Poorva Bindal, MD @PoorvaBindal
Lymphoma, Myeloma and Cell-based therapies @UMassChan | Former Fellow @BIDMCHealth @harvardmed | @UConnIM alum | 🇮🇳 🇺🇸 Boston, MA Joined April 2019-
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Poorva Bindal, MD retweeted
This month, we are excited to feature @PoorvaBindal , MD, as our Chair's Spotlight feature! Learn more about Dr. Bindal and her work by reading the full spotlight on our website! umassmed.edu/medicine/about…
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Poorva Bindal, MD retweeted
Tomorrow, I will start a 2-day, 160 mile @PanMass challenge bike ride to support innovative cancer research at @DanaFarber . Want to support my ride? Donate here: pmc.org/cc0369 Thanks!
Poorva Bindal, MD retweeted
Exhausted but filled with gratitude after the @ASTCT Clinical Research Training Course. A week spent with some of the most talented faculty in the field of #celltherapy and a gifted class of scholars who will replace us and advance our field. What a special community! 🙏🏽🥰🩺
Poorva Bindal, MD retweeted
Poorva Bindal, MD retweeted
Finally an analysis of SLiM MM versus traditional CRAB MM. Glad to see this. Was disappointing that the obvious lead-time bias was not pointed out, and instead the obviously better outcomes for SLiM MM (due to earlier detection/indolent biology) was used to make an argument for treating SLiM MM. When we see such results, IMO, rather than delve into a basic science explanation (clonal evolution etc etc etc), we should start by calling it what it is: lead-time bias. onlinelibrary.wiley.com/doi/full/10.11… Given how poorly the SLiM MM criteria have aged (2 year progression risk to CRAB MM actually 30%, rather than 80% which is what it was thought to be in 2014), this paper further reinforces that such patients should not be treated. (Also inclusion of such patients in MM newly diagnosed clinical trials will lead to improved outcomes compared to earlier trials, even if other treatments the same. Perhaps thats contributing to excellent outcomes of IMROZ VRd control arm) #mmsm @AaronGoodman33
Poorva Bindal, MD retweeted
The FDA just approved cilta-cel for early relapse in myeloma (1 prior line of therapy, including PI and IMiD, and refractory to lenalidomide). My thoughts on the approval of cilta-cel for early relapse in myeloma. An educational thread: #mmsm 1/
Poorva Bindal, MD retweeted
Belantamab/bortezomib/dexa (BVd) had a much better PFS than dara/bortezomib/dex (DVd) in a Phase 3 trial. What are we to make of this result? Lets analyze this in detail! An educational thread on appraisal, and my thoughts on how this may affect my practice/thinking. #mmsm
Poorva Bindal, MD retweeted
The difference in refractoriness to last line of therapy is a very important aspect when we look at performance of regimens in trials and compare trials. @PoorvaBindal wrote a paper about how this varies across trials, and isnt always reported. pubmed.ncbi.nlm.nih.gov/37170589/
Poorva Bindal, MD retweeted
Does a "mass effect" prevent optimal results with CARTs and bispecific antibodies (BsAb) in MM? 1) I suspect so, and we need to study this in detail to improve patient outcomes. 2) Until then, I think a reasonable case can be made for using local radiation therapy in some cases with large masses not controlled by prior or bridging treatment (stay until the end). Why? #mmSM 1/x
Poorva Bindal, MD retweeted
You prescribed iv iron to patient in iron deficiency anemia and 3 days later patient comes up with severe fatigue? Medicine residents!!!! Very very important to know.
@DrNikitaMehra @bagalbp @TataMemorial @atharvak03 @iitbombay @ActImmuno @ACTREC_TMC Congratulations to all! Great representation from India. Proud moment 👏🏼👏🏼👏🏼
@SurbhiSidanaMD @NBahlis It was a phenomenal session! Thank you for taking the time.
Poorva Bindal, MD retweeted
Lovely to meet all these amazing @HemOncWomenDocs at #ASH23 @PoorvaBindal @PallawiTorkaMD @nadahamad @SSundaramMD
Poorva Bindal, MD retweeted
Updated follow up from CLL cohort of BRUIN trial - high ORR though pts with prior BCL2i with a bit shorter PFS than BCL2i naive pts #ASH23
Poorva Bindal, MD retweeted
@DrFredLocke addressed the #FDA probe into “serious” risk of T cell malignancy after CAR T #ASH2023 The math is simple: ✅ 0.12% risk of TCL after Dx of B cell lymphoma ✅ 0.15% risk of TCL after CAR T ‼️8.6%‼️ risk of death if randomised to chemo/transplant instead of CAR T!
Poorva Bindal, MD retweeted
The majority of those who responded chose bortezomib as a safer option relative to carfilzomib. Some thoughts in this brief 🧵 below. There is a head to head trial comparing bortezomib to carfilzomib in transplant ineligible patients pubmed.ncbi.nlm.nih.gov/30819926/ Median age=72
Inspired by @End_myeloma question: In a patient that is frail and elderly who has disease progression on dara/len/dex, what proteasome inhibitor do you think is safer to use? (I am not adding ixazomib as an option- that’s neither safe nor effective!)
Tips for Success As an Academic Clinical Investigator | Fantastic read with practice, actionable tips! Thank you @StephanieLeeMD 👏🏼 ascopubs.org/doi/full/10.12…
Poorva Bindal, MD retweeted
Congrats to BIDMC fellowship alums @rushadpatell and @PoorvaBindal for their innovative work! Delighted to discuss our novel curriculum re medical cannabis in cancer patients at #ASCO23. @BIDMC_HOFellows @BIDMC_Medicine
At #ASCO23, Dr. @DeepaRangachari, director of @BIDMC_HOFellows, sat down to discuss her presentation on a novel medical #cannabis #education curriculum for #hematology/#oncology #fellows. Listen to the conversation here! oncdata.com/news/developin… #fellowship #MedEd @ASCO #hemeonc
Poorva Bindal, MD retweeted
Prophylactic use of anakinra, an IL-1 receptor inhibitor, reduced severe #neurotoxicity incidence in patients with r/r #lymphoma treated with anti-CD19 #CARTcells #immunotherapy @jaeparkmd @karthik_nath17 @Michel_Sadelain @MSKCancerCenter @MSK_DeptOfMed nature.com/articles/s4159…
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Rahul Banerjee, MD, F... @RahulBanerjeeMD
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🇩🇷_🇸�... @DrAbdulHamid786
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Jeffrey Sparks MD MMS... @jeffsparks
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