Paulos Lab @PaulosLab
T cell specialists lab! @EmorySurgery @WinshipAtEmory Atlanta, GA Joined May 2011-
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Check out Dr. @GuillermoORang1's new Cancer Research paper. We show that not all stem-like memory CD8 T cells are equal... Progressively enhancing stemness of adoptively transferred T cells with PI3Kδ blockade improves metabolism and anti-tumor immunity …rjournals-org.proxy.library.emory.edu/cancerres/arti…
Newest preprint paper by our team (@LesinskiLab & @PaulosLab) in biRxiv! @WinshipAtEmory @sitcancer Clinically relevant orthotopic pancreatic cancer models for adoptive T cell therapy biorxiv.org/content/10.110…
Excited to announce that this manuscript is officially out in the latest issue of JCI! Thanks again to all the coauthors and of course to my postdoc mentor Don Gibbons for his continual support! The model figure from these studies:
Excited to announce that this manuscript is officially out in the latest issue of JCI! Thanks again to all the coauthors and of course to my postdoc mentor Don Gibbons for his continual support! The model figure from these studies: https://t.co/x0ldb6Lqf2
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☀️A must read by our MSTP student @GuillermoORang1! The degree of T cell stemness differentially impacts the potency of adoptive cancer immunotherapy in a Lef-1 and Tcf-1 dependent manner. biorxiv.org/content/10.110…
⭐️A must read!!! Congrats to @LesinskiLab & team for stellar work in novel immunotherapy to impact #PancreaticCancer. Just out in @JCI_insight: insight.jci.org/articles/view/…. @sitcancer @ImmunologyAAI @WinshipAtEmory
⭐️A must read!!! Congrats to @LesinskiLab & team for stellar work in novel immunotherapy to impact #PancreaticCancer. Just out in @JCI_insight: insight.jci.org/articles/view/…. @sitcancer @ImmunologyAAI @WinshipAtEmory
We @PaulosLab honored to be #JITCTop10 for this coolio B cell ACT CD8 T cell paper. ;)
We @PaulosLab honored to be #JITCTop10 for this coolio B cell ACT CD8 T cell paper. ;)
Set your life on fire. Seek those who fan your flames. -Rumi
CD40-activated B cells to the rescue! jitc.bmj.com/content/10/12/…
CD40 agonism may circumvent a dysfunctional CD4 compartment to improve PD-1 blockade responsiveness, supporting a novel synergistic immunotherapeutic approach.jitc.bmj.com/content/10/12/…
Great work from @Zihai and lab. jitc.bmj.com/content/10/9/e…
Increased numbers of neutrophils and macrophages associated with cancer progression may be risk factors for anaphylaxis. jitc.bmj.com/content/10/12/…
The best of the best of the best, herein!! Woot @AyanaTRuffin
The best of the best of the best, herein!! Woot @AyanaTRuffin
💥Less is more: @MeganMWyatt’s new manuscript in @biorxivpreprint shows metabolically fit CAR T cells can be generated using fewer activation beads in @PaulosLab w/ @LesinskiLab @ImmuneCellsRUs. Props @GuillermoORang1 @hknochelmann @nelson_CD26 @Aubrey_Smith04 @WinshipAtEmory
💥Less is more: @MeganMWyatt’s new manuscript in @biorxivpreprint shows metabolically fit CAR T cells can be generated using fewer activation beads in @PaulosLab w/ @LesinskiLab @ImmuneCellsRUs. Props @GuillermoORang1 @hknochelmann @nelson_CD26 @Aubrey_Smith04 @WinshipAtEmory
‘Wolde ye bothe eate your cake, and haue your cake?’ -John Heywood, 1546 Uncoupling T-cell expansion from effector differentiation in cell-based immunotherapy pubmed.ncbi.nlm.nih.gov/24329803/
The @PaulosLab is VERY thrilled to welcome our #gamechanger postdoc fellow @AyanaTRuffin to @EmoryUniversity @WinshipAtEmory!
… and an essay in the NYT. 7/ nytimes.com/2022/06/20/opi…
#ASCO22 | June 3 | Education Session | Developmental Therapeutics "Tebentafusp for Uveal Melanoma" Panel Speaker: Melinda Yushak, MD, MPH #melsm ➡️ fal.cn/3pawg
Chrystal Paulos @Chrystal_Paulos
2K Followers 2K Following Director of Translational Research, Cutaneous Malignancies | Assoc. Prof. in Surgery & M+I Dept | @EmoryUniversity @EmorySurgery @WinshipAtEmory @Pauloslab
Delgoffe Lab @DelgoffeLab
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Dr. Patrick Hwu @PatrickHwuMD
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Bernard A Fox @BernardAFox
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Zihai Li, MD, PhD @Zihai
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Nataliya Prokhnevska�.. @nataliya_pro_
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Haydn Kissick @HaydnKissick
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Tullia Bruno, PhD @BcellBruno
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Nik Joshi @Joshilabyale
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Journal for ImmunoThe.. @jitcancer
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Gregory Lesinski @LesinskiLab
2K Followers 1K Following The Lesinski Laboratory is focused on understanding the interactions between the immune system and cancer. opinions are my own. #immunotherapy #GICancer
Aaron Ring @aaronmring
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Jennifer Guerriero, P.. @JennGuerriero
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MoSalah A-Hakeem * (�.. @M_S_Hakeem
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Hilal Nasir 🧬 🔬.. @HilalNasir8
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Abdullah Altaf, MD @AbdullahAltaf97
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Lucid Scientific, Inc.. @lucidsci
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Jaime A. Aponte-Ortiz.. @JAO_MDMS
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Linda Li @LindaLi1212699
4 Followers 172 Following
Ezekiel Olumuyide �.. @kiel_olumuyide
554 Followers 1K Following MD-PhD student at ISMMS | Cancer immunology enthusiasts | My own space = my views | 🇳🇬 to the world
Shipra Gandhi @gandhi_shipra
530 Followers 605 Following Breast oncologist, translational researcher @RoswellPark Tweets are my own and not medical advice.
May Daher @may_daher
915 Followers 448 Following Physician scientist at MD Anderson Cancer Center with focus on cellular therapy, gene editing and immunometabolism to treat cancer patients. Tweets are my own.
Pedro Noronha @PedroNCMT
55 Followers 362 Following Biomed Eng BSc studying to become a MSc Working as Technician at LIT Bon-vivant in between https://t.co/Omzsgba3PM
Onyisi Christiana Did.. @ODidamson
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Zelvera Usheva @ZUsheva
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Quint Studer @quint_studer
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Aaron Edwards @aedwards02
726 Followers 1K Following Co-Founder/CEO @KiraGenBio, MS/MBA @HarvardHBS. Past: @EliLillyandCo, @beamtx & @bluebirdbio. Tweets are my own.
Sarah Michalets @SMImmunologist
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Praveena Gorantla @risinphoenician
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Fatemeh Ardeshir, MD @ArdeshirFatemeh
264 Followers 570 Following Thoracic Oncologist@WinshipAtEmory Alum @TehUofMed@Caseuhmed @IUIntMed President @ASCO IMG Co Pub &Research,Fellow@AmPhilSociety - Listen, Learn & Recalibrate!
SamGreen @SamGree47355776
46 Followers 64 Following
Theysma @Theysma11582
7 Followers 2K Following Let us replace the worries beforehand with thinking and peace beforehand!
James Ross @JamesRossNeuro
159 Followers 306 Following Neuro-immunologist studying brain tumors and chronic viral infection in the @rafiahmed_lab at Emory University.🧠 #glioma #microglia #tcell SEEKING TT POSITION!
Melissa M Wolf @melissa_m_wolf
204 Followers 272 Following PhD - tumor immunology and metabolism - Rathmell Lab
Parviz Azimnasab-sork.. @ParvizSorkhabi
16 Followers 222 Following Ph.D. candidate in cancer biology at the University of Sao Paulo (USP) | A proud Husband | #Immunooncology | #Tcellbiology | #Cancerbiology
Jisue Kang @jisuekang11
116 Followers 536 Following MD-PhD Trainee ‘3X @UABMSTP BA ‘21 @WUSTL 💚 Aspiring surgeon & mucosal immunologist tweets & opinions are my own
Haidong Dong @hd_DongMDPhD
245 Followers 281 Following Iris and Winston Clement Professor, @MayoClinic. EIC of Cancer Immunology Immunotherapy @SpringerNature
Kalyani_Pyaram @ImmunolKalyani
311 Followers 305 Following Assistant Professor @ University of Kansas Med Ctr (she/her) Immunologist, newPI, Mom x2, wife of a scientist. Views are my own. #Pyaramlab #newPI #WomeninSTEM
Chrystal Paulos @Chrystal_Paulos
2K Followers 2K Following Director of Translational Research, Cutaneous Malignancies | Assoc. Prof. in Surgery & M+I Dept | @EmoryUniversity @EmorySurgery @WinshipAtEmory @Pauloslab
Delgoffe Lab @DelgoffeLab
6K Followers 427 Following Cancer Immunometabolism - Assoc. Professor - Director, Tumor Microenvironment Center - @PittTweet @UPMCHillmanCC - CoFounder, Novasenta - EiC, WILEY Immunology
Dr. Patrick Hwu @PatrickHwuMD
25K Followers 2K Following Moffitt Cancer Center President and CEO, @MoffittNews. Tumor immunologist. Inspired leader. Girl dad. #DocsWhoRock. Driven to save more lives from #cancer.
Jeff Rathmell @JeffRathmell
5K Followers 522 Following Vanderbilt Center for Immunobiology @VUMC_VCI; Immunometabolism in cancer and inflammatory diseases. Views are my own and do not represent any institution
Bernard A Fox @BernardAFox
6K Followers 5K Following Harder Chair #FoxLab @ChilesResearch /CEO @UbiVac #immunotherapy/@OHSUSOM /exPres&Ambassador @SITCancer /ex @theNCI /exDetroiter/M GO BLUE/❤️Pinot/Tweets my own
Zihai Li, MD, PhD @Zihai
3K Followers 737 Following Founding Director, Pelotonia Institute for Immuno-Oncology (@OhioStatePIIO) • Deputy Director of @OSUCCC_James for Translational Research • Views My Own
Nataliya Prokhnevska�.. @nataliya_pro_
738 Followers 436 Following T cell Immunologist. Postdoc @KamphorstAlice lab Mount Sinai, PhD @HaydnKissick Emory University. Ukrainian. Scientist. Tennis player. Baker. 👩🏻🔬🧬🎾🇺🇦
Haydn Kissick @HaydnKissick
1K Followers 697 Following Assistant Professor at Emory University. Interested in all things Immunology!
HoLab @PCHo_Lab
5K Followers 737 Following Scientist grew up in TAIWAN. Love immunology, cancer and metabolism. We choose our targets because they are exciting and challenging! 🇹🇼 🇺🇸 🇨🇭
Hazem Ghoneim @Hazemghoneim11
1K Followers 717 Following Assist. Professor, Dep of Microbial Infection & Immunity, College of Medicine, The Ohio State Univ. @OhioStateMed #Immunology #Epigenetics #Cancer Views my own
Tullia Bruno, PhD @BcellBruno
2K Followers 406 Following Bruno lab| 15+ years of cancer immunology | B cells and TLS in cancer | T cell enthusiast, B cell convert #scientist #womaninscience #sassyscientist
Nik Joshi @Joshilabyale
6K Followers 275 Following Michigan | JHSPH | @YaleIBIO | MIT | @yalemed #cancerimmunology, #immunotherapy and #cancer. Tweets not reflective of my employer.
Journal for ImmunoThe.. @jitcancer
8K Followers 2K Following The official journal of @SITCancer, covering all aspects of tumor immunology and cancer immunotherapy. #JITC Interim Editor-in-Chief: James Gulley (@gulleyj1)
Gregory Lesinski @LesinskiLab
2K Followers 1K Following The Lesinski Laboratory is focused on understanding the interactions between the immune system and cancer. opinions are my own. #immunotherapy #GICancer
Aaron Ring @aaronmring
9K Followers 828 Following Associate Professor at @FredHutch Studying #cytokines, (auto)antibodies, and #cancerimmunotherapy Founder: @SimchaTx, @Seranova, & Stipple Bio
HandLab @thehandiestlab
3K Followers 761 Following Microbiome & the immune system: best frenemies forever. Univ. of Pittsburgh/UPMC Children's Hospital/R.K. Mellon Institute for Pediatric Research #immigrant
Klebanoff_Lab @KlebanoffLab
3K Followers 2K Following A translational research lab @MSKCancerCenter focused on the immunobiology and therapeutic potential of genetically engineered #Tcells and #TCRs. Est.2016 @NYC.
Jennifer Guerriero, P.. @JennGuerriero
4K Followers 1K Following Macrophage Enthusiast, @Brighamsurgery @DFCI_BreastOnc | #TheMyeloidNetwork Co-Founder | wife and motherx3 | views=mine
Elizabeth McKenna @ElizSMcKenna
16K Followers 5K Following Executive Editor of Cancer Discovery @CD_AACR, published by @AACR. @BBS_Harvard/@DanaFarber alum. Native New Yorker. Views/likes/RTs are my own. She/her
Abanoub Gabra, MD MBA @Dr__Gabra
375 Followers 3K Following Coptic Made 🇺🇲🇪🇬 Incoming PGY4 Haempath fellow @UF - 2023 @ASCP Subspecialty Award Recipient - Journey of #Immigrant Physician - Founder @Board_Practice
Arun Wiita @apwiita
2K Followers 693 Following #Pathologist @UCSF fighting blood #cancer & #genetic disease through #proteomics. Advocate for #PhysicianScientist trainees, my 2 kiddos, and work/life balance.
Xiaoqi(Kevin) LI @kevinmartinlee
226 Followers 715 Following PhD@unmc|T-cell therapy|PDAC|Solid Tumor|Glycosylation|Resistance|Open to Wrok|Twitter is my own|RT≠E
Suman MITRA @at_Mitralab
258 Followers 566 Following immunotherapy lab @univ_lille @inserm interested in understanding and exploiting cytokine activity in tissue environments. 🇮🇳🏴🇳🇱🇺🇸🇸🇪🇫🇷
Cankun Wang @WangCankun
208 Followers 1K Following Biomedical Informatics Specialist at The Ohio State University Wexner Medical Center
Martha Arellano, MD @MArellanoMD
716 Followers 382 Following http://Professor @WinshipAtEmory; acute #leuk, MDS and other #hemonc. #leusm. opinions my own. Colombian,American. for civil rights & human rights.
Eliver Ghosn @EliverGhosn
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518 Followers 409 Following Innate immunologist, father 3X, big fan of cooking and grilling.
Kendall A. Smith @kasmithnyc
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Lugli Lab @luglilab
2K Followers 447 Following Immunology lab interested in memory T cell differentiation, adoptive cell transfer and cancer immunotherapy. Tweets by Enrico
Hussein Tawbi, MD, Ph.. @HTawbi_MD
2K Followers 755 Following #Melanoma medical oncologist and #immunotherapy & drug development investigator at @MDAndersonNews. Co-Director of the #BrainMets Clinic. Views are my own.
RafiAhmedLab @rafiahmed_lab
2K Followers 1K Following Science from the Rafi Ahmed lab at Emory University. Maintained by lab members
Marson Lab @MarsonLab
8K Followers 4K Following News from Dr. Alex Marson's lab @UCSF & @GladstoneInst, focusing on advances in immunology, CRISPR & genomics. Tweets represent personal views only.
Cameron Herting @cameron_herting
80 Followers 220 Following Medical Science Liaison - Solid Tumor Oncology Triathlete
Jessica Konen @jessica_konen
47 Followers 64 Following Cancer biologist @EmoryUniversity🔬 Avid dog lover 🐶 opinions = own
Christin Burd 🐀 @ChristinBurd
468 Followers 240 Following Ohio State James Comprehensive Cancer Center |Melanoma and Aging Researcher | Tweets are my own | She/Her
Nandini Acharya @NandiniAacharya
261 Followers 333 Following Assistant Professor @OhioState @OhioStatePIIO @OhioStateNeuro #Immunologist
Alejandra Mendoza @thepenkpanther
699 Followers 342 Following Assistant professor @scrippsresearch. Immunologist. Interested in how cellular networks shape immunity. (she/her)
Daniel Powell Lab @ U.. @DJPowellLab
518 Followers 115 Following Cancer Immunotherapy & Immunobiology @Pennmedicine #CellTherapy #Genetherapy #Inventor #CARTCell #CAR #ovarian #TILs #immunotherapy
Cell Press @CellPressNews
152K Followers 1K Following Cell Press partners with scientists across all disciplines to publish and share work that will inspire future directions in research. #ScienceThatInspires
Stacey Abrams @staceyabrams
2.8M Followers 2K Following Author of #RogueJustice (Out Now). Senior Counsel @RewiringAmerica. Other areas of focus: democracy + voting, public policy, small business & film+tv.
Dr Zoë Ayres @ZJAyres
83K Followers 22K Following Analytical Scientist 👩🔬 #AcademicMentalHealth advocate 🌱 Founder @academicvoices 💬 Author 📘 ADHDer 💚 'Furiously opinionated'🤭 she/her 🌈 Views my own
ACIR @ACIR_org
3K Followers 1K Following Accelerating Cancer Immunotherapy Research. A free weekly digest of the latest findings in the field. We also make cool cartoons :) Listen to @ImmunoTalks.
Hernandez Moura Silva @hernandezmsilva
940 Followers 292 Following Macrophage lover leading a lab at the Ragon Institute of MGH, MIT & Harvard. Assistant professor at MIT Biology. @HHMINEWS Freeman Hrabowski Scholar (he/him)
Diana Fulmer @DianaBFulmer
442 Followers 423 Following Cardiac Development • Epigenetics • Postdoc @JonEpsteinLab @PennMedicine 🫀🔬🧬🐭 🚨Tweets may contain science, bad jokes & political snark
Claire Pillsbury @cepillsbury
42 Followers 38 Following Postdoc @TheCrick | In the #Downwardlab | Studying tumor immunology in lung cancer relapse | she/her | 0% Twitter literate
D. Kevin Berchelmann @BrazenLeader
15K Followers 11K Following Grace & accountability can coexist. Executive #Coach | #Leadership Guru | #performance, #engagement & #accountability | Renaissance Man. Pithy responses.
Gena Foster, MD @DrGenaGFoster
206 Followers 521 Following Hematologist and PhD student at @YaleIBIO @joshilabyale studying T cells in cancer
Phoebe_C @Its_PhoebeC
87 Followers 179 Following PhD Candidate @DrDavilaLab @CUAnschutz | NSF GRFP Fellow | Venture Fellow @CUInnovations Engineering T-cells to fight cancer 👊 Tweets are my own
Hans-Peter Kiem @HPKiem
1K Followers 507 Following Director, Stem Cell and Gene Therapy @fredhutch. Interested in stem cell biology/transplantation and gene therapy/editing. Immediate Past President @asgctherapy
Early Career Immunolo.. @EarlyImmunology
5K Followers 126 Following The Early Career Immunology Digital Seminar Series highlights the work of up-and-coming junior investigators. #ECI #ECR
Dorina Avram @dorina_avram
294 Followers 325 Following Immunology Department - Moffitt Cancer Center; Professor, Mentor; LAB studies BCL11B and other fascinating regulators of immune responses in cancer & infections
Dr. Theodora Katsila @trilovitis
593 Followers 1K Following Biochemist. Consultant. Entrepreneur. Research Assistant Professor - Biomarker Discovery & Translational Research Lab Head @eiegr. Craving for brain teasers.
Christian Capitini @CapitiniMD
3K Followers 3K Following Pediatric oncologist/researcher @UWMadison @UWCarbone #immunotherapy #NKcells #CARTcells #GVHD #childhoodcancer Tweets are my own; RTs don't imply endorsement
Nour Shobaki @NourShobaki
195 Followers 909 Following PharmD PhD, Cancer Immunologist at Carl June Lab - CCI @PennMedicine #Immunology. My interests are Science, Philosophy, and Psychology
BlackInImmuno @BlackInImmuno
6K Followers 681 Following A collective of scientists celebrating, amplifying, and promoting the work of Black #Immunologists across the globe.
MIDS Program @MIDSProgramPitt
37 Followers 16 Following Microbiology and Immunology Diversity Scholars (MIDS) Program at the University of Pittsburgh
Mallary Greenlee Wack.. @MallaryWacker
232 Followers 332 Following Associate professor at CalPoly. Interested in innate immunity, extracellular vesicles, host-pathogen interactions, & undergraduate education/research.
Ana Codo (she/her) @anaacodo
248 Followers 914 Following Immunologist-in-training | PhD student @WCM_IMP | Lover of immunology, pets, and democracy | Views are my own | 🖤🐘🤍💜 | 🇧🇷🇺🇲
Md Nazmul Hossain @MNHossainMIB
292 Followers 2K Following PhD Fellow, RNA Biology Research Group, School of Biosciences, University of Birmingham, UK
Atlanta Airport @ATLairport
99K Followers 1K Following Welcome to Hartsfield-Jackson Atlanta International Airport (ATL). We're here to help Mon-Sun 8:30am - 5pm. For outside office hours, please call (800) 897-1910
Majid Kazemian @kazemianlab
274 Followers 219 Following Our lab focuses on integrating experimental and computational approaches to study host pathogen interaction in cancer and infectious diseases.
Margaret Gatti-Mays M.. @DrGattiMays
3K Followers 3K Following Co-Director @ohiostatemedonc and #BreastCancer Section Chief @OSUCCC_James |#Immunotherapy | #WomenInMedicine #BoyMom | #NIH alumnus #HoyaSaxa Tweets-My Own
Alexander McLellan @AlexMcLellan100
281 Followers 280 Following Professor in Immunology at Dept. Microbiology & Immunology, The University of Otago, Dunedin, New Zealand
#Bridge23 @sitcancer Amazing to be in Naples w @PAscierto for best #melanoma & #immunotherapy mtg of yr! Great science, clinically relevant discussions & reunion. Dinner tonight w mentors & mentees from >15 years of @MSKCancerCenter H/O fellowships. Brainstorming to #endcancer!
Great to reconnect with friends & present our work at the best Immunotherapy #Bridge23 meeting in Naples. Thanks @PAscierto for organizing a fantastic meeting to @endcancer ! @UCCancerCenter @UChicagoHemOnc @UChicagoCCB @UChicago @UChicagoMed @PCF_Science @PCFnews @SITCCancer
#Bridge23 | @AkashPatnaik7 from beside to bench in prostate cancer: IO combination therapies will have a role in the future treatment algorithm. #crpc @UChicagoMed @PAscierto
@DrBetofMDPhD and @jsmithymd rocking it from the debate stage in Italy at the Melanoma Bridge meeting and still friends after! What’s better- TIL or nivo + ipi for PD1 refractory melanoma?
#Bridge23 | @LesinskiLab Immunotherapy in #pancreaticcancer: where are we heading in the near future? @PAscierto @Chrystal_Paulos @WinshipAtEmory #Immunotherapy tinyurl.com/bdct5bvz
Great opening session at the Annual Winship Scientific Symposium @WinshipAtEmory #wheresciencebecomeshope
With my awesome colleagues at @WinshipAtEmory @LesinskiLab @PaulosLab at the poster session of annual Winship Symposium
Congrats to my friend Dr. Mark Rubinstein for new funding from the NIH on important work.
Congrats to #PIIO member Mark Rubinstein & Baylor collaborator @CampRamsay who received $3.2M grant from @theNCI to study disparities in survival outcomes between African American and white patients with colorectal cancer.
Congrats to EVP of Immunology Ananda Goldrath on receiving the Frederick W. Alt Award for New Discoveries in Immunology! The honor is awarded by @CancerResearch Institute to CRI postdoc fellows who have had a significant impact in the field of immunology. alleninstitute.org/news/cancer-re…
Do race and ethnicity affect response to CAR T cell therapy? Explore new findings, published in @BloodAdvances, described by @TargetedOnc: bit.ly/40uAJSA #CARTCell #CancerResearch #Immunotherapy #MultipleMyeloma #CART
Did you know? The Cancer Research Institute is ranked among the top 5% of all U.S. rated charities. Discover how CRI is transforming the lives of cancer patients on a global scale: bit.ly/3u0MMLe #CharityRatings #GiveWithConfidence #CancerResearch #GivingTuesday
So, my daughter got a puppy today! Then says "Sorry to overshadow your day Mom" Congrats to BOTH Dori and @KimrynRathmell
Couldn't be more proud of our fearless Chair, Dr. @KimrynRathmell, who has been appointed Director of the National Cancer Institute! We wish you all the best in your new role as @NCIDirector! Read the official press release from the @WhiteHouse here: bit.ly/46mI73s
Progressively enhancing stemness of adoptively transferred T cells with PI3Kδ blockade improves metabolism and anti-tumor immunity aacrjournals.org/cancerres/arti…
Many people to thank for all of their help. Could not have made it possible without @LesinskiLab @ThaxtonLab @armish @PaulosLab!
Proud to finally see this important part of my dissertation work be published in @CR_AACR! We demostrare that mouse and human T cells can acquire progressive levels of stemness and metabolic fitness by modulating PI3Kd signaling.
Progressively enhancing stemness of adoptively transferred T cells with PI3Kδ blockade improves metabolism and anti-tumor immunity aacrjournals.org/cancerres/arti…
Check out Dr. @GuillermoORang1's new Cancer Research paper. We show that not all stem-like memory CD8 T cells are equal... Progressively enhancing stemness of adoptively transferred T cells with PI3Kδ blockade improves metabolism and anti-tumor immunity …rjournals-org.proxy.library.emory.edu/cancerres/arti…
Excited to announce that this manuscript is officially out in the latest issue of JCI! Thanks again to all the coauthors and of course to my postdoc mentor Don Gibbons for his continual support! The model figure from these studies:
Targeting autotaxin enhances immune checkpoint blockade response: buff.ly/44AzwcD @jessica_konen @MDAndersonNews #Immunology #Oncology
This is the key--"most dysfunctional chromatin accessibility changes occurred within 6 hours". T cell dysfunction in tumors doesn't have to happen over extended times, but can start right away. A new wrinkle in T cell "exhaustion" (or just dysfunction or maladaptation?)
Most dysfunction chromatin accessibility changes occurred within 6 hours after T cells encountered tumor antigens. These early chromatin accessibility changes were stabilized and/or reinforced with continued tumor/antigen exposure, imprinting the dysfunctional state. 4/7
Read our team's report of long term followup of irAEs for melanoma patients treated in the adjuvant setting. @NYUGSOMimcg Extended Follow-Up of Chronic Immune-Related Adverse Events Following Adjuvant Anti-PD-1 Therapy for High-Risk Rese… pubmed.ncbi.nlm.nih.gov/37535354/
7th @AIMatMelanoma Women in Melanoma #WIM meeting. Absolutely my favorite meeting of the year- these women are such role models to me and have shaped my career in countless ways. @MunTheLoon @JaniceM10 @FunchainMD @GlitzaMDPhD @DrSapnaPatel @katyktsai
Asparagine restriction enhances CD8+ T cell metabolic fitness and antitumoral functionality through an NRF2-dependent stress response @ruoning_wang @NatMetabolism nature.com/articles/s4225…
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