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Following109
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Interested in adding a splash of water to your ligand discovery campaign? Check out our latest article: nature.com/articles/s4159…
A GUI that seamlessly integrates FLEXR electron density based multi-conformer model building into Coot1's modeling and validation tools. journals.iucr.org/j/issues/2024/…
Selective CK1α degraders exert antiproliferative activity against a broad range of human cancer cell lines. Exemplifies the power of collaboration at @StJudeResearch by CBT Chemistry Centers, @KlcoLab and @TheFischerLab funded by @AlexsLemonade. nature.com/articles/s4146…
The opus magnum of our PhD student Fatemeh, now @KymeraTx, is out in @BloodJournal in collaboration with the @CMullighan lab: The orally bioavailable GSPT1/2 degrader SJ6986 exhibits in vivo efficacy in acute lymphoblastic leukemia. ashpublications.org/blood/article-…
We're at it again, but even better! Please join us virtually or in person at St. Jude for 2023 Bringing Chemistry to Medicine! @StJudeResearch bit.ly/BC2M_2023
Like comparing apples to apples, comparing similar proteins can be challenging. Scientists in @TheFischerLab developed a tool to help, which garnered new insights into the chaperone protein HSP90—an essential target in cancer. Read about their work. bit.ly/3LMhQVf
FLEXR uses Ringer-based electron-density sampling to build explicit multi-conformer models for refinement, capturing conformations in ligand-binding sites that were undetected using other methods. #CrystallographicRefinement #ModelBuilding doi.org/10.1107/S20597…
Room-temperature crystallography reveals altered binding of small-molecule fragments to PTP1B doi.org/10.7554/eLife.…
Interested in water in ligand binding sites? Our newest paper applies RE-EDS to study the thermodynamics of water networks in protein cavities. pubs.acs.org/doi/10.1021/ac…
New research from @TheFischerLab published in the Journal of Medicinal Chemistry has revealed distinct targetable hotspots on #HSP90, an important target in cancer. bit.ly/3SRxpwt @ACSBioMed
Thrilled to see @TheFischerLab's latest work on how "Water Networks Repopulate Protein-Ligand Interfaces With Temperature" out in @angew_chem. onlinelibrary.wiley.com/doi/10.1002/an…
Excited to see our collaborative work on the “Degradation of Janus kinases in CRLF2-rearranged acute lymphoblastic leukemia” appear as a Plenary Paper in @BloodJournal with @CMullighan and #stjuderesearch CBT Chemistry Centers. authors.elsevier.com/a/1eDN%7E1UYwb…
What's under your mask? Happy #Movember2021! Support here: movember.com/m/mogul123?mc=1 Join here: movember.com/t/memstache?mc…
The Nabet lab @fredhutch is recruiting a highly motivated postdoc to join our supportive/collaborative team! Interested in developing targeted protein degradation technologies and advancing proximity-induced therapeutic strategies? Please RT & apply here: careers-fhcrc.icims.com/jobs/20699/pos…
Phenyl-Glutarimides improve PROTAC stability. Another great collaboration with the CBT ChemistryCenters @StJudeResearch and @TheFischerLab (and many others) just appeared in @angew_chem. onlinelibrary.wiley.com/doi/10.1002/an…
Postdoc position in computational structural biology in @TheFischerLab available right now! Please re-tweet :)
@TheFischerLab has an available #postdocposition in computational #structuralbiology for a very cool project on #ligand discovery bit.ly/FischerPDCSB @blkwomencompbio @StJudeResearch #compbio #LXChemBio
💥Enhanced sampling strikes again: we used aMD to see a buried apolar cavity open up to solvent, feeding this thermodynamic info to DOCK3.7 we saw some really cool new chemistry that also showed up in the beautiful crystals from Isha Singh 🎉🎉 #compchem #cadd @PNASNews
@TheFischerLab has an available #postdocposition in computational #structuralbiology for a very cool project on #ligand discovery bit.ly/FischerPDCSB @blkwomencompbio @StJudeResearch #compbio #LXChemBio
Expanding the chemical toolbox for bromodomain PHD finger transcription factor BPTF in a fun whirlwind collaboration with @fewill26 and @TheFischerLab. pubs.acs.org/doi/10.1021/ac…
Thanks to RSC @ChemistryWorld for a *cool* feature of our recent @ChemicalScience article pubs.rsc.org/en/content/art…
New research suggests that sampling only at cryogenic temperatures could be making things murky for structural data, leading to irritating cryo-artifacts chemistryworld.com/news/overrelia…
🎉 Issue 34 is here! 🎉 Marcus Fischer (@TheFischerLab) et al.'s recent #ChemSciPicks article is featured on the front cover 😍 Read it here ➡️ Temperature artifacts in protein structures bias ligand-binding predictions 🔗 ow.ly/htjA50G2PSZ 📍 @UCIrvine | @StJudeResearch
St. Jude Research @StJudeResearch
33K Followers 2K Following St. Jude Children’s Research Hospital: a leader in research & treatment of pediatric cancer & childhood diseases. #BestHospitals #StJudeResearch
Kresten Lindorff-Lars... @LindorffLarsen
15K Followers 2K Following Protein and coffee lover, father of two, professor of biophysics and sudo scientist at the #LinderstrømLang Centre for Protein Science 🇩🇰
John Chodera (he/him) @jchodera
9K Followers 7K Following Changing drug discovery one ratio of partition functions at a time. Heading up antiviral discovery for pandemics: https://t.co/uN4XpX1mjt https://t.co/YAg9PBYuBl
Gabriel Rocklin @grocklin
3K Followers 604 Following High-throughput protein design and biophysics | Asst Prof, Northwestern Pharmacology @NuFeinbergMed @NUSynBio.
Dan Nomura @DanNomura
19K Followers 9K Following Professor of Chemical Biology and Molecular Therapeutics at UC Berkeley; Departments of Chemistry and Molecular and Cell Biology; Co-Director of @MTI_UCB
JK Lyu @Jiankun_Lyu_
466 Followers 555 Following Assistant professor @RockefellerUniv, former postdoc in @BShoichet lab @UCSF.
HalicLab @LabHalic
704 Followers 260 Following Dept. of Structural Biology, St. Jude Children's Research Hospital @StJudeStructBio
London Lab @london_lab
4K Followers 663 Following A computational and chemical biology lab at the Weizmann Institute of Science.
Ryan Potts @pottslab
2K Followers 364 Following VP & Head of Induced Proximity Platform, @Amgen | Scientist | Father
Olalla Vázquez @OlallaLab
8K Followers 4K Following Professor of Chemical Biology at @Uni_MR. Optochemical tools for controlling biological processes at molecular level. Epigenetic chemical probes. Be Light!✨✨
Milka Kostić, PhD @MilkaKostic
4K Followers 3K Following Director of @DFCI_ChemBio pursuing innovation, translation & transformation through #chemicalbiology. Opinions and views strictly my own!
Soojung Yang @SoojungYang2
1K Followers 1K Following AI+simulation for biochemistry! | Postdoc @Stanford | Researcher @MSFTResearch | Previously @MIT PhD
Blythe @BrittanySe51458
0 Followers 81 Following Surfing addict, riding the waves. Craving a partner to catch the best swells and enjoy beach life.
nothing interesting @thientr25
1 Followers 24 Following
Prateek Bansal @thepdbguy
135 Followers 299 Following PhD @ChBE_Illinois | Computational Biophysics | Chemical Engineering @ICTMumbai1933 | 🏳️🌈(he/him)
Vajja Krishna Rao @VKRMedChem
180 Followers 2K Following Postdoctoral Research Fellow at the University of Alabama | UHN Toronto | IIT Kanpur | PhD from NIPER Mohali
Chase @Chase22555361
183 Followers 484 Following SMC, CWRU, UCSF, Columbia. My views are my own. Into rock climbing, basketball, chemistry, opioids, and GPCRs.
Crys Reed @crysreed84
0 Followers 3 Following
Lucas Souza @lucassansouza
112 Followers 222 Following PhD stud in Microbiology at @icb_usp and StrucBio at @univgroningen | Into biochemistry/physics of membrane proteins 🔬🧬🦠🏳️🌈 @[email protected]
Johannes Morstein @mo_hannes
1K Followers 1K Following Assistant Professor @CaltechCCE | Chemical Biologist
Jongwan Kim @Jongwani_
0 Followers 15 Following
Stoughphou @stoughphou35878
18 Followers 2K Following I hope that I will be mature and stable and survive the desperate situation and live a better life.
Matthew Bowler @moncourvoisier
700 Followers 1K Following 🇪🇺 🇬🇧 🇺🇸 🇫🇷 scientist, project leader @EMBL @esrfsynchrotron #beamline @ID30_MASSIF1 #kinases #pathogens co-editor 📓 @ActaCrystF opinions my own
Faten Okda @OkdaFaten
669 Followers 6K Following DVM, PhD, K99/R00 NIH/NIAID-Postdoc-molecular and diagnostic virology-infectiousdiseasesdepart-#Webby’s lab-WHO collaboration lab-influenza viruses-CEIRS.
Suresh Kumar, PhD @DrKumar_Suresh
114 Followers 353 Following Protein Biochemist and Structural Biologist
Hsp90 Chaperone Machi... @Hsp90Machine
435 Followers 176 Following
Brittany Pioso @brittpioso
97 Followers 313 Following (don’t ask me what year) year PhD candidate @ St. Jude Graduate School of Biomedical Sciences 👩🔬🧬🔬🧫 @stjuderesearch @kriwacki @stjudegraduate
huyt @neet9898
3 Followers 243 Following
Baharul Islam, Ph.D. @DrBee_9
82 Followers 390 Following Ph.D. in MedChem | Postdoc in Radiopharmaceuticals Development | Boston-based Biotech Scientist | Permanent Resident in the USA
Istaq Ahmad @istaqahmad
273 Followers 5K Following Research Coordinator Department of Neurology, AIIMS New Delhi India
Zuzanna Kozicka @zkozicka
683 Followers 500 Following TT Assist. Prof. @EPFL, Postdoc @DFCI @HarvardMed @BroadInstitute, previously PhD @LabThoma, Forbes 30U30 2023, @EdinburghChem (she/her)
Ilona Jóźwik @IlonaJozwik
284 Followers 1K Following Structural biologist, PhD @univgroningen, NL; Originally from Poland.
Iva Marković @MarkovichIva
84 Followers 265 Following 💎 Structural biology 🛠 Protein engineering 🟠 Cytokines Postdoc @SavvidesLab, @InflamResCen & @UGent || @VIBLifeSciences
Mohit @mohitasya
428 Followers 1K Following Team Leader @iDikic2 lab @Proxidrugs Ubiquitin enthusiast with expertise in structural biology
BenCree @ChemCree
242 Followers 1K Following Postdoc @RIKEN, PhD from @ColegroupNCL Newcastle University. Computational Chemist/Drug Design & Open Source Dev. Fan of SC2. An English flavoured scientist.
Sthitadhi Maiti @sthitadhi_m
302 Followers 3K Following Truthseeker, Chemistry Ph.D student at Arizona State University
Shantanu Shukla, Ph.D @shaanbdu
144 Followers 758 Following Postdoctoral fellow at Fred Hutchinson Cancer Center . Structure and dynamics of bacterial and viral proteins and their molecular function. Views are my own.
Cowen Lab @CowenLab
2K Followers 627 Following Research team at the University of Toronto working to better understand fungal pathogens and how to treat them! Account managed by @NM_Robbins
Carrie Crunk @Carrie_CrunkSJ
4 Followers 28 Following Providing support to the postdoctoral fellows at St. Jude Children's Research Hospital
Hannah Snoke @SnokeHannah
19 Followers 67 Following
van Oosten-Hawle lab @HawleLab
682 Followers 550 Following Twitter feed of the van Oosten-Hawle lab Assistant Professor @unccharlotte
Agard Lab @AgardLab
797 Followers 71 Following Structural Biology/Biochemistry Lab @UCSF #cryoEM Tweets by lab members
Kiran T. Patil @KiranPatil98
34 Followers 578 Following M.Pharm in Pharmaceutical(Medicinal) Chemistry @cup_bathinda 🇮🇳 | Pharmacist
BioBRU Lab @Bio_BRU
347 Followers 788 Following Official Twitter account of Edkins lab and the Biomedical and Biotechnology Research Unit (BioBRU) at Rhodes University, RSA. Views personal not Rhodes Uni.
Kasia Tych @BiophysK
2K Followers 4K Following Single molecule biophysicist, Tenure track assist. prof. at the University of Groningen. Enjoys food, bouldering, silliness & science. @biophysk.bsky.social
Anthony Harrison @antmarkharrison
147 Followers 110 Following Director of The Collaborative Library, Clinical Psychologist in Bradford, Teaching Fellow at King's College. Varied research interests. All views my own.
Ogunsola Oluwatosin @Ogunsolatosin_1
100 Followers 915 Following Lover of God|Mother|Biochemist|Data Analyst|Data Scientist| Drug Discovery enthusiast| Fellow, Women in Artificial Intelligence
Sara J. Weaver, Ph.D. @sarajweaver
989 Followers 2K Following Structural biologist in pharma. Post doc @GonenLab @UCLA. PhD @theJensenLab @Caltech. https://t.co/KqIWKvaWLd
MariaGiovannaEva @MGEPapadopoulos
29 Followers 126 Following
St. Jude Graduate Sch... @stjudegraduate
917 Followers 173 Following #StJude Graduate School of Biomedical Sciences: leading-edge science, unparalleled resources & unique clinical experiences for the next generation of scientists
Gabriele D'Uva @gabrieleduva
353 Followers 922 Following Researcher in #HeartRegeneration, #Cardiotoxicity and #Cancer. Professor of Molecular Biology at University of Bologna/IRCCS Sant'Orsola. President of RIE.
St. Jude Research @StJudeResearch
33K Followers 2K Following St. Jude Children’s Research Hospital: a leader in research & treatment of pediatric cancer & childhood diseases. #BestHospitals #StJudeResearch
Kresten Lindorff-Lars... @LindorffLarsen
15K Followers 2K Following Protein and coffee lover, father of two, professor of biophysics and sudo scientist at the #LinderstrømLang Centre for Protein Science 🇩🇰
John Chodera (he/him) @jchodera
9K Followers 7K Following Changing drug discovery one ratio of partition functions at a time. Heading up antiviral discovery for pandemics: https://t.co/uN4XpX1mjt https://t.co/YAg9PBYuBl
Structural Biology at... @StJudeStructBio
2K Followers 13 Following Dept. of Structural Biology, St. Jude Children's Research Hospital @StjudeResearch
Craig Crews @CraigMCrews
9K Followers 933 Following Yale Professor, Founder of @ArvinasInc, Halda Therapeutics, https://t.co/YoR6Yo3d3u, @[email protected]
Gabriel Rocklin @grocklin
3K Followers 604 Following High-throughput protein design and biophysics | Asst Prof, Northwestern Pharmacology @NuFeinbergMed @NUSynBio.
Jen Heemstra @jenheemstra
92K Followers 12K Following Professor and Chair of @WashUChem, proud member of @HeemstraLab. I'm a researcher, but I'm a #MentorFirst. Author of Labwork to Leadership.
Keith Hornberger @KRHornberger
12K Followers 260 Following TPD-med chem-hiking-cocktails / while I have a connection to Arvinas, all opinions expressed are mine and do not represent the views or positions of the company
Practical_Fragments @PracticalFrag
1K Followers 13 Following A blog founded by Teddy Zartler and run by Dan Erlanson for Fragment-based Drug Discovery devotees to discuss non-confidential issues regarding fragments.
Kriwacki Lab @kriwacki
1K Followers 115 Following The Kriwacki lab seeks to understand the role of conformational disorder in protein function. Account run by lab members. @StJudeStructBio
Frank Noe @FrankNoeBerlin
13K Followers 568 Following Scientist, #MachineLearning and #AI for the Sciences (esp. Physics/Chemistry). Scuba Diver and Traveler.
JK Lyu @Jiankun_Lyu_
466 Followers 555 Following Assistant professor @RockefellerUniv, former postdoc in @BShoichet lab @UCSF.
Tamir Gonen @gonenlab
6K Followers 455 Following Drug discovery; chemistry; Biophysics; Membrane proteins; #cryoEM; crystallography; #MicroED; Opinions my own. 👋👋👋
HalicLab @LabHalic
704 Followers 260 Following Dept. of Structural Biology, St. Jude Children's Research Hospital @StJudeStructBio
London Lab @london_lab
4K Followers 663 Following A computational and chemical biology lab at the Weizmann Institute of Science.
Ryan Potts @pottslab
2K Followers 364 Following VP & Head of Induced Proximity Platform, @Amgen | Scientist | Father
Jay Bradner, M.D. @jaybradner
23K Followers 913 Following Physician-scientist making medicines with friends, memories with family. EVP R&D at Amgen
The Roberts Lab @TheRobertsLab1
1K Followers 244 Following The lab of Charlie Roberts at @stjuderesearch studying SWI/SNF chromatin remodeling complex. Tweets are from lab members unless signed CR.
Milka Kostić, PhD @MilkaKostic
4K Followers 3K Following Director of @DFCI_ChemBio pursuing innovation, translation & transformation through #chemicalbiology. Opinions and views strictly my own!
Mehdi Mollapour PhD @MedMol
600 Followers 322 Following Professor of Urology, Biochemistry & Molecular Biology | Upstate Medical University
Doug Kojetin @DougKojetin
1K Followers 3K Following Structural biologist, molecular pharmacologist, & professor | #nuclearreceptors | #NMR | @VanderbiltU @VUBasicSciences @VandyBiochem @VanderbiltCSB | same on 🦋
The Klco Lab @KlcoLab
265 Followers 230 Following The Klco lab at @stjuderesearch - Defining the molecular and biological causes of pediatric myeloid tumors
Chia-Hsueh Lee @TheCHLeeLab
577 Followers 332 Following Associate Member, Dept. of Structural Biology, St. Jude Children's Research Hospital @StJudeStructBio
Richard @Richard_E_Lee
566 Followers 903 Following A medicinal chemist with a passion for antibacterial drug discovery. My thoughts are my own.
Roland Dunbrack 🏳�... @RolandDunbrack
4K Followers 2K Following Comp struct bio. Gay&proud 🏳️🌈. Views my own & not my employer's.
Johannes Morstein @mo_hannes
1K Followers 1K Following Assistant Professor @CaltechCCE | Chemical Biologist
Matthew Bowler @moncourvoisier
700 Followers 1K Following 🇪🇺 🇬🇧 🇺🇸 🇫🇷 scientist, project leader @EMBL @esrfsynchrotron #beamline @ID30_MASSIF1 #kinases #pathogens co-editor 📓 @ActaCrystF opinions my own
Christina Wang @cewang35
182 Followers 114 Following PhD candidate in the @Ogden_Lab at @stjudegraduate | Vandy ‘19| Views are my own
Kate Stafford @kastacholamine
2K Followers 3K Following AI/ML for proteins, small molecules, and everything in between. VP ML @Numerionlabsai (fka Atomwise). 🌈 Previously: UCSF, Columbia, DE Shaw Research, MIT.
Zuzanna Kozicka @zkozicka
683 Followers 500 Following TT Assist. Prof. @EPFL, Postdoc @DFCI @HarvardMed @BroadInstitute, previously PhD @LabThoma, Forbes 30U30 2023, @EdinburghChem (she/her)
Shantanu Shukla, Ph.D @shaanbdu
144 Followers 758 Following Postdoctoral fellow at Fred Hutchinson Cancer Center . Structure and dynamics of bacterial and viral proteins and their molecular function. Views are my own.
Cowen Lab @CowenLab
2K Followers 627 Following Research team at the University of Toronto working to better understand fungal pathogens and how to treat them! Account managed by @NM_Robbins
Matthew O’Meara @momeara
778 Followers 3K Following Assistant professor at UMich with a focus on computational pharmacology. (he/him)
Will Pomerantz @Fe_Will26
463 Followers 299 Following Prof. of Chemistry at UMN, Fluorophile, epigenetics afficiando, coffee geek, and proud dad
Riniker lab @ ETHZ @rinikerlab
918 Followers 28 Following
BioBRU Lab @Bio_BRU
347 Followers 788 Following Official Twitter account of Edkins lab and the Biomedical and Biotechnology Research Unit (BioBRU) at Rhodes University, RSA. Views personal not Rhodes Uni.
Kasia Tych @BiophysK
2K Followers 4K Following Single molecule biophysicist, Tenure track assist. prof. at the University of Groningen. Enjoys food, bouldering, silliness & science. @biophysk.bsky.social
Agard Lab @AgardLab
797 Followers 71 Following Structural Biology/Biochemistry Lab @UCSF #cryoEM Tweets by lab members
van Oosten-Hawle lab @HawleLab
682 Followers 550 Following Twitter feed of the van Oosten-Hawle lab Assistant Professor @unccharlotte
Ranok Therapeutics @RanokTx
334 Followers 119 Following Ranok is pioneering Chaperone-mediated Protein Degradation (CHAMP) technology to treat cancer. #proteindegradation
Understanding Life in... @AstburyCentre
3K Followers 1K Following Astbury Centre. Now posting on https://t.co/7zq5Rscxbv
@rikemw.bsky.social @rike_mw
926 Followers 1K Following
Nature Chemistry @NatureChemistry
260K Followers 1K Following A chemistry journal from @NaturePortfolio & @SpringerNature.
William L. Jorgensen @JorgensenWL
6K Followers 821 Following Chemistry Prof @ Yale; founding Editor JCTC; OPLS, TIPnP, FEP, Drug Design
Rommie Amaro @RommieAmaro
8K Followers 934 Following Professor @UCSanDiego. Computational chemist & biophysicist, multiscale modeler. Viruses. Cancer. Unapologetically molecular.
André Richters @AndreRichters
103 Followers 143 Following Scientist | Chemical Biology | Cancer Research | Drug Discovery | Targeted Degradation Strategies | Spartan Race Enthusiast
The Colombo Lab @lab_colombo
2K Followers 2K Following Giorgio Colombo's Computational Chemistry and Biology Lab; Always Room for Improvement; University of Pavia, Italy. @lab-colombo.bsky.social
Paul Robustelli @PaulRobustelli
4K Followers 1K Following Assistant Professor at Dartmouth College Computational Biophysics / Disordered Proteins / Molecular Recognition
Structural Biology @ActaCrystD
3K Followers 413 Following Acta Crystallographica Section D: Structural Biology is a leading structural biology journal published by the IUCr.
hai dao @ongnghiem
270 Followers 319 Following Assistant Member, St. Jude Faculty/Chemist, Chromatin Biochemist
Behnam Nabet @behnamnabet
1K Followers 525 Following Assistant Professor @fredhutch | dTAG designer | Proud Husband & Baba | He/Him/His
Dorothee Kern @DorotheeKern
1K Followers 78 Following Professor at Brandeis University and HHMI. Using biophysical techniques to unravel the dynamic personality of proteins and study their evolution.
Debora Marks @deboramarks
5K Followers 203 Following Mission: design of biological interventions for environment and human health (to save the world)
Simon Olsson @smnlssn
3K Followers 1K Following Associate Professor at @chalmersuniv. @WASP_Research Fellow. ELLIS Member.
Inês Chen @Ineschen0
386 Followers 86 Following Director of Scientific & Strategic Operations Department of Structural Biology St. Jude Children's Research Hospital @StJudeStructBio Opinions my own.
Björn Rissiek @BjrnRissiek
152 Followers 399 Following Father of one, likes neuroimmunology, T cells, purinergic signalling, nanobodies, fly fishing and electric guitars. My opinion are my own.
Angewandte Chemie @angew_chem
114K Followers 3K Following Angewandte Chemie, a journal of the German Chemical Society (GDCh, @GDCh_aktuell) - a leading journal in #chemistry published by @WileyGlobal in @Weinheim
ProfG @ProfG101
2K Followers 270 Following Professor at the University of York; workwise interested in enzymes, carbohydrate & chemical biology. I have stopped tweeting now. Views are my own.
M. Madan Babu @m_madan_babu
2K Followers 2K Following Dept. of Structural Biology, St. Jude Children's Research Hospital Chair in Biological Data Science Director, Center for Data Driven Discovery @StJudeStructBioYou might like
