Joanna Loizou @LoizouJoanna
Interested in the DNA damage response in human disease. Director of Translational Medicine at AstraZeneca. Views shared here are my own. Cambridge, UK Joined May 2018-
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It's great to see that our cover has been chosen for the July issue of @MolSystBiol. A very summery illustration of PRDX1 robots scavenging ROS in the nuclear pool, conceived by @A_Coll_Man and beautifully depicted by super artist @marillemaudit doi.org/10.15252/msb.2…
In their new @CellReports paper, researchers from former CeMM PI & @MedUni_Wien Assoc. Prof. Joanna Loizou (@LoizouJoanna) demonstrate how inhibiting the POLΘ enzyme can stop the growth of #cancer cells with mutations in #BRCA1 ✂️🧬 ➡️ bit.ly/3tBIc2l
Excited to share our work just published in Mol Cell: POLθ prevents MRE11-NBS1-CtIP-dependent fork breakage in the absence of BRCA2/RAD51 by filling lagging-strand gaps cell.com/molecular-cell…
Check out our new preprint on how metabolism impacts DNA damage and repair. Amazing collaboration with @SdelciL and led by the very talented @AmandineMorett and @KourtisSavvas ➡️biorxiv.org/content/10.110…
Check out our new preprint on how metabolism impacts DNA damage and repair. Amazing collaboration with @SdelciL and led by the very talented @AmandineMorett and @KourtisSavvas ➡️biorxiv.org/content/10.110…
Congrats to Joanna Loizou (@LoizouJoanna) on her new position at AstraZeneca UK. A “Loizou Square” in the CeMM building will remind us of all of the scientific contributions and the personal engagement. A heartfelt thank you to Joanna and her team by the CeMM Directors!
I've been holding onto this news for a minute. Excited that after 22 yrs in academia working on DDR mechanisms, I am joining @AstraZeneca to contribute to take DDR drugs to the clinics. I am really grateful to everyone I have worked with especially my team @CeMM_News @MedUni_Wien
Congratulations Chris and Nagy lab 🥼 all the best in Boston 🧫
Congratulations Chris and Nagy lab 🥼 all the best in Boston 🧫
We cannot be more proud of @ChrisWFell for his excellent PhD defense and thesis. His friendship and generous spirit will sorely be missed. This is only the beginning of an amazing scientific career: Boston, you are lucky to have him! @LBI_RUD @CeMM_News #phdlife
🆕Review out available in Early View ⚡️Exploring the genetic space of the DNA damage response for cancer therapy through CRISPR-based screens 🔓buff.ly/3IgcY7t 📝@LoizouJoanna @MedUni_Wien @CeMM_News #DNADamageResponse #DNARepair #CRISPRCas9 #CancerResearch
Great to take advantage of those hot summer nights to celebrate a newly accepted paper by @S_Zahalka and @GorkiThea. Thanks for the drinks @PhilippStarkl @MierShawig & @StefanieWidder and @LoizouJoanna & @villunger for “just passing” by. Plus @A_farawayhat @MaryemRadhouani
Our review is out covering CRISPR-based screens for interactions in the DNA damage response. Great work by Jordan Wilson, a PhD student in our lab @jordancjwilson. Thanks to Óscar @KP_twitt_llo for this exiting issue on academic drug development febs.onlinelibrary.wiley.com/doi/10.1002/18…
Want to investigate how DNA crosslinks induced by cisplatin are repaired? With @UnterlassLab we synthesized clickable cisplatin for visualization in nuclei, quantification of abundance in DNA and interactions with proteins. Great work by @AmandineMorett frontiersin.org/articles/10.33…
Great work Sara and team! Looking forward to reading it
👉 ALERT ⚡️👉👉 FIRST PREPRINT OF THE SDELCI LAB 🧐🤯 biorxiv.org/content/10.110…
andre nussenzweig lab @nussenza
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17K Followers 2K Following I'm a scientist 👨⚕️, author 📕and chair for genome stability in aging and disease at the University of CologneGaëlle Legube lab Ch.. @LabLegube
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2K Followers 484 Following The Luijsterburg lab at the LUMC in Leiden investigates DNA repair mechanisms during gene transcription.Steve Jackson Lab @SPJacksonGroup
4K Followers 136 Following Our research focuses on the DNA damage response and its links to health and diseaseMedUni Wien @MedUni_Wien
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2K Followers 71 FollowingBjörn Schumacher @schumacherbj
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2K Followers 484 Following The Luijsterburg lab at the LUMC in Leiden investigates DNA repair mechanisms during gene transcription.Steve Jackson Lab @SPJacksonGroup
4K Followers 136 Following Our research focuses on the DNA damage response and its links to health and diseaseDavid R. Liu @davidrliu
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1K Followers 57 Following Arena BioWorks is a biomedical research institute focused on uncovering the mechanisms of human disease to identify opportunities for therapeutic intervention.Sheila David @sheiladavidUCD
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648 Followers 515 Following Assistant Professor at the University of California IrvineAitken Lab @aitken_lab
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3K Followers 776 Following Director of Clinical Genomics, Royal Marsden Hospital. Prof of Translational Genomics, ICR. Views my own. Once and future Crystal Palace season ticket holder.CORTEIZ @crtzrtw
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228 Followers 298 Following Scientist interested in DNA repair at @AstraZeneca. Previous life at @Gurdoninstitute @SPJacksonGroup. Alumnus @GDSC_Sussex @keith_caldecott. 🇧🇷 🇮🇹 🇬🇧Almudena Serrano-Ben�.. @almuseben
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102 Followers 329 Following PhD student @SPJacksonGroup, @CRUK_CI, @Cambridge_UniMolecular Oncology @MolOncology
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2K Followers 110 Following Lab of Dr. Alexis Komor at the University of California, San Diego | Precision Genome Editing + The Chemical Biology of DNA Damage and RepairThe Clevers Lab @TheCleversLab
5K Followers 4 Following Hubrecht Institute, Utrecht, The Netherlandssijboulton @sijboulton
604 Followers 131 FollowingAthar Khalil @AtharKhalil17
170 Followers 261 Following Postdoctoral fellow @cwru @CWRUSOM 🇺🇲 /PhD Biomedical Sciences @AUB_Lebanon🇱🇧 I left my heart in #Beirut 💔Juliane Winkler @JulianeScience
882 Followers 880 Following Group Leader #NewPI @cancerCCR @MedUni_Wien | @UCSF Werb lab & @goga_lab alum | fascinated by #metastasis | @EMBOFellows | mom | 🇪🇺 | environmentalistAruna V Ramasamy @arunabio2011
70 Followers 629 FollowingManisha Debnath @Manisha_64
32 Followers 247 FollowingWith Andrew Tutt we define the landscape of therapy resistance mechanisms in gBRCAm advanced breast. Reversions dominate and come in multiple guises, other mechanisms visible but all result in RAD51 restoration 1/2. doi.org/10.1016/j.anno…
‘Always surround yourself with people who are better than you. Eventually you will become like them’. Beyond thankful for being part of this amazing lab!
A week late on posting this, but we had an early holiday celebration this year before people departed for vacation. Immensely grateful for this group of hard-working, hard-partying scientists!
Stellar work from @GiuseppinaDAle9, the @jacksonlab team past and present, and colleagues @UICPharm and @imbmainz, uncovering a novel "resolvase" that deals with genotoxic protein cross-links. science.org/doi/full/10.11…
@hanneslans @Jana79849530 @LoizouJoanna @AlbaMuniesaVarg Congratulations Hannes, Joanna, and all involved!
Happy to have been named as the MUW researcher of the month for December 2023! meduniwien.ac.at/web/forschung/…
📢Detection of oxaliplatin- and cisplatin-DNA lesions requires different global genome repair mechanisms that affect their clinical efficacy 🧬 Great study led by super-scientist @Jana79849530 in collaboration between @hanneslans and @LoizouJoanna labs 👏
Together with @Jana79849530, @LoizouJoanna, @AlbaMuniesaVarg and others we show that DDB2 promotes removal of oxaliplatin lesions by NER and that its cellular levels are predictive of the survival of oxaliplatin-treated CRC patients. Now out in NAR Cancer! academic.oup.com/narcancer/arti…
Together with @Jana79849530, @LoizouJoanna, @AlbaMuniesaVarg and others we show that DDB2 promotes removal of oxaliplatin lesions by NER and that its cellular levels are predictive of the survival of oxaliplatin-treated CRC patients. Now out in NAR Cancer! academic.oup.com/narcancer/arti…
@hanneslans @Jana79849530 @LoizouJoanna @AlbaMuniesaVarg Exciting work with important clinical implications. Congratulations!
@hanneslans @Jana79849530 @LoizouJoanna @AlbaMuniesaVarg Awesome to see it out. Congratulations Hannes and happy to have made a very minor contribution to this work.
How cool is it to witness the success of wonderful people? The best part of being a PI 🤩 Congratulations to 👉AMAZING @Lpascual90 👈and all co-authors 👏🎉🍾 Thanks to @marillemaudit for representing our work so beautifully! @CRGenomica @ERC_Research @CienciaGob @EmboMolMed
We are very happy to share with you the last paper of the Sdelci Lab published in @EmboMolMed where we decipher a new molecular mechanism for triple-negative breast cancer proliferation embopress.org/doi/full/10.15…. Follow us in this threat!🧵
We are very happy to share with you the last paper of the Sdelci Lab published in @EmboMolMed where we decipher a new molecular mechanism for triple-negative breast cancer proliferation embopress.org/doi/full/10.15…. Follow us in this threat!🧵
Happy to share that I've started a postdoc fellowship awarded by @Telethon_France 🤩 I'll be characterizing mitochondrial DNA maintenance proteins in health and disease 🔬🧬 in the @RadioBioPhysics team @UCA_Recherche. #mtDNA #SingleMolecule
Happy to share our review article, discussing DNA strand breaks at centromeres🧬Are they all toxic? We explore their origins and impact across cell cycle stages and quiescence - open access⬇️ doi.org/10.1016/j.semc…
Arrive early at registration Monday morning to secure your choice of conference merch #ACDTM23!
Our latest issue is a Focus on Genome Stability. Read more here: cell.com/molecular-cell…
An entire issue for Genome Stability! Nothing is more important 😜
Our latest issue is a Focus on Genome Stability. Read more here: cell.com/molecular-cell…
Happy to share our latest research on SLC15A4-TASL #innateimmunity & #autoimmunity #Lupus just out @NatureComms ! Thanks and congrats to all co-authors. More info👇
2 x SLC15A4-TASL @NatureComms! Check out our latest collaboration with @giuliosf @gsf_lab and @leoheinz. After discovering the TASL-SLC15A4 complex 3 years ago, we designed a screening assay monitoring its assembly and identified the inhibitor C5 1/4 nature.com/articles/s4146…
Congratulations to CeMM PI Christoph Bock @BockLab, Adjunct PI @abergthaler @Bergthalerlab & Prof. @Rizzi_Marta on their great inaugural lectures today @MedUni_Wien! CeMM Director @giuliosf held the laudation for our PIs, with Nobel Laureate Anton Zeilinger joining as a guest.
Celebrating @CisnerosMetztli F99/K00, @BethOsia F32, @HannahTrost1 lining up a postdoc w/ Titia DeLange, and @kaela_makins crushing her qualifying exam. @cityofhopeedu @jstarklab
2 x SLC15A4-TASL @NatureComms! Check out our latest collaboration with @giuliosf @gsf_lab and @leoheinz. After discovering the TASL-SLC15A4 complex 3 years ago, we designed a screening assay monitoring its assembly and identified the inhibitor C5 1/4 nature.com/articles/s4146…