Acquired Resistance to Therapy Network (ARTNet) @NCIARTNet
Official Account of @theNCI Acquired Resistance to Therapy Network (ARTNet). nciartnet.org Joined April 2020-
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At today's #ARTNetSCMeeting, co-chair Dr. Alan Hutson @Amherst73 of @RoswellPark provided updates on ARTNet's recent activities and upcoming initiatives. Associate member Dr. Jennifer Wargo @JenWargoMD of @UTMDAnderson shared exciting advances on how the microbiome shapes cancer development, immune responses, and immunotherapy outcomes. Her presentation highlighted emerging strategies to modulate the microbiome through diet, probiotics, and life style, opening new possibilities for cancer prevention and treatment. #CancerResearch #Microbiome #Immunotherapy #CancerPrevention
#ARTNetPublication New research in @CR_AACR reveals a promising strategy to overcome radioresistance in lung cancer. @BoyiGan, @ACKoongMDPhD, @StevenLin_MDPhD, @Dadi_Jiang, and colleagues identified DHODH as a key metabolic driver that protects tumor cells from ferroptosis while supporting DNA repair after radiation. Combining DHODH inhibition with radiotherapy and IFNγ/anti-PD-1 immunotherapy dramatically improved treatment response in preclinical models, highlighting a promising therapeutic strategy for lung cancer and potentially other solid tumors. Read the study: doi.org/10.1158/0008-5… #LungCancer #Radiotherapy #CancerResearch #Immunotherapy #Ferroptosis #Metabolism #AACR
Online now: Lactate binds and inhibits the innate immune sensor STING to promote tumor immune evasion dlvr.it/TTHSK0
In the latest issue! Excessive vascular integrity restricts anti-tumor immunity dlvr.it/TTJC8g
📢 Registration is now open for the NCI Workshop on Understanding Plasticity and its Role Across the Cancer Continuum! Join leading researchers to explore the molecular mechanisms of cell plasticity, its impact on cancer development, progression, and treatment response, and help shape future research directions. 💻 Virtual participation is open to the public 🗓️ Sept. 23–24, 2026 🔗 Register here: events.cancer.gov/dcb/plasticity…
To stay ahead of cancer, we need to understand how tumor cells adapt. This @theNCI study reveals how environmental stress can drive heritable changes in gene expression, offering new insights into one of cancer’s greatest challenges: drug resistance. go.nih.gov/iie4xBv
Introducing Tuesdays with Tony, a new weekly series from @NCIDirector Dr. Anthony 'Tony' Letai. Starting tomorrow, follow along on NCI’s LinkedIn and Instagram for Dr. Letai’s thoughts on NCI's work, the science we're tackling, and the questions we're trying to answer.
📢 Registration is now open for the @theNCI Workshop on "Understanding Plasticity and its Role Across the Cancer Continuum"! This workshop will bring together experts to explore the molecular mechanisms of cellular plasticity and its impact on cancer initiation, progression, therapeutic resistance, and treatment response. 🗓️ September 23–24, 2026 💻 In-person speakers & virtual public participation Register here: events.cancer.gov/dcb/plasticity… #CancerResearch #CancerBiology #CellPlasticity #TumorHeterogeneity #CancerPrevention #CancerInterception #NIH #NCI
Congratulations to @BoyiGan, @xingxing_zang, @StevenLin_MDPhD, and all co-authors on this outstanding study published in @CellCellPress! The team uncovers a powerful two-way connection between antitumor immunity and cuproptosis: CD8+ T cells enhance tumor sensitivity to copper-dependent cell death through the IFNγ–STAT1–IRF1–FDX1 axis, while cuproptotic tumor cells stimulate immune responses by acting as immunogenic cell death. Importantly, combining a cuproptosis inducer with anti-PD-L1 therapy helped overcome immunotherapy resistance across multiple preclinical models. A compelling example of how understanding cell death pathways can open new opportunities for cancer immunotherapy. sciencedirect.com/science/articl… #CancerResearch #Immunotherapy #Cuproptosis #CellPress #CancerImmunology
How do cancer-driving fusion proteins create their own vulnerabilities? A new #ARTNetPublication in @CR_AACR co-authored by Dr. Trever Bivona @BivonaLabUCSF shows that FET fusion oncoproteins impair ATM-mediated DNA damage repair, forcing tumors to rely on ATR signaling for survival. This collateral dependency may be exploited therapeutically with ATR inhibitors across multiple FET-rearranged cancers. pubmed.ncbi.nlm.nih.gov/41811428/ #CancerResearch #EwingSarcoma #DNARepair #PrecisionMedicine #ATRinhibitors
Delighted to share our @NatureCancer paper, out today, on determinants of ICB response in GBM (link in 🧵) With bulk and single-nucleus genomic profiling of 181 ICB-treated tumors, we found that tumor RNA subtype (and not TMB!) predicts survival and shapes acquired resistance.
🚀 Now live: rasinhibitors.com A continuously updated map of every RAS inhibitor & degrader in clinical development — 75 drugs, from Phase 1 to FDA approval. The entire clinical RAS pipeline at a glance, updated regularly. Feedback welcome! 👉 rasinhibitors.com
Now online: PI3K Regulates Wild-type RAS Signaling to Confer Resistance to KRAS Inhibition doi.org/10.1158/0008-5…
At today’s Cell States, Metabolism & Inflammatory Microenvironment #ARTNetWGMeeting, Dr. Fatima Mechta-Grigoriou @FatimaMechta from Institut Curie presented her work on "Spatial determinants of stromal heterogeneity rriving resistance to immunotherapy in cancer". Her fascinating research sparked a lively discussion on how the tumor microenvironment shapes therapeutic response and resistance.
Dr. Brian Druker joined the Precision Signals podcast to discuss Gleevec, precision oncology, and the future of cancer research 🎙️ Listen: youtube.com/watch?v=4a4o12…
🚀 Check this out — we’ve launched an AI for Cancer Webinar Catalog, updated weekly! nciartnet.org/en/resources/a… This curated catalog brings together AI in cancer research webinars from publicly available academic, industry, and professional organizations in one place. A great resource for staying current with the rapidly evolving AI-oncology landscape.
At today’s #ARTNetSCMeeting, co-chair Dr. Alan Hutson @Amherst73 of @RoswellPark provided network updates, and Dr. Ping Mu @PingMu_PhD of @YaleMed presented how his lab is leveraging AI tools to decode mechanisms of therapy resistance in prostate cancer.
🎙️ The inaugural episode of the ARTNet Podcast is now live! Listen here and share with colleagues, friends, and family: theartnetpodcast.riverside.com Join moderator Dr. David Goodrich @RoswellPark and featured speaker Dr. Jeffrey Tyner @OHSUKnight as they discuss cancer resistance, tumor evolution, and ARTNet’s mission to advance collaborative resistance research in accessible, science-grounded language. #ARTNet #NCI #CancerPlasticity #CancerAcquiredResistance #cancerfighter @theNCI
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