Steve Sweet @SteveMSweet
Scientist working at AstraZeneca, with interests in proteomics, cancer biology, clinical trials, bioinformatics, mass spectrometry, chromatin and DNA damage. astrazeneca.com Maryland, USA Joined May 2012-
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1/10📢Thrilled to announce our new preprint! In this work, we describe a new method called TREX for unbiased discovery of proteins that directly bind to a given region of an RNA of interest. And all this is from living cells under endogenous settings! #RNA biorxiv.org/content/10.110…
(1/8) I’m excited to show off our new work on low-input proteomics with a linear ion trap led by @teerap16 in collaboration with @erwinschoof and @jespervolsen! biorxiv.org/content/10.110… Here’s a quick tweetorial on how we measured single cells on a LIT
#ASMS2023 Check out our clinical proteomics work today at TP 712 "Quantitative Target Engagement for a KRASG12C Inhibitor in FFPE Tumor Tissue." Join us in pushing proteomics forward in the clinic at AstraZeneca, Washington DC careers.astrazeneca.com/job/gaithersbu…
Heading into this Mother’s Day weekend, was thinking about what I’d like so much more than bottomless mimosas or another scented candle. A little 🧵
Single-cell proteomics works now on complex tissues – Single Cell Deep Visual Proteomics (scDVP)! We are releasing a spatial map of single liver hepatocytes acquired by mass spectrometry bit.ly/scDVP Depth: 1,700 proteins. What is this about?
We have another great Clinical Proteomics position available, here in Gaithersburg, MD. Please feel free to reach out to me with any questions, and share with your networks! #proteomics #TeamMassSpec astrazeneca.wd3.myworkdayjobs.com/Careers/job/US…
Our group is recruiting! #clinical #proteomics lab manager position, based in Gaithersburg, MD. 🧪⚕️💊🩺Please share with your network 👍 bit.ly/3gi2BpG
We have a job opportunity for a postdoc with experience in proteomics data analysis to work in a CRUK funded project in collaboration with @HHochegger qmul.ac.uk/jobs/vacancies…
My colleague Pedro Cutillas is recruiting a postdoc for a proteomics project together with my lab. Please get in touch if you are interested qmul.ac.uk/jobs/vacancies…
Looking forward to talking about our @AstraZeneca Clinical Proteomics group and FAIMS-PRM at the @EvosepBio webinar on 29th Sep! #proteomics #TeamMassSpec evosep.com/webinars/webin…
🧵Why publishing in selective journals costs so much: Journals pay staff to handle papers (& pissed-off authors). If a journal gets 200 papers a month, pays 2 staff to handle them, but only publishes 20 papers, those 20 authors must pay the full cost of the staff salaries. (1/8)
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2K Followers 736 Following Director of the Tow Center for Developmental Oncology @MSKCancerCenter | #MSKKids oncologist | @KentsisResearch biologist | Views my own | Join us!Timothée Olivier, MD @Timothee_MD
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418 Followers 677 Following Assistant Professor @UZH_en @SIAF_UZH Precision Proteomics I Biomarker discovery I Immunology I Systems Biology. Previously @Cambridge_Uni @TheCrick @RalserLabFor those interested in what I'm up to, please find some information below. TLDR: I have started a glycoscience company aiming to accelerate glycoscience research.
Hello Glyco World. We are a new #glycotime company with the central aim of accelerating glycoscience research. We intend to do this in three ways: - consulting - analytical services - glyco standard manufacturing Find out more here: proteaglyco.com
1/10📢Thrilled to announce our new preprint! In this work, we describe a new method called TREX for unbiased discovery of proteins that directly bind to a given region of an RNA of interest. And all this is from living cells under endogenous settings! #RNA biorxiv.org/content/10.110…
In Houston for #ASMS2023 with six fantastic scientists from @talusbio. We'll be actively sharing what we're doing with the #TeamMassSpec community this week, from our research to our pipelines to our vision for the future. Here's where you can find us talusbio.github.io/talusbio-at-as…… 🧵
I’ll be up at 10am. Let’s go #TeamMassSpec! @SCIEXnews
#TeamMassSpec get up! Come hear the latest at the @SCIEXnews Symposium! Starting soon! I’ll be giving a talk on our initial work on the ZenoTOF 7600 w/EAD.
Preparations underway for the NAR editors’ meeting in Dublin this weekend. @NAR_Open
Our new preprint showcases the use of @QIAGEN AllPrep kit's flow-through protein fraction for high-quality proteomics (>9000 proteins) from tumor biopsies. This enables genomics, transcriptomics, and proteomics from the same sample for precision oncology. biorxiv.org/cgi/content/sh…
Heading into this Mother’s Day weekend, was thinking about what I’d like so much more than bottomless mimosas or another scented candle. A little 🧵
Today is the 100th anniversary of #FredMcLafferty’s birth (born May 11, 1923 in #Evanston, IL). His academic offspring in Evanston, celebrated his impact via the 1st #NationalProteoformDay. We cut cake & shared happy memories; consider joining us next year! Happy Birthday, Fred!
After many happy years at the University of Oxford, I am delighted to announce that I will shortly be joining the Genome Damage and Stability Centre, University of Sussex. Thank you @OxfordOncology, Hello @GDSC_Sussex
Repeating tasks with for-loops can get very ugly really fast. That's why I prefer to use functions instead of loops. The map() family from {purrr} gives you the perfect tools for that. You can learn to use them in 150 seconds in my newest video. (Link below) #rstats
Dear Parents in Science, @daniela_witten has our all of our backs
@mike_feigin Extra bonus is it increases the chances you will only have to be graduate director for a few weeks.
-Sample size: 49 -p-values: 0.045, 0.052, 0.029, 0.032 (i.e. prima facie p-hacking) -Scientific value: very little -Number of views on Twitter regardless: 3,000,000 Doesn’t this Huberman guy have any standards for the stuff he promotes to his huge audience? (via @alexabelson9)
A 2 min cold immersion to the neck and five, 30 second cold showers per week led to a significant reduction in abdominal fat and waist circumference in the men in this study; also multiple psychological improvements related to stress & wellbeing. pubmed.ncbi.nlm.nih.gov/36599485/
And here's the MS pricing for comparison. Caveats: - 2022 prices for the US - Same slight discount applied (you may get more or less) - Does not include "optional" extras like ESI sources etc. - These two performance metrics were chosen because almost all vendors provided them
For #TeamMassSpec and those that think sequencing will be vastly cheaper than mass spectrometry.
My mum wasn’t allowed to study #science from the age of 16 because she was a girl. I feel incredibly proud that, only one generation later, I’ve gotten to where I am today, doing the job I’m doing.
Great work @ProteomicsNews. So what is the solution? Generate spectral libraries at smaller peptide loads? Scaling product ion intensity based on their m/z to account for loss in the orbi?
Time-of-Flight Fragmentation Spectra Generated by the Proteomic Analysis of Single Human Cells Do Not Exhibit Atypical Fragmentation Patterns | buff.ly/3WErZWj #proteomics
It was six years ago, and my mate, Pink, had just been told he was going to die. He accepted the news with a grace I can only marvel at, but he said he’d a list of things he’d still like to do. We sat in a pub one night and read it over. Eight things? Four months? Ok. Deal. 🧵