Tan. Sign up to find out more about "Medical therapy for weight loss: from research to reality" ⬇️ x.com/imperialmed/st…
This event will include presentations from MDR's @gfrost59, @TomasLab_ICL and Prof Tricia Tan. Sign up to find out more about "Medical therapy for weight loss: from research to reality" ⬇️ x.com/imperialmed/st…
imperial.ac.uk/imperial-membr… Be part of the Endocrine Metabolic G-protein coupled receptors (EM GPCRs) Meeting 2024 Join us in Birmingham on 22 and 23 April 2024
Jim Johnson, PhD @JimJohnsonSci
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453 Followers 228 Following interested in #mitochondria and #metabolism. 🇮🇹🇪🇸🇺🇸 Professor at UAM university 🐠Wade-Martins Lab @WadeMartinsLab
2K Followers 338 Following Molecular Neurodegeneration Lab (Richard Wade-Martins) Oxford Parkinson's Disease Centre (@OxfordPDCentre) & Alzheimer's Research UK (@ARUKThamesV) Network.Aishwarya Vedula @AishwaryaVedul
20 Followers 153 FollowingMitochondrial sites of contact with the nucleus. Michelangelo Campanella and Brindha Kannan @QMUL, discuss recent studies on membrane contact sites between #mitochondria and the #nucleus, incl. work by @SheinerLab (hubs.la/Q02v9j2M0) in Viewpoint: hubs.la/Q02v9q910
Human ESCRT-I and ALIX function as scaffolding helical filaments in vivo biorxiv.org/content/10.110…
🏆 CBMR Professor Jens Juul Holst is named to the inaugural 2024 TIME100 Health! @TIME's annual list of 100 individuals recognizes the impact, innovation, and achievement of the world’s most influential individuals in global health this year. He is recognised alongside Dr. Dan…
Sneaking the gif just under the size limit for #FluorescenceFriday (COS cell labeled for actin ⚪️ microtubules 🩷 clathrin 🟠 and DNA 🔵)
I am pleased to report that my septicemia has receded. Blood cultures are thus far negative, and I feel more energetic. For details, you can read the thread (but you don’t need to). The important bit is: the next genetic screens won’t need to be performed up in heaven.
For #FluorescenceFriday, one of my favourite imaging session ever, with Håkon Høgset, imaging neutrophils and macrophages in #zebrafish On a @LeicaMicro SP2 confocal (!) 😎
Our paper in Endocrinology "Impact of COVID-19 on the Endocrine System – a mini-review" pubmed.ncbi.nlm.nih.gov/34543404/ was one of the top 10 percent of articles in 2022-2023, as assessed by rate of citation @drsophieclarke @robertobaggio99 @ImperialMDR @ImperialBRC
A new paper out (with our humble contribution): blocking ERO-1α reduces ER H2O2, shielding cells from fat-induced harm Non-esterified fatty acid palmitate facilitates oxidative endoplasmic reticulum stress and apoptosis of β-cells by upregulating ERO-1α sciencedirect.com/science/articl…
#FluorescenceFriday #cellbiology #bioart Mitochondrial dynamics in a cultured pig kidney cell (LLC-PK1) at 3 volumes/min for 97 min by two-photon Bessel beam plane illumination microscopy. doi.org/10.1038/nmeth.…
Membrane mimetic-dependence of GPCR energy landscapes dlvr.it/T6Kx1h
Setmelanotide in 19 patients with acquired hypothalamic #obesity thelancet.com/journals/landi…
Researchers created mechanochromic cholesteric liquid crystal elastomers that change color with mechanical deformation. This tech could have big implications for visual signaling. Find out more: ow.ly/t6jr50RuAsF
Make a boy a sandwich and he’ll eat for a day. Teach a boy to make sandwiches and your entire kitchen will be a disaster zone.
#FluorescenceFriday #cellbiology #bioart @wonderofscience 4D organelle remodeling in dividing HeLa cells. Please expand to see greater detail. Left: 3D volumes of chromosomes, mitochondria, and the endoplasmic reticulum (ER) in whole cells. Middle: Inner details revealed in…
New! Online now: The mitochondrial multi-omic response to exercise training across rat tissues dlvr.it/T6KTp8
FLIM unmixing is a powerful method for Live cell multicolor imaging. In a recent article from the team led by Ludovic Galas, SPY650-FastAct, SPY620-DNA and SiR700-actin were used to illustrate the principle using a @LeicaMicro FALCON system and the intuitive phasor plot…
It’s time for the last new #Type1DiabetesGrandChallenge #research project spotlight! 🌟 Prof @daveyboyhod, Dr @IldemAkerman & Dr @BroichhagenJ are pioneering new approaches to replace, protect and regenerate insulin-making beta cells in the pancreas. 👉 orlo.uk/Lg1xS
Enjoying the opportunity to team up with @IldemAkerman and @BroichhagenJ to apply some of our understanding of incretin receptors to type 1 diabetes!
It’s time for the last new #Type1DiabetesGrandChallenge #research project spotlight! 🌟 Prof @daveyboyhod, Dr @IldemAkerman & Dr @BroichhagenJ are pioneering new approaches to replace, protect and regenerate insulin-making beta cells in the pancreas. 👉 orlo.uk/Lg1xS
Limiting intracellular accumulation of ceramides in hPSC-β cells remarkably enhanced their function, as indicated by improvements in #insulin processing and glucose-stimulated insulin secretion #islets #stemcells #diabetes @CellStemCell cell.com/cell-stem-cell…