Chi na-eme @P_Chinemerem
PhD Candidate: 3D protein structures. Tweets are personal views. Now that you're here, a reminder to care for your mental health Nigeria Joined June 2018-
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Our last monthly webinar this year will be given by @Vecchiology from @Jacobs_Med_UB. To register please go to: us02web.zoom.us/webinar/regist… In the CryoEM current practices webinar, our users share tips and tricks that help you in your CryoEm journey.
🗣️New results from the lab fresh off the virtual press @biorxivpreprint — Biophysical Basis of Paracellular Barrier Modulation by a Pan-Claudin-Binding Molecule 🧵 biorxiv.org/content/10.110…
🗣️New work from the lab provides structures of the full Clostridium perfringens enterotoxin (CpE) bound to its human receptor claudin-4 sciencedirect.com/science/articl…
Cryo-EM Structures of Clostridium perfringens Enterotoxin Bound to its Human Receptor, Claudin-4 | bioRxiv biorxiv.org/content/10.110…
New work from the lab: 🔶Cryo-EM Structures of Clostridium perfringens Enterotoxin Bound to its Human Receptor, Claudin-4🔸 biorxiv.org/content/10.110…
Today in @Nature we present the results of our exploration of the soluble protein universe and the design of functional soluble membrane proteins with @CasperGoverde @GoldbachNico @befcorreia 1/6 nature.com/articles/s4158…
We demonstrate that using constrained design we are able to preserve functional epitopes in these analogues, such as antibody or toxin binding sites, for example for human claudins 1 and 4 - important cancer drug targets. 4/6
Now published @CommsBio “Structural and biophysical insights into targeting of claudin-4 by a synthetic antibody fragment”. nature.com/articles/s4200… 🧵
EVENT - CCP4-BCA Protein Crystallography Summer School 2024 Applications are now open for the upcoming, exciting CCP4-BCA Protein Crystallography Summer School 2024, hosted at the John Innes Centre 🗓️ Deadline - 10 June 2024 Apply and find out more: okt.to/GuFZwa
Go see Chi at #BPS2024.
If you’re at #bps2024 come check out my poster tomorrow at the Exhibit Hall AB, or say hi 😊 #bps #BIBPS #blackinbiophysics
If you’re at #bps2024 come check out my poster tomorrow at the Exhibit Hall AB, or say hi 😊 #bps #BIBPS #blackinbiophysics
The lab is hiring PhD students and PDRAs for 2024 start! Projects going in proteomics/mass spectrometry and virology.
A two-year postdoctoral position is available in my group at the Institut Pasteur in Paris. If you (or someone you know) are interested in viruses and/or structural biology, you can find more details below. Please retweet it :) research.pasteur.fr/en/job/postdoc…
Thanks to @Vecchiology and @kapoorsrajan for making this work come to life.
Check out our newest paper in the @Vecchiology lab here: mdpi.com/2072-6651/15/1…. We used both SAXS and x ray crystallography to provide a novel insight into the first step in Clostridium perfringens enterotoxin activation, oligomerization and cytotoxicity.
Come and do PhD with us. We have interesting research areas, and Erudites and amazing Faculty members and researchers.
@CrystalUminski Congratulations Dr. Uminski 🥳🥳🍾🍾
In this new preprint we used cryo-EM and a novel Fab to determine a 2.6 Å structure of 22 kDa claudin-4 bound to a 14 kDa bacterial enterotoxin domain. biorxiv.org/content/10.110…
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