Landmark Trials @LandmarkTrials
Collecting practice-changing clinical trials in Internal Medicine + subspecialties to promote EBM knowledge among medical learners - https://t.co/7oxB3t6Geg LMTrials.com Joined July 2021-
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@HannahBozell Quick plug for @LandmarkTrials and @2minmed Med: - EMPEROR trials - PUSH-AHF - EAGLES trial (Lancet 2016) - ED initiated Bup (PMID 25919527) Peds: - RIVUR (wildest methods ever) - 2014 Cochrane review against SABAs in Bronchiolitis - AAP SIDS Task Force work in the 80s-90s
The ORBITA-2 trial demonstrated that PCI was more effective than a placebo procedure at reducing anginal symptoms among patients with stable angina. Full article: nejm.org/doi/full/10.10… #Cardiotwitter #Cardiology #EBM #MedTwitter
Snyder et al demonstrated that testosterone treatment for hypogonadism in middle-aged and elderly men did NOT reduce the chances of fractures (3.5% in the testosterone group and 2.46% in the placebo group). Full article: nejm.org/doi/full/10.10… #MedEd #Medstudent #MedTwitter
First update for 2024! We've added summaries for 4 more practice-changing trials to our website LMTrials.com. Thank you to all those who have suggested pertinent articles for us to include! #EBM #Medstudent #MedTwitter
There are no approved targeted therapies for KRAS-mutant colorectal caner. Fakih et al just demonstrated that the TKRAS G12C inhibitor sotorasib + panitumumab improved PFS in metastatic colorectal cancer with KRAS G12C mutations. Published in @NEJM nejm.org/doi/full/10.10…
Can we do a better job of preventing ventilator acquired pneumonia? Ehrmann et al showed that 3 days of inhaled amikacin reduced the rates of VAP in patients ventilated >72 hrs. Original article: nejm.org/doi/full/10.10… #MedEd #MedTwitter #Medstudent #criticalcare #antibiotics
In patients with severe pneumonia requiring ICU care, those who received hydrocortisone had a lower risk of death as well as mechanical ventilation according to recent findings by Dequin et al. Original article: nejm.org/doi/full/10.10…… #MedTwitter #MedStudentTwitter #MedEd
🧬Eskander et al demonstrated that adding pembrolizumab immunotherapy to standard paclitaxel+carboplatin chemotherapy for advanced endometrial cancer resulted in longer progression-free survival (median PFS 13.1 vs 8.7 months). Original article: nejm.org/doi/full/10.10… #MedEd
🧠The recent DECSA trial demonstrated that for chronic subdural hematoma, patients who got standalone dexamethasone had worse outcomes than those who underwent surgery. Dexamethasone did NOT demonstrate non-inferiority. Read the trial: nejm.org/doi/full/10.10…
A new drug group for HTN? The BrigHTN Phase 2 trial of baxdrostat, an aldosterone synthase inhibitor, demonstrated dose-dependent reduction in blood pressure in patients with resistant HTN. Original study: nejm.org/doi/full/10.10… #MedEd #hypertension #EBM #Clinicaltrial
Gabriel Aleixo @chefaleixomd
3K Followers 2K Following Penny’s dad. from chef to MD, from 🇧🇷 to 🇺🇸, IM at @clevelandclinic, Hemonc fellow at @pennmedicine. Views and opinions are my own but I am sharing anyways.
Abhishek Gohel @abgohel
14K Followers 276 Following Neurologist & Epileptologist • Post-doc in Epilepsy • DM in Neurology • MD Medicine • NIMHANS & Amrita Alumnus • Long position on Video-EEG for better outcomes
Med Peds Hospitalist @medpedshosp
14K Followers 4K Following Professor of Medicine and Pediatrics. CCLCM of CWRU. Father and husband. TKD Master. 🥋 RT ≠ endorsement. Governor @OhioACP
Khalid Jazieh @kjazieh
518 Followers 410 Following Hem/Onc fellow @MayoHemeOnc. Former IM and chief resident @CCF_IMCHIEFS, graduate of @Alfaisaluniv. Founder of @LandmarkTrials. Into EBM and Medical History.
Jim Grace MD @jimgracemd
87 Followers 221 Following Med Peds Hospitalist. I believe in health care for all and coffee for those who want it. my ideas are my own, likes and retweets are not endorsements
Chris Gitter @cbgitter
210 Followers 396 Following Dog dad | MS3 @ @MedicalCollege | Pharm/Tox '20 @UWMadison | Interests: IM + nephrology | @CPFC and WI sports fan | Views = mine
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Noman Butt @nomanbutt411
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~Abdulrahman @amalmizel95
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Dr.Sandhiya @SandhiyaRamasa3
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Evender Kapoor @EvenderKapoor
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Michael Sauer @michaelcsauer
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Mabusi @MabusiMd
330 Followers 2K Following PGY-1 IM | Views are my own | MedEd | Critical Reasoning | Language enthusiast 🇹🇿🇪🇸🏴🤟| Photographer | Aspiring PCCM | POCUS enthusiast
Ahmed Issa @Ahmedissakhram
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Udit Parikh @DrParikhJrMost
131 Followers 287 Following MD Internal Medicine PGY1 👨⚕️ Sports is my 'way of living'. Into poetry, music and more! Manchester United ♥️ Team India 🇮🇳
John Joyce @JohnJoyce1224
10 Followers 53 Following Internal Medicine Resident at SUNY Upstate Medical University
kaisar alhakim @DrKaisarRx
83 Followers 116 Following Bringing expertise and compassion to pharmaceutical practice. Advocate for evidence-based healthcare and effective communication 🇺🇸🇮🇶
Taymia Ejaz @Taymia9
25 Followers 832 Following Medical student. #Amcolian Man United's Red bandi. Enjoys Alo Samosay & Siyasi phadday. Farangi/Angrezi tv series fan #TWD #BB
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fathima zerin @Onkoresident
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Mohammed Yusuf @Mohammed9297814
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Abdulmohsen Alqasabi @AbdulmohsenQas
0 Followers 7 Following سواعدكم تصنع أجمل الأحلام … تبني أعجب العجب. متخصص في الأمراض المعدية، Infectious Disease Specialist
Maithreyi Govind @MaithreyiG
38 Followers 137 Following Internal medicine resident👩⚕️ Love to 👩🎨🤠 ☘️🌺🌻💚 St John's Medical college and hospital Bangalore,India
Rawan.H @rawan_hijazy
137 Followers 423 Following
Radwan Alkhatib @AlkhatibRadwan
976 Followers 696 Following Incoming IM PGY-1 @ClevelandClinic. Teaching Assistant & alumnus ‘23 @alfaisaluniv. A first-gen doctor, Aspiring Cardiologist | Enjoying 🏊🏻♂️👨🏻🍳 🌎
Hanieh Tabatabaei @HaniehTaba
544 Followers 1K Following PGY-1 IM Resident @TexasTech | Research Collaborator @MayoClinic | Med School @MBRUniversity 🩺| Interested in Preventive Cardiology and Health Disparities🫀
G6 @V8H8H
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Dr.Naved Anjum @drnavi001
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ياسَمين 🪷 @sunbird79
749 Followers 5K Following the medical intern next door 👩🏻⚕️ || “his gift-curse is how in sunbeams he feels not heat, but the emotion of our star”
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wolf @zulukuntakinte
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Sapna Mittal @sapna0703
280 Followers 836 Following Pursuing DM Neuro from AIIMS Delhi. MD Medicine (MPSMC, Jamnagar). MBBS (BJMC, Ahmedabad)
Ryan Bailey (he/him/h.. @ryanBailey_med
65 Followers 373 Following Medical Student C’o 2025 at Long School of Medicine. Opinions are my own. Research Liaison for @UTSOMResearch
Asad @DrMAARC
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Waseem Nabi @iwaseemnabi
230 Followers 1K Following Medicine | Kashmiri | Shepherd | Believer | Bookbae | Tidsoptimist | #FOAMed Stalker | Strong predilection towards people with inner peace.
Elias Meseret @EliasMeseret32
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A R O Y @seetrips
856 Followers 489 Following Chairman, Council of Elders•Unbowed, Unbent, Undaunted • 🫢🤫🤘 📌RT not endorsement
矢吹 拓 Taku Yabuk.. @tyabu7973
4K Followers 416 Following 栃木県で病院と診療所を行き来している総合診療医です。 医学情報を中心につぶやいていきます。 Youtube channel 青島・矢吹のゆる〜く読みますか！ https://t.co/rpoEVxzhFU… 医師の教養 https://t.co/nn8zB8axYe やってます
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606 Followers 511 Following IM PGY2 @CooperIMRes | Upcoming 3rd-Year Chief Resident @CooperIMRes | Research Fellow GI - Advanced Endoscopy @Mayoclinic | MD'20 @LAUMCRH
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56 Followers 113 Following MD candidate, MSc in Data Science. Actively engaged in researching the applications of big data and artificial intelligence within the medical field.
VC @viccostales
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NEJM @NEJM
942K Followers 436 Following The New England Journal of Medicine is the world’s leading medical journal and website.
Khalid Jazieh @kjazieh
518 Followers 410 Following Hem/Onc fellow @MayoHemeOnc. Former IM and chief resident @CCF_IMCHIEFS, graduate of @Alfaisaluniv. Founder of @LandmarkTrials. Into EBM and Medical History.
Ashley Hickman @AshleyHickmanMD
291 Followers 181 Following @mayohemeonc Fellow | @MayoMN_IMRES ‘22 | @uamshealth ‘19 | Interest: symptom management, rural health, wellness, outdoors⚕️Opinions are my own
Antonious Z. Hazim, M.. @AHazimMD
502 Followers 594 Following Hematology Oncology Fellow at @MayoClinic | Thoracic malignancies, cellular and immunotherapy, phase 1 clinical trials | #oncology #cancer | Views my own
Gwasanaeth Tystiolaet.. @PHWEvidence
851 Followers 748 Following Cefnogi penderfyniadau ar sail tystiolaeth mewn @iechydcyhoeddus. Supporting evidence informed decision making for @publichealthW. Rt/follow not endorsement.
Am J Epidemiology @AmJEpi
18K Followers 201 Following American Journal of Epidemiology. Published by Oxford University Press on Behalf of the Johns Hopkins Bloomberg School of Public Health. https://t.co/ZFpyAoYxCS
NEJM Journal Watch @JWatch
59K Followers 119 Following Save time and stay informed. Our physician-editors offer you clinical perspectives on key research and news.
Annals of Int Med @AnnalsofIM
70K Followers 3K Following Annals publishes content to inform medical professionals and society, advance standards of medical research, and improve the health of people worldwide.
NEJM Evidence @NEJMEvidence
30K Followers 2K Following NEJM Evidence, a new journal from NEJM Group, presents innovative #OriginalResearch and fresh, bold ideas in #ClinicalTrial design and clinical decision-making.
Cochrane Training @cochranetrain
8K Followers 133 Following Cochrane Training provides learning for anyone who wants to contribute to systematic reviews and evidence-informed health care.
BMJ @bmj_company
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The Cochrane Library @CochraneLibrary
81K Followers 139 Following The Cochrane Library is THE place to find the most up-to-date evidence-based systematic reviews.
Cochrane @cochranecollab
127K Followers 141 Following Cochrane systematic reviews are recognized globally as the gold standard in health evidence. Trusted evidence. Informed decisions. Better health.
Journal of Clinical E.. @JClinEpi
9K Followers 2K Following Journal of Clinical Epidemiology publishes articles on innovative methods for conducting, synthesizing, disseminating, and translating health care research.
Students4BE @Students4BE
14K Followers 2K Following Students 4 Best Evidence - engaging students globally in evidence-based healthcare. Supported by @CochraneUK and @Cochranecollab #EBM #FOAMed
JAMA @JAMA_current
486K Followers 747 Following JAMA is an international peer-reviewed general medical journal published weekly online and in print, and a member of the @JAMANetwork family of journals.
The BMJ @bmj_latest
505K Followers 7K Following The BMJ is patient centred, evidence based, and independent. Help us improve the health of our world with the best science, journalism, education, and comment
JAMA Internal Medicin.. @JAMAInternalMed
107K Followers 519 Following JAMA Internal Medicine is a member of the JAMA Network, a consortium of peer-reviewed, general medical and specialty publications.
The Lancet @TheLancet
747K Followers 471 Following Welcome to The Lancet, one of the world’s leading medical journals, published weekly since 1823.@HannahBozell Quick plug for @LandmarkTrials and @2minmed Med: - EMPEROR trials - PUSH-AHF - EAGLES trial (Lancet 2016) - ED initiated Bup (PMID 25919527) Peds: - RIVUR (wildest methods ever) - 2014 Cochrane review against SABAs in Bronchiolitis - AAP SIDS Task Force work in the 80s-90s
@kjazieh Good point! Work ethics and enthusiasm to learning are the basis of whatever comes later. Btw, I recently started using @LandmarkTrials to review landmark trials in gastroenterology and I love it! Great job there! 🤩
In this randomized clinical trial, among adults with #obesity, a remotely delivered, self-directed behavioral lifestyle intervention, vs usual care, resulted in a statistically significant difference in #weightloss that was not clinically important. ja.ma/3HC5dKO
@LandmarkTrials Great thread! A great recent trial was EMPULSE (acute HF): nature.com/articles/s4159…. Also a note that although not indicated for this, in the VERTIS-CV trial (my least favorite SGLT2i ertugliflozin) HR for HHF was 0.70 (0.54-0.90) nejm.org/doi/full/10.10… for what that’s worth.
awesome thread on major SGLT-2 trials !
Landmark trial thread🧵 This series of tweets will be about key trials studying SGLT-2 inhibitors in heart failure. While initially studied for DM, these meds were shown to improve CV outcomes in CHF patients, regardless of DM status. #MedEd #EBM #CardioTwitter #clinicaltrials
@LandmarkTrials Similar results in patients with rheumatic AF in the INVICTUS trial. Things not going right with rivaroxaban, old is gold!
@LandmarkTrials Chronic heart failure patients and euvolaemic patients. Dont forget that bit. Not all b blockers in severe chronic hf are positive -BEST trial- negative.
Why ITT is key on RCTs ?? Great 🧵
Intention-to-treat (ITT) analysis is an important concept in EBM and clinical trials. But what is it, and why is it preferred for RCTs? This thread will explain ITT and hopefully clarify the most important aspects of it: #EBM #Clinicaltrial #MedEd #medstudenttwitter #biostats
@LandmarkTrials Me eating pizza as I read this
❤️ What is evidence-based practice? ❤️ What is 'best available research evidence'? ❤️ Resources to help you understand and search for evidence ❤️ How do you get involved with @cochranecollab as a student? Find out more from @CochraneUK: buff.ly/33oQWyW
The Cochrane Handbook for Systematic Reviews of Interventions includes the official guidance on the methods used in Cochrane systematic reviews. Check it here: training.cochrane.org/handbook
First week of fellowship is off to a great start! Excited to work with this amazing team! @MayoClinic @MayoCancerCare @MayoHemeOnc
Classic !
Gines et al demonstrated that IV albumin following paracentesis helped avoid renal and electrolyte complications. [Gastroenterology, 1998]. See more: LMTrials.com Original: gastrojournal.org/article/0016-5… #MedTwitter #MedEd #GITwitter #Medstudenttwitter #EBM
Wondering how to design a descriptive study? @leskocar, @ProfMattFox, & @edwardsjk outline components of a good descriptive question and provide guidance for conducting useful descriptive analyses! ow.ly/Yn4350JOYhI
Our latest update is live! We've added 5 new trials, including the AFIRE cardiology trial, the PIONEER 1 diabetes trial, and the RxPONDER trial for breast cancer. You can find all our trial summaries at LMTrials.com #MedEd #MedStudentTwitter #internalmedicine #EBM
Really great explanation
This can be confusing, but the excellent explanation below by @tom_siegfried should hopefully clarify! Source: sciencenews.org/blog/context/s…
Just because a treatment has been shown to lead to statistically significant improvements in symptoms does not necessarily mean that these improvements will be clinically significant (i.e. meaningful or relevant to patients). buff.ly/2GGQ6T9
This #RCT evaluated infliximab withdrawal in pts with #Crohns disease in remission on infliximab maintenance therapy. Time to relapse was significantly shorter among patients who discontinued IFX than those who continued therapy. eviden.cc/3xOBtVG #GITwitter #MedTwitter
🎧 Pop your headphones in and learn all about the #systematicreview. An hour-long podcast where Fiona Stewart from @cochranecollab talks through the what, why and how of a systematic review.
New episode from the @ScienceBasement Podcast made with @cochranecollab! @DidioGiuliano & @wooblecopter interview Fiona Stewart reviewer at Cochrane. Listen on: @Spotify buff.ly/2SUISkt @iTunes buff.ly/3vAIpSr @SoundCloud buff.ly/3wcgoB6 #tttv2021 #scicomm
@LandmarkTrials = great compendium of “RCT in medicine”. Thanks @kjazieh @ClevelandClinic and your colleague 🙏🙏
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