Molecular Biophysics Unit, IISc @MBU_IISc
Molecular Biophysics Unit (MBU) is a part of IISc that pursues cutting edge research in the areas of molecular biophysics and structural biology mbu.iisc.ac.in Bengaluru, India Joined July 2020-
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Measuring Hydroxyl Exchange Rates in Glycans Using a Synergistic Combination of Saturation Transfer and Relaxation Dispersion NMR | Journal of the American Chemical Society @MBU_IISc #HydroxylExchange #Glycans #NMR @nmr900 pubs.acs.org/doi/10.1021/ja…
We are excited to start the new year by sharing the latest paper from our lab @MBU_IISc, @iiscbangalore in @NAR_Open. Here, we report that the RTEL1 helicase interacts directly and functionally with the replication protein A (RPA). (1/5) @NIRANJANSAARC academic.oup.com/nar/article/do…
Our recent work "The alteration of structural network upon transient association between proteins studied using graph theory" is out now in Protein: Structure Function and Bioinformatics @WileyBiomedical doi.org/10.1002/prot.2… @tandon_himani @caps_ncbs @MBU_IISc @iiscbangalore
Our work on the "Comparison of structural networks across homologous proteins" is out in PROTEINS: Structure, Function, and Bioinformatics | Wiley Online Journal @WileyBiomedical onlinelibrary.wiley.com/doi/abs/10.100… @MBU_IISc
#glycotime Out now in GLYCOBIOLOGY! Very chuffed to see this out as it's our first Glycan work !!! doi.org/10.1093/glycob… Thanks to @RamrayB @hurryram @PenmatsaLab for discussions and insights! Also, thanks to @AnneImberty & @GlycobiologyUK for the smooth editorial process.
#glycotime Out now in GLYCOBIOLOGY! Very chuffed to see this out as it's our first Glycan work !!! doi.org/10.1093/glycob… Thanks to @RamrayB @hurryram @PenmatsaLab for discussions and insights! Also, thanks to @AnneImberty & @GlycobiologyUK for the smooth editorial process.
jbc.org/article/S0021-… Out now in @jbiolchem. Had a wonderful time working with @ShovamayeeMaha and @Sangeethayoga, who did all the heavy lifting !! Would like to acknowledge @India_Alliance, NSM (HPC grant @IndiaDST) @SankhyaSutraLab @DBTIndia @iiscbangalore @MBU_IISc
jbc.org/article/S0021-… Out now in @jbiolchem. Had a wonderful time working with @ShovamayeeMaha and @Sangeethayoga, who did all the heavy lifting !! Would like to acknowledge @India_Alliance, NSM (HPC grant @IndiaDST) @SankhyaSutraLab @DBTIndia @iiscbangalore @MBU_IISc
We are organizing our annual symposium, "NuBS23," tomorrow from 9 AM onwards at the Faculty Hall, IISc Main Building. Please join us to learn about our latest works and hear from our plenary speakers, @gsahu_iisc and @AshhadSufyan.
Very happy to share our recent study on characterization and comparison of permanent and transient intra-protein inter-domain interactions. doi.org/10.1002/prot.2…
Finally our research on thioamide modification and its implications in membrane permeability and bioavailability of cyclic peptides is out! Congratulations to the entire team! nature.com/articles/s4146… @hiteshvrm @b_khatrii @NishantRaj33828 @SohiniBioPharma @MBU_IISc
Its a pleasure to announce the publication of our latest work on the cryoEM structure of QacA resolved using Indian camelid antibodies in @embojournal . Fantastic effort by @PujaMajumder91 @shah_med @Pragyaahuja_6 and @Athreya_Arunabh.embopress.org/doi/full/10.15…
Excited to announce the publication of our study on the architecture of the ratGAT1 in the cytosol-facing, GABA bound state @NatureSMB. Brilliant effort @SmrutiR60158682 and well supported by @DeepthiJoseph @ArchishmanDakua @AthreyaArunabh nature.com/articles/s4159…
Very happy to share our study uncovering the mechanism of DNA binding by an IDP! The disordered domain of CytR binds DNA through a fully folded minor conformation. @AthiNaganathan @BODHISATWANANDI @MBU_IISc science.org/doi/10.1126/sc…
doi.org/10.1021/acs.jc… Out now in JCTC!! Very proud of @RajeswariAppad1 for this wonderful effort!! And loved the collaboration with @PaulRobustelli @koduruJayakris1 and @BonomiMax Also, thanks to @iiscbangalore, National Supercomputing Mission @IndiaDST @DBTIndia for ₹₹
doi.org/10.1021/acs.jc… Out now in JCTC!! Very proud of @RajeswariAppad1 for this wonderful effort!! And loved the collaboration with @PaulRobustelli @koduruJayakris1 and @BonomiMax Also, thanks to @iiscbangalore, National Supercomputing Mission @IndiaDST @DBTIndia for ₹₹ https://t.co/2cWAezVsYD
Now out @BiophysJ! I had a wonderful time working with @MadhusmitaTri on this. Our fascination with packing & non-affine displacement in membrane continues. doi.org/10.1016/j.bpj.… Also, thanks to @LeventalLab & @BiophysJ for the smooth editorial process. #PhysicsOfGlass #Lipids
After an awesome talk by @RommieAmaro last month, we have Prof. Kragelund (@BBKrage) e-visiting next week (Tues May 9, 5:30 PM IST). Birthe is one of those rare experimentalist who truly appreciates/harnesses the power of simulation-assisted integrative modeling. Can't wait!!
After an awesome talk by @RommieAmaro last month, we have Prof. Kragelund (@BBKrage) e-visiting next week (Tues May 9, 5:30 PM IST). Birthe is one of those rare experimentalist who truly appreciates/harnesses the power of simulation-assisted integrative modeling. Can't wait!! https://t.co/LQtfTFxDPl
We are organizing a 9-day workshop at IISc on (computational) membrane biophysics (July 6-15). Please visit the workshop webpage for details: sites.google.com/view/nsm-works… Supported by National Supercomputing Mission @IndiaDST @iiscbangalore @MBU_IISc (Registration deadline: May 21)
Congratulations Harshith @SHarshiN4! Work from our laboratory is now online. Plasticity manifolds and degeneracy govern circadian oscillations of neuronal intrinsic properties in the suprachiasmatic nucleus (1/n) doi.org/10.1016/j.isci…
Our recent work is online now- excellent work by @sumanmishra0802 and Anupam. Thanks to MoE STARS for supporting this work.
Our recent work is online now- excellent work by @sumanmishra0802 and Anupam. Thanks to MoE STARS for supporting this work.
In this recent work, we developed a nanoparticle based SARS-CoV-2 vaccine which induces robust humoral response in mice and neutralizes Omicron with appreciable titers, with low scaffold antibodies. The vaccine remains antigenic upto 1mo of refrigeration. doi.org/10.3390/v15020…
Check out the latest study by @KKanjow from RV lab that investigates the folding pathway of WT & a stabilised version of RBD of SARS-CoV2, highlighting the mechanism for enhanced immunogenicity of the latter. @gopinathchatt @SameerMalladi Link:pubs.acs.org/doi/10.1021/ac…
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@MadhusmitaTri and I investigate the 3D packing defects and non-affine displacements ( & their dynamics) in heterogeneous membranes. And implications on preferential partitioning of TM peptides and permeation pathways for small molecules in membrane with fluid phase coexistence.
Using Packing Defects in Heterogeneous Biological Membrane as a Lens to Explore Protein Localization Propensity and Small Molecule ... biorxiv.org/cgi/content/sh… #biorxiv_biophys
@MBU_IISc @gopinat90716989 @JayantikaBhowm1 Congratulations to all the authors!! 🎉🎉
@Priyank67495046 @MBU_IISc Only in-person. Btw, we are having an alumni meet on the weekend preceding the meeting (21-22 Jan). We shall be sending the details soon. Do spread the word. Not sure if freshly graduated folks like you are on the alumni email list.
@PenmatsaLab @nazia_hussain7 @ShabareeshPrv @SOURISSH @AnanthBurada @MBU_IISc @NCBS_Bangalore @EduMinOfIndia Congratulations to all the authors @PenmatsaLab , cool paper!
@PenmatsaLab @nazia_hussain7 @ShabareeshPrv @SOURISSH @AnanthBurada @MBU_IISc @NCBS_Bangalore @EduMinOfIndia Congratulations to the team…It’s indeed an incredible piece of work ..
@JayantikaBhowm1 @PenmatsaLab @ShabareeshPrv @SOURISSH @AnanthBurada @MBU_IISc @NCBS_Bangalore @EduMinOfIndia Thank you Jayantika! Congratulations for your manuscript!!!
Do not miss the “Alumni meet” tab part of the website. There are fun alumni events that are part of this, and are scheduled to precede the MBU50 symposium. Scheduled for the weekend before (21-22 Jan 2023). #mbu50
We at @MBU_IISc are quite excited to announce that we are celebrating 50 years of MBU with an in-person conference [Mon-Wed, 23-25 January 2023]. Please join us in celebrating our Golden Jubilee #mbu50. For details and registration: sites.google.com/view/mbu50/
Check out our work on the surprising deleterious effects of synonymous mutations in operonic systems. The high mutational sensitivity of ccdA antitoxin is linked to codon optimality academic.oup.com/mbe/advance-ar…
Our latest preprint on the pore dynamics of pannexin isoforms explored using cryoEM structures of PANX3, PANX1-WT, PANX1-R217H disease mutant and PANX1-W74R/R75D that mimics PANX2 pore. biorxiv.org/content/10.110…
Also, happy to announce that Jagannath will be co-hosting this monthly event with me from Oct2022. Thanks @Jmondal_tifrh for willing to come onboard. It will be wonderful to co-host with you and bring in new energy and ideas in this series. Here is the list of next four speakers.
Prof. @Jmondal_tifrh (TIFR-Hyderabad) is the next speaker in the #integrativemodeling seminar series. Title:Towards an integrative model for bacterial chromosome Tues, Sept 13 (5:30 PM IST, 2 PM CEST, 8 AM ET) Register here: mbu.iisc.ac.in/IMSS/index.html
Great meeting Debasisa Mohanty, our close friend since PhD days @MBU_IISc @iiscbangalore who has recently taken over as the Director of National Institute of Immunology, New Delhi @deb030903 @rajesh_gokhale @NImmunology @DBTIndia
We wrote an invited review (to appear in J. of Memb. Bio.), where we collate/discuss the various mechanics based mesoscopic models for protein-mediated membrane deformation studies. With an appeal to consider the chemical diversity while developing models. preprints.org/manuscript/202…
Congratulations Dr. Pavithraa Seenivasan @PaveeSeeni on your Ph.D. from @MBU_IISc @iiscbangalore ! All the best for a wonderful career ahead! Read more about her outstanding work on efficient phase coding in place cells & more in this thread! A thread (1/n)
A spotlight on the GAT1 structure by Baruch Kanner that also covers some of our recent work by @DeepthiJoseph7 @embojournal doi.org/10.15252/embj.… GABA transport goes structural cell.com/trends/pharmac…
Really enjoyed Rajarshi's talk about his theoretical/ modeling work on anomalous diffusion due to activity and packing. Tomorrow (2:30-5:30 PM, with snacks- break @MBU_IISc), he will give 2 back-to-back lectures on “Brownian motion: from Einstein (normal) to anomalous diffusion”
Divyansh has just completed his PhD at the Indian Institute of Science, Bangalore, with research that investigated how neural mechanisms maintain their function in varied biological environments. (2/7)
An integrative synthesis of work from different groups, especially over the past decade, by @PaveeSeeni arguing that the efficient information coding framework is not confined to sensory coding, but spans all scales including molecular signaling. (1/n) sciencedirect.com/science/articl…
Out in @jctc_papers now! All work done by Gaurav. Bravo for your bold outlook! Special thanks to @DST National Supercomputing Mission for grant that helps us take on such projects. Current implementation of the model is available on the Github repository github.com/codesrivastava…
We have a revised version on bioRixv now. doi.org/10.1101/2021.1… Hoping to get some reconstitution folks interested with the question "If you titrate your vesicles with multiple types of curvature proteins, how much does the sequence of titration matter?"
Happy Independence Day! 🇮🇳 Today's celebrations on campus included flag hoisting by the Director, a cultural programme, a Freedom Run & Freedom March. #AzadiKaAmritMahotsav #HarGharTiranga #IndependenceDay2022
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