Near weekly occurrence. Pts dropping $20k, and within 1 yr have recurred and have variable permanent side fx. Now have no data how to follow, how to salvage, optimal dose & ADT, biomarkers work?
Is scam of the decade, select MDs doing off trial that will be exposed soon enough
@AmarUKishan@NRGonc@EORTC@NCCN@alison_tree@rtdess@HimanshuNagarMD 4/n This was validated post-hoc in RTOG 9408 trial of RT+/- ST-ADT. Zach, @DrHowardSandler and I spent days at RTOG HQ counting “cores” from path reports. Same thing, even FIR in small sample size PCSM was numerically better with ADT during 1st 10 years of fu.
@AmarUKishan@NRGonc@EORTC@NCCN 2/n
The benefit of ADT is irrespective of RT dose from MARCAP (<74 vs >74Gy), EORTC 22991 (70 vs 74 vs 78Gy), and RTOG 0815 (DE-EBRT vs Combo-brahcy) sealed the deal. No interaction by dose and ADT benefit.
@alison_tree@rtdess@HimanshuNagarMD
1/n
The SOC for men with intermediate risk (IR) PCa getting RT is RT+ST-ADT (4-6 months).
@AmarUKishan and I led the 1st MARCAP meta-analysis of >5000 men with >13 yr median fu showing the clear benefit of ST-ADT w/ RT.
@NRGonc@EORTC@NCCN
@PreetBharara#AskPreet According to the Washington Post Merrick Garland slow-walked DOJ investigation of Trump's efforts to overthrow the government. Does the DOJ support the rule of law?
@PredictProstate Unfortunately ProtecT relies on older IMRT. MIRAGE found significant reduction in early side effects MRIdian MRI-Linac as opposed to CT guided SBRT.
@DrSpratticus We need a well designed randomized trials comparing focal therapy and active surveillance. I'm afraid that the group of patient for whom focal is advised varies widely among those who recommend this therapy.
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